Review
Biochemistry & Molecular Biology
Flavio Alexandre Carvalho, Natalia Valadares de Moraes, Antonio Eduardo Miller Crotti, Eduardo Jose Crevelin, Andre Gonzaga dos Santos
Summary: In this review, the chemical composition, content, pharmacological activities, and toxicity of the essential oils (EOs) from Casearia species were investigated. The EOs exhibited a wide range of bioactivities, including cytotoxicity, anti-inflammatory, antiulcer, antimicrobial, antidiabetic, antioxidant, antifungal, and antiviral activities. The main components associated with these activities were identified. However, data on the toxicity of these EOs are limited. Further investigation and exploitation of Casearia EOs are necessary.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Applied
Abubakar Siddiq Salihu, Wan Mohd Nuzul Hakimi Wan Salleh, Tomisin Happy Ogunwa
Summary: This study investigated the chemical composition, acetylcholinesterase inhibition, and molecular docking of the essential oil from Knema hookeriana Warb. The essential oil primarily consisted of beta-caryophyllene, germacrene D, delta-cadinene, germacrene B, and bicyclogermacrene. The essential oil exhibited acetylcholinesterase activity with an IC50 value of 70.5 μg/mL. Molecular docking studies showed that beta-caryophyllene and delta-cadinene had good binding affinities towards AChE.
NATURAL PRODUCT RESEARCH
(2023)
Article
Multidisciplinary Sciences
Valtcho D. Zheljazkov, Filippo Maggi
Summary: The study showed that distillation can improve the compositional profile of cannabinoids in hemp biomass, converting cannabinoid acids into cannabinoids like CBD and CBC. Distilled hemp biomass had higher cannabinoid content compared to non-distilled, with the addition of CBN in the distilled biomass.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Applied
Antonella Porrello, Alessandro Vaglica, Natale Badalamenti, Vincenzo Ilardi, Maurizio Bruno
Summary: This study analyzed the chemical composition of the essential oils from aerial parts of a rare species of Nepeta collected in two locations in Sicily and found that the main constituents were β-pinene, γ-terpinene, β-caryophyllene, and germacrene D. The chemical profile of these essential oils was compared with previous studies on Nepeta taxa oils.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Alessandro Vaglica, Antonella Porrello, Gianfranco Fontana, Natale Badalamenti, Vincenzo Ilardi, Maurizio Bruno
Summary: In this study, the chemical composition of the essential oil of Geocaryum capillifolium, a rare species collected in Sicily, was analyzed. The main constituents were sesquiterpene hydrocarbons. Comparison with the oils of related genera revealed unique chemical characteristics of this species' essential oil.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Rossella Gagliano Candela, Vincenzo Ilardi, Natale Badalamenti, Maurizio Bruno, Sergio Rosselli, Filippo Maggi
Summary: This study evaluated the chemical composition of essential oils from different geographical locations of Teucrium species, revealing the main volatile components and discussing their chemotaxonomic relationship with other plant members of respective botanical sections.
NATURAL PRODUCT RESEARCH
(2021)
Article
Plant Sciences
Valquiria Bruna Guimaraes Silva, Beatriz Meyruze Barros da Fonseca, Julio Cesar Ribeiro de Oliveira Farias de Aguiar, Daniela Maria do Amaral Ferraz Navarro, Alisson Macario de Oliveira, Thiago Henrique Napolea, Maria Tereza dos Santos Correia, Vera Lucia de Menezes Lima, Wendeo Kennedy Costa, Marcia Vanusa da Silva
Summary: The aim of this study was to evaluate the antinociceptive and anti-inflammatory potential of Psidium cattleyanum leaves essential oil. Gas chromatography-mass spectrometry (GC/MS) was used to analyze the oil. The results showed that the essential oil has significant antinociceptive and anti-inflammatory effects, and has potential for application in the pharmaceutical and food industry.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Immunology
Andreza Larissa do Nascimento, Joyce Bezerra Guedes, Wendeo Kennedy Costa, Bruno Oliveira de Veras, Julio Cesar Ribeiro de Oliveira Farias de Aguiar, Daniela Maria do Amaral Ferraz Navarro, Maria Tereza dos Santos Correia, Thiago Henrique Napoleao, Alisson Macario de Oliveira, Marcia Vanusa da Silva
Summary: This study is the first to identify the components of Eugenia pohliana essential oil and evaluate its antinociceptive and anti-inflammatory activities. The major components of the oil are (E)-beta-caryophyllene, delta-cadinene, and alpha-cadinol. The results showed that the essential oil has significant antinociceptive and anti-inflammatory effects, acting through the activation of opioid receptors.
INFLAMMOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Godfried Dougnon, Michiho Ito
Summary: The study found that Chromolaena odorata essential oil has sedative activity in mice, with caryophyllene oxide identified as the key compound responsible for this effect. Caryophyllene oxide showed potent CNS depressant effects and effectively reduced locomotor activity in mice. Interestingly, the precursor beta-caryophyllene also exhibited sedative activity, highlighting the potential of sesquiterpene compounds for managing sleep and CNS-related disorders.
Article
Plant Sciences
Jesus Pala-Paul, Lachlan M. Copeland, Joseph J. Brophy
Summary: Trachymene incisa subsp. incisa is an Australian endemic taxon with variations in leaf trichomes abundance and length. Analysis of essential oil composition shows significant differences in sesquiterpene hydrocarbons between the particularly hairy variant and the typical glabrous one, leading to identification of three different chemotypes based on main compounds.
Article
Agronomy
Li-Chen Peng, Lean-Teik Ng
Summary: This study indicates that appropriate nitrogen and phosphorus fertilization positively affects the yield of biomass, essential oils, and bioactive compounds in field cultivated Vitex negundo.
Article
Chemistry, Applied
Somayeh Arabjafari, Pooran Golkar, Mostafa Tarkesh Esfahani, Marzieh Taghizadeh
Summary: This study evaluated the chemical constituents of essential oils from different accessions of Dorema ammoniacum and Dorema aucheri collected in Iran. The major fractions in the oils were sesquiterpene hydrocarbons, with variations in compounds among different accessions. Future medicinal use can be considered using enriched sesquiterpene hydrocarbon accessions of Dorema.
NATURAL PRODUCT RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Rayane Cristine Santos da Silva, Isabel Renata de Souza Arruda, Carolina Barbosa Malafaia, Marcilio Martins de Moraes, Thaissa Silva Beck, Claudio Augusto Gomes da Camara, Nicacio Henrique da Silva, Marcia Vanusa da Silva, Maria Tereza dos Santos Correia, Clarissa Piccinin Frizzo, Giovanna Machado
Summary: This study found that the essential oil of Tetragastris catuaba leaves, as well as its nanoemulsion form, can significantly reduce biofilm formation and planktonic growth of Enterococcus faecalis and Listeria monocytogenes, suggesting their potential applications in preventing and controlling bacterial biofilm contamination.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Flavio A. Carvalho, Fernando B. Oda, Eduardo J. Crevelin, Antonio E. M. Crotti, Andre G. dos Santos
Summary: This study evaluated the chemical composition of the essential oil from different varieties and states of Casearia sylvestris leaves, finding that dried leaves had higher essential oil yield compared to fresh leaves, with changes in volatile composition during leaf drying and hydrodistillation. Differences in chemical composition between varieties and states of leaves could potentially impact the biological activities of the essential oil.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Plant Sciences
Joyce Bezerra Guedes, Andreza Larissa do Nascimento, Wendeo Kennedy Costa, Bruno Oliveira de Veras, Julio Cesar Ribeiro de Oliveira Farias de Aguiar, Daniela Maria do Amaral Ferraz Navarro, Thiago Henrique Napoleao, Marcia Vanusa da Silva, Alisson Macario de Oliveria, Maria Tereza dos Santos Correia
Summary: In this study, the essential oil extracted from Eugenia gracillima leaves was evaluated for its acute toxicity and anti-inflammatory, antinociceptive, and behavioral effects in mice. The results showed that the essential oil has potential for the development of pharmaceutical formulations with analgesic and anti-inflammatory actions in non-toxic concentrations.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Neurosciences
Elisangela Dos Santos, Joyce Alencar Santos Radai, Kamilla Felipe do Nascimento, Anelise Samara Nazari Formagio, Natalia de Matos Balsalobre, Edward Benjamin Ziff, Elisabete Castelon Konkiewitz, Candida Aparecida Leite Kassuya
Summary: This study demonstrates that the essential oil from Psidium guineense leaves has anti-nociceptive and anti-hyperalgesic effects in acute and continuous treatment, and exhibits anxiolytic and antidepressive effects in the experimental state of chronic pain.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Chemistry, Applied
Vanessa Winiewski, Mariana Mesquita Fonseca, Marcos Jose Salvador, Eduardo Lemos de Sa, Maria Elida Alves Stefanello
Summary: Three new naphthoquinones and eleven known compounds were isolated from the tubers of Sinningia mauroana. The ethyl acetate and ethanol extracts showed high antioxidant capacity, while the hexane extract displayed weak antioxidant capacity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Environmental Sciences
Thiago Barros, Jhonattas D. C. Carregosa, Alberto Wisniewski Jr, Antonio C. D. Freitas, Reginaldo Guirardello, Leandro Ferreira-Pinto, Lucas Bonfim-Rocha, Veeriah Jegatheesan, Lucio Cardozo-Filho
Summary: This study explores an alternative method for black liquor treatment through gasification, identifying liquid products mainly belonging to classes O3 and O4 under reaction at 500 degrees Celsius, and gaseous products including hydrogen and methane with high overall selectivity. The economic analysis shows that black liquor gasification has relatively low costs and is an interesting route for obtaining combustible gases and value-added bioproducts.
Article
Chemistry, Multidisciplinary
Joselaine C. Santana, Ana Claudia M. da Silva, Ana Karla Abud, Alberto Wisniewski Jr, Luciane P. C. Romao
Summary: A method using glycerol as a green solvent for pretreatment of biomasses was developed. Optimization of the pretreatment conditions resulted in a sustainable and efficient process for biomass degradation.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2022)
Article
Reproductive Biology
Beatriz de Matos Manoel, Suyane da Silva Moreira, Gabriela Morelli Zampieri, Luisa Machado Pinheiro, Barbara Campos Jorge, Ana Carolina Casali Reis, Candida Aparecida Leite Kassuya, Arielle Cristina Arena
Summary: This study demonstrates that maternal exposure to tamoxifen can affect reproductive and behavioral parameters in male offspring. Tamoxifen exposure leads to changes in body weight, delayed onset of puberty, and alterations in sperm count and motility in the epididymis.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Chemistry, Physical
Tarcisio Martins Santos, Wenes Ramos da Silva, Jhonattas de Carvalho Carregosa, Caroline Carriel Schmitt, Renata Moreira, Klaus Raffelt, Nicolaus Dahmen, Alberto Wisniewski
Summary: In this study, the chemical profile of the organic compounds produced from the non-catalytic pyrolysis of sugarcane bagasse was compared with that obtained from the catalytic upgrading of the vapor phase. The presence of a Ni-based catalyst and a reactive atmosphere led to significant changes in the chemical profile, resulting in higher deoxygenation and an increase in the content of alcohols and phenolic compounds. The results suggest that the thermal conversion of sugarcane bagasse under an H-2 atmosphere and the presence of Ni-based catalysts can enhance the production of bio-oil with a higher content of phenolic species.
Article
Medicine, Legal
Luis Fernando Benitez Macorini, Rafael Souza Maris, Thiago Chaves Teixeira, Caren Naomi Aguero Ito, Angela Midori Kuraoka-Oliveira, Flavia Barbieri Bacha, Angela Julieth Buitrago Mejia, Marcos Jose Salvador, Candida Aparecida Leite Kassuya, Arielle Cristina Arena
Summary: The toxicological potential of Gomphrena celosioides ethanolic extract (EEGC) as a medicinal plant was investigated. The results showed that EEGC has a high safety profile and does not exhibit significant toxicity in animals.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Microbiology
Luis Felipe Garcia Leal Mouta, Raquel Souza Marques, Cristiane Yumi Koga-Ito, Marcos Jose Salvador, Elisa Maria Aparecida Giro, Fernanda Lourencao Brighenti
Summary: The study evaluated the effect of Cymbopogon citratus essential oil and its association with chlorhexidine on the composition and acidogenicity of cariogenic microcosm biofilms. The results showed that this combination reduced the total bacterial counts and aciduric bacteria in the biofilms, and also decreased their acidogenicity. Furthermore, C. citratus essential oil enhanced the effect of chlorhexidine on the microcosm biofilms.
Article
Plant Sciences
Natalia de Matos Balsalobre, Elisangela Dos Santos, Sidney Mariano Dos Santos, Arielle Cristina Arena, Elisabete Castelon Konkiewitz, Edward Benjamin Ziff, Anelise Samara Nazari Formagio, Candida Aparecida Leite Kassuya
Summary: The aim of this study was to investigate the analgesic and anti-arthritic properties of EOAE and viridiflorol using in vivo models.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Pedro E. S. do Nascimento, Vilma M. J. Prado, Raphael A. de Jesus, Wenes R. da Silva, Alberto Wisniewski Jr., Jose C. F. Sa Filho, Arie F. Blank, Daniel A. de Souza, Elma R. S. A. Wartha, Paulo C. L. Nogueira, Valeria R. S. Moraes
Summary: Research on plant bioactive compounds has evolved extraction methods. This study optimized ultrasound-assisted extraction (UAE) and microwave-assisted extraction (MAE) to extract flavonoids from Croton grewioides Baill. The extracts were analyzed using ultra high-resolution mass spectrometry (FT-Orbitrap MS) to determine the molecular formula and propose chemical structures. Chemometric analysis showed that MAE was most effective in extracting antioxidant compounds.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Silvia Cordeiro das Neves, Flavio Henrique de Araujo, Willian Ayala Correa, Allana Cristina Faustino Martins, Henrique Rodrigues Scherer Coelho, Marcelo Luiz Brandao Vilela, Valter Aragao do Nascimento, Candida Aparecida Leite Kassuya, Denis Pires de Lima, Adilson Beatriz, Rodrigo Juliano Oliveira, Roberto da Silva Gomes
Summary: In this study, the genotoxic potential, cell-killing potential, and interactions of phthalide 1 with cyclophosphamide and cisplatin were evaluated. The results showed that 1 increased the frequency of chromosomal damage, cell death, and splenic phagocytosis. The association of 1 with cyclophosphamide and cisplatin demonstrated a chemopreventive effect and reduced the frequency of chromosomal damage.
Article
Plant Sciences
Laura Priscila Toledo Bernal, Maicon Matos Leitao, Joyce Alencar Santos Radai, Claudia Andrea Lima Cardoso, Joyce dos Santos Lencina, Thiago Leite Fraga, Arielle Cristina Arena, Saulo Euclides Silva-Filho, Candida Aparecida Leite Kassuya
Summary: This study investigated the analgesic and anti-inflammatory properties of the ethanolic extract from Serjania erecta leaves (EESE) in mice. The results showed that EESE reduced pain response, inhibited leukocyte migration, and decreased neutrophil chemotaxis. Furthermore, EESE exhibited no cytotoxicity in vitro. These findings support the traditional use of S. erecta as a natural analgesic agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Ingred Suellen Carvalho Carregosa, Jhonattas de Carvalho Carregosa, Wenes Ramos Silva, Alberto Wisniewski Jr
Summary: This study investigated the conversion of water hyacinth biomass into bio-oil and biochar using a rotary kiln reactor at varying temperatures (400, 500, and 600°C). The highest yield of liquid fraction was obtained at 500°C, while 400 and 600°C resulted in higher production of biochar and pyrolytic gas. The bio-oils obtained had a calorific value of 68% compared to petroleum-derived fuels and were rich in acids, alcohols, phenols, and sugar derivatives. Comprehensive analysis revealed the high oxygen and nitrogen content in the bio-oil produced at 500°C. The study highlights the potential of rotary kiln reactor pyrolysis for producing value-added products from water hyacinth biomass.
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
(2023)
Article
Chemistry, Multidisciplinary
Ignes R. dos Santos, Pedro G. C. Lucena, Alex S. Moraes, Jhonattas C. Carregosa, Tarcisio M. Santos, Alberto Wisniewski Jr, Jandyson M. Santos
Summary: In 2019, a significant amount of oil reached the northeast coast of Brazil, causing damage to the environment and local economy. A study was conducted to investigate the source of the oil pollution using geochemical biomarkers and forensic protocols. The analysis of oil samples from the Pernambuco coast revealed a cluster of samples with biomarker distributions consistent with the 2019 spill, but two samples showed distinct differences, suggesting a separate origin unrelated to the mysterious spill.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2023)
Review
Chemistry, Multidisciplinary
Isis Gardenia Alves Santos, Alberto Wisniewski Junior
Summary: The presence of active sulfur compounds in crude oils has negative effects on market value, as well as high toxicity and environmental impact through the generation of combustion by-products. The use of scavenger agents for the treatment of crude oils can help minimize and mitigate these impacts. This review provides a comprehensive literature on the use of scavenger agents and briefly discusses the development of new sequestering agents.
REVISTA VIRTUAL DE QUIMICA
(2023)
