期刊
REVISTA BRASILEIRA DE PSIQUIATRIA
卷 30, 期 3, 页码 243-245出版社
ASSOC BRASILEIRA PSIQUIATRIA
DOI: 10.1590/S1516-44462008000300011
关键词
bipolar disorder; brain-derived neurotrophic factor; mania depression; oxidative stress; thiobarbituric acid reactive substances
类别
Objective and Method: There is a growing amount of data indicating that alterations in brain-derived neurotrophic factor and increased oxidative stress may play a role in the pathophysiology of bipolar disorder In light of recent evidence demonstrating that brain-derived neurotrophic factor levels are decreased in situations of increased oxidative stress, we have examined the correlation between serum thiobarbituric acid reactive substances, a measure of lipid peroxidation, and serum brain-derived neurotrophic factor levels in bipolar disorder patients during acute mania and in healthy controls. Results: Serum thiobarbituric acid reactive substances and brain-derived neurotrophic factor levels were negatively correlated in bipolar disorder patients (r = -0.56; p = 0.001), whereas no significant correlation was observed in the control group.. Conclusion: These results suggest that alterations in oxidative status may be mechanistically associated with abnormal low levels of brain-derived neurotrophic factor observed in individuals with bipolar disorder.
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