Article
Medicine, General & Internal
Min-Kyung Kim
Summary: Parafibromin has significant clinicopathologic significance in hepatocellular carcinoma (HCC), with elevated expression being correlated with microvascular invasion, hepatitis virus infection-induced occurrence, and poorer tumor differentiation. HCC patients with elevated parafibromin expression also have poorer recurrence-free and overall survival.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Yannan Bai, Yuane Lian, Xiaoping Chen, Jiayi Wu, Jianlin Lai, Funan Qiu, Songqiang Zhou, Zijing Zhu, Yifeng Tian, Yaodong Wang, Yinghong Yang, Maolin Yan
Summary: A newly developed 3-IHC-based classifier has been shown to accurately predict recurrence and survival outcomes in patients with early- and intermediate-stage HCC after curative liver resection.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Bin Zheng, Heng Wang, Jin-Xue Wang, Zheng-Hong Liu, Pu Zhang, Dahong Zhang
Summary: The study found that the expression of RMI2 in HCC tissue was significantly higher than that in adjacent normal tissues, and was correlated with the histological grade and stage of HCC. RMI2 was identified as an independent prognostic indicator for HCC.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Review
Oncology
Tian-Run Lv, Hai-Jie Hu, Parbatraj Regmi, Fei Liu, Fu-Yu Li
Summary: Sarcomatoid hepatocellular carcinoma (SHCC) is a rare subtype of primary liver malignancies. Compared to conventional hepatocellular carcinoma (HCC), SHCC has worse prognosis and exhibits more aggressive behavior.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Michele Paudice, Chiara Maria Biatta, Giulia Scaglione, Alessia Parodi, Serafina Mammoliti, Melita Moioli, Maria Grazia Centurioni, Fabio Barra, Simone Ferrero, Franco De Cian, Katia Mazzocco, Valerio Gaetano Vellone
Summary: Endometrial cancer is a growing disease with an increase in aggressive histotypes. This study investigated potential prognostic markers and found that Bcl-2 and PR may have prognostic significance in high-grade non-endometrioid carcinoma patients.
Article
Biotechnology & Applied Microbiology
Qinglin Zhang, Jiadong Pan, Fangmei An, He Nie, Qiang Zhan
Summary: This study found that decreased expression of SLC39A1 is associated with clinical features and survival rates in early-stage hepatocellular carcinoma (EHCC), with patients showing lower expression having poorer prognosis. The expression level of SLC39A1 may serve as a potential diagnostic and prognostic biomarker for EHCC patients.
Article
Oncology
Peng-Cheng Wang, Zhi-Qiang Hu, Shao-Lai Zhou, Song-Yang Yu, Li Mao, Sheng Su, Jia Li, Ning Ren, Xiao-Wu Huang
Summary: Infiltrating immune cells in the tumor microenvironment play a crucial role in tumor progression and patient prognosis, making them promising targets for immunotherapy research. This study investigated the spatial distributions of immune cell subpopulations in HCC and normal liver tissues, providing insights into potential interactions among different immune cell types that could impact the effectiveness of immunotherapies for HCC. The findings offer a theoretical basis for further research in HCC immunotherapy.
Article
Medical Laboratory Technology
Meng Zhang, Yuan Wang, Jing Wang, Xuening Li, Aijun Ma, Xudong Pan
Summary: LRG1 was found to be a promising indicator for predicting cardioembolic stroke, with independent risk factors and comparable predictive performance to BNP and LAD. The combined predictive model including LRG1, BNP, and LAD greatly improved the prediction effect. Additionally, a positive correlation between LRG1 levels and stroke severity in the CE group was observed, suggesting its potential for predicting stroke outcomes.
CLINICA CHIMICA ACTA
(2021)
Review
Biochemistry & Molecular Biology
Joon Hyuk Choi, Swan N. Thung
Summary: Hepatocellular carcinoma is a primary liver cancer with molecular heterogeneity. Accurate diagnosis of HCC is crucial for patient management and prognosis. This review provides an update on HCC pathology.
Article
Oncology
Seongsik Bang, Seungyun Jee, Hwangkyu Son, Hyebin Cha, Jongmin Sim, Yeseul Kim, Hosub Park, Jaekyung Myung, Hyunsung Kim, Seungsam Paik
Summary: High expression of ASAP1 in HCC patients is associated with aggressive clinicopathological characteristics and poor clinical outcomes, indicating ASAP1 as a prognostic biomarker in HCC patients.
PATHOLOGY & ONCOLOGY RESEARCH
(2022)
Article
Oncology
Lujun Chen, Hao Huang, Ziyi Huang, Junjun Chen, Yingting Liu, Yue Wu, An Li, Junwei Ge, Zhang Fang, Bin Xu, Xiao Zheng, Changping Wu
Summary: This study investigated tissue-resident CD8(+)T cells in hepatocellular carcinoma and intrahepatic cholangiocarcinoma. The expression levels of CD103 and CD8 in tumor tissues were correlated with tumor progression and prognosis, suggesting their potential as prognostic markers in liver cancer. Evaluation of tissue-resident CD103(+)CD8(+)T cells may also be useful for assessing treatment response.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Silvia Cagnin, Rossella Donghia, Andrea Martini, Pasqua Letizia Pesole, Sergio Coletta, Endrit Shahini, Giulia Boninsegna, Alessandra Biasiolo, Patrizia Pontisso, Gianluigi Giannelli
Summary: The GALAD score shows promise as a prognostic tool for hepatocellular carcinoma (HCC), with implications for improving patient management and treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Chaoying Wu, Ting Li, Wenjun Cheng
Summary: This study analyzed the expression of APOE in endometrial cancer and its impact on patients' long-term prognostic survival. The results showed that APOE is overexpressed in endometrial cancer tissues and is correlated with clinical and pathological characteristics and survival rate. Kaplan-Meier survival analysis revealed that high APOE expression is associated with shorter survival time.
Review
Oncology
Manon Falette Puisieux, Anna Pellat, Antoine Assaf, Claire Ginestet, Catherine Brezault, Marion Dhooge, Philippe Soyer, Romain Coriat
Summary: Hepatocellular carcinoma (HCC) is a major health problem and the fourth leading cause of cancer-related mortality worldwide. The prognosis for advanced HCC is poor, and the selection of optimal treatment remains a challenge. However, recent studies have shown that the combination of atezolizumab and bevacizumab can significantly improve survival and is recommended as the first-line treatment for advanced HCC. Other treatments, such as regorafenib and cabozantinib, can be considered for disease progression. Transarterial chemoembolization is also an alternative treatment for patients with intermediate-stage HCC. The accurate estimation of liver function is crucial for therapeutic management.
Article
Oncology
Lejia Sun, Xindi Ke, Ai Guan, Bao Jin, Jiangming Qu, Yinhan Wang, Xiang Xu, Changcan Li, Hang Sun, Hengyi Xu, Gang Xu, Xinting Sang, Yifei Feng, Yueming Sun, Huayu Yang, Yilei Mao
Summary: The poor prognosis of hepatocellular carcinoma (HCC) is closely related to the characteristics of the tumor microenvironment (TME). Recent studies have shown that the microbiome in the TME can influence cancer progression. This study explored the intratumoral microbiome in HCC TME and found that microbial profiles and community networks differed between tumors and adjacent normal tissues. The hepatotype was identified as a potential independent prognostic factor for patients with resected HCC.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)