Article
Clinical Neurology
Dejan Georgiev, Sanja Roskar, Anja Cus, Leonora Wilkinson, Marjan Jahanshahi
Summary: This study examined the acute effects of STN-DBS on proactive interference (PI) and retroactive interference (RI) during verbal learning in Parkinson's disease patients. The results showed that stimulation increased PI but had no effect on RI, indicating a role of STN in inhibitory control during memory encoding or recall.
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
Roxanne Lofredi, Cem-Georg Auernig, Siobhan Ewert, Friederike Irmen, Leon A. Steiner, Ute Scheller, Bernadette C. M. van Wijk, Simon Oxenford, Andrea A. Kuhn, Andreas Horn
Summary: Lead-DBS is a reliable and easy-to-use software tool for precise localization of deep brain stimulation electrodes. This study investigates the differences introduced by different raters and imaging types in the manual refinement process of electrode localization using Lead-DBS. The results show similar outcomes for all users, with an increase in variability when using postoperative MRI and standard space normalization. These findings contribute to the understanding of Lead-DBS and its potential use in formal training and imaging research in the field of deep brain stimulation.
Article
Geriatrics & Gerontology
Ritesh A. Ramdhani, Jeremy Watts, Myriam Kline, Toni Fitzpatrick, Martin Niethammer, Anahita Khojandi
Summary: This study investigated the effects of high-frequency and low-frequency STN-DBS on spatiotemporal gait kinematics in patients with advanced Parkinson's disease. It was found that high-frequency STN-DBS significantly improved trunk and lumbar kinematics.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Stephane Prange, Zhengyu Lin, Mikail Nourredine, Teodor Danaila, Chloe Laurencin, Ouhaid Lagha-Boukbiza, Mathieu Anheim, Helene Klinger, Nadine Longato, Clelie Phillipps, Jimmy Voirin, Gustavo Polo, Emile Simon, Patrick Mertens, Anne-Sophie Rolland, David Devos, Elise Metereau, Christine Tranchant, Stephane Thobois
Summary: This study compared the risk and etiological factors, clinical management, and consequences of Parkinson's disease patients with or without mania following STN-DBS surgery. The study found that postoperative mania was related to ventral limbic subthalamic stimulation, and relocating the stimulation to the sensorimotor STN, reducing or discontinuing dopamine agonists, and using low-dose clozapine could alleviate mania symptoms, with similar motor and nonmotor outcomes.
ANNALS OF NEUROLOGY
(2022)
Article
Neurosciences
Louise M. Jorgensen, Tove Henriksen, Skirmante Mardosiene, Ottilia Wyon, Sune H. Keller, Bo Jespersen, Gitte M. Knudsen, Dea S. Stenbaek
Summary: This study investigates the association between the cerebral 5-HT system and non-motor symptoms in patients with Parkinson's disease (PD), as well as the effects of turning deep brain stimulation (DBS) in the subthalamic nucleus (STN) on cognition and mood. The findings suggest that 5-HT1BR binding is related to working memory performance and affective bias, while the turning off of DBS can lead to decreased vigor in patients. The study also suggests that preservation of serotonergic functions may predict the effects of DBS-STN.
Article
Clinical Neurology
Jan Roediger, Till A. Dembek, Gregor Wenzel, Konstantin Butenko, Andrea A. Kuehn, Andreas Horn
Summary: A data-driven model was developed to suggest optimal stimulation parameters for Parkinson's disease patients undergoing deep brain stimulation treatment, improving motor outcomes while minimizing the risk of side effects caused by stimulation. This approach may provide guidance for future DBS programming.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Asra Askari, Brandon J. Zhu, Xiru Lyu, Kelvin L. Chou, Parag G. Patil
Summary: The study found that STN DBS has differential effects on rigidity in upper and lower extremities in patients with Parkinson's disease. However, there was no significant difference in tremor or bradykinesia between the upper and lower extremities. Even though there were slight differences in the maximal-effect loci for stimulation between the upper and lower extremities, they were not statistically resolved.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Multidisciplinary Sciences
Anika Frank, Jonas Bendig, Inaki Schniewind, Witold H. Polanski, Stephan B. Sobottka, Heinz Reichmann, Katja Akgun, Tjalf Ziemssen, Lisa Klingelhoefer, Bjorn H. Falkenburger
Summary: This study found that deep brain stimulation surgery may be associated with neuronal damage, but stimulation itself does not have an impact.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Maria Antonietta Volonte, Giacomo Clarizio, Sebastiano Galantucci, Pietro Giuseppe Scamarcia, Rosalinda Cardamone, Lina Raffaella Barzaghi, Monica Falautano, Pietro Mortini, Giancarlo Comi, Massimo Filippi
Summary: This study evaluated the long-term effectiveness of STN-DBS treatment on advanced PD patients over a span of 14 years. Results showed significant improvement in tremor, rigidity, and daily dopaminergic dose, but no lasting effect on axial symptoms and cognitive functions. STN-DBS remains an effective therapy for advanced PD patients, extending the period of acceptable quality of life despite disease progression.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Hui Li, Dapeng Li, Wuyang Yang, Huifang Yan, Zifang Zhao, Haibo Yang
Summary: This study demonstrated the effectiveness of subthalamic deep brain stimulation (STN-DBS) as a symptom-based treatment for pediatric patients with pantothenate kinase-associated neurodegeneration (PKAN), providing relief and functional improvement.
WORLD NEUROSURGERY
(2022)
Article
Neurosciences
Bowen Chang, Jiaming Mei, Chi Xiong, Peng Chen, Manli Jiang, Chaoshi Niu
Summary: This study reported a case of a PD patient who significantly improved symptoms after undergoing bilateral globus pallidus interna combined with subthalamic nucleus variable frequency DBS treatment, exploring a new approach for treating dystonia disorders.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Jing Wei, Zhifan Zou, Jiping Li, Yuqing Zhang
Summary: Deep-brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for motor symptoms of advanced Parkinson's disease (PD). This study aimed to investigate the local field potential (LFP) distribution patterns in dorsomedial and dorsolateral subparts of STN. The results showed weaker gamma oscillations and coherence in the dorsomedial part compared to the dorsolateral part, indicating the potential of targeting the dorsomedial STN for DBS in PD.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Yuhan Wang, Chencheng Zhang, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: This study aimed to evaluate optimal stimulation parameters for treating dystonia with STN-DBS. Results showed that the optimal parameters vary among patients, with improvement rate being linearly dependent on stimulation parameters. Adverse effects include dyskinesia and depression.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Florian Lange, Hazem Eldebakey, Alexandra Hilgenberg, Benedikt Weigl, Marie Eckert, Angela DeSunda, Hermann Neugebauer, Robert Peach, Jonas Roothans, Jens Volkmann, Martin M. Reich
Summary: Through studying 24 patients, we found strong connections between stimulation-induced dysarthria and brain regions associated with motor speech control, especially highlighting the disruption of corticobulbar fibers that may cause spastic dysarthria. These findings provide insights into the mechanism of dysarthria caused by deep brain stimulation of the subthalamic nucleus and may guide individual reprogramming attempts for Parkinson's patients based on pathophysiological understanding of the affected networks.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Multidisciplinary Sciences
Charles W. Lu, Daniel E. Harper, Asra Askari, Matthew S. Willsey, Philip P. Vu, Andrew D. Schrepf, Steven E. Harte, Parag G. Patil
Summary: Stimulation of the zona incerta can reduce heat pain perception, but does not affect warmth perception or pressure pain. These findings provide a mechanistic explanation for sensory changes observed in Parkinsonian patients undergoing subthalamic deep brain stimulation and identify the zona incerta as a potential target for neuromodulation of pain.
SCIENTIFIC REPORTS
(2021)