期刊
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
卷 22, 期 2, 页码 239-248出版社
SOC BRASILEIRA FARMACOGNOSIA
DOI: 10.1590/S0102-695X2011005000211
关键词
antimicrobial; characteristics immunomodulator micrographic zarzaparrilla
资金
- Organization of American States (OAS) [AICD/AE-089]
- National Council for Science and Technology (CONCYT) [FODECYT 18-2000, 42-2006]
- RIBIOFAR Network of the Ibero-American
Smilax domingensis Willd., Smilacaceae, known as zarzaparrilla, is a climbing shrub from Tropical America. The rhizome is popularly used in medicine as anti-infl ammatory, antiseptic, and tonic. Since 1983 studies are being conducted in Guatemala for validation of the ethnobotanical uses, particularly in vitro demonstration of antimicrobial activity, using wild material, with high variability and some taxonomic problems. This article reports the taxonomic determination, cultivation of drug material, evaluation of use by in vitro and in vivo pharmacological assays, and phytochemical characterization. Extracts from cultivated material was evaluated by antimicrobial, antiinfl ammatory, analgesic and immunomodulatory models, confi rming the antimicrobial and immunomodulatory activities. Phytochemistry was done in the crude drug and extracts. Quality control parameters are described (micrographic drawings and phytochemical characteristics). Evidence is presented that cultivated rhizome has antimicrobial and immunomodulatory activities, validating the popular use and helping the industrial development of phytopharmaceutical products.
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