Article
Cell Biology
Ludivine Raby, Pamela Volkel, Shaghayegh Hasanpour, Julien Cicero, Robert-Alain Toillon, Eric Adriaenssens, Isabelle Van Seuningen, Xuefen Le Bourhis, Pierre-Olivier Angrand
Summary: This study reports on a zebrafish line with a null allele of eed, a key component of PRC2, and reveals severe defects in digestive organs and brain neuronal differentiation in homozygous eed-deficient mutants, leading to death. Additionally, loss of PRC2 function in zebrafish increases larval activity and highlights its potential as a model for studying human pathologies linked to PRC2 dysfunction and reduced H3K27me3 levels.
Review
Cell Biology
Sneha S. Varghese, Sangeeta Dhawan
Summary: Pancreatic beta-cells play a crucial role in regulating glucose homeostasis, and dysregulation of PRC-dependent epigenetic control is associated with beta-cell failure in diabetes. This review explores the multifaceted contributions of PRC modules in beta-cell specification, maintenance, and adaptation, as well as their interaction with signaling pathways. It also highlights the translational relevance of understanding the epigenetic regulation of beta-cell homeostasis in the context of diabetes and insulinomas.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Plant Sciences
Adji Baskoro Dwi Nugroho, Sujeong Kim, Sang Woo Lee, Dong-Hwan Kim
Summary: Polycomb group proteins (PcG) are important for developmental programs in plants. CLF, a PcG component in Arabidopsis, has a homolog in Brassica rapa ssp. trilocularis, called BrCLF. BrCLF participates in developmental processes, stress signaling, and stress-responsive metabolism in B. rapa. This study contributes to understanding the molecular mechanism of PcG-mediated regulation in development and stress responses in B. rapa.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Satoshi Kaito, Atsushi Iwama
Summary: Polycomb repressive complexes play a crucial role in maintaining hematopoietic stem cells and mutations in corresponding genes are associated with hematologic malignancies, leading to resistance to chemotherapy and poor prognosis. Recent studies have revealed that these gene mutations are druggable targets, and inhibitors have shown therapeutic efficacy for tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Dong-Hwan Kim
Summary: Polycomb repressive complexes (PRCs) are crucial for the growth and development of eukaryotes, with conserved components among most eukaryotes. The study of PRCs' gene silencing in plants has contributed to the understanding of the epigenetic control of developmental programs. This review provides current knowledge on PcG-mediated gene regulation, focusing on its role in various aspects of plant development and the molecular mechanisms involved, specifically in Arabidopsis plants.
JOURNAL OF PLANT BIOLOGY
(2023)
Review
Oncology
Min Gao, Yongwen Li, Peijun Cao, Hongyu Liu, Jun Chen, Shirong Kang
Summary: This paper reviews the importance of PRC2 in the development and progression of lung cancer, and explores its role in tumor immunity, cellular behavior regulation, and drug treatment.
FRONTIERS IN ONCOLOGY
(2023)
Review
Genetics & Heredity
Pooja Flora, Gil Dalal, Idan Cohen, Elena Ezhkova
Summary: Resident stem cells in adult tissues play a crucial role in maintaining, repairing, and regenerating tissues throughout organisms' lifetimes. The process of stem cell renewal and differentiation is tightly regulated, with epigenetic regulators such as polycomb group proteins playing a key role in maintaining homeostasis and regenerative balance in adult tissues.
Article
Plant Sciences
Tianqing Zhu, Jiwen Hu, Xiaowei Yang, Lisheng Kong, Juanjuan Ling, Junhui Wang, Sanping An
Summary: This study characterizes the PRC2 core component genes in the conifer species P. abies, revealing their involvement in cell reprogramming during seed and embryo development. These findings may contribute to a better understanding of embryonic potential and development in conifers.
Article
Cell Biology
Chao Yu, Tingting Li, Jialu Li, Binbin Cui, Na Liu, George Bayliss, Shougang Zhuang
Summary: In this study, the role and mechanism of PRC2 in acute kidney injury (AKI) were investigated. The results showed that inhibition of PRC2 activity by targeting EED could protect against cisplatin-induced AKI by promoting the survival and proliferation of renal tubular cells and inhibiting inflammatory response.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Oncology
Maksim Erokhin, Olga Chetverina, Balazs Gyorffy, Victor V. Tatarskiy, Vladic Mogila, Alexander A. Shtil, Igor B. Roninson, Jerome Moreaux, Pavel Georgiev, Giacomo Cavalli, Darya Chetverina
Summary: PRC2 is a complex involved in transcriptional repression through histone methylation, with dysregulation linked to tumor development. This study analyzed clinical correlations of PRC2 subunit genes in tumor samples, identifying cancer types responsive to PRC2 inhibition and potential sensitivity markers for PRC2-targeting drugs.
Article
Agronomy
Zhongling WU, Jiehua QIU, Huanbin SHI, Chuyu LIN, Jiangnan YUE, Zhiquan LIU, Wei XIE, Naweed I. N. Aqvi, Yanjun KOU, Zeng TAO
Summary: This study reveals the essential role of the core subunits of PRC2 in the pathogenicity of Magnaporthe oryzae to rice. These subunits are required for the establishment of H3K27me3 modification, which is involved in the transcriptional regulation of numerous genes. Interestingly, the de-repression of genes associated with H3K27me3 modification is closely related to effector-mediated host immunity and host environment adaption.
Article
Biotechnology & Applied Microbiology
Shujing Liu, Minerva S. Trejo-Arellano, Yichun Qiu, D. Magnus Eklund, Claudia Koehler, Lars Hennig
Summary: The study demonstrates that H2Aub plays a crucial role in H3K27me3 deposition and is required for PRC1-mediated transcriptional changes in both genes and transposable elements in Marchantia.
Review
Genetics & Heredity
Sabrina Fischer, Lisa Marie Weber, Robert Liefke
Summary: The Polycomb repressive complex 2 (PRC2) is an essential chromatin regulatory complex that represses the transcription of various developmental genes. The composition and functionality of PRC2 have changed during evolution to adapt to different biological needs.
EPIGENETICS & CHROMATIN
(2022)
Article
Developmental Biology
Haley E. Brown, Brandon P. Weasner, Bonnie M. Weasner, Justin P. Kumar
Summary: This study reveals that reduced Polycomb expression leads to abnormal development in Drosophila imaginal discs, causing the transformation of eyes into wings. Disruption of the Vestigial-Scalloped complex not only blocks wing formation, but also results in the organization of multiple domains into other imaginal discs and tissues.
Review
Oncology
Ning Liu, Chunsheng Yang, Ang Gao, Meili Sun, Deguan Lv
Summary: This review summarizes new findings on the role of miR-101 in cancer and the potential mechanisms of targeted gene degradation and microenvironmental regulation.
Article
Automation & Control Systems
Tianping Zhang, Hailin Tang, Xiaonan Xia, Yang Yi
Summary: In this article, a new decentralized adaptive neural output feedback control scheme based on first-order command filter is proposed for stochastic nonstrict-feedback interconnected systems with prescribed performance, input quantization, actuator failures, and unmodeled dynamics. The proposed method effectively eliminates unknown smooth functions, estimates immeasurable states, processes unmodeled dynamics, and compensates for the effects of quantization and actuator failures. The effectiveness of the proposed method is verified through numerical and example simulations, demonstrating its ability to ensure system stability and time-varying constraint satisfaction.
INTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL
(2022)
Correction
Oncology
Neng Wang, Qi Wang, Hailin Tang, Fengxue Zhang, Yifeng Zheng, Shengqi Wang, Jin Zhang, Zhiyu Wang, Xiaoming Xie
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Yutian Zou, Shaoquan Zheng, Xinhua Xie, Feng Ye, Xiaoqian Hu, Zhi Tian, Shu-Mei Yan, Lu Yang, Yanan Kong, Yuhui Tang, Wenwen Tian, Jindong Xie, Xinpei Deng, Yan Zeng, Zhe-Sheng Chen, Hailin Tang, Xiaoming Xie
Summary: FGFR4 inhibition enhances sensitivity to anti-HER2 treatment in resistant breast cancer cells by triggering ferroptosis.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Fu Peng, Li Wang, Liang Xiong, Hailin Tang, Junrong Du, Cheng Peng
Summary: Breast cancer is the leading cause of death among women worldwide, and its incidence has sharply increased since 2008. Triple negative breast cancer (TNBC) is responsible for the majority of breast cancer-related deaths due to its aggressive growth and rapid metastasis. Maackiain (MA), a natural compound found in Chinese herbs, has been found to have anti-cancer effects in TNBC, suppressing cell proliferation, migration, and invasion. It also inhibits tumor growth and induces apoptosis through modulation of GADD45 alpha and miR-374a. These findings suggest the potential of MA as a drug candidate for TNBC therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Song Wu, Ruilin Pan, Jibu Lu, Xiaoling Wu, Jingdong Xie, Hailin Tang, Xing Li
Summary: In this study, we identified 15 ferroptosis-related genes associated with the prognosis of TNBC and developed a prognostic prediction model. The model showed satisfactory predictive ability and could potentially affect the prognosis of TNBC by regulating the tumor microenvironment.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Maryam Kohansal, Ali Ghanbarisad, Reza Tabrizi, Abdolreza Daraei, Mojtaba Kashfi, Hailin Tang, Cailu Song, Yongming Chen
Summary: tRNA-derived fragments (tRFs) have been identified as potential biomarkers for gastric cancer (GC). This study analyzed 10 articles investigating the clinical significance of tRFs in GC, and found that several tRFs were significantly upregulated or downregulated in GC compared to controls. The study also reviewed the functions of tRFs in gene expression regulation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Oncology
Xingyue Wang, Peng Li, Xiangxiang Jing, Yun Zhou, Yongfu Shao, Min Zheng, Junrui Wang, Haitao Ran, Hailin Tang
Summary: By constructing camouflaged nanoparticles PFH/ART@PLGA/Fe3O4-eFA, the challenges of poor water solubility of drugs in targeted therapy can be overcome. In vitro and in vivo experiments showed that the release of drugs induced by LIFU irradiation can suppress tumor growth through ROS generation and tumor cell ferroptosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Peng Liu, Zehao Wang, Xueqi Ou, Peng Wu, Yue Zhang, Song Wu, Xiangsheng Xiao, Yuehua Li, Feng Ye, Hailin Tang
Summary: Metastasis of breast cancer remains a major cause of cancer-related death globally. Recent research indicates that circRNAs are associated with tumorigenesis and metastasis in breast cancer. However, the biological mechanism of circRNAs in liver metastatic breast cancer is still unclear. In this study, we identified circEZH2 through microarray analysis and confirmed its existence and expression in liver metastases of breast cancer. We demonstrated that circEZH2 is upregulated in liver metastases and predicts poor prognosis in breast cancer patients. Functionally, circEZH2 promotes the vitality and invasion of breast cancer cells, and its knockdown has the opposite effects. Furthermore, circEZH2 overexpression promotes tumorigenesis and liver metastasis in vivo. Mechanistically, circEZH2 acts as a sponge for miR-217-5p, leading to upregulation of KLF5, which activates FUS transcription and facilitates the back-splicing program of circEZH2. Additionally, KLF5 transcriptionally upregulates CXCR4, thereby accelerating epithelial-mesenchymal transition in breast cancer. In conclusion, we have identified a novel feedback loop involving FUS/circEZH2/KLF5/CXCR4, and circEZH2 may serve as a potential biomarker and therapeutic target for breast cancer patients.
Article
Chemistry, Multidisciplinary
Yutian Zou, Feng Ye, Yanan Kong, Xiaoqian Hu, Xinpei Deng, Jindong Xie, Cailu Song, Xueqi Ou, Song Wu, Linyu Wu, Yi Xie, Wenwen Tian, Yuhui Tang, Chau-Wei Wong, Zhe-Sheng Chen, Xinhua Xie, Hailin Tang
Summary: This study utilizes single-cell RNA sequencing to construct a high-resolution map of the tumor ecosystem in liver and brain metastases of breast cancer. The results show remarkable reprogramming of immunosuppressive cells in the metastatic ecosystem, as well as the negligible expression of PD-1 and PD-L1/2 in CD8+ T cells and cancer/immune/stromal cells. The interactions between LAG3-LGALS3 and TIGIT-NECTIN2 are found to play dominant roles in immune escape.
Article
Pharmacology & Pharmacy
Zhengyuan Yu, Hailin Tang, Shaomu Chen, Yufeng Xie, Liyan Shi, Shuhua Xia, Min Jiang, Jiaoyang Li, Dongqin Chen
Summary: This study explores the role of the long non-coding RNA (lncRNA) LOC85009 in docetaxel (DTX) resistance of lung adenocarcinoma (LUAD) and reveals its potential as a target for reversing DTX resistance. The findings demonstrate that LOC85009 is lowly expressed in DTX-resistant LUAD cells and that its overexpression inhibits DTX resistance, cell proliferation, and triggers apoptosis. Furthermore, it is discovered that LOC85009 is transferred from LUAD cells to DTX-resistant LUAD cells via exosomes, where it inhibits DTX resistance, proliferation, autophagy, and induces apoptosis.
DRUG RESISTANCE UPDATES
(2023)
Article
Cell Biology
Yan Zeng, Wei Du, Zhongying Huang, Song Wu, Xueqi Ou, Jinhui Zhang, Cheng Peng, Xiaoqing Sun, Hailin Tang
Summary: Breast cancer is the most common cancer worldwide and is the leading cause of female mortality. Recent studies have shown that circRNAs are associated with the progression of breast cancer. Exploring circRNAs could lead to the development of targeted therapies for breast cancer liver metastasis and improving patient outcomes.
CELL DEATH DISCOVERY
(2023)
Article
Medicine, Research & Experimental
Aiqun Liu, Baohong Jiang, Cailu Song, Qizhi Zhong, Yufan Mo, Ruiqin Yang, Ciyu Chen, Cheng Peng, Fu Peng, Hailin Tang
Summary: In this study, it was found that isoliquiritigenin (ISL) inhibits the expression of circ0030018, which plays a critical role in the growth and invasion of glioma. Silencing circ0030018 significantly reduces glioma growth and invasion, and enhances oxidative stress in glioma cells. Mechanistic studies revealed that circ0030018 functions through the miR-1236/HER2 signaling pathway. These findings suggest that circ0030018 could serve as a potential biomarker or therapeutic target for glioma.
Article
Pharmacology & Pharmacy
Zhi Jiang, Qiuping Zou, Qicheng Chen, Junhong Zhang, Hailin Tang, Jingbao Chen, You Qin, Liming Yang, Zhiqiang Chen, Lixing Cao
Summary: This study investigated the mechanism and pharmacological effect of Wuda Granule (WDG) on gastrointestinal motility disorder (GMD) through network analysis, animal experiments, and clinical trials. The results showed that WDG improved GMD by inhibiting inflammation and promoting gastrointestinal motility, providing new insights and references for future research and clinical treatment of GMD.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Immunology
Xiao Zhang, Pengpeng Zhang, Ansheng Cong, Yanlong Feng, Hao Chi, Zhijia Xia, Hailin Tang
Summary: This review explores the complex molecular networks of thymic epithelial tumors (TETs), focusing on key aspects such as chromosomal abnormalities, gene mutations and expressions, gene rearrangements, and epigenetic changes. It also examines the influence of the tumor microenvironment on TET behavior and therapeutic responses. A thorough understanding of these features can enhance diagnostic accuracy, refine prognostic assessments, and tailor targeted therapeutic strategies for TETs.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Genetics & Heredity
Abdolmajid Ghasemian, Hadeel A. Omear, Yaser Mansoori, Pardis Mansouri, Xinpei Deng, Farzaneh Darbeheshti, Elham Zarenezhad, Maryam Kohansal, Babak Pezeshki, Zhangling Wang, Hailin Tang
Summary: Colorectal cancer is a fatal cancer, and lncRNAs play regulatory roles in cell proliferation and immune responses via the JAK/STAT signaling pathway, making them potential biomarkers and therapeutic targets.
FRONTIERS IN GENETICS
(2023)
