Review
Developmental Biology
Naoya Yamaguchi, Holger Knaut
Summary: Cell-extracellular matrix interactions are essential for cell anchoring and migration, with focal adhesions (FAs) playing a key role. However, the role of FAs in vivo is still not well understood.
Article
Microbiology
Courtney M. Klappenbach, Nicholas M. Negretti, Jesse Aaron, Teng-Leong Chew, Michael E. Konkel
Summary: Our study reveals that C. jejuni infection alters the size and topology of focal adhesions in epithelial cells, leading to changes in cell adhesion strength and motility. The increased phosphorylation of paxillin and altered turnover at focal adhesions may contribute to the effects on cell behavior. Additionally, inhibiting protein synthesis or using specific mutants of C. jejuni can partially reverse these effects, suggesting a potential mechanism for the observed restricted intestinal repair in infected animals.
Article
Biochemistry & Molecular Biology
Yu-Shan Lin, Yi-Hsin Lin, MyHang Nguyen Thi, Shih-Chuan Hsiao, Wen-Tai Chiu
Summary: The dysregulation of store-operated Ca2+ entry (SOCE) is associated with cancer progression. Upregulation of stromal interaction molecule 1 (STIM1) promotes cancer cell migration, invasion, and metastasis, while excessive Ca2+ can have a negative impact on cancer metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yu Mei, Kai Li, Zhicheng Zhang, Mengmeng Li, Hong Yang, Hui Wang, Xuemei Huang, Xinyuan Li, Shuhua Shi, Huanjie Yang
Summary: Despite the long-lasting responses of androgen-deprivation therapy, prostate cancer often progresses to metastatic castration-resistant prostate cancer. This study identified miR-33b-3p as a tumor suppressor in prostate cancer, with overexpression inhibiting migration and invasion of highly metastatic cells. The study also found that DOCK4 is a direct target of miR-33b-3p, suggesting a potential therapeutic strategy for overcoming the poor efficacy of proteasome inhibitors in metastatic prostate cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiaxian Zhu, Ting Long, Lingfang Gao, Yan Zhong, Ping Wang, Xiaoyan Wang, Zuguo Li, Zhiyan Hu
Summary: In this study, RPL21 was found to be involved in promoting CRC metastasis by regulating FA formation in a LAMP3-dependent manner. The interaction between RPL21 and LAMP3 may serve as a potential therapeutic target against CRC.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Medicine, Research & Experimental
Wenlong Zhang, Bincan Jiang, Hecheng Zhu, Ailan Cheng, Can Li, Haoxuan Huang, Xuewen Li, Yirui Kuang
Summary: miR-33b is a critical microRNA that is down-regulated in cancer cells and affects the biological behavior of cancer cells by regulating multiple signaling pathways. The abnormal expression of miR-33b is associated with the clinicopathological data and prognosis of tumor patients. This study systematically summarizes the regulatory mechanisms of miR-33b and provides potential hints and direction for future miR-33b-related research.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Hongtao He, Muliang Ding, Tao Li, Wenzhi Zhao, Lu Zhang, Peng Yin, Wei Zhang
Summary: This study discovers that NORAD, a non-coding RNA highly expressed in osteosarcoma cells, can be delivered to osteosarcoma cells through extracellular vesicles (EVs) released by bone mesenchymal stem cells (BMSCs), thereby promoting proliferation and invasion of osteosarcoma. NORAD is found to interact with miR-30c-5p and KLF10, and regulates the miR-30c-5p/KLF10 axis to influence the development and metastasis of osteosarcoma.
LABORATORY INVESTIGATION
(2022)
Article
Cell Biology
Xinyi Ren, Xiaopu Guo, Zihan Liang, Renxian Guo, Shaohui Liang, Han Liu
Summary: Cell migration is a complex process that involves the coordination of various cellular components. In this study, we discovered a novel interaction between IQGAP1 and Hax1, which plays a significant role in focal adhesion turnover and directional cell migration. Our findings suggest that Hax1 acts as a link between dynamic focal adhesions and IQGAP1, facilitating efficient cell migration. Perturbation of the IQGAP1/Hax1 interaction impairs focal adhesion turnover and inhibits directional cell migration.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Giulia Spennati, Lisa F. Horowitz, David J. McGarry, Dominika A. Rudzka, Garett Armstrong, Michael F. Olson, Albert Folch, Huabing Yin
Summary: Metastasis is the primary cause of cancer patient mortality, and studying this process using organotypic liver and brain slices shows promise in closely replicating the tumour microenvironment for in vitro testing. Different invasion patterns and behaviors were observed in the breast cancer cells within the brain and liver slices, with variations in cell stiffness and adhesion forces influencing invasiveness. Inhibition of the Ras/MAPK/ERK pathway resulted in reduced invasiveness, highlighting the potential of organotypic tissue slices to better mimic in vivo conditions during cancer cell metastasis compared to traditional in vitro models.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Hung-Chih Lo, Wei-Jyun Hua, Hsin Yeh, Zhi-Hu Lin, Li-Chen Huang, Yi -Ru Ciou, Runcheng Ruan, Kai-Fan Lin, Ai -Jung Tseng, Alexander T. H. Wu, Wei-Hung Hsu, Chi -Hong Chao, Tung-Yi Lin
Summary: This study demonstrates that GMI protein inhibits lung cancer metastasis by suppressing cell migration and disrupting cell adhesion. GMI also induces degradation of integrins and increases expression of epithelial markers, leading to reduced pulmonary lesions in mice.
Article
Cell Biology
Elizabeth Riffo, Mario Palma, Matias Hepp, Diego Benitez-Riquelme, Vicente A. Torres, Ariel F. Castro, Roxana Pincheira
Summary: SALL2/Sall2 is a transcription factor associated with development, neuronal differentiation, and cancer. Sall2 promotes cell migration by modulating focal adhesion dynamics and transcriptionally regulating integrin beta 1 expression and FAK autophosphorylation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Xu Zhao, Jizhao Wang, Rui Zhu, Jing Zhang, Yunfeng Zhang
Summary: DLX6-AS1 regulates cisplatin sensitivity of lung squamous cell carcinoma cells through the miR-181a-5p/miR-382-5p/CELF1 axis, playing a key role in promoting secondary cisplatin resistance. Targeting DLX6-AS1 may be a novel approach to overcome cisplatin resistance in lung squamous cell carcinoma.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Fengqi Zhou, Binbin Wang, Hong Wang, Lang Hu, Junxia Zhang, Tianfu Yu, Xiupeng Xu, Wei Tian, Chunsheng Zhao, Haifeng Zhu, Ning Liu
Summary: This study demonstrates that circMELK acts as an oncogene in GBM, regulating mesenchymal transition and GSC maintenance by sponging miR-593. EphB2 is involved in the circMELK/miR-593 axis induced GBM tumorigenesis. This finding suggests a potential novel therapeutic target for gliomas.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Elizabeth Riffo, Mario Palma, Matias Hepp, Diego Benitez-Riquelme, Vicente A. Torres, Ariel F. Castro, Roxana Pincheira
Summary: SALL2/Sall2 is a transcription factor that plays a positive role in cell migration, and its deficiency can lead to decreased cell motility and altered focal adhesion dynamics. Sall2 promotes cell migration by regulating integrin beta 1 expression and FAK autophosphorylation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Peiling Zhang, Xiaofei Cao, Mingmei Guan, Dailing Li, Hong Xiang, Qian Peng, Yun Zhou, Chengyin Weng, Xisheng Fang, Xia Liu, Haibo Mao, Qiao Li, Guolong Liu, Lin Lu
Summary: This study elucidated the oncogenic role and biological function of copine VIII (CPNE8) in gastric cancer (GC). Increased expression of CPNE8 was positively correlated with metastasis and served as an independent prognostic risk factor for poor survival. CPNE8 promoted cell proliferation, migration, and invasiveness in GC. Additionally, CPNE8 was significantly associated with the tumor microenvironment and predicted poor efficacy of immune checkpoint therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Agricultural Engineering
Hu Cheng, Jiapeng Zhang, Yueyi Chen, Wenrui Zhang, Rongting Ji, Yang Song, Wei Li, Yongrong Bian, Xin Jiang, Jianming Xue, Jiangang Han
Summary: A one-pot co-pyrolysis strategy using potassium/calcium carbonate and biowaste-derived hydrochar was proposed to prepare hierarchical porous biochars (HPBs). The pore structure of HPBs could be controlled by adjusting the mass ratios of different carbonates. HPBs exhibited hydrophobicity, nitrogen doping, graphitization, and surface functional groups, and showed unexpectedly high sorption quantity for diethyl phthalate. The sorption mechanisms were identified as Lewis acid-base interaction, pi-pi stacking interaction, hydrogen bonding interaction, partitioning, and pore filling.
BIORESOURCE TECHNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Neel M. Butala, Kamil F. Faridi, Hector Tamez, Jordan B. Strom, Yang Song, Changyu Shen, Eric A. Secemsky, Laura Mauri, Dean J. Kereiakes, Jeptha P. Curtis, C. Michael Gibson, Robert W. Yeh
Summary: This study compares the differences between the DAPT Study population and a contemporary population of US patients receiving percutaneous coronary intervention, and finds that the benefits of prolonged DAPT are attenuated in the modern population, while the risk of bleeding persists.
Article
Cardiac & Cardiovascular Systems
Allen Wang, Enrico G. Ferro, Yang Song, Jiaman Xu, Tianyu Sun, Robert W. Yeh, Jordan B. Strom, Daniel B. Kramer
Summary: Frailty is common in patients undergoing LAAC and is associated with increased risks of long hospital stay, readmissions, and short-term mortality.
Article
Health Care Sciences & Services
Ahmed Ahmed, Yang Song, Rishi K. Wadhera
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Engineering, Environmental
Qi Qin, Bingwei Yang, Jing Liu, Erqun Song, Yang Song
Summary: The exposure of PCB29-pQ was found to promote aerobic glycolysis in breast cancer through the activation of GLUT1 signaling pathway. Inhibition of GLUT1 reversed the effects on migration and invasion of MDA-MB-231 cells induced by PCB29-pQ, and repression of GLUT1 also suppressed breast cancer metastasis in nude mice inoculated with 4T1-luc cells.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Engineering, Biomedical
Yangyang Song, Xue Tan, Yanan Gao
Summary: In this study, a liposome decorated with platelet membrane was developed to enhance the specific tumor-targeting capability and antitumor responses of photodynamic therapy (PDT) in breast cancer treatment. The results showed that the platelet membrane-decorated liposome could effectively improve the cellular internalization of the loaded drug and generate sufficient reactive oxygen species (ROS) to inhibit tumor growth. The study provides a biomimetic strategy to improve the therapeutic efficacy of PDT in breast cancer.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2022)
Article
Green & Sustainable Science & Technology
Liqin Wang, Li Zhao, Yunxian Zhang, Dan Li, Lihua Chen, Zimin Wei, Xiaomeng Chen, Chaonan Pan, Yangyang Song
Summary: This study aimed to investigate the role of metabolic regulators in promoting organic N transformation and reducing N losses during composting. Results showed that adding metabolic regulators significantly increased organic N content and reduced N losses, especially in composting of garden waste.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Cardiac & Cardiovascular Systems
Nino Mihatov, Ramya C. Mosarla, Ajay J. Kirtane, Sahil A. Parikh, Kenneth Rosenfield, Siyan Chen, Yang Song, Robert W. Yeh, Eric A. Secemsky
Summary: This study found that PAD was associated with worse limb outcomes and survival among patients with AMI and CS. Compared to those without PAD, patients with PAD had higher risks of in-hospital mortality, amputation, and out-of-hospital mortality.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Automation & Control Systems
Yongzhuang Liu, Yang Song, Wenshuai Gao
Summary: This paper addresses the approximate bisimulation problem for switched nonlinear systems with mode-dependent dwell time. It presents a criterion for incremental stability and a solvable criterion for the case of linear subsystems. Additionally, a symbolic model that is approximately bisimilar to the original system is developed using the grid-based approach, with the corresponding bisimilar precision provided.
JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS
(2022)
Article
Optics
Huajun Cai, Yang Song, Yunjing Ji, Zhenhua Li, Anzhi He
Summary: Background-oriented schlieren tomography (BOST) is an effective method for flowfield measurement, which utilizes ray deflection in an inhomogeneous field and is sensitive to refractive index gradient. In this article, a calculation method of projection matrix based on radial basis function (RBF) is proposed, allowing direct reconstruction of the 3D distribution of refractive index. Numerical simulations and experiments verify the accuracy and stability of the proposed method, providing a new solution for 3D instantaneous flowfield measurement.
Article
Environmental Sciences
Bingwei Yang, Yuting Wang, Changyu Fang, Erqun Song, Yang Song
Summary: Exposure to PBDEs metabolite PBDEQ induces ROS and mitochondrial dysfunction, promoting NLRP3 inflammasome activation through the TLRs-NF-kappa B signaling pathway. Additionally, bromine metabolism and K+ efflux are involved in the activation of this inflammatory response.
ENVIRONMENTAL POLLUTION
(2022)
Article
Computer Science, Interdisciplinary Applications
Tiange Xiang, Yang Song, Chaoyi Zhang, Dongnan Liu, Mei Chen, Fan Zhang, Heng Huang, Lauren O'Donnell, Weidong Cai
Summary: We propose a novel weakly-supervised framework for classifying whole slide images (WSIs), which integrates information at both local and regional levels for better classification performance.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Environmental Sciences
Xinjia Zhang, Yang Song, Sitong Qian, Shijun Wang, Donghang Wu
Summary: This study provides a comprehensive dataset of known brownfield sites and their distributions in China, analyzing their spatial distribution patterns and hotspots. Factors influencing brownfield formation are identified and the importance of understanding the spatial distribution for land use planning and redevelopment is emphasized.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2022)
Article
Soil Science
Yufei Yu, Jia Li, Yang Song, Zhengyan Zhang, Songguo Yu, Meiling Xu, Yangyang Zhao
Summary: This study evaluated the effects of polyethylene (PE) and polypropylene (PP) microplastics on the growth of pak choi. The results showed that the toxic effects varied among different plastic types, concentrations, and particle sizes. PP microplastics, especially those with small particle sizes, had negative impacts on the growth and antioxidant capacity of pak choi. In contrast, PE exposure improved the activities of antioxidant enzymes in pak choi, potentially counteracting the negative effects. The findings also suggested that PP and PE may indirectly inhibit pak choi growth by reducing soil aeration.
APPLIED SOIL ECOLOGY
(2022)
Article
Health Care Sciences & Services
Nicholas Chiu, Rahul Aggarwal, Yang Song, Rishi K. Wadhera
Summary: This study compared patient-reported experiences at safety-net and non-safety-net hospitals in the US, finding that the implementation of the VBP program did not improve patient experience at safety-net hospitals compared to non-safety-net hospitals.