Review
Food Science & Technology
Soheila Abachi, Genevieve Pilon, Andre Marette, Laurent Bazinet, Lucie Beaulieu
Summary: This article focuses on recent studies on hypoglycemic, lipid-lowering, cholesterol-lowering, and anti-obesity fish peptides. The aim is to provide more knowledge for the design and discovery of anti-MetS compounds by comparing different extraction, isolation, and purification methods.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Nutrition & Dietetics
Lucia Melguizo-Rodriguez, Victor J. Costela-Ruiz, Enrique Garcia-Recio, Elvira De Luna-Bertos, Concepcion Ruiz, Rebeca Illescas-Montes
Summary: The prevalence of hypovitaminosis D has been increasing in developed countries due to lifestyle changes and unhealthy habits. Scientific evidence shows an inverse relationship between vitamin D deficiency and metabolic syndrome (MetS), with supplementation helping improve outcomes in individuals with MetS. Maintaining optimal vitamin D concentrations is proposed as a preventive strategy against MetS.
Article
Multidisciplinary Sciences
Shaza B. Zaghlool, Anna Halama, Nisha Stephan, Valborg Gudmundsdottir, Vilmundur Gudnason, Lori L. Jennings, Manonanthini Thangam, Emma Ahlqvist, Rayaz A. Malik, Omar M. E. Albagha, Karsten Suhre, Abdul Badi Abou-Samra
Summary: This study translates T2D subtypes previously identified in European individuals to an Arab population and identifies specific metabolic and proteomic signatures for each subtype, providing further understanding of the pathogenesis of these subtypes.
NATURE COMMUNICATIONS
(2022)
Review
Endocrinology & Metabolism
Pablo Panico, Myrian Velasco, Ana Maria Salazar, Arturo Picones, Rosa Isela Ortiz-Huidobro, Gabriela Guerrero-Palomo, Manuel Eduardo Salgado-Bernabe, Patricia Ostrosky-Wegman, Marcia Hiriart
Summary: Exposure to arsenic in drinking water is a global health problem associated with an increased risk of developing metabolic diseases. Metabolic syndrome is a complex pathology that results from the interaction between environmental and genetic factors, and is linked to an increased risk of developing type 2 diabetes, cardiovascular diseases, and cancer.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Itay Aizenbud, Asaf Wilensky, Galit Almoznino
Summary: Periodontal disease is a chronic inflammatory condition that leads to bone and tooth loss. It has been linked to various systemic diseases, including diabetes and obesity. These diseases are part of the metabolic syndrome cluster, which significantly increases the risk of cardiovascular diseases, diabetes, and stroke. This review aims to investigate the correlation between periodontal disease and the components and outcomes of the metabolic syndrome cluster, providing insights into the fundamental mechanisms that link each condition with the metabolic syndrome. Understanding this interplay can lead to more effective treatments considering the broader impact of managing periodontal disease on systemic disease treatment, and vice versa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Weiyue Zhang, Xin Guo, Lulu Chen, Ting Chen, Jiayu Yu, Chaodong Wu, Juan Zheng
Summary: The ketogenic diet (KD) has shown promising effects in managing various cardio-metabolic diseases (CMDs) like obesity, heart failure, and hypertension, but remains controversial in diabetes and dyslipidemia. Current evidence suggests that KD is generally protective against obesity-related cardiovascular diseases (CVDs) but contradictory in diabetes and other metabolic disorder-related CVDs. More rigorous research focusing on clinical safety, treatment duration, and plan of KDs is needed to address the existing controversies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Jisun Bang, Sang Ah Lee, Gwanpyo Koh, Soyeon Yoo
Summary: This study investigated the association between glucagon to insulin ratio and metabolic syndrome in patients with type 2 diabetes. The results showed that the fasting glucagon to insulin ratio was inversely associated with metabolic syndrome, indicating a higher risk of metabolic syndrome with lower fasting glucagon to insulin ratio.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Federica Del Chierico, Melania Manco, Simone Gardini, Valerio Guarrasi, Alessandra Russo, Marzia Bianchi, Valentina Tortosa, Andrea Quagliariello, Blegina Shashaj, Danilo Fintini, Lorenza Putignani
Summary: The study identified fecal microbiota signatures associated with metabolic abnormalities in young patients with obesity. Different microbial markers were found to be associated with high blood pressure, low HDL cholesterol, high MS risk, WBCs, severe obesity, and impaired glucose tolerance. Some gut bacteria were detrimental in exacerbating metabolic risk factors, while others were beneficial in improving cardiovascular health.
ACTA DIABETOLOGICA
(2021)
Article
Immunology
Eleana Bolla, Nikolaos Tentolouris, Petros P. Sfikakis, Maria G. Tektonidou
Summary: This study aimed to evaluate the prevalence of Metabolic Syndrome (MetS) in antiphospholipid syndrome (APS) patients and its associations with cardiovascular risk biomarkers, physical activity, and subclinical atherosclerosis. The results showed that MetS was present in approximately one-fourth of APS patients and was associated with arterial thrombosis, cardiovascular risk biomarkers, physical activity, and subclinical atherosclerosis. This suggests that MetS plays an important role in cardiovascular risk stratification and management in APS.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Endocrinology & Metabolism
Niansi Pan, Shimei Yang, Xiaohong Niu
Summary: This review discusses the prevalence of MetS in LADA and the risk and role of insulin resistance in the development of LADA from the perspectives of inflammatory factors, environmental factors, and the gut microbiota, aiming to improve our understanding of this condition.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Obstetrics & Gynecology
Maryam Kazemi, Joy Y. Kim, Stephen A. Parry, Ricardo Azziz, Marla E. Lujan
Summary: The systematic review and meta-analysis revealed that Black women with polycystic ovary syndrome have a greater tendency for adverse cardiometabolic risk profile compared to White women, despite lower triglyceride levels. These findings emphasize the importance of considering these disparities in diagnostic, monitoring, and management practices in Black women.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
A. M. Wegeberg, T. Okdahl, S. Riahi, N. Ejskjaer, F. Pociot, J. Storling, B. Brock, C. Brock
Summary: This study found that increased serum levels of IL-12/IL-23p40 and ICAM-1 were associated with decreased heart rate variability in type 2 diabetes patients, while VEGF-C levels were related to response to standing. The results suggest significant associations between neurocardiac regulation and serum markers, indicating potential systemic changes in inflammation, endothelial, and lymphatic function that collectively impact cardiovascular function. Further exploration of IL-12/IL-23p40, ICAM-1, and VEGF-C as cardiovascular biomarkers in type 2 diabetes is warranted for potential improvement in patient care strategies.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Integrative & Complementary Medicine
Dastan M. Khoshnaw, Abhijit A. Ghadge
Summary: Yoga is considered a low-impact mind-body stress-relieving exercise that researchers are studying for its potential benefits in managing metabolic disorders. However, current literature on the effects of yoga on metabolic syndrome risk factors shows mixed results, calling for more rigorous research to evaluate its efficacy and long-term impacts. Understanding yoga's biochemical and molecular mechanisms of action on various metabolic pathways is also crucial.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Health Care Sciences & Services
Jin Suk Ra
Summary: The study identified that the combined effects of metabolic syndrome and obesity can increase the likelihood of developing cardiovascular diseases in postmenopausal women, while combining multiple metabolic abnormalities and obesity does not further increase this likelihood. Additionally, combining metabolic syndrome and non-obesity also increases the prevalence of cardiovascular diseases.
Letter
Endocrinology & Metabolism
Anna K. Schuetz, Ingrid Schuetz-Fuhrmann, Marietta Stadler, Hannah Staudinger, Julia K. Mader
DIABETES TECHNOLOGY & THERAPEUTICS
(2022)
Editorial Material
Endocrinology & Metabolism
Felix Aberer, Othmar Moser, Faisal Aziz, Caren Sourij, Haris Ziko, Jacqueline Lenz, Farah Abbas, Anna M. Obermayer, Harald Kojzar, Peter N. Pferschy, Alexander Mueller, Christina Unteregger, Marlies Leitner, Tamara Banfic, Max L. Eckstein, Nadine Wachsmuth, Susanne Kaser, Julia K. Mader, Norbert J. Tripolt, Harald Sourij
Review
Endocrinology & Metabolism
Lutz Heinemann, Trung Nguyen, Timothy S. S. Bailey, Ahmed Hassoun, Bernd Kulzer, Teresa Oliveria, Yves Reznik, Harold W. W. de Valk, Julia K. K. Mader
Summary: Innovations in syringe and pen needle technology have significantly improved insulin delivery for people with diabetes. Advances in needle design, including shorter lengths and finer gauges, have led to improved injection experience. Coupled with education on proper injection technique, these advancements contribute to better clinical outcomes and patient satisfaction. Insulin syringes and pens will continue to be reliable and cost-effective means of insulin delivery, especially in developing countries.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Martina Brunner, Othmar Moser, Reingard Raml, Maximilian Haberlander, Beate Boulgaropoulos, Barbara Obermayer-Pietsch, Eva Svehlikova, Thomas R. Pieber, Harald Sourij
Summary: Methods for glucagon analysis in the past were not specific and had a narrow sensitivity range, leading to inaccurate results. Newer methods have shown that actual glucagon levels are lower than previously thought. This study compared glucagon levels in healthy individuals and diabetes patients using two different methods and found that the choice of method can significantly affect the results.
Letter
Endocrinology & Metabolism
Jasmin R. Kastner, Tina Poettler, Julia Kopanz, Daniel A. Hochfellner, Matt Romey, Petra M. Baumann, Douglas Muchmore, Paul J. Strasma, Julia K. Mader
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Simon Heller, Tadej Battelino, Timothy S. Bailey, Thomas R. Pieber, Ulrike Hoevelmann, Leona Plum-Moerschel, Anita E. Melgaard, Ronnie Aronson, Linda A. DiMeglio, Thue Johansen, Thomas Danne
Summary: This study analyzed the safety and efficacy of dasiglucagon, a glucagon analogue, in treating severe hypoglycemia in patients with type 1 diabetes. The results showed that dasiglucagon had a similar safety profile as reconstituted glucagon and was more effective in glucose recovery compared to placebo.
DIABETES OBESITY & METABOLISM
(2023)
Letter
Endocrinology & Metabolism
Hood Thabit, Charlotte Boughton, Womba Mubita, Jose Rubio, Julia K. Mader, Parth Narendran, Mark Evans, Lalantha Leelarathna, Malgorzata E. Wilinska, Catherine Fullwood, Alice M. Gregory, Roman Hovorka, Martin K. Rutter
DIABETES OBESITY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Norbert J. Tripolt, Sebastian J. Hofer, Peter N. Pferschy, Faisal Aziz, Sylvere Durand, Fanny Aprahamian, Nitharsshini Nirmalathasan, Mara Waltenstorfer, Tobias Eisenberg, Anna M. A. Obermayer, Regina Riedl, Harald Kojzar, Othmar Moser, Caren Sourij, Heiko Bugger, Abderrahim Oulhaj, Thomas R. Pieber, Matthias Zanker, Guido Kroemer, Frank Madeo, Harald Sourij
Summary: The effects of fasting on glucose metabolism were examined in non-obese and obese participants and people with type 2 diabetes. The results showed that after 36 hours of fasting, glucose, insulin, and C-peptide levels were significantly decreased. Non-obese participants had higher glucose levels but lower insulin levels after 36 hours of fasting, while no significant differences were observed in obese participants or people with diabetes. Insulin sensitivity improved in all cohorts after 36 hours of fasting. Metabolomics analysis revealed subtle baseline differences and attenuated metabolic response to fasting in obese participants and people with diabetes.
Article
Endocrinology & Metabolism
Thomas R. Pieber, Kristine N. Arfelt, Roman Cailleteau, Marlies Hart, Soumitra Kar, Ines Mursic, Eva Svehlikova, Martina Urschitz, Hanne Haahr
Summary: This study compared the frequency and recovery of hypoglycemia after double or triple doses of once-weekly insulin icodec and once-daily insulin glargine U100. The study also compared the symptomatic and hormonal responses to hypoglycemia between the two treatments. The results showed that there was no significant difference in the risk of hypoglycemia between icodec and glargine U100, but icodec elicited slightly higher symptomatic and endocrine responses during hypoglycemia compared to glargine U100.
Article
Multidisciplinary Sciences
Uffe Soholm, Melanie Broadley, Natalie Zaremba, Patrick Divilly, Giesje Nefs, Jill K. Carlton, Julia Mader, Petra Martina Baumann, Mikel Gomes, Gilberte J. Martine-Edith, Daniel Pollard, Dajana Rath, Simon Heller, Ulrik J. Pedersen-Bjergaard, Rory McCrimmon, Eric Renard, Mark Evans, Bastiaan de Galan, Thomas A. Forkmann, Stephanie Amiel, Christel Hendrieckx, Jane Speight, Pratik Choudhary, Frans Pouwer
Summary: The aim of this study was to determine the acceptability and psychometric properties of the Hypo-METRICS app, which is designed to assess the impact of hypoglycemia on daily functioning in people with insulin-treated diabetes. Participants completed daily check-ins for 10 weeks using the app and answered questions about their subjective daily functioning. The results showed high completion rates, satisfactory psychometric properties, and demonstrated that the app is acceptable and reliable for exploring the daily impact of hypoglycemia.
Article
Endocrinology & Metabolism
Sandra Pfleger, Renald Mecani, Barbara Semlitsch, Anja Krall, Gerald Sendlhofer, Julia K. Mader, Andreas Wedrich
Summary: For patients with insulin-treated type 2 diabetes mellitus undergoing elective surgery, a standardized insulin and meal regimen on the day of surgery can lead to better management of diabetes in terms of blood glucose levels. Both standardized and well-defined insulin and meal regimens resulted in better average blood glucose levels in the perioperative period, especially in the morning after the surgery.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Gillian L. Garden, Fariba Shojaee-Moradie, Ewan J. Hutchison, Brian M. Frier, Kenneth M. Shaw, Simon R. Heller, Gerd Koehler, Julia K. Mader, Declan Maher, Graham A. Roberts, David L. Russell-Jones
Summary: This study compared the use of continuous glucose monitoring (CGM) with self-monitored blood glucose (SMBG) in insulin-treated diabetic pilots certified to fly commercial aircraft. The results showed that CGM is a credible alternative to SMBG for monitoring glucose levels.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Veronika Tandl, Christoph Haudum, Katharina Eberhard, Barbara Hutz, Ines Foessl, Ewald Kolesnik, Andreas Zirlik, Dirk von Lewinski, Daniel Scherr, Nicolas Verheyen, Thomas Pieber, Barbara Obermayer-Pietsch
Summary: Serum concentrations of AMH decrease with increasing BMI, possibly due to either an adverse effect of adiposity on AMH production or dilution from greater blood volume. We investigated the relationships between AMH levels and body composition parameters in adult males and found that body weight, lean mass, and body surface area were better predictors of AMH than measures of adiposity. Since both lean mass and body surface area correlate with plasma volume better than adipose tissue, we conclude that hemodilution of AMH does occur in adult males and should be considered for normalization in future studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Johan Jendle, Peter Adolfsson, Pratik Choudhary, Klemen Dovc, Alexander Fleming, David C. Klonoff, Julia K. Mader, Nick Oliver, Jennifer L. Sherr, Jan Soupal, Lutz Heinemann
Summary: Interoperability of medical devices and data used in diabetes therapy is crucial for seamless integration and sharing of data, while adhering to regulatory and legal frameworks.
Letter
Endocrinology & Metabolism
Hood Thabit, Charlotte Boughton, Womba Mubita, Jose Rubio, Stuart Allen, Robert Heugh, Julia K. Mader, Parth Narendran, Mark Evans, Lalantha Leelarathna, Malgorzata E. Wilinska, Catherine Fullwood, Clifford Garratt, Roman Hovorka, Martin K. Rutter
DIABETES OBESITY & METABOLISM
(2023)
