Review
Biology
Liang Liu, Yinxian Wen, Qubo Ni, Liaobin Chen, Hui Wang
Summary: Prenatal ethanol exposure can lead to fetal developmental damage and increased susceptibility to chronic diseases in adults. Ethanol affects fetal development through direct and indirect effects mediated by glucocorticoids. It alters epigenetic modifications and programming of neuroendocrine axes. Differences in ethanol metabolic enzymes and sensitivity to glucocorticoids may contribute to severity and sex differences. Offspring exposed to ethanol during pregnancy show catch-up growth with abundant nutrition after birth but are more likely to develop diseases in adverse environments.
BIOLOGICAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Brianna F. Moore, Katherine A. Sauder, Allison L. B. Shapiro, Tessa Crume, Gregory L. Kinney, Dana Dabelea
Summary: The study assessed the impact of fetal exposure to cannabis on adiposity and glucose-insulin traits in early life. The results suggest that fetal exposure to cannabis may be associated with increased adiposity and fasting glucose in childhood.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Jacqueline G. Parchem, Huihui Fan, Lovepreet K. Mann, Qiuying Chen, Jong H. Won, Steven S. Gross, Zhongming Zhao, Heinrich Taegtmeyer, Ramesha Papanna
Summary: Monochorionic-diamniotic twin pregnancies, which share a single placenta, can lead to unique complications and disturbances in blood flow, such as twin-twin transfusion syndrome (TTTS). This study used TTTS as a model to investigate fetal metabolic adaptations to cardiovascular stress. Metabolomic analyses of amniotic fluid samples showed alterations in fatty acid, glucose, and steroid hormone metabolism in TTTS cases, suggesting that the fetal heart can adapt to hemodynamic stress by modulating glucose metabolism, with potential differences in individual fetuses' ability to respond to cardiovascular stress.
Review
Nutrition & Dietetics
Flavio A. Francisco, Lucas P. J. Saavedra, Marcos D. F. Junior, Catia Barra, Paulo Matafome, Paulo C. F. Mathias, Rodrigo M. Gomes
Summary: This review discusses the critical role of perinatal early nutritional disorders and glycotoxins in the developmental origins of health and disease, focusing on their involvement in metabolic disorders and potential health consequences of perinatal exposure to glycotoxins.
Review
Medicine, General & Internal
Taylor B. Scheidl, Amy L. Brightwell, Sarah H. Easson, Jennifer A. Thompson
Summary: Recent studies have shown that the quality of adipose tissue, rather than its quantity, contributes to the risk of obesity-related diseases. Adipose-derived stem cells give rise to adipocytes during the development of adipose depots. In adult depots, progenitor cells serve as a reservoir for replacing aging adipocytes and increasing lipid storage capacity.
Review
Biochemistry & Molecular Biology
Caitlyn E. Bowman, Zoltan Arany, Michael J. Wolfgang
Summary: Pregnancy is a nutritionally sensitive stage, and communication between mother and fetus through metabolites is crucial. Studies on humans and animals provide insights into the metabolic adaptations of the fetus, placenta, and mother during pregnancy. Understanding the dynamic nature of maternal-fetal metabolic communication may lead to the discovery of new biomarkers and therapeutic targets for metabolic disorders in pregnancy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Sandra de Sousa Barcelos, Karolina Batista Nascimento, Tadeu Eder da Silva, Rafael Mezzomo, Kaliandra Souza Alves, Marcio de Souza Duarte, Mateus Pies Gionbelli
Summary: Prenatal nutrition has long-term consequences on animal development and progeny. This study aimed to summarize and identify knowledge gaps in fetal-programming studies in beef cattle using data from 35 publications. The findings showed an association between prenatal energy and protein supply and offspring birth weight, weaning weight, and daily weight gain of pregnant beef cows. However, there is a lack of research on zebu animals, offspring sex, and the effects of interactions between different stressors during pregnancy.
Article
Pharmacology & Pharmacy
Qian-Qian Zhou, Hai -Tao Xiao, Fan Yang, Yong-Dan Wang, Ping Li, Zu-Guo Zheng
Summary: The development and application of traditional drugs, especially inhibitors, has become the mainstream drug development. Targeted protein degradation (TPD) technology, based on the ubiquitin-proteasome system (UPS) and the autophagy-lysosomal pathway (ALP), has emerged as a promising method to remove specific disease-related proteins. Different TPD strategies, such as PROTAC, MG, LYTAC, CMA-targeting chimeras, AUTAC, ATTEC, and AUTOTAC, can change undruggable protein targets in human cells to druggable, expanding the therapeutic prospect of refractory diseases.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Cynthia Barrera, Valeska Castillo, Rodrigo Valenzuela, Carina A. Valenzuela, Diego F. Garcia-Diaz, Miguel Llanos
Summary: This study aimed to determine the effects of a nutritional intervention during pregnancy and lactation on metabolic alterations of obese female progenitors' offspring and on the involvement of the endocannabinoid system (ECS). The results showed that the intervention normalized some hormonal parameters and hepatic mRNA levels of ECS components, improving the condition of the obese offspring.
Article
Medicine, General & Internal
Janine Zoellkau, Laura Swiderski, Alexander Schmidt, Friederike Weschenfelder, Tanja Groten, Dirk Hoyer, Uwe Schneider
Summary: This study found that gestational diabetes can alter fetal autonomic control, increase fetal vagal tone, and have a positive correlation with maternal blood glucose levels and birth weight. However, there wasn't a significant correlation between fetal movement index and birth weight, but it did attenuate the positive correlation between maternal blood glucose levels and birth weight.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Hadas Ben-Assayag, Rafael Y. Brzezinski, Shlomo Berliner, David Zeltser, Itzhak Shapira, Ori Rogowski, Sharon Toker, Roy Eldor, Shani Shenhar-Tsarfaty
Summary: This study aimed to determine the prevalence of metabolically healthy individuals and characterize the transition from metabolic health to dysfunction. It found that roughly one-quarter of apparently healthy adults meet the current definitions of metabolic health. The transition from health to metabolic dysfunction is accompanied by inflammation and changes in several non-metabolic syndrome biomarkers. Aggressive screening for these biomarkers, blood pressure, and hsCRP might help identify apparently healthy individuals at increased risk of developing metabolic syndrome.
CARDIOVASCULAR DIABETOLOGY
(2023)
Review
Physiology
Vinicius Schiavinatto Mariano, Patricia Aline Boer, Jose Antonio Rocha Gontijo
Summary: The research suggests that low birth weight may be linked to environmental disruption during gestation, with animal models illustrating the mechanism of arterial hypertension caused by dietary disturbance. Additionally, functional studies indicate that maternal low-protein intake leads to renal dysfunction, ultimately increasing blood pressure.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Environmental Sciences
Lisa Koshko, Sydney Scofield, Lucas Debarba, Lukas Stilgenbauer, Patrick Fakhoury, Hashan Jayarathne, J. Eduardo Perez-Mojica, Ellen Griggs, Adelheid Lempradl, Marianna Sadagurski
Summary: Maternal exposure to environmental contaminants like benzene during pregnancy can disrupt the neurodevelopment of the fetus and lead to long-lasting effects on metabolism. Specifically, exposure to benzene impacts hypothalamic development, resulting in metabolic dysregulation and increased neuro-inflammation in the offspring. These findings highlight the importance of avoiding exposure to environmental contaminants to protect the health of future generations.
Article
Biochemistry & Molecular Biology
Dan Chen, Ying-ying Wang, Sheng-peng Li, Hui-min Zhao, Feng-juan Jiang, Ya-xian Wu, Ying Tong, Qing-feng Pang
Summary: Maternal propionate supplementation can prevent glucose and lipid metabolic disturbance in IUGR, increase birth weight, improve liver function and energy expenditure.
Review
Endocrinology & Metabolism
Sumudu Nimali Seneviratne, Shaman Rajindrajith
Summary: The prevalence of obesity and type 2 diabetes mellitus has been rapidly increasing, and current prevention efforts are not successful. Fetal programming provides a new concept for lifelong prevention of obesity and type 2 diabetes mellitus. The World Health Organization now advocates a life-course approach to prevent/control obesity, starting with pre-conceptional and antenatal maternal health. This review summarizes current data on fetal programming of obesity and type 2 diabetes mellitus, including potential causative factors, mechanisms, and interventions to reduce its impact.
WORLD JOURNAL OF DIABETES
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Catherine Christie
JOURNAL OF CARDIOVASCULAR NURSING
(2015)
Article
Nutrition & Dietetics
Claudia Sealey-Potts, Zhiping Yu, Colleen Alexander, Catherine Christie
TOPICS IN CLINICAL NUTRITION
(2015)
Editorial Material
Nutrition & Dietetics
Catherine Christie, Gail P. A. Kauwell, Christine A. Stapell
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2016)
Editorial Material
Nutrition & Dietetics
Catherine Christie, Judith A. Gilbride
JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION
(2010)
Article
Education & Educational Research
Julia A. Watkins, Catherine Christie, Pamela Chally
JOURNAL OF AMERICAN COLLEGE HEALTH
(2008)
Article
Nutrition & Dietetics
AR Smith, C Christie
JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION
(2004)