Article
Pharmacology & Pharmacy
Jinjun Wu, Muyan Kong, Yanmei Lou, Leyan Li, Chunlin Yang, Huifang Xu, Yuqi Cui, Hong Hao, Zhenguo Liu
Summary: This study found that FMNT significantly enhances endothelial function and promotes angiogenesis through activating Erk1/2- and Akt-mediated eNOS/NO signaling pathway. Simultaneous activation of Erk1/2 and Akt signaling is required for FMNT-induced promotion of endothelial function, providing evidence for potential clinical applications in conditions related to vascular insufficiency.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Haoliang Li, Renhao Jiang, Lejing Lou, Chao Jia, Linfang Zou, Mochuan Chen
Summary: Formononetin demonstrated dose-dependent promotion of skin flap viability by reducing oxidative stress and inflammation and enhancing angiogenesis. Its antioxidant effects were mediated through Nrf2 activation, indicating its potential as a candidate drug for enhancing skin flap survival.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Nahla E. El-Ashmawy, Eman G. Khedr, Naglaa F. Khedr, Samar A. El-Adawy
Summary: This study aimed to investigate the potential role of Mont, a cysteinyl leukotriene receptor antagonist, in mitigating EMT in TNBC and SEC bearing mice, and the underlying molecular mechanisms with or without sirtuin-1 inhibitor (Sirt). The results showed that Mont and/or Sirt decreased cell proliferation, migration, and suppressed EMT in both in vitro and in vivo experiments. The treatments downregulated sirtuin-1 and vimentin expression, upregulated E-cadherin expression, and inhibited angiogenesis. The cotreatment with Sirt and Mont exhibited more effective anti-tumor activity, possibly due to the inhibition of sirtuin-1 and AKT-activated pathways and subsequent inhibition of EMT.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yi Dai, Yuxingzi Chen, Yong Chen, Zheng Xu, Jinhua Ding
Summary: The effect of formononetin on the PTEN/Akt pathway and angiogenesis in transplanted breast cancer tumors in nude mice was investigated. Different doses of formononetin or taxol were administered to groups of nude mice with transplanted tumors. It was found that formononetin up-regulates PTEN expression, decreases Akt phosphorylation, and inhibits tumor growth and angiogenesis in breast cancer cells.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Oncology
Therese Dix-Peek, Caroline Dickens, Tanya N. Augustine, Boitumelo P. Phakathi, Eunice J. van den Berg, Maureen Joffe, Oluwatosin A. Ayeni, Herbert Cubasch, Sarah Nietz, Christopher G. Mathew, Mahtaab Hayat, Alfred I. Neugut, Judith S. Jacobson, Paul Ruff, Raquel A. B. Duarte
Summary: Black African populations are genetically diverse and have different genetic variants compared to European populations. This study found no association between four specific genetic variants associated with breast cancer in non-African populations and breast cancer in black southern African women. However, an association was identified between a specific genotype and invasive lobular carcinoma. The results suggest that genetic biomarkers of breast cancer risk in European populations may not be relevant for sub-Saharan African populations.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Oncology
Osamu Maehara, Goki Suda, Mitsuteru Natsuizaka, Taku Shigesawa, Gouki Kanbe, Megumi Kimura, Masaya Sugiyama, Masashi Mizokami, Masato Nakai, Takuya Sho, Kenichi Morikawa, Koji Ogawa, Shinya Ohashi, Shingo Kagawa, Hideaki Kinugasa, Seiji Naganuma, Naoto Okubo, Shunsuke Ohnishi, Hiroshi Takeda, Naoya Sakamoto
Summary: Fibroblast growth factors (FGFs) and their receptors (FGFRs) play an important role in maintaining cancer stem-like cells in esophageal squamous cell carcinoma (ESCC). This study reveals that FGFR2, particularly the IIIb isoform, is highly expressed in non-CSCs, inducing keratinocyte differentiation and decreasing CSC populations. Analysis using The Cancer Genome Atlas (TCGA) dataset shows a significant correlation between FGFR2 expression and cancer cell differentiation in ESCC clinical samples, suggesting FGFR2-AKT signaling as a potential therapeutic target for ESCC.
CANCER BIOLOGY & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Chong Lu, Yu Zhao, Jing Wang, Wei Shi, Fang Dong, Yue Xin, Xiangwang Zhao, Chunping Liu
Summary: The study showed that miR-182-5p is highly expressed in breast cancer tissues and cells, and its overexpression promotes tumor angiogenesis. EVs carrying miR-182-5p from breast cancer cells enhance proliferation, migration, and angiogenesis of endothelial cells through the CMTM7/EGFR/AKT signaling axis, promoting tumorigenesis and metastasis.
MOLECULAR MEDICINE
(2021)
Article
Oncology
Kamil Mieczkowski, Kamila Kitowska, Marcin Braun, Barbara Galikowska-Bogut, Monika Gorska-Arcisz, Dominika Piasecka, Konrad Stawiski, Anna J. Zaczek, Dariusz Nejc, Radzislaw Kordek, Hanna M. Romanska, Rafal Sadej
Summary: This study demonstrates the impact of FGFR2 signaling on the interaction between PR and ER in breast cancer cells, and suggests the potential of FGFR2 as a therapeutic target for breast cancer treatment.
MOLECULAR ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Qianying Tao, Yingxue Qi, Jiayi Gu, Die Yu, Yuxin Lu, Jianwen Liu, Xin Liang
Summary: The metastasis and angiogenesis of breast cancer has always been a difficult problem for treatment. It has recently been discovered that Von Willebrand Factor (vWF) plays a role in tumor metastasis and angiogenesis. Knocking down vWF inhibits breast cancer cell metastasis, while overexpression of vWF promotes vascular proliferation. Furthermore, vWF down-regulates the expression of miR-205-5p and up-regulates the expression of VEGF-A through the PI3K/Akt signaling pathway.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Cell Biology
Peng Zhang, Liang Chen, Fenfang Zhou, Zhiwen He, Gang Wang, Yongwen Luo
Summary: Prostate cancer (PCa) is a common male malignancy with unclear progression mechanisms. This study found that NRP1, highly expressed in PCa, was associated with poor prognosis in PCa patients. Functionally, NRP1 depletion inhibited PCa cell proliferation and migration, while NRP1 overexpression promoted these processes. Mechanistically, NRP1 was regulated by HIF1 alpha and interacted with EGFR, leading to EGFR phosphorylation and activation of the AKT signaling pathway, promoting PCa progression. Additionally, the NRP1 inhibitor EG01377 inactivated the EGFR/AKT signaling axis and suppressed PCa progression.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Maryam Akbarzadeh, Ainaz Mihanfar, Shabnam Akbarzadeh, Bahman Yousefi, Maryam Majidinia
Summary: The PI3K/AKT/mTOR signaling pathway plays a crucial role in cancer and has been found to interact with miRNAs, which is important for understanding cancer biology.
Article
Immunology
Chao Jia, Fei Hu, Di Lu, Haidong Jin, Hongwei Lu, Enxing Xue, Dengying Wu
Summary: Formononetin has anti-inflammatory properties and exhibits protective effects in osteoarthritis, suggesting its potential as a therapeutic agent for the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Oncology
Alakananda Basu, Christoffer Briggs Lambring
Summary: This article discusses the importance of breast cancer in women in the United States and the role of Akt isoforms in the development of breast cancer. While Akt isoforms share similar structures, they exhibit redundant, distinct, and opposite functions in breast cancer. Understanding the isoform-specific function of Akt is critical for effectively targeting the Akt signaling pathway in cancer therapy.
Article
Biochemistry & Molecular Biology
Monika Mlinaric, Ivan Lucic, Lidija Milkovic, Ines V. da Silva, Ivana Tartaro Bujak, Vesna Musani, Graca Soveral, Ana Cipak Gasparovic
Summary: Aquaporin 3 (AQP3) is a membrane protein that transports hydrogen peroxide, water, and glycerol. It is implicated in tumor progression and malignancy in breast cancer and may be a target for therapy. This study examined the relationship between AQP3 expression, disruption of lipid raft harboring EGFR, and the EGFR/PI3K/Akt signaling pathway in breast cancer cell lines. The results indicate that AQP3 may not directly affect the PI3K/Akt pathway but rather its role is cell-line specific.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Sherihan Salaheldin Abdelhamid Ibrahim, Sarah A. Abd El-Aal, Ahmed M. Reda, Samar El Achy, Yasmine Shahine
Summary: The study focuses on the evaluation of the anti-cancer activity of cimetidine and vitamin C in breast cancer by targeting mast cell mediators and inhibiting the PI3K/AKT/mTOR cue. The combination therapy shows promising results in reducing tumor growth, angiogenesis, oxidative stress, and promoting apoptosis.
SCIENTIFIC REPORTS
(2022)