Editorial Material
Multidisciplinary Sciences
Mark A. Travis, Chiara Romagnani
Summary: Active control of the immune system is necessary to prevent inflammatory bowel disease. Cell populations that promote the generation of immunosuppressive regulatory T cells in the gut have been identified.
Article
Plant Sciences
Feihong Zhu, Hehe Chen, Meifei Xu, Xiajun Zhang, Jing Yu, Yali Pan, Weixin Zhu
Summary: The study found that Cryptotanshinone (CT) can attenuate the infarct region in the MCAO model, increase the percentage of CD4(+)CD25(+)FOXP3(+) Treg cells in the peripheral blood, and recover the protein level of FOXP3 and the phosphorylation of STAT5 in CD4(+)CD25(+) Treg cells.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Athmane Teghanemt, Kara Misel-Wuchter, Jace Heath, Andrew Thurman, Priyanjali Pulipati, Garima Dixit, Ramasatya Geesala, David K. Meyerholz, Thorsten Maretzky, Alejandro Pezzulo, Priya D. Issuree
Summary: Regulatory T (T reg) cells are vital in maintaining tolerance and preventing fatal autoimmunity. This study reveals the importance of Tet enzymes and DNA demethylation in promoting Treg cell differentiation in the thymus. Tet3 is specifically involved in the development of CD4 single-positive thymocytes and plays a critical role in TCR-dependent IL-2 production, which is essential for chromatin remodeling and the upregulation of FoxP3.
Article
Biology
Severine Menoret, Laurent Tesson, Severine Remy, Victor Gourain, Celine Serazin, Claire Usal, Aude Guiffes, Vanessa Chenouard, Laure-Helene Ouisse, Malika Gantier, Jean-Marie Heslan, Cynthia Fourgeux, Jeremie Poschmann, Carole Guillonneau, Ignacio Anegon
Summary: In this study, a Foxp3-EGFP rat transgenic line was created to genetically tag CD4(+) and CD8(+) FOXP3(+) regulatory T cells. CD4(+)EGFP(+) Treg were found to be 5-10 times more frequent than CD8(+)EGFP(+) Treg. RNAseq analysis provided insights into the transcriptome of CD8(+) Treg, allowing for a better understanding of their phenotype and function.
Article
Immunology
Eros Di Giorgio, Liqing Wang, Yan Xiong, Lanette M. Christensen, Tatiana Akimova, Rongxiang Han, Arabinda Samanta, Matteo Trevisanut, Claudio Brancolini, Ulf H. Beier, Wayne W. Hancock
Summary: The Mads/Mef2 family of transcription factors regulate differentiation in various cell types and are involved in physiological feedback loops. Disruption of their interaction with Hdac9 can lead to the development of pathologic states, including cancer. These transcription factors also indirectly control tumor progression by regulating antitumor immunity, particularly in Treg cells, adding complexity to the study of Treg biology.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Multidisciplinary Sciences
Stuart M. Brierley
Summary: Gut infection can trigger localized immune responses that cause harmless foods to be perceived as harmful, leading to persistent pain. Defense against bacterial infection may drive pain when eating food.
Article
Biochemistry & Molecular Biology
Allison E. Norlander, R. Stokes Peebles
Summary: T regulatory cells (Tregs) play a crucial role in reducing and resolving inflammation as part of the adaptive immune system. Prostaglandin I-2 (PGI(2)) exerts potent anti-inflammatory effects on immune cells and promotes the formation and function of Tregs. Therefore, therapeutic supplementation of PGI(2) may be a promising treatment for various autoimmune or inflammatory diseases by enhancing Treg function.
DNA AND CELL BIOLOGY
(2021)
Review
Immunology
Jeffrey A. Bluestone, Brent S. McKenzie, Joshua Beilke, Fred Ramsdell
Summary: Regulatory T (Treg) cells play a crucial role in maintaining peripheral tolerance and preventing various immune-related diseases. They are able to develop in both the thymus and peripheral tissues through the expression of a transcription factor called FOXP3. Treg cells exert their tolerogenic effects by using multiple mechanisms, such as producing inhibitory cytokines, suppressing T effector cells, and modulating antigen-presenting cell function. Recently, there has been a focus on genetically engineering Treg cells to enhance their therapeutic potential, leading to ongoing clinical trials. This review highlights the advancements and challenges in harnessing Treg cells as a new approach for treating diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Deepika Watts, Marthe Janssen, Mangesh Jaykar, Francesco Palmucci, Marc Weigelt, Cathleen Petzold, Angela Hommel, Tim Sparwasser, Ezio Bonifacio, Karsten Kretschmer
Summary: In NOD mice, transient loss of Foxp3(+) Treg cells is sufficient to induce severe insulitis and persistent hyperglycemia. This highlights the vital role of Foxp3(+) Treg cell activity in controlling autoimmune diabetes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Adrian Liston, Meryem Aloulou
Summary: CD8(+)Foxp3(+) cells, often neglected, have regulatory functions similar to CD4(+)Foxp3(+)Treg cells but with distinct characteristics.
IMMUNOLOGY LETTERS
(2022)
Article
Oncology
Antoine Freuchet, Apolline Salama, Severine Bezie, Laurent Tesson, Severine Remy, Romain Humeau, Hadrien Regue, Celine Serazin, Lea Flippe, Part Peterson, Nadege Vimond, Claire Usal, Severine Menoret, Jean-Marie Heslan, Franck Duteille, Frederic Blanchard, Magali Giral, Marco Colonna, Ignacio Anegon, Carole Guillonneau
Summary: This study highlights the crucial role of IL-34 in immune homeostasis and CD4(+) Treg suppressive function. The study also demonstrates the therapeutic potential of IL-34 in human transplantation and autoimmunity.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ram Hari Pokhrel, Ben Kang, Maheshwor Timilshina, Jae-Hoon Chang
Summary: This study explored the role of AMPK in Treg function and stability during aging. The findings suggest that AMPK alpha 1-deficient Tregs are unable to effectively control inflammation, potentially due to decreased CD25 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Ningning Xue, Ying Wang, Hao Cheng, Hantian Liang, Xinzou Fan, Fengqiong Zuo, Xin Zeng, Ning Ji, Qianming Chen
Summary: This study demonstrates the important role of Treg cells in maintaining immune homeostasis in the oral mucosa and proposes a novel disease model of oral inflammation. Furthermore, the results show that Treg cell therapy is effective in suppressing oral inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Zengdi Zhang, Oscar C. Salgado, Bing Liu, Zahra Moazzami, Kristin A. Hogquist, Michael A. Farrar, Hai-Bin Ruan
Summary: This article investigates the role of the O-GlcNAc transferase (OGT)-STAT5 axis in regulating the immunomodulatory function and metabolic homeostasis of Treg cells. The results show that OGT deficiency in Treg cells makes mice more susceptible to high-fat diet-induced obesity and insulin resistance, while constitutive STAT5 activation in Treg cells protects against adipose tissue expansion and impaired glucose and insulin metabolism. Targeting the OGT-STAT5 axis can enhance Treg cell function to combat obesity and related metabolic disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biology
Vania Lopez Ruiz, Jacques Robert
Summary: Amphibians play a crucial role in bridging the evolutionary gap between mammals and ancient vertebrates. Understanding their immune system, which is similar to that of mammals, is important for disease research. The African clawed frog, Xenopus laevis, is a good model for studying the immune system, particularly during early development stages. This review summarizes the knowledge about the innate and adaptive immune system of X. laevis and compares it with other amphibians. It also discusses the response of amphibians to viral, bacterial, and fungal infections.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Oncology
Nandita Noronha, Gregory Ehx, Marie-Christine Meunier, Jean-Philippe Laverdure, Catherine Theriault, Claude Perreault
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Allergy
Erika Van Nieuwenhove, John S. Barber, Julika Neumann, Elien Smeets, Mathijs Willemsen, Emanuela Pasciuto, Teresa Prezzemolo, Vasiliki Lagou, Laura Seldeslachts, Bert Malengier-Devlies, Mieke Metzemaekers, Sarah Hassdenteufel, Axelle Kerstens, Rob van der Kant, Frederic Rousseau, Joost Schymkowitz, Daniele Di Marino, Sven Lang, Richard Zimmermann, Susan Schlenner, Sebastian Munck, Paul Proost, Patrick Matthys, Christine Devalck, Nancy Boeckx, Frank Claessens, Carine Wouters, Stephanie Humblet-Baron, Isabelle Meyts, Adrian Liston
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Genetics & Heredity
Jean-David Larouche, Assya Trofimov, Leslie Hesnard, Gregory Ehx, Qingchuan Zhao, Krystel Vincent, Chantal Durette, Patrick Gendron, Jean-Philippe Laverdure, Eric Bonneil, Caroline Cote, Sebastien Lemieux, Pierre Thibault, Claude Perreault
Article
Immunology
Els Wauters, Karin Thevissen, Carine Wouters, Francesca Maria Bosisio, Frederik De Smet, Jan Gunst, Stephanie Humblet-Baron, Diether Lambrechts, Adrian Liston, Patrick Matthys, Johan Neyts, Paul Proost, Birgit Weynand, Joost Wauters, Sabine Tejpar, Abhishek D. Garg
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Oncology
Arnold Bolomsky, Meike Vogler, Murat Cem Kose, Caroline A. Heckman, Gregory Ehx, Heinz Ludwig, Jo Caers
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2020)
Article
Surgery
Gregory Ehx, Caroline Ritacco, Muriel Hannon, Sophie Dubois, Loic Delens, Evelyne Willems, Sophie Servais, Pierre Drion, Yves Beguin, Frederic Baron
Summary: RAPA mitigates GVHD by decreasing T cell engraftment and differentiation, inhibiting CD8(+) T cell activation and increasing long-term IL-2 secretion to support Treg proliferation, while maintaining graft-versus-leukemia effects. The impact of RAPA on Treg and CD8(+) T cells is dependent on IL-2 signaling, with therapeutic options interfering with IL-2 antagonizing the promotion of Treg by RAPA. Synergistic effects may be achieved by combining RAPA with drugs like 5-azacytidine.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Biophysics
Caroline Ritacco, Gregory Ehx, Celine Gregoire, Coline Daulne, Evelyne Willems, Sophie Servais, Yves Beguin, Frederic Baron
Summary: Research has shown that different subsets of regulatory T cells (Treg) exhibit varying abilities to phosphorylate STAT5 in response to IL-2 or IL-7 stimulation, and the frequencies of these Treg subtypes may change in patients with chronic graft-versus-host disease (GVHD).
BONE MARROW TRANSPLANTATION
(2021)
Correction
Oncology
Arnold Bolomsky, Meike Vogler, Murat Cem Koese, Caroline A. Heckman, Gregory Ehx, Heinz Ludwig, Jo Caers
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Immunology
Gregory Ehx, Jean-David Larouche, Chantal Durette, Jean-Philippe Laverdure, Leslie Hesnard, Krystel Vincent, Marie-Pierre Hardy, Catherine Theriault, Caroline Rulleau, Joel Lanoix, Eric Bonneil, Albert Feghaly, Anca Apavaloaei, Nandita Noronha, Celine M. Laumont, Jean-Sebastien Delisle, Luca Vago, Josee Hebert, Guy Sauvageau, Sebastien Lemieux, Pierre Thibault, Claude Perreault
Summary: An analysis of the immunopeptidome in AML patients identified tumor-specific antigens (TSAs) which were derived from non-coding genomic regions and associated with intron retention and epigenetic changes. These TSAs may serve as attractive targets for AML immunotherapy.
Article
Biophysics
Justine Courtois, Caroline Ritacco, Sophie Dubois, Lorenzo Canti, Benoit Vandenhove, Laurence Seidel, Coline Daulne, Jo Caers, Sophie Servais, Yves Beguin, Gregory Ehx, Frederic Baron
Summary: The study found that itacitinib can reduce the engraftment of human T cells, increase the frequency of regulatory T cells, and alleviate xGVHD in NSG mice transplanted with hPBMC.
BONE MARROW TRANSPLANTATION
(2021)
Letter
Oncology
Lorenzo Canti, Kevin K. Arien, Isabelle Desombere, Stephanie Humblet-Baron, Pieter Pannus, Leo Heyndrickx, Aurelie Henry, Sophie Servais, Evelyne Willems, Gregory Ehx, Stanislas Goriely, Laurence Seidel, Johan Michiels, Betty Willems, Maria E. Goossens, Yves Beguin, Arnaud Marchant, Frederic Baron
Article
Oncology
Lorenzo Canti, Stephanie Humblet-Baron, Isabelle Desombere, Julika Neumann, Pieter Pannus, Leo Heyndrickx, Aurelie Henry, Sophie Servais, Evelyne Willems, Gregory Ehx, Stanislas Goriely, Laurence Seidel, Johan Michiels, Betty Willems, Adrian Liston, Kevin K. Arien, Yves Beguin, Maria E. Goossens, Arnaud Marchant, Frederic Baron
Summary: Response to SARS-CoV-2 mRNA vaccination in allogeneic hematopoietic stem cell transplantation recipients is influenced by chronic GVHD and rituximab therapy. Immunological markers could assist in identifying allo-HCT patients at risk of poor antibody response to mRNA vaccination.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Cell Biology
Anca Apavaloaei, Leslie Hesnard, Marie-Pierre Hardy, Basma Benabdallah, Gregory Ehx, Catherine Theriault, Jean-Philippe Laverdure, Chantal Durette, Joel Lanoix, Mathieu Courcelles, Nandita Noronha, Kapil Dev Chauhan, Sebastien Lemieux, Christian Beausejour, Mick Bhatia, Pierre Thibault, Claude Perreault
Summary: This study characterizes the MHC I-associated peptide (MAP) repertoire of human induced pluripotent stem cells (iPSCs) and identifies a set of pluripotency-associated MAPs (paMAPs). These paMAPs are absent in normal tissues and adult stem cells but are expressed in iPSCs and multiple adult cancers. Some of these paMAPs are immunogenic, but their expression in tumors is associated with activation of immune evasion pathways. The authors propose that inhibiting these pathways in combination with immune targeting of paMAPs could be a potential treatment strategy for poorly differentiated cancers.
Article
Multidisciplinary Sciences
Assya Trofimov, Philippe Brouillard, Jean-David Larouche, Jonathan Seguin, Jean-Philippe Laverdure, Ann Brasey, Gregory Ehx, Denis-Claude Roy, Lambert Busque, Silvy Lachance, Sebastien Lemieux, Claude Perreault
Summary: Based on the analysis of TCR sequences from over 1,000 individuals, it was found that the TCR repertoire is comprised of two distinct types of TCRs, regulated by thymic output and TDT activity. The Neonatal TCRs are associated with diseases, while TDT-dependent TCRs are produced in large quantities during infancy and related to AIRE gene mutations.
Meeting Abstract
Hematology
Caroline Ritacco, Gregory Ehx, Lorenzo Canti, Sophie Dubois, Benoit Vandenhove, Sophie Servais, Yves Beguin, Stephanie Humblet-Baron, Frederic Baron
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2020)