Article
Biochemistry & Molecular Biology
Linyuan Shen, Tianci Liao, Jingyun Chen, Jianfeng Ma, Jinyong Wang, Lei Chen, Shunhua Zhang, Ye Zhao, Lili Niu, Changjun Zeng, Mailin Gan, Li Zhu
Summary: The study identified miR-221 and miR-222 and their target genes MyoG and Tnnc1 as key regulators during skeletal muscle regeneration, both regulated by GEN. GEN promotes satellite cell differentiation during skeletal muscle regeneration by inhibiting the expression of miR-221/222.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yuefan Guo, Guangxue Wang, Zhongrui Wang, Xin Ding, Lu Qian, Ya Li, Zhen Ren, Pengfei Liu, Wenjing Ma, Danni Li, Yuan Li, Qian Zhao, Jinhui Lu, Qinchuan Li, Qinhong Wang, Zuoren Yu
Summary: The miR-221/222 cluster plays a crucial role in regulating CSCs in NSCLC, affecting tumor initiation, metastasis, and drug resistance. Reck, identified as a key direct target gene of miR-221/222, plays a critical role in the activation of the Notch1 signaling pathway in NSCLC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Knyrim, Sindy Rabe, Claudia Grossmann, Michael Gekle, Barbara Schreier
Summary: miR-221/222 in cardiomyocytes play a role in beta-adrenergic regulation of LTCC function, calcium handling, and beating frequency, leading to slower depolarization-dependent Ca2+ entry and increased proportion of non-responding cells. This study expands our knowledge about the role of these miRs in cardiac ion channel regulation.
CELL AND BIOSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jiajia Hu, Jiawei Zhang, Meng Yu, Zukai Liu, Yan Zou, Liwen Hong, Tianyu Zhang, Jing Sun, Minhua Zheng, Xuekai Zhu, Zhengting Wang, Sanhong Liu
Summary: This study revealed that the levels of miR-221 and miR-222 were significantly increased in colorectal cancer patients, serving as sensitive diagnostic markers. Both miR-221 and miR-222 were found to directly regulate the expression of CD4, impacting the number of CD4(+) T cells.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Review
Medicine, Research & Experimental
Maria Teresa Di Martino, Mariamena Arbitrio, Daniele Caracciolo, Alessia Cordua, Onofrio Cuomo, Katia Grillone, Caterina Riillo, Giulio Carida, Francesca Scionti, Caterina Labanca, Caterina Romeo, Maria Anna Siciliano, Maria D'Apolito, Cristina Napoli, Martina Montesano, Valentina Farenza, Valentina Uppolo, Michele Tafuni, Federica Falcone, Giuseppe D'Aquino, Natale Daniele Calandruccio, Francesco Luciano, Licia Pensabene, Pierosandro Tagliaferri, Pierfrancesco Tassone
Summary: Among deregulated microRNAs, miR-221 has been extensively studied for its oncogenic role in human malignancies and its involvement in chronic liver injury and inflammation. Silencing of miR-221 shows promise as a therapeutic intervention. This systematic review demonstrates the importance of miR-221 as a valuable therapeutic target in molecular medicine.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Oncology
Jia Yang, Zhiling Yan, Yingying Wang, Jinmei Xu, Rui Li, Chuanyin Li, Shuyuan Liu, Li Shi, Yufeng Yao
Summary: Our study suggests that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222 may play important roles in the development of CIN or CC.
Article
Oncology
Fei Tian, Peiyun Wang, Dan Lin, Jiajia Dai, Qibing Liu, Yu Guan, Yang Zhan, Yichen Yang, Wenpeng Wang, Jiefu Wang, Jia Liu, Lei Zheng, Yan Zhuang, Jun Hu, Junfeng Wang, Dalu Kong, Kegan Zhu
Summary: The study identified an upregulated gene cluster miR-221/222 in serum exosome samples of CRC patients with liver metastasis, predicting poor overall survival. In vitro and in vivo experiments confirmed that miR-221/222 promotes the aggressive nature of CRC and formation of a premetastatic niche. These results suggest miR-221/222 as a potential therapeutic target and prognostic marker for CRC.
Article
Medicine, Research & Experimental
Ju-Yeon Kim, Eun Jung Jung, Jae-Myung Kim, Youngsim Son, Han Shine Lee, Seung-Jin Kwag, Ji-Ho Park, Jin-Kyu Cho, Han-Gil Kim, Taejin Park, Sang-Ho Jeong, Chi-Young Jeong, Young-Tae Ju
Summary: miR-221 and miR-222 play a significant role in the progression and invasion of breast cancer cells by regulating the target gene ANXA3. The expression levels of miR-221/222 are associated with aggressive characteristics of breast cancer, and downregulation of ANXA3 through increased expression of miR-221/222 reduces breast cancer progression and increases the effectiveness of chemotherapy.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Immunology
Eric J. Wigton, Yohei Mikami, Ryan J. McMonigle, Carlos A. Castellanos, Adam K. Wade-Vallance, Simon K. Zhou, Robin Kageyama, Adam Litterman, Suparna Roy, Daisuke Kitamura, Emily C. Dykhuizen, Christopher D. C. Allen, Hui Hu, John J. O'Shea, K. Mark Ansel
Summary: MicroRNAs regulate cell fate decisions by post-transcriptionally tuning networks of mRNA targets, with the miR-221/222 family identified as positive regulators of Ig class switch recombination. Endogenous miR-221/222 controls B cell CSR to IgE and IgG1, while Foxpl and Arid1a are confirmed as key modulators of CSR to IgE and IgG1 through genetic depletion or pharmacological inhibition.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Shang Cai, Jiayan Ma, Yong Wang, Yuxing Cai, Liwei Xie, Xiangying Chen, Yingying Yang, Qiliang Peng
Summary: miR-221/222 has the potential to serve as diagnostic tools for papillary thyroid carcinomas (PTC). By pooling published studies and conducting comprehensive bioinformatics analysis, we found that miR-221/222 exhibits high diagnostic accuracy in PTC and is closely related to the molecular pathogenesis of the disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Lianjie Hou, Xiong Tong, Shuyun Lin, Mingfang Yu, Wen-Chu Ye, Meiying Xie
Summary: The study showed that Deoxynivalenol (Don) downregulated miR-221/222 in intestinal epithelial cells, leading to apoptosis and proliferation inhibition. Exosome treatment reversed the effect and targeted Phosphatase and tensin homolog (PTEN) to alleviate Don-induced damage in intestinal epithelial cells. This research expands the understanding of how miR-221/222 and PTEN regulate intestinal epithelial cells defending against Don-induced damage and offers a new approach to protect intestinal development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Han Zhong Pei, Zhiyong Peng, Xiaomei Zhuang, Xiaobo Wang, Bo Lu, Yao Guo, Yuming Zhao, Dengyang Zhang, Yunjun Xiao, Tianshun Gao, Liuting Yu, Chunxiao He, Shunjie Wu, Suk-Hwan Baek, Zhizhuang Joe Zhao, Xiaojun Xu, Yun Chen
Summary: Acute myeloid leukemia (AML) is a hematological malignancy characterized by impaired differentiation and uncontrolled proliferation of myeloid blasts. YOD1, a deubiquitinase, is found to be downregulated in AML patients, and it stabilizes the tumor suppressor p53 through deubiquitination. The expression of YOD1 is suppressed by miR-221/222, and overexpression of YOD1 enhances the therapeutic effects of FLT3 inhibitors in AML cells.
CELL DEATH DISCOVERY
(2023)
Article
Nanoscience & Nanotechnology
Tsai-Chun Lai, Chiang-Wen Lee, Mei-Hsiang Hsu, Yu-Chen Chen, Shu-Rung Lin, Shu-Wha Lin, Tzu-Lin Lee, Shin-Yu Lin, Shu-Hao Hsu, Jaw-Shiun Tsai, Yuh-Lien Chen
Summary: This study elucidated the mechanisms of how high glucose (HG) and particulate matter (PM) induce endothelial inflammation, as well as the protective effect of nanocurcumin (NCur) in alleviating inflammation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Medicine, General & Internal
Aiste Kondrotiene, Albertas Dauksa, Daina Pamedytyte, Mintaute Kazokaite, Aurelija Zvirbliene, Dalia Dauksiene, Vaida Simanaviciene, Raimonda Klimaite, Ieva Golubickaite, Rytis Stakaitis, Valdas Sarauskas, Rasa Verkauskiene, Birute Zilaitiene
Summary: Expressions of miR-21, miR-221, miR-222, and miR-181b are associated with clinicopathological parameters and high expression levels are related to adverse outcomes. Gender and age are identified as independent prognostic factors for patients with papillary thyroid carcinoma.
Article
Cell Biology
Liansheng Zheng, Boshi Yan, Guoliang Jin, Weijie Han, Hailong Wang, Zhepeng Wang, Yongqiang Ma, Yuanyuan Nian, Xianmei Meng, Zhenyu Jiang
Summary: circ_0003159 inhibits the development of gastric cancer by binding to miR-221-3p/miR-222-3p and regulating the expression of LIFR.
JOURNAL OF MOLECULAR HISTOLOGY
(2022)
Article
Oncology
Qin-Hong Xu, Ying Xiao, Xu-Qi Li, Lin Fan, Can-Can Zhou, Liang Cheng, Zheng-Dong Jiang, Guang-Hui Wang
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2020)
Article
Cell Biology
Shan Shao, Tao Qin, Weikun Qian, Xuqi Li, Wei Li, Liang Han, Dong Zhang, Zheng Wang, Qingyong Ma, Zheng Wu, Erxi Wu, Jianjun Lei
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Medicine, Research & Experimental
Cancan Zhou, Jie Li, Weikun Qian, Yangyang Yue, Ying Xiao, Tao Qin, Qingyong Ma, Xuqi Li
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Cell Biology
Shan Shao, Tao Qin, Weikun Qian, Yangyang Yue, Ying Xiao, Xuqi Li, Dong Zhang, Zheng Wang, Qingyong Ma, Jianjun Lei
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Cell Biology
Yunhua Wu, Enmeng Li, Zijun Wang, Tianli Shen, Cong Shen, Dong Liu, Qiuying Gao, Xuqi Li, Guangbing Wei
Summary: TMIGD1 overexpression inhibits abdominal adhesion formation, protects peritoneal mesothelial cells from oxidative stress injury, and enhances cell adhesion capability.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Medicine, General & Internal
Man Xu, Jian Zang, Shanquan Luo, Jianhua Wang, Xuqi Li
Summary: Patients with nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT) in a non-endemic area of China showed similar survival rates and toxicities compared to endemic areas, with distant metastasis and local/regional relapses as the main failure patterns. In non-endemic areas, induction chemotherapy combined with concurrent chemoradiotherapy may benefit locally advanced NPC.
Article
Engineering, Biomedical
Guangbing Wei, Zijun Wang, Ruilin Liu, Cancan Zhou, Enmeng Li, Tianli Shen, Xingjie Wang, Yunhua Wu, Xuqi Li
Summary: In this study, hybrid polydopamine (PDA)-KGF nanoparticles (PDA-KGF NPs) combined with hyaluronate (Ha) were successfully prepared to effectively prevent the occurrence of abdominal adhesions, promote the repair of injured peritoneal mesothelial cells, and reduce collagen deposition and fibrosis, as well as inhibit inflammatory response.
ACTA BIOMATERIALIA
(2022)
Article
Integrative & Complementary Medicine
Xiaoqiang Shi, Yunhua Wu, Enmeng Li, Li Zhang, Yanfei Ma, Guangbing Wei, Xuqi Li, Shufeng Wang
Summary: This study validated the potential of naringin (NG) to reduce intraperitoneal adhesions in a rat model. High-dose NG significantly reduced inflammatory reactions, oxidative stress, collagen deposition, and fibroblast formation, and improved gastrointestinal dynamics.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Xin Chen, Liang Sheng, Jiguang Ma, Dan Qi, Xuqi Li, Zheng Wang, Zheng Wu, Lucas Wong, Jason H. Huang, Erx Wu, Qingyon Ma, Dong Zhang
Summary: Cigarette smokers have a higher risk of pancreatic cancer, but the mechanisms of cigarette metabolites are not fully understood. This study demonstrates that NNK, a component of cigarette smoke, promotes the growth and migration of pancreatic cancer cells and the progression of chronic pancreatitis to pancreatic cancer. These findings provide potential strategies and targets for early prevention and treatment of pancreatic cancer.
Article
Immunology
Yuqian Liu, Shenjie Wang, Yixuan Wang, Yifei Li, Xiaoyan Zhu, Xin Lai, Xuanping Zhang, Xuqi Li, Xiao Xiao, Jiayin Wang
Summary: Tumor mutation burden (TMB) is a widely recognized biomarker for predicting the efficacy of immunotherapy, but its use remains controversial. This study examines the causes of this controversy and identifies the conflict between incomplete biostatistics rules and the variety of clinical samples as a critical issue. The challenges of mutation detection in clinical practice are illustrated, and potential strategies for overcoming these conflict issues are discussed to enable the application of TMB in real clinical settings.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Mengke Zhu, Chao Wei, Haijiang Wang, Shangning Han, Lindi Cai, Xiaowen Li, Xinhua Liao, Xiangming Che, Xuqi Li, Lin Fan, Guanglin Qiu
Summary: This study investigates the effects and underlying mechanism of SIRT1 on autophagy and malignant biological behavior of gastric cancer cells under conditions of glucose deprivation. Results show that SIRT1 regulates the activity of FoxO1 and upregulates the expression of Rab7 through deacetylation, thereby affecting autophagy in gastric cancer cells. Decreasing the expression of SIRT1, FoxO1 or Rab7 significantly inhibits autophagy levels, increases sensitivity to glucose deprivation, and enhances the inhibition of proliferation, migration, and invasion, as well as apoptosis in gastric cancer cells induced by glucose deprivation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Surgery
Xiaoqiang Shi, Hainan Guo, Chao Zhu, Guanglin Qiu, Ting Liang, Jie Lian, Yanfei Ma, Shufeng Wang, Xuqi Li
Summary: This study evaluated the feasibility and application value of mixed reality technology in primary retroperitoneal tumor surgery. The results showed that MR could assist PRT resection and had the potential to improve the rate of complete tumor resection.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2023)
Article
Oncology
Longwen Xu, Mengjie Liu, Jie Lian, Enmeng Li, Chang Dongmin, Xuqi Li, Wenjuan Wang
Summary: We developed a Treg-related classifier and generated a prognostic nomogram that predicts recurrence-free survival in stage I-III colon cancer. This classifier can identify high-risk patients for more personalized and effective therapy. The performance of the classifier was validated using multiple datasets and compared with other signatures.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Surgery
Zijun Wang, Enmeng Li, Cancan Zhou, Bolun Qu, Tianli Shen, Jie Lian, Gan Li, Yiwei Ren, Yunhua Wu, Qinhong Xu, Guangbing Wei, Xuqi Li
Summary: In this study, an optimized mouse model was used to observe the progression of abdominal adhesions. The inflammatory response was found to be activated early in the process, peaking on day 3 and then gradually decreasing until stabilization on day 7. Collagen and fibronectin formation also occurred early and increased until remaining stable on day 7. Live mice observation and RNA sequencing revealed potential key targets involved in abdominal adhesion formation at different time points. The establishment of a standard process for describing the evolution of abdominal adhesions will facilitate future adhesion-related studies.
JOURNAL OF INVESTIGATIVE SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Tianli Shen, Yunhua Wu, Xingjie Wang, Zijun Wang, Enmeng Li, Cancan Zhou, Chenyang Yue, Zhengdong Jiang, Guangbing Wei, Jie Lian, Qinhong Xu, Xuqi Li
Summary: A compound called honokiol, found in magnolia tree bark, has been found to significantly reduce the formation of internal scar tissue after abdominal surgery in mice. This could potentially prevent complications such as infertility or bowel obstructions caused by peritoneal adhesions. The mechanism behind this reduction in scar tissue formation is believed to be related to the activation of a stress-response protein called SIRT3. These findings suggest a new therapeutic strategy for preventing post-surgical peritoneal adhesions.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
