期刊
ONCOTARGET
卷 6, 期 11, 页码 9531-9541出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.3371
关键词
podoplanin; small cell lung cancer; cancer-associated fibroblasts
资金
- National Cancer Center Research and Development Fund [23-A-12, 23-K-18]
- Foundation for the Promotion of Cancer Research
- 3rd-Term Comprehensive 10-Year Strategy for Cancer Control
- Advanced research for medical products Mining Programme of the National Institute of Biomedical Innovation (NIBIO)
- JSPS KAKENHI [24659185]
- Grants-in-Aid for Scientific Research [24659185] Funding Source: KAKEN
Cancer-associated fibroblasts (CAFs) expressing podoplanin (PDPN) are a favorable prognosticator in surgically resected small cell lung cancer (SCLC). Here we explore whether CAFs expressing PDPN influence proliferation of SCLC cells. Compared with control group (SCLC cells co-cultured with CAFs-Ctrl), numbers of SCLC cells co-cultured with CAFs overexpressing PDPN were decreased. Suppression of PDPN expression by shRNA in CAFs resulted in increased numbers of SCLC cells. In surgically resected human SCLC specimens, the frequency of Geminin-positive cancer cells was significantly higher in the cases with PDPN-positive CAFs than in the cases with PDPN-negative CAFs. Thus CAFs expressing PDPN inhibit growth of SCLC cells, suggesting that CAFs expressing PDPN represent a tumor inhibitory stromal cell component in SCLC.
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