Article
Health Care Sciences & Services
Rei Noguchi, Yuki Yoshimatsu, Yooksil Sin, Takuya Ono, Ryuto Tsuchiya, Hiroshi Yoshida, Tohru Kiyono, Yutaka Yonemura, Tadashi Kondo
Summary: Pseudomyxoma peritonei (PMP) is a condition characterized by the accumulation of mucus in the peritoneal cavity due to a mucinous tumor. The standard treatment for PMP is complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. However, due to high recurrence rates and the invasive nature of the treatment, 30-40% of patients are unable to receive standard therapy, highlighting the need for novel treatments. In this study, a new PMP cell line, NCC-PMP1-C1, was established from metastatic PMP tissue, providing a potential resource for basic and pre-clinical research and drug screening for metastatic PMP.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Joel M. Baumgartner, Amitabh Srivastava, Nelya Melnitchouk, Michael G. Drage, Aaron R. Huber, Raul S. Gonzalez, Phoenix Bell, Elizabeth Wu, Murray Resnick, Kiran Turaga, Elizabeth Poli, Jesus Esquivel, Jeremiah Deneve, Kaitlyn J. Kelly, Jula Veerapong, Andrew M. Lowy
Summary: In the absence of perforation or presence of extra-appendiceal mucin or cells, recurrence of localized LAMNs is extremely rare; however, patients with any of these pathologic findings require careful follow-up.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Nutrition & Dietetics
David Swain, Gemma Mason, Allison Yates, Sara Burke, Tom Cecil, Faheez Mohamed, Sanjeev Dayal, Alexios Tzivanakis, Brendan Moran
Summary: Home parenteral nutrition is feasible and effective in selected patients with pseudomyxoma peritonei, serving as either a bridge to transplant or definitive treatment. However, as expected, patients with more aggressive tumors have worse outcomes.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Surgery
David N. Hanna, Cameron Schlegel, Muhammad O. Ghani, Andrew Hermina, Alexander S. Mina, Katlyn McKay, Christina E. Bailey, Deepa Magge, Kamran Idrees
Summary: This study evaluated the use of a linear cutting stapler for full-thickness diaphragm resection (FT-DR) in cytoreductive surgery. The stapled group showed improved postoperative pulmonary outcomes compared to the conventional group.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Pathology
Marie Csanyi-Bastien, France Blanchard, Aude Lamy, Jean-Christophe Sabourin
Summary: The study presented a case of a 25-year-old female diagnosed with an isolated left ovarian tumor in the context of PMP. Histological examination revealed an ovarian teratoma containing an appendiceal-like structure with mucocele and LAMN, without any associated lesion of the appendix on full histological analysis. Molecular characterization of the ovarian lesion showed co-KRAS and GNAS mutations, as described in PMP of appendiceal origin, emphasizing the need to actively search for tetatomatous signs in a context of ovarian PMP.
DIAGNOSTIC PATHOLOGY
(2021)
Article
Oncology
Ichiaki Ito, Abdelrahman M. G. Yousef, Saikat Chowdhury, Princess N. Dickson, Zahra A. Naini, Michael G. White, Karianne G. Fleten, Kjersti Flatmark, Keith F. Fournier, Natalie W. Fowlkes, John Paul Shen
Summary: The activity and safety of intraperitoneal paclitaxel in orthotopic PDX models of mucinous appendiceal adenocarcinoma supports the evaluation of intraperitoneal paclitaxel in a prospective clinical trial of this rare tumor type.
Letter
Oncology
Mari C. Vazquez-Borrego, Melissa Granados-Rodriguez, Florina I. Bura, Ana Martinez-Lopez, Blanca Rufian-Andujar, Francisca Valenzuela-Molina, Lidia Rodriguez-Ortiz, Sergio Haro-Yuste, Ana Moreno-Serrano, Rosa Ortega-Salas, Rafael Pineda-Reyes, Carmen Michan, Jose Alhama, Antonio Romero-Ruiz, Alvaro Arjona-Sanchez
Summary: In this study, the efficacy of a small-molecule KRAS(G12D) inhibitor, MRTX1133, was tested in a high-grade PMP xenograft mouse model carrying a KRAS(G12D) mutation. The results showed a profound inhibition of tumor growth, associated with a reduction in cell proliferation, an increase in apoptosis, and a reduction in the MAPK and PI3K/AKT/mTOR signaling pathways.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Article
Oncology
Lei Liang, Xuedi Han, Nan Zhou, Hongbin Xu, Jun Guo, Qian Zhang
Summary: Preoperative ultrasound can predict the pathological grade and resectability of PMP. Various ultrasound features are independent prognostic markers for inadequate cytoreduction in PMP patients. Portal infiltration and mesenteric involvement are significant predictors of lower survival rates in PMP patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shigeki Kusamura, Adele Busico, Elena Conca, Iolanda Capone, Luca Agnelli, Daniele Lorenzini, Silvia Brich, Marta Angelini, Chiara Costanza Volpi, Desire Viola Trupia, Vincenzo Lagano, Tommaso Torelli, Annunziata Gloghini, Dario Baratti, Marcello Guaglio, Massimo Milione, Marcello Deraco, Federica Perrone
Summary: This study aimed to explore the mechanisms by which KRAS and GNAS mutations contribute to immune evasion in PMP, as well as to identify potential therapeutic and prognostic targets. The study found immunosuppressive factors such as GM-CSF, A2AR, and PD-L1 in PMP, which were unrelated to GNAS and KRAS status.
Article
Multidisciplinary Sciences
Jonathan Weitz, Kevin Christian Montecillo Gulay, Tatiana Hurtado de Mendoza, Herve Tiriac, Joel Baumgartner, Kaitlyn Kelly, Jula Veerapong, Andrew M. Lowy
Summary: This paper presents a new method for studying pseudomyxoma peritonei (PMP) using patient-derived ex vivo organotypic slices. This method allows real-time visualization and interrogation of the tumor types and maintains the integrity of the tumor microenvironment (TME). It provides a way to assess cellular viability, functional readouts, and to analyze changes in the immune landscape and epithelial cell content using flow cytometry.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Oncology
Mingjian Bai, Shilong Wang, Ruiqing Ma, Ying Cai, Yiyan Lu, Nianzong Hou, Guowei Liang, Hongbin Xu, Man Zhang
Summary: This study identified five independent prognostic factors for predicting the survival of PMP patients and established a nomogram with reasonable discrimination ability for individual risk prediction.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Nikolaj Milandt, Thomas Birkelund, Morten Engholm
Summary: This case demonstrates that chylopericardium can be life-threatening, highlighting the importance of acute echocardiography in the critical management of patients with unexplained shock.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pirjo Nummela, Annamari Heiskanen, Soili Kytola, Caj Haglund, Anna Lepisto, Tero Satomaa, Ari Ristimaki
Summary: Pseudomyxoma peritonei (PMP) is a highly mucinous adenocarcinoma originating most commonly from the appendix, and alterations in the sialic acid linkage pattern in PMP tumors may play a role in the dissemination and progression of the disease.
Article
Medicine, General & Internal
Pedro Villarejo-Campos, Mariano Garcia-Arranz, Siyuan Qian, Santos Jimenez de los Galanes, Victor Dominguez-Prieto, Juan Felipe Velez-Pinto, Ismael Guijo Castellano, Montiel Jimenez-Fuertes, Hector Guadalajara, Damian Garcia-Olmo
Summary: This study investigated the immunohistochemical and biological characteristics of mucin in patients with cellular and acellular pseudomyxoma peritonei, and found that MUC-2 and mucin-5AC were the primary components of mucin in both types. Additionally, Pseudomonas was the most common bacterial genus colonizing the mucin. These findings have significant implications for the diagnosis and treatment of pseudomyxoma peritonei.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Bing Wang, Ruiqing Ma, Guanjun Shi, Zhenpeng Yang, Huazhen Tang, Shuai Lu, Yuying Wang, Jinxiu Qu, Benqiang Rao, Hongbin Xu
Summary: This study retrospectively analyzed the preoperative nutritional status of 165 patients with Low-grade Appendiceal Mucinous Neoplasms (LAMNs) and identified prognostic factors for survival. The results showed that preoperative nutritional status, prior surgical score, completeness of cytoreduction, and hyperthermic intraperitoneal chemotherapy were independent predictors of prognosis. Complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy can benefit patients in terms of survival.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Annie S. Anderson, Richard M. Martin, Andrew G. Renehan, Janet Cade, Ellen R. Copson, Amanda J. Cross, Chloe Grimmett, Laura Keaver, Angela King, Elio Riboli, Clare Shaw, John M. Saxton, Rebecca Beeken, Giota Mitrou
Summary: With the increasing number of cancer survivors, there is a growing realization that excess body fat may impact the quality of survivorship. While past discussions focused on unintended weight loss and interventions to increase weight in cancer patients, there is now a need to study the benefits of intentional fat loss and muscle maintenance for overweight and obese survivors.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Annie S. Anderson, Andrew G. Renehan, John M. Saxton, Joshua Bell, Janet Cade, Amanda J. Cross, Angela King, Elio Riboli, Falko Sniehotta, Shaun Treweek, Richard M. Martin, Rebecca Beeken, Giota Mitrou
Summary: Research shows that weight loss and increased physical activity can effectively reduce the risk of cancer incidence, but there are still gaps in understanding how these factors are related to cancer and their specific impact on cancer risk. More studies on non-pharmacological weight management are urgently needed in order to support cancer risk reduction and control the growing global burden of cancer.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
P. A. Sutton, S. T. O'Dwyer, J. Barriuso, O. Aziz, C. R. Selvasekar, A. G. Renehan, M. S. Wilson
Summary: Repeat cytoreductive surgery with HIPEC can result in favorable survival outcomes, especially for patients with PMP. Detailed patient assessment through an expert multidisciplinary team meeting is recommended based on our findings.
SURGICAL ONCOLOGY-OXFORD
(2021)
Letter
Gastroenterology & Hepatology
Hermann Brenner, Hengjing Li, Daniel Boakye, Xuechen Chen, Michael Hoffmeister
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Robert D. Morgan, Cristina Ferreras, Isabel Peset, Egle Avizienyte, Andrew G. Renehan, Richard J. Edmondson, Alexander D. Murphy, Shibani Nicum, Thomas Van Brussel, Andrew R. Clamp, Diether Lambrechts, Cong Zhou, Gordon C. Jayson
Summary: This study evaluated the clinical significance of co-localisation of c-MET and VEGFR-2, as well as the association between VEGF pathway-related gene polymorphisms and survival outcomes in women with epithelial ovarian cancer receiving bevacizumab treatment. The results showed that high c-MET/VEGFR-2 co-localisation and VEGFR-2 rs2305945 G/G variant were associated with worse survival outcomes.
Article
Oncology
Britt W. Jensen, Julie Aarestrup, Kim Blond, Marit E. Jorgensen, Andrew G. Renehan, Dorte Vistisen, Jennifer L. Baker
Summary: Consistent childhood overweight or obesity may increase the rates of adult obesity-related cancer and decrease the rates of breast cancer. Adult-onset T2D confers additional risk for obesity-related cancer, but the effect does not differ across childhood BMI trajectories.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Michael E. Kelly, Niall J. O'Sullivan, Jarlath C. Bolger, Francesco Polignano, Haney Youssef, Andrew Renehan, Lee Malcomson, Sue Alves, Tom Cecil, Jurgen Mulsow, Brendan Moran, Faheez Mohamed
Summary: This study reviewed data from the UK and Ireland Colorectal Peritoneal Metastases Registry to assess the influence of age on the efficacy of cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) for colorectal peritoneal metastases. The results indicated that age did not appear to impact morbidity or long-term survival following CRS and HIPEC. Good survival outcomes were observed when complete cytoreduction was achieved.
BRITISH JOURNAL OF CANCER
(2023)
Article
Computer Science, Information Systems
Jiarun Cao, Elke M. van Veen, Niels Peek, Andrew G. Renehan, Sophia Ananiadou
Summary: The automatic extraction of relations between gene mutations and cancer entities from cancer literature using text mining is crucial for precision cancer medicine. In this study, we propose a deep learning model that can jointly extract mutations and their associated cancers. By using two different knowledge bases and integrating them using sentence-based and attribute-aware methods, our model outperforms baseline models and achieves high F1 scores on three public datasets.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Meeting Abstract
Economics
S. Thapa, K. Payne, P. Thokala, L. Malcomson, A. G. Renehan
Article
Oncology
Peter Mbanu, Mark P. Saunders, Hitesh Mistry, Joe Mercer, Lee Malcomson, Saif Yousif, Gareth Price, Rohit Kochhar, Andrew G. Renehan, Marcel van Herk, Eliana Vasquez Osorio
Summary: This study investigates the ability of clinical and radiomics variables in predicting cCR in patients with rectal cancer pre-chemoradiotherapy. The combination of radiomics and clinical variables showed improved predictability in the training and validation sets.
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2022)
Article
Oncology
Charlotte Watson, Nophar Geifman, Andrew G. Renehan
Summary: Latent class trajectory models are often used to identify clinically meaningful patient subgroups, but there is uncertainty and over-reliance on certain evaluation criteria in model selection. Small modifications in model specifications can significantly change the model results, and these models are hypotheses generating and should not be directly implemented in clinical practice.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Meeting Abstract
Oncology
A. Gilbert, J. Webster, S. Brown, J. Copeland, S. Ruddock, R. Adams, M. Harrison, R. Muirhead, A. Renehan, D. Sebag-Montefiore, M. Hawkins
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Andres Tamm, Helen J. S. Jones, William Perry, Des Campbell, Rachel Carten, Jim Davies, Algirdas Galdikas, Louise English, Alex Garbett, Ben Glampson, Steve Harris, Khurum Khan, Stephanie Little, Lee Malcomson, Sheila Matharu, Erik Mayer, Luca Mercuri, Eva J. A. Morris, Rebecca Muirhead, Ruth Norris, Catherine O'Hara, Dimitri Papadimitriou, Niels Peek, Andrew Renehan, Gail Roadknight, Naureen Starling, Marion Teare, Rachel Turner, Kinga A. Varnai, Harpreet Wasan, Kerrie Woods, Chris Cunningham
Summary: This study presents the process of collating colorectal cancer data in the UK and explores the potential use of this data source. By utilizing natural language processing and data integration, longitudinal histories of individual patients can be reconstructed for analysis. The results show that algorithms for analyzing routinely collected data have been refined to provide a rich dataset for researching the natural history, treatment variation, and optimal management of colorectal cancer.
BMJ HEALTH & CARE INFORMATICS
(2022)
Letter
Gastroenterology & Hepatology
Nadin Hawwash, Glen P. Martin, Matthew Sperrin, Andrew G. Renehan
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Meeting Abstract
Surgery
K. L. Parmar, C. Slawinski, L. Malcomson, D. OReilly, J. W. Valle, M. Braun, J. H. Naish, S. R. Williams, A. G. Renehan
BRITISH JOURNAL OF SURGERY
(2021)