Review
Immunology
Ding-Yu Rao, De-Fa Huang, Mao-Yan Si, Hua Lu, Zhi-Xian Tang, Zu-Xiong Zhang
Summary: As an important mediator of information transfer between cells, exosomes play a unique role in regulating tumor growth, supporting vascular proliferation, tumor invasion, and metastasis. Exosomes can be used as a potential tool for non-invasive liquid biopsy due to their presence in various body fluids. This study reviews the role of exosomes in liquid biopsy, tumor microenvironment formation, and epithelial-mesenchymal transition in non-small cell lung cancer (NSCLC). It also discusses the occurrence of EGFR+ exosomes and the role of exosomes and their contents in non-invasive detection and potential therapeutic targets in EGFR-mutated lung cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Integrative & Complementary Medicine
Yuan Liang, Tiehua Zhang, Siyuan Jing, Peng Zuo, Tiezhu Li, Yongjun Wang, Shaochen Xing, Jie Zhang, Zhengyi Wei
Summary: 20(S)-Rg3, a triterpenoid saponin, was confirmed to be an EGFR-TKI and play a key role in regulating the EGFR/Ras/Raf/MEK/ERK signal pathway. It can inhibit A549 cell proliferation by blocking the cell cycle at the G0/G1 phase through downregulating CDK2, Cyclin A2, and Cyclin E1.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Xiao Li, Wei Liu, Chong Geng, Tingting Li, Yanni Li, Yaoyu Guo, Chunhui Wang
Summary: This study demonstrated that Ginsenoside Rg3 could effectively inhibit colon cancer cell invasion and metastasis by suppressing the Notch-Hes1-EMT signaling pathway.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Oncology
Francesca Iommelli, Viviana De Rosa, Cristina Terlizzi, Rosa Fonti, Rosa Camerlingo, Maria Patrizia Stoppelli, C. Allison Stewart, Lauren Averett Byers, David Piwnica-Worms, Silvana Del Vecchio
Summary: Notch1 and EGFR are two different surface receptors in cancer cells, with high levels of active Notch1 leading to resistance to EGFR inhibitors by regulating the promoter activity of the EGFR gene and causing a reversible shift of driver dependence from EGFR to Notch1.
Article
Oncology
Ming Yang, Shi Chang Liu, Ding Jun Hao, Liang Yan, Zhong Kai Liu, Xin Hua Yin
Summary: RP11-867G2.8 is highly expressed in chordoma and promotes the malignant behavior of chordoma cells by regulating the expression of FUT4. These findings are important for further understanding the development of chordoma and identifying potential target genes for chordoma treatment.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yeon-Jee Kahm, In-Gyu Kim, Rae-Kwon Kim
Summary: Cancer stem cells (CSCs) pose challenges for cancer treatment, and this study discovers that RanBP1 is highly expressed in lung cancer stem cells (LCSCs) and glioma stem cells (GSCs). Upregulated expression of RanBP1 is associated with CSC marker proteins, regulators, and poor patient prognosis. RanBP1 can modulate the cancer microenvironment and may serve as a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Jing Zhao, Wenxi Tan, Lingyi Zhang, Jian Liu, Mengyuan Shangguan, Junyu Chen, Benzheng Zhao, Yuanqing Peng, Manhua Cui, Shuhua Zhao
Summary: This study identified that FGFR3 overexpression enhances DDP-resistance in ovarian cancer by promoting EGFR phosphorylation and activating the PI3K/AKT pathway. FGFR3 was found to be co-expressed with EGFR, and silencing FGFR3 inhibited the activation of the PI3K/AKT pathway and hindered drug resistance and tumor cell development. Targeting FGFR3 and inhibiting EGFR phosphorylation were observed to promote the therapeutic effect of DDP in nude mice.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cell Biology
Yongrong Yan, Peipei Zhao, Zihuan Wang, Zhen Liu, Zhizhi Wang, Jinglan Zhang, Yanqing Ding, Xing Hua, Lina Yu
Summary: PRMT5 is highly expressed in colorectal cancer and controls the proliferation, cell cycle progression, and EMT of CRC cells by regulating the EGFR/Akt/GSK3 beta signaling cascades.
Article
Oncology
Po-Chun Tseng, Chia-Ling Chen, Kang-Yuan Lee, Po-Hao Feng, Yu-Chih Wang, Rahmat Dani Satria, Chiou-Feng Lin
Summary: The study reveals that tumor cells may escape from IFN-gamma immunosurveillance through EMT, and inhibiting SHP2 activation can enhance IFN-gamma-induced anticancer activities in lung cancer.
Article
Oncology
Junxiong Wang, Shuo Yang, Li Min, Shengtao Zhu, Shuilong Guo, Shutian Zhang
Summary: ECT2 is significantly elevated in PDAC tissues and cells and correlates with advanced disease progression, distant metastases, and overall survival. ECT2 promotes proliferation, migration, and invasion in PDAC cells, as well as tumor growth and metastasis in vivo. ECT2 is involved in the post-translational regulation of Grb2 and also impacts EGFR levels through degradation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Hui Xu, Jin Wang, Murad Al-Nusaif, Huipeng Ma, Weidong Le
Summary: In this study, we identified CCL2 as a key gene involved in the metastasis and epithelial-mesenchymal transition of non-small cell lung cancer (NSCLC). CCL2 activates the PI3K/Akt/mTOR axis and inhibits the autophagy signaling pathway, promoting the progression of NSCLC.
CELL PROLIFERATION
(2023)
Article
Cell Biology
Lin-lin Zhang, Qi Li, Dian-sheng Zhong, Wei-jian Zhang, Xiao-jie Sun, Yu Zhu
Summary: The study revealed that lung adenocarcinoma patients with high expression of MCM5 and HDAC1 had poor survival, as these factors could promote proliferation and invasion of lung cancer cells. Astragaloside IV can block the interaction between HDAC1 and MCM5, inhibiting the malignant progression of lung cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Lin-lin Zhang, Qi Li, Dian-sheng Zhong, Wei-jian Zhang, Xiao-jie Sun, Yu Zhu
Summary: The interaction between MCM5 and HDAC1 exacerbates the EMT dependent malignant progression of lung cancer. Overexpression of MCM5 and HDAC1 promotes proliferation and invasion in lung cancer cells. Astragaloside IV can block the interaction between HDAC1 and MCM5, inhibiting the progression of lung cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Xishan Chen, Renba Liang, Huan Lin, Kaihua Chen, Li Chen, Ge Tian, Xiaodong Zhu
Summary: Downregulation of CD166 inhibited CSC-related genes and decreased pEGFR and pERK expression in vitro and in vivo. The sphere formation and tumorigenesis ability of CD166-shRNA cells were significantly reduced. Additionally, EGF-stimulated CD166-shRNA cells showed an increase in CSC-like traits by activating the EGFR/ERK1/2 signaling pathway.
Article
Medicine, Research & Experimental
Mohit Rajput, Ragini Singh, Navneendra Singh, Rana P. Singh
Summary: The study revealed that the EGFR signaling pathway regulates DNA damage repair, survival, and epithelial-mesenchymal transition (EMT) responses in prostate cancer cells through transcriptional regulation of Rad51. This suggests a novel role of the EGFR-Erk1/2/Akt-Rad51 axis in modulating EMT and DNA repair pathways in prostate cancer resistance mechanisms.