Review
Biochemistry & Molecular Biology
Tatiana V. V. Kirichenko, Yuliya V. V. Markina, Anastasia I. I. Bogatyreva, Taisiya V. V. Tolstik, Yurgita R. R. Varaeva, Antonina V. V. Starodubova
Summary: This article reviews the key functions of adipokines in the inflammatory mechanisms, complications, and associated diseases of obesity. Through an extensive search on the role of adipokines in the pathogenesis of obesity, existing research findings are summarized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Masato Hayashi, Misaki Iwashita, Yuki Nishimura, Takanori Shinjo, Tomomi Sano, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Tomoichiro Asano, Fusanori Nishimura
Summary: The research shows that Ccl19KI mice exhibit more inflammatory signs and enlarged adipose tissue, and a 40% fat diet exacerbates the effects of CCL19 overexpression. These findings suggest that these mice could be a suitable model for studying metabolic disorders in overweight Asians.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Review
Physiology
Victoria R. Kwiat, Gisienne Reis, Isela C. Valera, Kislay Parvatiyar, Michelle S. Parvatiyar
Summary: Obesity is closely associated with autoimmune diseases, with leptin playing a crucial role. Obesity not only enhances immune system activation but also leads to chronic inflammation and development of autoimmune diseases. In addition, other factors such as sustained platelet activation, gut dysbiosis, and aging are also linked to obesity and autoimmune diseases.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Medicine, General & Internal
Stefania Masone, Nunzio Velotti, Silvia Savastano, Emanuele Filice, Rossana Serao, Antonio Vitiello, Giovanna Berardi, Vincenzo Schiavone, Mario Musella
Summary: Research has shown that obesity and excess body weight are associated with an increased risk of thyroid cancer, potentially through impacting immune cells and production of pro-inflammatory factors, the action of insulin, and chronic inflammation pathways.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Helena Sanchez-Ortega, Carlos Jimenez-Cortegana, Jose P. Novalbos-Ruiz, Ana Gomez-Bastero, Jose G. Soto-Campos, Victor Sanchez-Margalet
Summary: Asthma and obesity are highly prevalent diseases with a significant impact on public health. Obesity exacerbates the development and severity of asthma through the secretion of proinflammatory cytokines and mediators, such as leptin, by adipose tissue. This systematic review and meta-analysis examine the relationship between leptin and asthma during obesity. The results indicate significant differences in leptin levels and support the relevant role of leptin in the pathophysiology of asthma in obese individuals. Further studies are needed to better understand the relationship between leptin and asthma in obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Kategowdru Vijayakumar Soujanya, Appukuttan Padmanabhan Jayadeep
Summary: The incidence of obesity is increasing globally, leading to various health problems. Consumption of whole grains and millets, rich in phytochemicals, can reduce the risk of metabolic disorders and chronic diseases. The phytochemicals in grains have anti-inflammatory effects and can inhibit markers associated with inflammation and adipogenesis.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Review
Medicine, General & Internal
Thomas-Gabriel Schreiner, Tudor-Marcel Genes
Summary: Through independent research and literature review, this study demonstrates the association between obesity and multiple sclerosis, with a focus on the causal relationship between obesity in childhood and adolescence and the development of MS. While research on the pathophysiological mechanisms of obesity and MS has made progress, further studies are needed to explain the unknown aspects of this association.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Ioannis G. Lempesis, Nicole Hoebers, Yvonne Essers, Johan W. E. Jocken, Rosemary Dineen, Ellen E. Blaak, Konstantinos N. Manolopoulos, Gijs H. Goossens
Summary: This study investigated the inflammatory signatures of abdominal and femoral subcutaneous adipose tissue in postmenopausal women with normal weight or obesity. The results showed that women with obesity had larger adipocytes and higher plasma concentrations of leptin and plasminogen activator inhibitor (PAI)-1. Both abdominal and femoral subcutaneous adipose tissue released leptin and monocyte chemoattractant protein (MCP)-1, but the release of MCP-1 was higher in abdominal adipose tissue. Additionally, gene expression of inflammatory factors differed between abdominal and femoral adipose tissue.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Wiktoria Feret, Krzysztof Safranow, Ewa Kwiatkowska, Aleksandra Daniel, Kazimierz Ciechanowski
Summary: This study investigates the role of leptin and chosen cytokines in the development of malnutrition-inflammation syndrome (MIS) and erythropoietin resistance. The results show a negative correlation between leptin and erythropoietin resistance, while IL-6 shows the opposite. IL-6 is more linked to hemodialysis parameters and vintage, while TNF-alpha and leptin are more dependent on body composition.
Article
Biochemistry & Molecular Biology
Frederique Van de Velde, D. Margriet Ouwens, Arsene-Helene Batens, Yves Van Nieuwenhove, Bruno Lapauw
Summary: Systemic improvements in inflammation and insulin resistance are observed after gastric bypass surgery, but changes in adipokine and myokine expression patterns only partially reflect these improvements. Expression of markers of inflammation and insulin/glucose metabolism in other tissues may be inconsistent and divergent.
Article
Respiratory System
L. Baltieri, E. Cazzo, D. A. Oliveira Modena, R. C. Gobato Rentel, L. C. Martins, E. A. Chaim
Summary: This study aimed to investigate the correlation between levels of adipokines and inflammatory mediators and lung function in individuals with obesity and bronchial asthma symptoms. The results showed that an increase in interleukin-6 in the sputum was associated with worse pulmonary function, even in patients with controlled asthma, especially in measures of airway permeability.
Article
Oncology
Maria K. Lagou, George S. Karagiannis
Summary: Declining thymic functions, whether due to old age or acute involution caused by stress, infectious disease, or cytoreductive therapies, have been associated with increased cancer risk. Obesity has also been linked to cancer development and progression, with chronic inflammation, hormone production, and hyperinsulinemia as key factors. This study focuses on the molecular and cellular mechanisms of obesity-induced thymic involution as an intermediary pathology leading to cancer, and suggests targeted thymic regeneration strategies for obese individuals at high risk of cancer.
SEMINARS IN CANCER BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Marlena Budek, Jaroslaw Nuszkiewicz, Anna Piorkowska, Jolanta Czuczejko, Karolina Szewczyk-Golec
Summary: GEP-NENs are rare neoplasms with diagnostic and clinical challenges. Inflammation and obesity are risk factors that contribute to tumor development, with released inflammatory factors playing a role in tumor progression.
Review
Biochemistry & Molecular Biology
Gabriela Barros, Pablo Duran, Ivana Vera, Valmore Bermudez
Summary: There is a possible link between obesity and psoriasis, with factors such as dietary habits, lifestyle, genetic factors, and the microbiome playing a role. Chronic inflammation caused by obesity may be a key factor in the development of psoriasis. Therefore, managing inflammation could be a potential target for treating psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Risa Kondo, Ren Ozawa, Taiyo Satomi, Kaho Funabayashi, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna
Summary: The study aimed to investigate the association between maternal stress and placental dysfunction, as well as offspring development. Maternal stress was found to alter placental functions, leading to lower birth weight in offspring. In the offspring fed with a normal diet, maternal stress impaired glucose tolerance and altered adipokine secretion in adipose tissue and/or liver. The female offspring of stress-induced dams showed lighter body weight, lower adipose tissue, and smaller adipocytes, especially in the high-fat diet group. These findings suggest that placental dysregulation and fetal programming underlie the long-lasting abnormal conditions and responses to metabolic challenges in maternal stress-induced offspring.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
