Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation

Genetic investigation of FOXE1 polyalanine tract in thyroid diseases: New insight on the role of FOXE1 in thyroid carcinoma

(2017) Rihab Kallel et al.   Cancer Biomarkers

Unraveling the pathogenesis ofARXpolyalanine tract variants using a clinical and molecular interfacing approach

(2015) Isabel Marques et al.   Molecular Genetics & Genomic Medicine

A Novel Feed-Forward Loop between ARIH2 E3-Ligase and PABPN1 Regulates Aging-Associated Muscle Degeneration

(2014) Vered Raz et al.   AMERICAN JOURNAL OF PATHOLOGY

Misfolded Polyglutamine, Polyalanine, and Superoxide Dismutase 1 Aggregate via Distinct Pathways in the Cell

(2014) Saskia Polling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The unresolved puzzle why alanine extensions cause disease

(2013) Reno Winter et al.   BIOLOGICAL CHEMISTRY

Putting Huntingtin “Aggregation” in View with Windows into the Cellular Milieu

(2013) Danny M. Hatters   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Reduced polyalanine-expanded Arx mutant protein in developing mouse subpallium alters Lmo1 transcriptional regulation

(2013) Kristie Lee et al.   HUMAN MOLECULAR GENETICS

A Platform to View Huntingtin Exon 1 Aggregation Flux in the Cell Reveals Divergent Influences from Chaperones hsp40 and hsp70

(2013) Angelique R. Ormsby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of amyloidogenic protein oligomerization in neurodegenerative disease

(2013) Gregor P. Lotz et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mechanistic Insight into the Pathology of Polyalanine Expansion Disorders Revealed by a Mouse Model for X Linked Hypopituitarism

(2013) James Hughes et al.   PLoS Genetics

Polyalanine-independent Conformational Conversion of Nuclear Poly(A)-binding Protein 1 (PABPN1)

(2012) Reno Winter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical Chemistry of Polyglutamine: Intriguing Tales of a Monotonous Sequence

(2012) Ronald Wetzel   JOURNAL OF MOLECULAR BIOLOGY

Tracking protein aggregation and mislocalization in cells with flow cytometry

(2012) Yasmin M Ramdzan et al.   NATURE METHODS

Congenital Hydrocephalus and Abnormal Subcommissural Organ Development in Sox3 Transgenic Mice

(2012) Kristie Lee et al.   PLoS One

Length-Dependent Aggregation of Uninterrupted Polyalanine Peptides

(2011) Joseph P. Bernacki et al.   BIOCHEMISTRY

Assessing the contribution of heterogeneous distributions of oligomers to aggregation mechanisms of polyglutamine peptides

(2011) Andreas Vitalis et al.   BIOPHYSICAL CHEMISTRY

The Rate of PolyQ-Mediated Aggregation Is Dramatically Affected by the Number and Location of Surrounding Domains

(2011) Amy L. Robertson et al.   JOURNAL OF MOLECULAR BIOLOGY

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Conformation Sensors that Distinguish Monomeric Proteins from Oligomers in Live Cells

(2010) Yasmin M. Ramdzan et al.   CHEMISTRY & BIOLOGY

ARX spectrum disorders: making inroads into the molecular pathology

(2010) Cheryl Shoubridge et al.   HUMAN MUTATION

Tracking Mutant Huntingtin Aggregation Kinetics in Cells Reveals Three Major Populations That Include an Invariant Oligomer Pool

(2010) Maya A. Olshina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-ATG-initiated translation directed by microsatellite expansions

(2010) T. Zu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three human ARX mutations cause the lissencephaly-like and mental retardation with epilepsy-like pleiotropic phenotypes in mice

(2009) Kunio Kitamura et al.   HUMAN MOLECULAR GENETICS

Dual modes of rabies P-protein association with microtubules: a novel strategy to suppress the antiviral response

(2009) G. W. Moseley et al.   JOURNAL OF CELL SCIENCE

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

(2009) Pei-Hsien Ren et al.   NATURE CELL BIOLOGY

Molecular mechanisms underlying polyalanine diseases

(2009) C. Messaed et al.   NEUROBIOLOGY OF DISEASE