期刊
ONCOTARGET
卷 6, 期 32, 页码 32634-32645出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.4728
关键词
cancer invasion; cell-cell interaction; protrusion; microtubule; laminin
资金
- NIH [U54CA143868, R01CA174388]
- NCI [K99CA181352]
Recent work suggests that the dissemination of tumor cells may occur in parallel with, and even preceed, tumor growth. The mechanism for this early invasion is largely unknown. Here, we find that mammary epithelial cells (MECs) induce neighboring breast carcinoma cells (BCCs) to cross the basement membrane by secreting soluble laminin. Laminin continuously produced by MECs induce long membrane cellular protrusions in BCCs that promote their contractility and invasion into the surrounding matrix. These protrusions depend on microtubule bundles assembled de novo through laminin-integrin beta 1 signaling. These results describe how non-cancerous MECs can actively participate in the invasive process of BCCs.
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