期刊
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
卷 38, 期 4, 页码 681-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.rdc.2012.09.001
关键词
Bisphosphonate; Safety; Side effects; Osteonecrosis of the jaw; Atypical femoral fracture; Atrial fibrillation; Esophageal cancer; Esophagitis
类别
Bisphosphonates are antiresorptive medications widely prescribed for treating osteoporosis. In placebo-controlled clinical trials they have been shown to significantly reduce the risk of osteoporotic fractures. However, reports of atypical femoral fractures and osteonecrosis of the jaw have emerged with long-term use, raising questions regarding their long-term safety. Additionally, questions have also emerged regarding the association between bisphosphonates and other rare adverse events, such as esophageal cancer and atrial fibrillation. This article summarizes the current knowledge regarding the major side effects associated with the use of bisphosphonates, identifies at-risk populations for these side effects, and provides guidance for their use.
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