Article
Medicine, General & Internal
Jeongmin Lee, Min-Hee Kim, Jung-Min Lee, Sang-Ah Chang
Summary: This study aimed to investigate the effects of pitavastatin therapy on serum adiponectin levels and high-molecular-weight (HMW) adiponectin in patients with type 2 diabetes, as well as their correlation with insulin sensitivity. The results showed that pitavastatin therapy did not significantly change serum adiponectin or HMW adiponectin levels, and it did not affect insulin sensitivity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Ye Seul Yang, Hack-Lyoung Kim, Sang-Hyun Kim, Min Kyong Moon
Summary: Dyslipidemia is a treatable risk factor for cardiovascular disease in diabetes patients, but the success rate in controlling LDL-C is suboptimal. Setting target goals for LDL-C control based on accurate risk assessment is essential. This article provides a summary of the latest evidence on lipid management in diabetes patients and presents a consensus on LDL-C treatment goals based on duration of diabetes, presence of CVD, target organ damage, or major cardiovascular risk factors. Recommendations for LDL-C goals vary depending on patient characteristics.
DIABETES & METABOLISM JOURNAL
(2023)
Review
Immunology
Shen Lu, Yanrong Li, Zhaojun Qian, Tiesuo Zhao, Zhiwei Feng, Xiaogang Weng, Lili Yu
Summary: This article reviews the role and research progress of the inflammasome in insulin resistance (IR) and type 2 diabetes mellitus (T2DM), emphasizing on the structure, activation, and regulation of several main inflammasomes. The therapeutic options associated with inflammasome for the treatment of T2DM, particularly NLRP3-related agents, are also discussed. In summary, this review provides insights into the involvement of the inflammasome in IR and T2DM and highlights its potential as a therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Food Science & Technology
Mengjiao Wang, Min Chen, Rui Guo, Yangyang Ding, Haihui Zhang, Yuanqing He
Summary: This review summarizes the role of sulforaphane in improving T2DM and its potential mechanisms, especially in insulin resistance, glucose metabolism, lipid metabolism, oxidative stress, and inflammatory factors. It also emphasizes the effects of sulforaphane on T2DM complications and provides evidence for further research and development as a hypoglycemic drug.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Benjamin Schroeder, Sabine Kahl, Michael Roden
Summary: Individuals with obesity or type 2 diabetes have an increased risk of developing non-alcoholic fatty liver disease, with altered adipose tissue function and hepatic mitochondrial dysfunction playing key roles in the pathogenesis. Genetic testing for high-risk individuals, particularly for the rs738409(G) SNP of the PNPLA3 gene, could improve future screening strategies.
LIVER INTERNATIONAL
(2021)
Review
Immunology
Zheng Zhou, Bao Sun, Dongsheng Yu, Chunsheng Zhu
Summary: Type 2 diabetes mellitus, a common metabolic disease, is associated with gut microbiota dysbiosis. Remodeling the gut microbiota may be a potential strategy for treating T2DM and its complications.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Mohammad Reza Nazem, Mojgan Asadi, Maryam Adelipour, Niloofar Jabbari, Abdolamir Allameh
Summary: This study evaluated the effects of zinc supplementation on oxidative status and glycaemic parameters in overweight patients with type 2 diabetes mellitus (T2DM). The results showed that zinc supplementation for 8 weeks significantly improved the oxidative balance and controlled the glycaemic indices in these patients.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Review
Nutrition & Dietetics
Wanbao Yang, Wen Jiang, Shaodong Guo
Summary: This article reviews the effects of different components of macronutrients on insulin sensitivity and their underlying mechanisms, highlighting the importance of adjusting the intake of beneficial food compounds for the prevention of insulin resistance and type 2 diabetes.
Review
Medicine, General & Internal
Sarantis Livadas, Rodis Paparodis, Panagiotis Anagnostis, Alessandra Gambineri, Jelica Bjekic-Macut, Tijana Petrovic, Bulent O. Yildiz, Dragan Micic, George Mastorakos, Djuro Macut
Summary: Women with polycystic ovary syndrome (PCOS) are at higher risk for dysglycemia and type 2 diabetes compared to healthy BMI-matched women of reproductive age. The incidence of this disorder varies among studies, and there is no consensus on the best screening method and frequency. Universal screening with oral glucose tolerance test is suggested to identify and manage glycemic abnormalities in young women with PCOS, regardless of age or BMI status. Regular follow-up and lifestyle interventions, such as balanced diet and exercise, are important for this specific population.
Article
Multidisciplinary Sciences
Shaza B. Zaghlool, Anna Halama, Nisha Stephan, Valborg Gudmundsdottir, Vilmundur Gudnason, Lori L. Jennings, Manonanthini Thangam, Emma Ahlqvist, Rayaz A. Malik, Omar M. E. Albagha, Karsten Suhre, Abdul Badi Abou-Samra
Summary: This study translates T2D subtypes previously identified in European individuals to an Arab population and identifies specific metabolic and proteomic signatures for each subtype, providing further understanding of the pathogenesis of these subtypes.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Desh Deepak Singh, Ali A. Shati, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Ihn Han, Eun-Ha Choi, Dharmendra K. Yadav
Summary: There are common molecular mechanisms and underlying pathology, such as insulin resistance and impaired synaptic plasticity, between type 2 diabetes mellitus and dementia. Analyzing risk factors is crucial for disease development and clinical management.
Article
Endocrinology & Metabolism
Soo Jin Yun, In-Kyung Jeong, Jin-Hye Cha, Juneyoung Lee, Ho Chan Cho, Sung Hee Choi, SungWan Chun, Hyun Jeong Jeon, Ho-Cheol Kang, Sang Soo Kim, Seung-Hyun Ko, Gwanpyo Koh, Su Kyoung Kwon, Jae Hyuk Lee, Min Kyong Moon, Junghyun Noh, Cheol-Young Park, Sungrae Kim
Summary: According to the latest guidelines, the achievement of LDL-C targets in Korean patients with type 2 diabetes mellitus is suboptimal.
DIABETES & METABOLISM JOURNAL
(2022)
Review
Endocrinology & Metabolism
Vittoria Russo, Rui Chen, Reina Armamento-Villareal
Summary: Chronic hyperglycemia and insulin resistance from type 2 diabetes mellitus may lead to hypogonadotropic hypogonadism in men, which in turn affects bone health and increases fracture risk. Having both hypogonadism and T2DM may predispose men to a higher risk of fractures, but there is limited research on this topic to date.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Michalis Michailidis, Despina Moraitou, Despina A. Tata, Kallirhoe Kalinderi, Theodora Papamitsou, Vasileios Papaliagkas
Summary: This review article discusses the shared pathophysiological connections between Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM), emphasizing the role of insulin in the brain and the mechanistic interplay between the two diseases. The findings highlight the need for routine evaluation and treatment of cognitive impairment in T2DM patients and the evaluation of insulin levels or T2DM in AD patients. The hypothesis of AD as a type 3 diabetes is strongly supported.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
A. G. Unnikrishnan, R. K. Sahay, Uday Phadke, S. K. Sharma, Parag Shah, Rishi Shukla, Vijay Viswanathan, S. K. Wangnoo, Santosh Singhal, Mathew John, Ajay Kumar, Mala Dharmalingam, Subodh Jain, Shehla Shaikh, Willem J. Verberk
Summary: Through studying newly diagnosed T2DM patients in India, it is found that they have high cardiovascular disease risk. This indicates the need for further extension of ASCVD risk identification programs and prevention strategies to reduce the occurrence of cardiovascular diseases.
