Septic encephalopathy: does inflammation drive the brain crazy?

Neurotransmitter receptor alterations in hepatic encephalopathy: A review

(2013) Nicola Palomero-Gallagher et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Sepsis definitions: time for change

(2013) Jean-Louis Vincent et al.   LANCET

Matrix Metalloproteinase-2 and Metalloproteinase-9 Activities are Associated with Blood–Brain Barrier Dysfunction in an Animal Model of Severe Sepsis

(2013) Felipe Dal-Pizzol et al.   MOLECULAR NEUROBIOLOGY

Association between Endothelial Dysfunction and Acute Brain Dysfunction during Critical Illness

(2012) Christopher G. Hughes et al.   ANESTHESIOLOGY

Stress, neurotransmitters, corticosterone and body–brain integration

(2012) Francisco Mora et al.   BRAIN RESEARCH

Sensing of microbial molecular patterns by Toll-like receptors

(2012) Dong Hyun Song et al.   IMMUNOLOGICAL REVIEWS

Associations of markers of inflammation and coagulation with delirium during critical illness

(2012) Timothy D. Girard et al.   INTENSIVE CARE MEDICINE

The Effect of Clonidine, an Alpha-2 Adrenergic Receptor Agonist, on Inflammatory Response and Postischemic Endothelium Function During Early Reperfusion in Healthy Volunteers

(2012) Maximilien Gourdin et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia

(2012) Morten S. Thomsen et al.   JOURNAL OF NEUROIMMUNOLOGY

Memory Deficits Induced by Inflammation Are Regulated by α5-Subunit-Containing GABAA Receptors

(2012) Dian-Shi Wang et al.   Cell Reports

Deleterious Impact of a γ-Aminobutyric Acid Type A Receptor Preferring General Anesthetic When Used in the Presence of Persistent Inflammation

(2011) Kevin Boegel et al.   ANESTHESIOLOGY

The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness*

(2011) Jessica R. Adams Wilson et al.   CRITICAL CARE MEDICINE

Evaluation of delirium in elderly: A hospital-based study

(2011) Vishal Khurana et al.   Geriatrics & Gerontology International

Traffic of leukocytes and cytokine up-regulation in the central nervous system in sepsis

(2011) Clarissa M. Comim et al.   INTENSIVE CARE MEDICINE

α2-Adrenoceptors do not Mediate Neuroprotection in Acute Ischemic Stroke in Mice

(2011) Marc Brede et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

β-Adrenoceptor activation depresses brain inflammation and is neuroprotective in lipopolysaccharide-induced sensitization to oxygen-glucose deprivation in organotypic hippocampal slices

(2011) Tina Markus et al.   Journal of Neuroinflammation

Midazolam suppresses interleukin-1β-induced interleukin-6 release from rat glial cells

(2011) Kumiko Tanabe et al.   Journal of Neuroinflammation

 -Adrenergic Receptor Antagonism Prevents Anxiety-Like Behavior and Microglial Reactivity Induced by Repeated Social Defeat

(2011) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

Cholinergic Deficiency Hypothesis in Delirium: A Synthesis of Current Evidence

(2011) T. T. Hshieh et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

RhoA and NF-κB are involved in lipopolysaccharide-induced brain microvascular cell line hyperpermeability

(2011) F. He et al.   NEUROSCIENCE

Neuroinflammation in Delirium: A Postmortem Case-Control Study

(2011) Barbara C. van Munster et al.   REJUVENATION RESEARCH

Effects of the α7 Nicotinic Acetylcholine Receptor Agonist Gts-21 on the Innate Immune Response in Humans

(2011) Matthijs Kox et al.   SHOCK

The β2-adrenoceptor agonist clenbuterol elicits neuroprotective, anti-inflammatory and neurotrophic actions in the kainic acid model of excitotoxicity

(2010) Lorna C. Gleeson et al.   BRAIN BEHAVIOR AND IMMUNITY

Alterations in the brain electrical activity in a rat model of sepsis-associated encephalopathy

(2010) Ilker M. Kafa et al.   BRAIN RESEARCH

Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: The MIND randomized, placebo-controlled trial*

(2010) Timothy D. Girard et al.   CRITICAL CARE MEDICINE

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Brain-derived neurotrophic factor and neuron-specific enolase, but not S100β, levels are associated to the occurrence of delirium in intensive care unit patients

(2010) Carmen Grandi et al.   JOURNAL OF CRITICAL CARE

Systemic infection and delirium: when cytokines and acetylcholine collide

(2010) Willem A van Gool et al.   LANCET

Effect of rivastigmine as an adjunct to usual care with haloperidol on duration of delirium and mortality in critically ill patients: a multicentre, double-blind, placebo-controlled randomised trial

(2010) Maarten MJ van Eijk et al.   LANCET

Plasma tryptophan and tyrosine levels are independent risk factors for delirium in critically ill patients

(2009) P. P. Pandharipande et al.   INTENSIVE CARE MEDICINE

NOS2 Gene Deficiency Protects from Sepsis-Induced Long-Term Cognitive Deficits

(2009) M. Weberpals et al.   JOURNAL OF NEUROSCIENCE

Effects of Midazolam on Brain Injury After Transient Focal Cerebral Ischemia in Rats*

(2009) Baiping Lei et al.   JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY

RIVASTIGMINE REVERSES HABITUATION MEMORY IMPAIRMENT OBSERVED IN SEPSIS SURVIVOR RATS

(2009) Clarissa M. Comim et al.   SHOCK

Noradrenaline reuptake inhibitors limit neuroinflammation in rat cortex following a systemic inflammatory challenge: implications for depression and neurodegeneration

(2008) Joan B. O'Sullivan et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease

(2008) Luigina Romani et al.   NATURE

Systemic infection and inflammation in acute CNS injury and chronic neurodegeneration: Underlying mechanisms

(2008) J.L. Teeling et al.   NEUROSCIENCE