Article
Gastroenterology & Hepatology
Sameer K. Berry, Rani Berry, David Recker, Jeffrey Botbyl, Lucy Pun, William D. Chey
Summary: Digital gut-directed hypnotherapy (GDH) treatment program can improve symptoms of IBS, including abdominal pain and stool problems. There was no significant difference in effectiveness between digital GDH and digital muscle relaxation (MR), but the GDH treatment group had more abdominal pain responders.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Theodora Kalli, Tilemachos Koutouratsas, George Karamanolis, Maria Gazouli
Summary: The study found a significant association between the rs696217 genetic polymorphism and IBS susceptibility, with the GG and GT genotypes as well as the G allele being linked to IBS risk, while the T allele may have a protective effect. There was no correlation between ghrelin gene polymorphisms and different IBS subtypes.
Article
Medicine, General & Internal
Girish K. Pati, Chinmayee Kar, Jimmy Narayan, Kanishka Uthansingh, Manas Behera, Manoj K. Sahu, Debakanta Mishra, Ayaskanta Singh
Summary: This study evaluated the variation in symptoms of female IBS patients during different phases of the menstrual cycle, finding that they were more symptomatic during the menstrual phase, particularly experiencing constipation, significant limitations in daily activities, and lower quality of life.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Gastroenterology & Hepatology
MaryJane O. Williams, Mary Sedarous, Brittany Dennis, Vanessa Dlamini, Obioma Nwaiwu, Linda Nguyen, Philip N. Okafor
Summary: Analysis of 12 irritable bowel syndrome trials revealed a median FI of 6, suggesting how easily statistical significance based on a threshold p-value may be overturned.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Christopher Ma, Stephen E. Congly, Kerri L. Novak, Paul J. Belletrutti, Maitreyi Raman, Matthew Woo, Christopher N. Andrews, Yasmin Nasser
Summary: The management of chronic symptomatic functional bowel disorders (FBDs) in the United States incurs considerable healthcare resource use and cost, with pharmacologic therapies being more commonly prescribed than nonpharmacologic interventions. Combination treatment strategies are more likely to be implemented by primary care physicians, highlighting the need to improve comprehensive FBD management.
Review
Medicine, General & Internal
Lynne McFarland, Tarkan Karakan, Ali Karatas
Summary: After screening 521 studies, 42 randomized controlled trials were included in this study, with 4 probiotics showing significant reduction in abdominal pain, particularly B. coagulans MTCC5260. Mild-moderate adverse events were reported in 51% of the trials, but none were more associated with the probiotics compared to controls.
Review
Medicine, General & Internal
Silvia Bonetto, Sharmila Fagoonee, Edda Battaglia, Mario Grassini, Giorgio Maria Saracco, Rinaldo Pellicano
Summary: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder with significant impact on quality of life and healthcare costs. Personalized management is required, including physician-patient relationship, patient education, dietary advice, stress reduction, nonpharmacological and pharmacotherapy. The involvement of gastrointestinal microbiota in IBS treatment presents opportunities for modulation through probiotics, prebiotics, synbiotics, and fecal microbiota transplantation.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2021)
Article
Gastroenterology & Hepatology
Eric D. Shah, Brian E. Lacy, William D. Chey, Lin Chang, Darren M. Brenner
Summary: Tegaserod demonstrated significant clinical efficacy in treating irritable bowel syndrome with constipation in women, providing symptom relief and exhibiting good tolerability, with no significant cardiovascular events observed in patients with low cardiac risk factors.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Juan J. Sebastian Domingo
Summary: Irritable bowel syndrome is a common functional bowel disorder with significant impact on patients' daily lives and society's economy. It is characterized by abdominal pain, bloating, and altered bowel movements, and its etiology and pathophysiological mechanism are still unknown.
Article
Gastroenterology & Hepatology
Manol Jovani, Wenjie Ma, Kyle Staller, Amit D. Joshi, Po-Hong Liu, Long H. Nguyen, Paul Lochhead, Yin Cao, Idy Tam, Kana Wu, Edward L. Giovannucci, Lisa L. Strate, Andrew T. Chan
Summary: This study aimed to explore the association between bowel movement frequency and incident diverticulitis. The results showed an inverse association between more frequent bowel movements and the risk of developing diverticulitis. This association was not modified by age, BMI, physical activity, laxative use, or fiber intake.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jill E. Elwing, Hadi Atassi, Benjamin D. Rogers, Gregory S. Sayuk
Summary: Irritable bowel syndrome (IBS) is a multifactorial disorder with limited effectiveness of current therapies, leading to the need for novel treatment options. Future development focuses on serotonergic and endogenous opioid receptor systems, as well as emerging therapies like the endogenous cannabinoid system. The diverse etiologies of IBS present a great potential for the development of new therapies in the future.
EXPERT OPINION ON EMERGING DRUGS
(2022)
Article
Gastroenterology & Hepatology
Vivek C. Goodoory, Cho Ee Ng, Christopher J. Black, Alexander C. Ford
Summary: This study examined willingness to pay for medications among individuals with irritable bowel syndrome (IBS). The results showed that women and individuals with an annual income of 30,000 pounds or more were more likely to be willing to pay for medication. In addition, individuals with lower IBS-related quality of life were more willing to pay for a medication that could improve their symptoms.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
David J. Kearney, Kendra J. Kamp, Meghan Storms, Tracy L. Simpson
Summary: This study described the prevalence of irritable bowel syndrome (IBS) and other gastrointestinal symptoms in veterans with posttraumatic stress disorder (PTSD) and found a relationship between PTSD severity and gastrointestinal symptoms.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Agata Furgala, Katarzyna Ciesielczyk, Magdalena Przybylska-Felus, Konrad Jablonski, Krzysztof Gil, Malgorzata Zwolinska-Wcislo
Summary: This study aimed to assess the postprandial response, including gut peptide secretion and gastric myoelectric activity, in patients with constipation-predominant irritable bowel syndrome (IBS-C). The results showed that IBS-C patients had significantly elevated preprandial levels of gastrin and insulin, while VIP and ghrelin levels were decreased. Moreover, the gastric motility was impaired in IBS-C patients. These findings suggest that disturbances in the postprandial concentration of gut peptides may contribute to abnormal gastric function and intestinal motility, leading to exacerbation of clinical symptoms in IBS patients.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Qiang-Song Wang, Yi-Lun Wang, Wen-Yan Zhang, Kuang-Dai Li, Xiong-Fei Luo, Yuan-Lu Cui
Summary: IBS, especially IBS-D, affects approximately 9-20% of the global population, with traditional treatments often causing side effects. Natural medicines, such as puerarin, have gained attention for their beneficial effects in recent years. Puerarin has been found to reverse IBS-D symptoms by regulating gut microbiota and various physiological processes.
Article
Gastroenterology & Hepatology
Max J. Schmulson, Jazmin Chiu-Ugalde, Adolfo Saez-Rios, Aurelio Lopez-Colombo, Gualberto J. Mateos-Perez, Jose Maria Remes-Troche, Sergio Sobrino-Cossio, Julio C. Soto-Perez, Jose L. Tamayo de la Cuesta, Oscar T. Teramoto-Matsubara, Juan C. Lopez-Alvarenga
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2020)
Article
Gastroenterology & Hepatology
Ami D. Sperber, Shrikant Bangdiwala, Douglas A. Drossman, Uday C. Ghoshal, Magnus Simren, Jan Tack, William E. Whitehead, Dan L. Dumitrascu, Xuicai Fang, Shin Fukudo, John Kellow, Edith Okeke, Eamonn M. M. Quigley, Max Schmulson, Peter Whorwell, Timothy Archampong, Payman Adibi, Viola Andresen, Marc A. Benninga, Bruno Bonaz, Serhat Bor, Luis Bustos Fernandez, Suck Chei Choi, Enrico S. Corazziari, Carlos Francisconi, Albis Hani, Leonid Lazebnik, Yeong Yeh Lee, Agata Mulak, M. Masudur Rahman, Javier Santos, Mashiko Setshedi, Ari Fahrial Syam, Stephen Vanner, Reuben K. Wong, Aurelio Lopez-Colombo, Valeria Costa, Ram Dickman, Motoyori Kanazawa, Ammar Hassanzadeh Keshteli, Rutaba Khatun, Iradj Maleki, Pierre Poitras, Nitesh Pratap, Oksana Stefanyuk, Sandie Thomson, Judith Zeevenhooven, Olafur S. Palsson
Summary: FGIDs have a high prevalence globally, especially among women. Individuals with FGIDs experience lower quality of life and require more frequent medical visits. The proportion of irritable bowel syndrome patients diagnosed using the Rome IV criteria is lower compared to the Rome III criteria.
Article
Immunology
Rene Arredondo-Hernandez, Max Schmulson, Patricia Orduna, Gamaliel Lopez-Leal, Angel-Mario Zarate, Gerardo Alanis-Funes, Luis David Alcaraz, Rubi Santiago-Cruz, Miguel A. Cevallos, Antonio R. Villa, Samuel Ponce-de-Leon Rosales, Yolanda Lopez-Vidal
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2020)
Article
Gastroenterology & Hepatology
Max Schmulson, Marco Gudino-Zayas, Albis Hani
Summary: This study investigated the impact of COVID-19 on Neurogastroenterology practice in Latin America. Findings showed a negative impact on practice and wellness of Neurogastroenterologists, with a decrease in office consultations and elective endoscopies, high implementation but low remuneration of Telemedicine, and reductions in salaries and working hours for personnel. Country differences were observed regarding COVID-19 effects and Telemedicine policies.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Max Schmulson, Uday C. Ghoshal, Giovanni Barbara
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Letter
Gastroenterology & Hepatology
Max Schmulson, Maria Fernanda Davalos De la Rosa, Laura Linares-Garcia, Alizon Sujey Morales-Guzman, Rita Balbuena, Clara Lau
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Editorial Material
Gastroenterology & Hepatology
Max Schmulson
Summary: This editorial analyzes multiple studies to find that probiotics may not have a significant effect on gastroenteritis symptoms and their efficacy may vary by strain. Additionally, in treating Irritable Bowel Syndrome, adequately powered randomized controlled trials are needed to determine the optimal probiotic species, dosage, and treatment duration.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Ami D. Sperber, Tamar Freud, Imran Aziz, Olafur S. Palsson, Douglas A. Drossman, Dan L. Dumitrascu, Xuicai Fang, Shin Fukudo, Uday C. Ghoshal, John Kellow, Rutaba Khatun, Edith Okeke, Eamonn M. M. Quigley, Max Schmulson, Magnus Simren, Jan Tack, William E. Whitehead, Peter Whorwell, Shrikant Bangdiwala
Summary: Gastrointestinal disorders such as irritable bowel syndrome can have negative effects on patients' lives. This study found that 40.3% of surveyed individuals met the criteria for disorders of gut-brain interaction and that DGBI in multiple anatomic gastrointestinal regions is associated with increased psychological comorbidity, healthcare utilization, and IBS severity.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Erwin Chiquete, Jesus Alegre-Diaz, Ana Ochoa-Guzman, Liz Nicole Toapanta-Yanchapaxi, Carlos Gonzalez-Carballo, Adrian Garcilazo-Avila, Rogelio Santacruz-Benitez, Raul Ramirez-Reyes, Rosa Maria Wong-Chew, Guadalupe Guerrero, Max Schmulson, Jaime Berumen, Valeria Sandoval-Rodriguez, Eduardo Ruiz-Ruiz, Carlos Cantu-Brito
Summary: In Mexico, prevalent chronic diseases and indigenous ethnicity are risk factors associated with death in COVID-19 patients.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Alejandro Robles, Mohammad Bashashati, Karina Espino, Irene Sarosiek, Max Schmulson, Marc Zuckerman
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Aaron Shanker, Alejandro Robles, Abhizith Deoker, Irene Sarosiek, Nasser Ebrahimi Daryani, Ali Rezaie, Nima Rezaei, Max Schmulson, Marc Zuckerman, Mohammad Bashashati
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Gastroenterology & Hepatology
M. Schmulson, M. F. Davalos, J. Berumen
REVISTA DE GASTROENTEROLOGIA DE MEXICO
(2020)
Article
Gastroenterology & Hepatology
Diego Rivera-Lechuga, Angel Daniel Santana-Vargas, Ernesto Escamilla-Diego, Luis Charua-Guindic, Max Schmulson
REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Kanchana Myneedu, Max J. Schmulson, Mohammad Bashashati
Article
Gastroenterology & Hepatology
M. J. Schmulson, A. C. Frati-Munari
REVISTA DE GASTROENTEROLOGIA DE MEXICO
(2019)