Article
Medicine, Research & Experimental
Yuanyuan Li, Yanting Wang, Jie Li, Zihang Ling, Wei Chen, Liping Zhang, Qinchao Hu, Tong Wu, Bin Cheng, Yun Wang, Juan Xia
Summary: Tacrolimus is commonly used in treatments of patients with organ transplants and immune diseases, and recommended for oral potentially malignant disorders. Research shows that tacrolimus can block oral carcinogenesis by inhibiting epithelial cell proliferation independent of its immunosuppressive effects.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
Petr Shegay, Anastasia A. Zabolotneva, Olga P. Shatova, Aleksandr Shestopalov, Andrei D. Kaprin
Summary: Lactic acid, once considered a toxic byproduct of metabolism, has been found to have various functions in living organisms. It acts as a signaling molecule and regulates metabolic processes, cell differentiation, and inflammatory response. Lactate also plays a role in providing stemness and promoting unlimited cell growth, which is utilized by malignant tumors. This review aims to summarize the functions of lactate in cell metabolism and its involvement in carcinogenesis, considering the evolutionary significance of the Warburg effect.
Article
Oncology
Soo-Mi Kweon, Gayeoun Kim, Yunseong Jeong, Wendong Huang, Ju-Seog Lee, Keane K. Y. Lai
Summary: Liver cancer, one of the deadliest cancers, may be influenced by the little-known gene midnolin, which has been found to correlate with poor prognosis in patients and may have a significant impact on liver cancer development.
Article
Medicine, General & Internal
Joshua Christy, Emad Kandah, Kavitha Kesari, Venkatasiva Peram
Summary: Non-Hodgkin's lymphoma presenting as a soft tissue sarcoma is rare, with only 0.11% of cases reported. This case study highlights successful treatment of the patient with six cycles of chemotherapy, resulting in reduction of the mass and absence of fluorodeoxyglucose-avid uptake on PET-CT scans. MRI also showed near-normal intensity, indicating potential disease remission. Further PET-CT scans will be needed to determine the progression of the disease.
Review
Surgery
Gonzalo Sapisochin, Taizo Hibi, Christian Toso, Kwan Man, Marina Berenguer, Julie Heimbach, Tim F. Greten, Trevor J. Pugh, Laura A. Dawson, Vincenzo Mazzaferro
Summary: Transplant oncology in hepato-biliary cancer involves using transplant medicine and surgery to improve cancer patients' survival and quality of life. Liver transplantation is the only solid organ transplant proven to cure cancer in selected hepato-biliary cancer cases. The future contributions of transplant oncology in this field include an evolutionary approach to cancer care, research on self and non-self recognition systems, exploration of innovative endpoints, and extending surgical limitations in multidisciplinary approaches.
Article
Cell Biology
Lingyu Zhao, Lili Ren, Shuangshu Gao, Jun Wang, Xiaobo Li, Lei Zhang, Yuanyuan Zhu, Hanjie Li
Summary: Immunotherapies have revolutionized cancer treatment, but face challenges such as low response rate and resistance. Understanding the tumor immune niche is crucial, and single-cell genomics technologies can help dissect it and improve immunotherapies. This advancement holds promise for developing more effective and precise treatments for human cancers.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Review
Cell Biology
Mikhail Blagosklonny
Summary: This article proposes hallmarks of aging based on a hierarchical principle and the hyperfunction theory. It suggests that unlike cancer, aging is not a molecular disease, but rather a result of normal intracellular signaling pathways becoming hyperfunctional, leading to a range of age-related diseases.
Article
Medicine, General & Internal
Deepika Gupta, Vikarn Vishwajeet, Mohammed Ramzan, Poonam Abhay Elhence
Summary: This article presents a rare case of ALK-positive ALCL involving the left thigh and anterior chest wall in a 12-year-old male child. The diagnosis relied on excluding other relevant diseases and confirming the diagnosis through immunohistochemistry and fluorescence in-situ hybridisation.
Article
Pharmacology & Pharmacy
Rong Liu, Zifeng Deng, Mo Lin, Fengkai Ruan, Guangping Luo, Zhen Luo, Liangding Dou, Lei Wang, Guihua Qiu, Zhi Huang, Xin Hou, Dai Wang, Dongbei Guo, Haitao Zhou, Ran An, Youliang Yao, Yongxing Zhang
Summary: This study reveals the impact of arsenic on the transformation of human bronchial epithelial cells. Both short-term and long-term exposure can promote G1/S transition, with AKAP95 playing a regulatory role in this process. Additionally, arsenic exposure leads to mitochondrial dysfunction.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Engineering, Environmental
Heng-Dao Lin, Yi-Kuan Tseng, Chiou-Hwa Yuh, Ssu-Ching Chen
Summary: The study reveals that repeated exposure to low concentrations of 4-ABP may promote cellular proliferation and migration, inducing liver cancer. Additionally, a correlation between the Ras-ERK pathway and 4-ABP-induced HCC was observed in vitro and in vivo.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Shuai Chen, Jianghong Cheng, Yanhong Zhong, Ruimin Liu, Zhongxian Lu, Xianyang Luo
Summary: The deletion of the Gab2 gene has a preventive effect on chronic liver inflammation and hepatocellular carcinoma. Gab2 can accelerate tumor growth and progression in hepatocarcinogenesis by activating IL-6 and MDSCs. This study provides novel insights into the role of Gab2 in autoimmune tolerance during hepatocarcinogenesis.
Review
Oncology
Joao Manzi, Camilla. O. O. Hoff, Raphaella Ferreira, Renata Glehn-Ponsirenas, Gennaro Selvaggi, Akin Tekin, Christopher. B. B. O'Brien, Lynn Feun, Rodrigo Vianna, Phillipe Abreu
Summary: The liver is a common primary tumor site, responsible for about 5% of all cancers and over 8% of cancer-related deaths worldwide. Hepatocellular carcinoma (HCC) is the most prevalent type of liver cancer, accounting for approximately 75% of all primary liver tumors. Liver transplantation is a major therapeutic tool in the treatment of HCC, but it faces challenges of tumor recurrence and graft rejection. Cell-free DNA has emerged as a new tool for decision-making in the context of HCC treatment, and this article summarizes its main aspects, exploring its strengths and weaknesses.
Article
Oncology
Georgina E. Riddiough, Qaiser Jalal, Marcos Perini, Ali W. Majeed
Summary: Surgical resection for hepatic neoplasms provides the best chance of cure but relies on the liver's ability to regenerate. Liver regeneration may also drive tumour recurrence, but overall survival in patients undergoing these procedures has not been shown to worsen.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Medicine, General & Internal
Sophie Pilleron, Helen Gower, Maryska Janssen-Heijnen, Virginia Claire Signal, Jason K. Gurney, Eva J. A. Morris, Ruth Cunningham, Diana Sarfati
Summary: This systematic review identified age disparities in cancer survival using colon and lung cancer as examples. The study found that factors such as sex, ethnicity, socioeconomic status, stage at diagnosis, cancer site, morphology, number of nodes examined, and treatment strategy greatly influenced the magnitude of age disparities in survival. Further research is needed to better understand these age disparities in colon and lung cancer survival.
Article
Oncology
Peter Kar Han Lau, Carleen Cullinane, Susan Jackson, Rachael Walker, Lorey K. Smith, Alison Slater, Laura Kirby, Riyaben P. Patel, Bianca von Scheidt, Clare Y. Slaney, Grant A. McArthur, Karen E. Sheppard
Summary: The combination of adoptive cell transfer (ACT) with BRAF-MEK and CDK4/6 inhibitors has shown to be highly efficacious against BRAF(V600) melanoma, providing prolonged and deep anti-tumor responses. This study offers additional pre-clinical evidence to support the combination of BRAF-MEK-CDK4/6 inhibitors and ACT in clinical trials.