期刊
NUTRIENTS
卷 7, 期 9, 页码 7781-7797出版社
MDPI
DOI: 10.3390/nu7095364
关键词
vitamin B-12 intake; serum vitamin B-12; dairy; milk; yoghurt; cheese; meat; fish and shellfish; eggs
资金
- Netherlands Organization for Health Research and Development (ZonMw), the Hague [6130.0031]
- NZO (Dutch Dairy Association), Zoetermeer
- MCO Health, Almere
- NCHA (Netherlands Consortium Healthy Ageing) Leiden/Rotterdam
- Ministry of Economic Affairs, Agriculture and Innovation, the Hague [KB-15-004-003]
- Wageningen University, Wageningen
- VU University Medical Center, Amsterdam
- Nutricia Research Foundation
Low vitamin B-12 concentrations are frequently observed among older adults. Malabsorption is hypothesized to be an important cause of vitamin B-12 inadequacy, but serum vitamin B-12 may also be differently affected by vitamin B-12 intake depending on food source. We examined associations between dietary sources of vitamin B-12 (meat, fish and shellfish, eggs, dairy) and serum vitamin B-12, using cross-sectional data of 600 Dutch community-dwelling adults (65 years). Dietary intake was assessed with a validated food frequency questionnaire. Vitamin B-12 concentrations were measured in serum. Associations were studied over tertiles of vitamin B-12 intake using P for trend, by calculating prevalence ratios (PRs), and splines. Whereas men had significantly higher vitamin B-12 intakes than women (median (25th-75th percentile): 4.18 (3.29-5.38) versus 3.47 (2.64-4.40) g/day), serum vitamin B-12 did not differ between the two sexes (mean +/- standard deviation (SD): 275 +/- 104 pmol/L versus 290 +/- 113 pmol/L). Higher intakes of dairy, meat, and fish and shellfish were significantly associated with higher serum vitamin B-12 concentrations, where meat and dairypredominantly milk were the most potent sources. Egg intake did not significantly contribute to higher serum vitamin B-12 concentrations. Thus, dairy and meat were the most important contributors to serum vitamin B-12, followed by fish and shellfish.
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