Article
Medicine, Research & Experimental
Shijie Wang, Wenwen Wei, Yuncang Yuan, Bin Sun, Dong Yang, Nan Liu, Xudong Zhao
Summary: In this study, CAR-T cells targeting cell surface GRP78 protein were generated and shown to efficiently kill GBM tumor cells and glioma stem cells both in vitro and in vivo, suppressing tumor growth without obvious off-target effects or tissue injuries.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Nadia Trivieri, Alberto Visioli, Gandino Mencarelli, Maria Grazia Cariglia, Laura Marongiu, Riccardo Pracella, Fabrizio Giani, Amata Amy Soriano, Chiara Barile, Laura Cajola, Massimiliano Copetti, Orazio Palumbo, Federico Legnani, Francesco DiMeco, Leonardo Gorgoglione, Angelo L. Vescovi, Elena Binda
Summary: In this study, we identified a subset of self-activating stem cells in high-grade gliomas that are capable of activating regulatory growth signaling. These self-activating stem cells possess distinct functional and molecular features compared to their growth factor-dependent counterparts. Regardless of the GBM subtype, these self-activating stem cells exhibit higher tumorigenic potential and their transcriptomic fingerprints reflect the original tumor, suggesting their potential as diagnostic and therapeutic markers. Additionally, we found that inhibiting two key regulators, Wnt5a and EphA2, can attenuate the tumorigenic and invasive abilities of these stem cells, leading to improved survival.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Xueran Chen, Wanxiang Niu, Xiaoqing Fan, Haoran Yang, Chenggang Zhao, Junqi Fan, Xuebiao Yao, Zhiyou Fang
Summary: In this study, it was found that Oct4A can impact the tumorigenic activity of glioblastoma and its stability is maintained through palmitoylation. Oct4A palmitoylation helps to integrate Sox4 and Oct4A in the SOX2 enhancement subregion, thereby maintaining the stem performance of glioma stem cells. The study also designed Oct4A palmitoylation competitive inhibitors that can inhibit the self-renewal ability and tumorigenicity of glioma stem cells.
Article
Oncology
Maria Patrizia Mongiardi, Mariachiara Buccarelli, Alessia Formato, Elisa Orecchini, Maria Salbini, Valentina Ricci, Tiziana Orsini, Sabrina Putti, Silvia Chiesa, Lucia Ricci-Vitiani, Quintino Giorgio D'Alessandris, Roberto Pallini, Andrea Levi, Maria Laura Falchetti
Summary: Glioblastoma is an aggressive primary brain tumor with poor prognosis. A recent clinical trial showed that the multikinase inhibitor regorafenib can significantly increase the overall survival of glioblastoma patients. However, little is known about the molecular mechanisms of regorafenib's effectiveness. This study found that regorafenib can limit glioblastoma cell proliferation but might also induce an invasive phenotype.
Review
Biochemistry & Molecular Biology
Hyunkoo Kang, Haksoo Lee, Dahye Kim, Byeongsoo Kim, JiHoon Kang, Hae Yu Kim, HyeSook Youn, BuHyun Youn
Summary: Glioblastoma (GBM) is a highly malignant brain tumor that is resistant to current therapies. This review focuses on the resistance mechanisms of GBM, particularly towards temozolomide (TMZ), and summarizes the recent findings on the intrinsic and extrinsic mechanisms of chemoresistance in GBM stem cells (GSCs). It also discusses novel therapeutic strategies, such as molecular targeting, autophagy inhibition, oncolytic viral therapy, drug repositioning, and targeting of GSC niches, to eliminate GSCs and improve GBM therapy.
Article
Oncology
Alberto Visioli, Nadia Trivieri, Gandino Mencarelli, Fabrizio Giani, Massimiliano Copetti, Orazio Palumbo, Riccardo Pracella, Maria Grazia Cariglia, Chiara Barile, Luigi Mischitelli, Amata Amy Soriano, Pietro Palumbo, Federico Legnani, Francesco Dimeco, Leonardo Gorgoglione, Graziano Pesole, Angelo L. Vescovi, Elena Binda
Summary: This study demonstrates that distinct pools of GSCs enrich the functional inter-cluster variances in GBM patients. Two novel functional biomarkers that selectively represent GSCs pools were identified, capable of discriminating GBM patient stratification, survival, and drug response. These findings provide the groundwork for personalized diagnostic and prognostic strategies, as well as patient-selective treatment protocols.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Simona Daniele, Valeria La Pietra, Rebecca Piccarducci, Deborah Pietrobono, Chiara Cavallini, Vincenzo Maria D'Amore, Linda Cerofolini, Stefano Giuntini, Pasquale Russomanno, Michela Puxeddu, Marianna Nalli, Martina Pedrini, Marco Fragai, Claudio Luchinat, Ettore Novellino, Sabrina Taliani, Giuseppe La Regina, Romano Silvestri, Claudia Martini, Luciana Marinelli
Summary: Glioblastoma multiforme (GBM) is characterized by high invasiveness, resistance to treatment, and poor survival, with abnormal p53 function, overexpression of MDM2/4, and involvement of the CXCR4 pathway. Inhibiting CXCR4/MDM2/4 shows promise in reducing GBM proliferation and invasion, including in cancer stem cell components.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Luisa Salvatori, Silvia Malatesta, Barbara Illi, Maria Patrizia Somma, Cinzia Fionda, Helena Stabile, Rosaria Anna Fontanella, Carlo Gaetano
Summary: Glioblastoma multiforme (GBM) has high mortality and recurrence rates. Glioblastoma Stem Cells (GSCs) contribute to malignancy resilience. Nitric Oxide (NO) has shown anti-cancer efficacy in GBM cells and can enhance the sensitivity of GSCs to TMZ.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Cristina Almenglo, Pilar Caamano, Maximo Fraga, Jesus Devesa, Jose A. Costoya, Victor M. Arce
Summary: GBM, the most common and aggressive primary brain tumor in adults, presents vast genetic variation and phenotypic diversity, making therapeutic strategy development challenging. Transformation of primary mouse embryo astrocytes into immortalized cultures with neural stem cell characteristics provides a model for studying gliomagenesis and testing drug effectiveness throughout GBM's natural history.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Leonardo Delello Di Filippo, Juliana Hofstatter Azambuja, Jessyca Aparecida Paes Dutra, Marcela Tavares Luiz, Jonatas Lobato Duarte, Luiza Ribeiro Nicoleti, Sara Teresinha Olalla Saad, Marlus Chorilli
Summary: Glioblastoma multiforme (GBM) is the most common primary brain cancer with aggressive development and increasing resistance to drugs like temozolomide (TMZ). Functionalized nanocarriers can serve as an efficient and safe strategy for delivering TMZ, improving its biopharmaceutical properties and potentially repurposing its use in anti-GBM therapy.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Pathology
Lingfei Li, Yuxin Yin, Jinping Zhang, Xiaoxu Wu, Jin Liu, Jia Chai, Yanru Yang, Mingyang Li, Qingge Jia, Yixiong Liu
Summary: In this study, it was found that USP18 was up-regulated in glioblastoma, promoting the growth and proliferation of glioblastoma stem cells (GSCs), affecting the epithelial-mesenchymal transition (EMT), and being associated with poor clinical prognosis of patients.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Oncology
Nguyen Thi Thanh Ho, Chinmay Satish Rahane, Subrata Pramanik, Pok-Son Kim, Arne Kutzner, Klaus Heese
Summary: This review discusses the significance of the gene pair |-SRGAP2-FAM72-| in the treatment of GBM and other cancers, as well as the potential of neural stem cells in regenerative medicine. It highlights the role of the SRGAP2-Family with sequence similarity 72 (FAM72) master gene in cell renewal and differentiation, emphasizing the importance of monitoring this gene for cancer prevention and treatment.
Article
Biochemistry & Molecular Biology
Anna L. Koessinger, Catherine Cloix, Dominik Koessinger, Dieter Henrik Heiland, Florian J. Bock, Karen Strathdee, Kevin Kinch, Laura Martinez-Escardo, Nikki R. Paul, Colin Nixon, Gaurav Malviya, Mark R. Jackson, Kirsteen J. Campbell, Katrina Stevenson, Sandeep Davis, Yassmin Elmasry, Asma Ahmed, Jim O'Prey, Gabriel Ichim, Oliver Schnell, William Stewart, Karen Blyth, Kevin M. Ryan, Anthony J. Chalmers, Jim C. Norman, Stephen W. G. Tait
Summary: This study investigated the therapeutic potential of targeting anti-apoptotic BCL-2 proteins in glioblastoma (GBM), the most common malignant brain tumor in adults. The study found that the expression levels of anti-apoptotic BCL-xL and MCL-1 were consistently increased in GBM compared with non-malignant cells and tissue. Furthermore, patient-derived GBM stem-like cells also displayed higher expression of anti-apoptotic BCL-2 family members. Sequential inhibition of BCL-xL and MCL-1 led to robust anti-tumor responses in vivo.
CELL DEATH AND DIFFERENTIATION
(2022)
Review
Biochemistry & Molecular Biology
Wookyeom Yang, Dasol Kim, Dae Kyoung Kim, Kyung Un Choi, Dong Soo Suh, Jae Ho Kim
Summary: Ovarian cancer is a fatal gynecological malignancy, and its treatment remains a challenge. Cancer stem cells (CSCs) play a key role in cancer relapse and treatment resistance, with their malignancy regulated by cell surface receptors and intracellular factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Philippe Aretz, Donata Maciaczyk, Suad Yusuf, Rudiger V. Sorg, Daniel Haenggi, Hongjia Liu, Hongde Liu, Tikam Chand Dakal, Amit Sharma, Ramakrishna Bethanabatla, Silke Neumann, Jarek Maciaczyk
Summary: The study reveals the crucial role of beta-catenin in attracting monocytes towards GBM cells and suggests that the interaction between beta-catenin and CCL2 may contribute to the maintenance of GSCs by modulating immune cell interaction and promoting GBM growth and recurrence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Jeppe Haslund-Vinding, Jane Skjoth-Rasmussen, Lars Poulsgaard, Kaare Fugleholm, Christian Mirian, Andrea Daniela Maier, Thomas Santarius, Frantz Rom Poulsen, Torstein Meling, Jiri Junior Bartek, Petter Forander, Vibeke Andree Larsen, Bjarne Winther Kristensen, David Scheie, Ian Law, Morten Ziebell, Tiit Mathiesen
Summary: Developed a new grading system for meningiomas based on microscopic analyses of resection margins and sensitive radiological analyses, named Copenhagen Grading. This grading system was described for six pilot patients and appeared complementary in improving the management of meningiomas. Copenhagen Grading is prospectively implemented as a clinical standard at Rigshospitalet, Copenhagen, showing promise to be the most sensitive and specific imaging modality available for meningiomas.
ACTA NEUROCHIRURGICA
(2022)
Review
Clinical Neurology
Jarnail Bal, Michael Bruneau, Moncef Berhouma, Jan F. Cornelius, Luigi M. Cavallo, Roy T. Daniel, Sebastien Froelich, Emmanuel Jouanneau, Torstein R. Meling, Mahmoud Messerer, Pierre-Hugues Roche, Henry W. S. Schroeder, Marcos Tatagiba, Idoya Zazpe, Dimitrios Paraskevopoulos
Summary: Non-vestibular schwannomas, including trigeminal and jugular foramen schwannomas, are relatively rare and require detailed investigation for management. This article provides insight into the main principles defining management and surgical strategy, aiming to formulate recommendations for these tumors.
ACTA NEUROCHIRURGICA
(2022)
Review
Clinical Neurology
Jarnail Bal, Michael Bruneau, Moncef Berhouma, Jan F. Cornelius, Luigi M. Cavallo, Roy T. Daniel, Sebastien Froelich, Emmanuel Jouanneau, Torstein R. Meling, Mahmoud Messerer, Pierre-Hugues Roche, Henry Schroeder, Marcos Tatagiba, Idoya Zazpe, Dimitrios Paraskevopoulos
Summary: This article discusses the surgical management and strategies for non-vestibular schwannomas, aiming to provide recommendations for the treatment of these tumors. The research team conducted an extensive systematic review, discussing preoperative radiological investigations, ophthalmological assessments, surgical and radiotherapy strategies, and follow-up management.
ACTA NEUROCHIRURGICA
(2022)
Article
Clinical Neurology
Guillaume Baucher, Lucas Troude, Alexandre Roux, Anderson Loundou, Mohamed Boucekine, Torstein Meling, Pierre-Hugues Roche
Summary: This study retrospectively analyzed 87 patients who underwent surgical resection of skull base meningiomas including EAC, showing that EAC is effective in preserving visual acuity, especially in patients with preoperative normal visual function. Preoperative DVA is significantly associated with postoperative DVA, and 78% of cases with postoperative ocular motor nerve dysfunction recovered.
NEUROSURGICAL REVIEW
(2022)
Article
Clinical Neurology
Sayied Abdol Mohieb Hosainey, Benjamin Lassen Lykkedrang, Torstein R. Meling
Summary: This study found that 33% of patients who required VP shunting after brain tumor surgery experienced one or more shunt failures during long-term follow-up, with success rates of 77%, 71%, and 67% at 1, 5, and 10 years, respectively. Factors such as age, sex, tumor location, primary/revision craniotomy, external ventricular drainage placement, ventricular entry, post-craniotomy hemorrhage, post-shunting meningitis/infection, and multiple shunt revisions were not significant risk factors for shunt failure.
NEUROSURGICAL REVIEW
(2022)
Review
Oncology
Marco Vincenzo Corniola, Torstein R. Meling
Summary: Intracranial meningiomas are common primary lesions of the central nervous system, and surgery is the main treatment approach. However, the management of recurrences after initial surgery is still debated. This article summarizes current practice and compares surgical and non-surgical alternatives in the management of meningioma recurrence, highlighting surgery as the state-of-the-art approach.
Article
Oncology
Gabriele Capo, Alessandro Moiraghi, Valentina Baro, Nadim Tahhan, Alberto Delaidelli, Andrea Saladino, Luca Paun, Francesco DiMeco, Luca Denaro, Torstein Ragnar Meling, Enrico Tessitore, Cedric Yves Barrey
Summary: This study aimed to assess the surgical outcome and identify possible outcome predictors for elderly patients with spinal meningiomas. The research found that functional preoperative score and age at surgery were correlated with functional outcome. Surgical resection had a positive impact on functional outcome, suggesting the importance of surgery for elderly patients with spinal meningiomas.
Article
Health Care Sciences & Services
Sandrine Morel, Isabel C. Hostettler, Georg R. Spinner, Romain Bourcier, Joanna Pera, Torstein R. Meling, Varinder S. Alg, Henry Houlden, Mark K. Bakker, Femke van't Hof, Gabriel J. E. Rinkel, Tatiana Foroud, Dongbing Lai, Charles J. Moomaw, Bradford B. Worrall, Jildaz Caroff, Pacome Constant-dits-Beaufils, Matilde Karakachoff, Antoine Rimbert, Aymeric Rouchaud, Emilia Gaal-Paavola, Hanna Kaukovalta, Riku Kivisaari, Aki Laakso, Behnam Rezai Jahromi, Riikka Tulamo, Christoph M. Friedrich, Jerome Dauvillier, Sven Hirsch, Nathalie Isidor, Zolt Kulcsar, Karl O. Lovblad, Olivier Martin, Paolo Machi, Vitor Mendes Pereira, Daniel Rufenacht, Karl Schaller, Sabine Schilling, Agnieszka Slowik, Juha E. Jaaskelainen, Mikael von und zu Fraunberg, Jordi Jimenez-Conde, Elisa Cuadrado-Godia, Carolina Soriano-Tarraga, Iona Y. Millwood, Robin G. Walters, Helen Kim, Richard Redon, Nerissa U. Ko, Guy A. Rouleau, Antti Lindgren, Mika Niemela, Hubert Desal, Daniel Woo, Joseph P. Broderick, David J. Werring, Ynte M. Ruigrok, Philippe Bijlenga
Summary: This study found that the location of intracranial aneurysms (IAs), awareness of risk factors, age, and gender are associated with the likelihood of an IA being diagnosed incidentally or ruptured. Evaluating the associations between patient and IA characteristics can help refine disease models and develop risk instruments for clinicians to make personalized decisions.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Editorial Material
Health Care Sciences & Services
Mari Nygard, Stale Nygard
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Letter
Clinical Neurology
Marco V. Corniola, Kristof Egervari, Maria I. Vargas, Torstein R. Meling
JOURNAL OF NEUROSURGICAL SCIENCES
(2023)
Article
Oncology
Rebecca Rootwelt Winther, Eva Skovlund, Joakim Stray Andreassen, Lisa Arvidsson, Jonathan Halvardson, Ole Solheim, Jiri Bartek, Stein Kaasa, Marianne Jensen Hjermstad, Einar Osland Vik-Mo
Summary: Metastases to the brain are serious and often fatal. This study identified factors that predict survival after surgery for these metastases, and created a prognostic index to guide decision-making. The index was validated on patients from other hospitals and found to be effective.
Letter
Clinical Neurology
Georgios Mavrovounis, Torstein R. Meling, Jesus Lafuente, Kostas N. Fountas, Andreas K. Demetriades
GLOBAL SPINE JOURNAL
(2023)
Review
Medicine, General & Internal
Victor Volovici, Iris S. Verploegh, Djaina Satoer, Noelle J. M. C. Vrancken Peeters, Yasmin Sadigh, Mervyn D. I. Vergouwen, Joost W. Schouten, Gavin Bruggeman, Dana Pisica, Gizem Yildirim, Ayca Cozar, Femke Muller, Ana-Maria Zidaru, Kelsey Gori, Nefeli Tzourmpaki, Esther Schnell, Mbaye Thioub, Kimberly Kicielinski, Pieter-Jan van Doormaal, Nikolay Velinov, Mahjouba Boutarbouch, Michael T. Lawton, Giuseppe Lanzino, Sepideh Amin-Hanjani, Ruben Dammers, Torstein R. Meling
Summary: In this systematic review and meta-analysis of IA treatment literature, studies claiming safety, effectiveness, or durability of IA treatment had methodological flaws and incomplete reporting of relevant outcomes supporting these claims.
Article
Clinical Neurology
Felix Behling, Michael Bruneau, Jurgen Honegger, Moncef Berhouma, Emmanuel Jouanneau, Luigi Cavallo, Jan Frederick Cornelius, Mahmoud Messerer, Roy Thomas Daniel, Sebastien Froelich, Diego Mazzatenta, Torstein Meling, Dimitrios Paraskevopoulos, Pierre-Hugues Roche, Henry W. S. Schroeder, Idoya Zazpe, Eduard Voormolen, Massimiliano Visocchi, Ekkehard Kasper, Jens Schittenhelm, Marcos Tatagiba
Summary: This study examined the sampling methods and diagnostic value of invasive growth of meningiomas in neurosurgical departments, and found significant variations in sampling methods among departments. A structured sampling method is needed to optimize the diagnosis of invasive growth of meningiomas.
Article
Clinical Neurology
C. Zoia, G. Mantovani, E. Suero Molina, M. Muether, A. Scerrati, P. De Bonis, J. F. Cornelius, P. H. Roche, M. Tatagiba, E. Jouanneau, R. Manet, H. W. S. Schroeder, L. M. Cavallo, E. M. Kasper, T. R. Meling, D. Mazzatenta, R. T. Daniel, M. Messerer, M. Visocchi, S. Froelich, M. Bruneau, G. Spena
Summary: This paper provides a narrative review on the current state and future trends in endoscopic orbital surgery, discussing its significant impact on neurosurgery.