期刊
REVUE NEUROLOGIQUE
卷 165, 期 12, 页码 1023-1028出版社
MASSON EDITEUR
DOI: 10.1016/j.neurol.2009.09.012
关键词
Microglia; Macrophages; Multiple sclerosis; Neuroinflammation; Neurodegeneration
资金
- Association pour la recherche Sur la sclerose en plaques (ARSEP) or Society for Research on Multiple Sclerosis)
Diffuse neurodegeneration is now considered to be the main cause of irreversible neurological disability in multiple sclerosis (MS). Demonstration of a diffuse inflammatory reaction in the MS brain led to the assumption that diffuse neuroinflammation induces diffuse neurodegeneration. Macrophages/microglia accumulate throughout the MS brain and are, therefore, considered the main culprits implicated in the development of neurodegeneration. However, recent advances in the understanding of macrophage/microglia functions and origins have now challenged that view. This report is a summary of these advances, and discusses their contribution to the perception of macrophage/microglia functions in MS-associated neurodegeneration. (C) 2009 Elsevier Masson SAS. All rights reserved.
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