Article
Biochemistry & Molecular Biology
Magdalena Wytrwal, Malgorzata Sekula-Stryjewska, Agata Pomorska, Ewa Oclon, Ewa Zuba-Surma, Szczepan Zapotoczny, Krzysztof Szczubialka
Summary: This study investigated the covalent binding of recombinant human bone morphogenetic protein-2 and -7 in stem cells and its effects on cell adhesion, migration, and osteogenesis. The presence of both proteins enhanced cell adhesion but limited cell motility, while the presence of single proteins promoted cell migration activity. Additionally, the coexistence of the proteins significantly increased early osteogenic marker expression.
Article
Engineering, Biomedical
Sarah A. Schoonraad, Alan A. Jaimes, Arjun J. X. Singh, Kiera J. Croland, Stephanie J. Bryant
Summary: This study investigates the osteogenic effects of tethered BMP-2 and BMP-9 on human MSCs encapsulated in a hydrogel. The results show that tethered BMP-2 and BMP-9 both effectively enhance osteogenesis of MSCs, leading to a mature osteoblast phenotype.
ACTA BIOMATERIALIA
(2023)
Article
Multidisciplinary Sciences
Sabrina H. Rossi, Izzy Newsham, Sara Pita, Kevin Brennan, Gahee Park, Christopher G. Smith, Radoslaw P. Lach, Thomas Mitchell, Junfan Huang, Anne Babbage, Anne Y. Warren, John T. Leppert, Grant D. Stewart, Olivier Gevaert, Charles E. Massie, Shamith A. Samarajiwa
Summary: Current diagnostic strategies are unable to differentiate between benign and malignant small renal masses accurately, leading to unnecessary surgery in 20% of patients. The MethylBoostER machine learning model, utilizing DNA methylation data, can classify pathological subtypes of renal tumors and provide a more confident presurgical diagnosis, potentially improving treatment decision-making.
Article
Chemistry, Medicinal
Anirban Sardar, Alisha Ansari, Sampa Gupta, Shradha Sinha, Shubham Pandey, Divya Rai, Mukesh Kumar, Rabi Sankar Bhatta, Ritu Trivedi, Koneni Sashidhara
Summary: A series of compounds were designed and synthesized using molecular hybridization approach. Among them, compound 47 was identified as the most potent osteoanabolic agent, promoting osteogenesis via the non-canonical p38 pathway mediated by RUNX2 and BMP2. It has the potential to be used as a lead for future bone metabolic disorder treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Hyun Seok, Hee-Youl Kim, Dong-Cheol Kang, Jung-Ho Park, Jong Hoon Park
Summary: The study compared the bone regeneration ability of bone scaffolds using particle and block bones with rhBMP-2, showing that rhBMP-2 with block bones resulted in significantly higher bone volume but also led to the formation of adipose tissue and void spaces.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Olga Katzendorn, Inga Peters, Natalia Dubrowinskaja, Hossein Tezval, Pouriya Faraj Tabrizi, Christoph A. von Klot, Joerg Hennenlotter, Marcel Lafos, Markus A. Kuczyk, Juergen Serth
Summary: Our study revealed a significant association between TACSTD2 methylation and disease progression and clinical course of RCC, indicating a potential role of this gene in the development of RCC.
Article
Engineering, Biomedical
Jonathan Dorogin, Henry B. B. Hochstatter, Samantha O. O. Shepherd, Justin E. E. Svendsen, Morrhyssey A. A. Benz, Andrew C. C. Powers, Karly M. M. Fear, Jakob M. M. Townsend, James S. S. Prell, Parisa Hosseinzadeh, Marian H. H. Hettiaratchi
Summary: By using yeast surface display, unique BMP-2-specific affibodies were identified to modulate the release and activity of BMP-2, offering a promising approach for controlling BMP-2 delivery in clinical applications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Sihan Lin, Shi Yin, Junfeng Shi, Guangzheng Yang, Xutao Wen, Wenjie Zhang, Mingliang Zhou, Xinquan Jiang
Summary: In this study, the dose of bone morphogenetic protein-2 (BMP-2) was reduced and its safety and efficacy were improved through the regulation of magnesium ion (Mg2+). Magnesium ion enhanced cellular bioenergetic levels and the osteoinductivity of BMP-2. A co-delivery system, fabricated using microfluidic and 3D printing technologies, was able to rapidly and robustly induce bone regeneration.
BIOACTIVE MATERIALS
(2022)
Article
Oncology
Y. Hu, L. Yu, F. Xia, F. Liang, C. Cheng, Y. Huang, L. Xiao
Summary: The expression of BMP-10 is significantly correlated with the pathological characteristics and prognosis of EC patients, with lower expression leading to poorer TFS and OS rates.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Gaoli Xu, Chenxi Shen, Haiyan Lin, Jian Zhou, Ting Wang, Ben Wan, Munerah Binshabaib, Tymour Forouzanfar, Guochao Xu, Nawal Alharbi, Gang Wu
Summary: This study synthesized a novel biomimetically-precipitated nanocrystalline calcium phosphate (BpNcCaP) with internally incorporated bone morphogenetic protein-2 (BpNcCaP + BMP-2), demonstrating its potential application in repairing large-volume bone defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Cheol Hee Jeong, Song-Yi Lim, Jo Eun Um, Hyo Won Lim, Kyu Ho Hwang, Kyeong-Mee Park, Jun Seop Yun, Dohun Kim, Jong-Ki Huh, Hyun Sil Kim, Jong In Yook, Nam Hee Kim, Yoon Hae Kwak
Summary: This study introduces micellized bone morphogenetic protein-2 (mPTD-BMP-2), a next-generation osteogenic supplement that combines protein transduction domain (PTD) and nano-sized micelle formulation technique to improve transduction efficiency and stability. The use of PTD represents a novel approach, and our results demonstrate the superiority of mPTD-BMP-2 over rh-BMP-2 in terms of in vivo pharmacokinetic profile and osteogenic potential, particularly in a rat tibial model of distraction osteogenesis.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Eun Young Jeon, Seung-Hoon Um, Jaeho Park, Youngmee Jung, Cheol-Hong Cheon, Hojeong Jeon, Justin J. Chung
Summary: In this study, a complex coacervate consisting of fucoidan and poly-l-lysine (PLL) was fabricated to encapsulate BMP-2, avoiding denaturation and enhancing therapeutic action. The coacervate showed superior binding ability to BMP-2 and allowed for prolonged release, improving its bioactivity and protection against antagonist and proteolysis. The coated coacervate on collagen sponges demonstrated bioactivity and localized bone regenerating ability in vitro and in vivo evaluations.
Article
Biotechnology & Applied Microbiology
Xianggang Wang, Zhengyan Li, Zhonghan Wang, He Liu, Yutao Cui, Yuzhe Liu, Ming Ren, Hongsheng Zhan, Zuhao Li, Minfei Wu, Jincheng Wang
Summary: The study developed a thermosensitive hydrogel loaded with BMP-2 and OPG to promote bone formation and inhibit osteoclast activity, which was then used to construct 3D-printed composite scaffolds. These scaffolds facilitated osteogenic differentiation, reduced osteoclastic activation, and improved bone ingrowth and osseointegration through sustained release of BMP-2 and OPG.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Medicine, General & Internal
Thomas Fuchs, Josef Stolberg-Stolberg, Philipp A. Michel, Patric Garcia, Susanne Amler, Dirk Wahnert, Michael J. Raschke
Summary: The study evaluates the effectiveness of rhBMP-2 treatment on long bone non-unions, showing significantly faster bone healing and higher union rates after rhBMP-2 application. Femoral and tibial non-unions in particular seem to benefit from rhBMP-2 application.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Theresa Farhat, Amel Dudakovic, Jay H. Chung, Andre J. van Wijnen, Rene St-Arnaud
Summary: The catalytic subunit of DNA-PKcs plays a negative regulatory role in osteoblast differentiation, and inhibitors of DNA-PKcs may have therapeutic potential for bone regeneration and metabolic bone diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
