Article
Immunology
Yang Fang, Yi Yang, Chengcheng Liu
Summary: This study proposes a new method to extract features from phylogenetic profiles for predicting pathogen-host interactions (PHIs). The performance of this approach is better than structure-based and machine learning-based methods, and combining phylogenetic profile features with structure-based methods can be applied to explore PHI and discover new unknown biological relationships.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Lisa Lasswitz, Francisco J. Zapatero-Belinchon, Rebecca Moeller, Kirsten Huelskoetter, Timothee Laurent, Lars-Anders Carlson, Christine Goffinet, Graham Simmons, Wolfgang Baumgaertner, Gisa Gerold
Summary: In this study, CD81 is identified as a host factor for the globally emerging chikungunya virus and related alphaviruses, promoting viral genome replication in human and mouse cells while being dispensable for virus entry. The cholesterol-binding ability of CD81 is crucial for its function as an alphavirus host factor, broadening our understanding of the alphavirus replication process by reprogramming cells into virus replication factories.
Article
Biotechnology & Applied Microbiology
M. Kusari, L. Dey, A. Mukhopadhyay
Summary: The study developed a database of Chikungunya virus-human protein-protein interactions, aiming to facilitate the understanding of disease pathogenesis and vaccine research progress.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Fisheries
Gulshan Kumar, P. Gireesh-Babu, K. V. Rajendran, Mukunda Goswami, Aparna Chaudhari
Summary: Three decades after its first outbreak, the shrimp white spot virus (WSV) is still a global cause of concern. The pathogenesis of WSV is not clearly understood, despite the identification of several candidate host receptor proteins. In this study, protein-protein docking was used to evaluate the interaction between the WSV envelope protein VP28 and four host receptors. Furthermore, gain-of-function experiments confirmed that none of the receptors alone were sufficient to make cells permissive to WSV, suggesting the involvement of co-receptors.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Virology
Marissa C. Locke, Lindsey E. Fox, Bria F. Dunlap, Alissa R. Young, Kristen Monte, Deborah J. Lenschow
Summary: IFN-alpha, but not IFN-beta, is an important host regulator of chronic CHIKV pathogenesis that acts within the first 48 hours of infection to limit persistent viral RNA and the number of cells that survive CHIKV infection. Different cell types have varying dependence on type I IFNs, highlighting the importance of delineating early host-pathogen interactions for understanding chronic disease progression.
JOURNAL OF VIROLOGY
(2022)
Review
Veterinary Sciences
Souvik Ghosh, Yashpal S. Malik
Summary: Picobirnaviruses are bisegmented double-stranded RNA viruses detected in a wide range of animal species and environmental samples. There is ongoing debate about the true host of these viruses.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Asahiro Morishita, Kyoko Oura, Tomoko Tadokoro, Koji Fujita, Joji Tani, Tsutomu Masaki
Summary: The liver is a non-immunological organ involved in metabolic activities, nutrient storage, and detoxification. Resident immune cells in the liver drive immunological reactions and certain microRNAs are associated with the immune response to pathogens, although the exact mechanism of miRNA interference in these interactions remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jian Luo, Jinzhi Xu, Chaolu Xie, Zuoming Zhao, Junrui Guo, Yuan Wen, Tian Li, Zeyang Zhou
Summary: This study reveals the mechanism by which microsporidia manipulate host mitochondrial fragmentation (HMF), thus providing references for understanding the interactions between microsporidia and host mitochondria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Virology
Solene Cottis, Adrien A. Blisnick, Anna-Bella Failloux, Kenneth D. Vernick
Summary: Mosquito-borne diseases, caused by viruses and parasites, result in over 700 million infections annually. Anopheles and Aedes mosquitoes are the primary vectors for malaria and arboviruses. While Anopheles mosquitoes are the main vector for the alphavirus o'nyong-nyong virus (ONNV), which is closely related to chikungunya virus (CHIKV) vectored by Aedes mosquitoes, they also harbor a complex natural virome of RNA viruses, including pathogenic arboviruses. The vector specificity between these arboviruses is poorly understood, but this article summarizes intrinsic and extrinsic factors associated with it and evaluates the risk of vector shift by ONNV or CHIKV.
Review
Microbiology
Atsushi Tanaka, Youichi Suzuki
Summary: Chikungunya virus (CHIKV) is transmitted to humans by Aedes mosquito bites, causing symptoms such as fever, headache, rash, and arthralgia. Despite the lack of specific drugs, recent studies have highlighted host factors that limit virus replication, offering important insights for pharmacological treatment development against CHIKVF.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Microbiology
Sineewanlaya Wichit, Nuttamonpat Gumpangseth, Rodolphe Hamel, Sakda Yainoy, Siwaret Arikit, Chuchard Punsawad, Dorothee Misse
Summary: Chikungunya and Zika viruses have globally re-emerged over the past 60 years and there is currently no specific antiviral treatment. Understanding viral-host interactions is crucial for developing targeted therapeutics, but limited information is available in this area at present.
Article
Virology
Peiqi Yin, Xia Jian, Yihan Liu, Yuwen Liu, Lu Lv, Haoran Cui, Leiliang Zhang
Summary: By generating a systematic CHIKV-human protein-protein interaction map, this study identified novel connections and provided insights into the rewiring of host cell functions by CHIKV. The interaction between viral protein E1 and STUB1 was found to regulate the degradation of E1 through ubiquitination. Additionally, inhibiting VCP blocked CHIKV infection, suggesting its potential as a therapeutic target.
Review
Biotechnology & Applied Microbiology
Leon Kemper, Andreas Hensel
Summary: Campylobacter jejuni, causing severe enteritis, has unique features and adapts effectively to environmental conditions. The review summarizes the strategies of C. jejuni for host-pathogen interaction, providing insights for future drug development.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Plant Sciences
Supratim Basu, Elena Sineva, Liza Nguyen, Narattam Sikdar, Jong Won Park, Mikhail Sinev, Madhurababu Kunta, Goutam Gupta
Summary: This article introduces a novel therapy for citrus Huanglongbing (HLB) and apple fire blight by enhancing the innate immunity of the host plants. The researchers constructed chimeras with observed or predicted antibacterial activity and demonstrated their effectiveness in clearing the causative bacteria and augmenting the host's immune response.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Immunology
Shuang Tang, Jie Li, Yung-Fu Chang, Wencheng Lin
Summary: Avian leukosis virus (ALV) causes various diseases, including tumor formation and decreased fertility. In addition, ALV induces immunosuppression, increasing susceptibility to other microbial infections and the risk of vaccine failure against other diseases. Evidence shows an interaction between ALV and the host.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Sunit K. Singh
CURRENT HIV RESEARCH
(2016)
Review
Virology
Meghana Rastogi, Nikhil Sharma, Sunit Kumar Singh
Article
Multidisciplinary Sciences
Nikhil Sharma, Kanhaiya L. Kumawat, Meghana Rastogi, Anirban Basu, Sunit K. Singh
SCIENTIFIC REPORTS
(2016)
Article
Virology
Meghana Rastogi, Neha Srivastava, Sunit K. Singh
JOURNAL OF MEDICAL VIROLOGY
(2018)
Article
Virology
Meghna Agrawal, Meghana Rastogi, Smriti Dogra, Neha Pandey, Anirban Basu, Sunit K. Singh
Summary: In this study, the role of miRNAs during CHPV infection in human microglial cells was investigated. A total of 12 differentially expressed miRNAs were identified, and analysis revealed their involvement in interferon response and cytokine and chemokine signaling. Weighted gene coexpression network analysis identified hub genes potentially correlated to CHPV-induced neuroinflammation.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Meghna Agrawal, Neha Pandey, Meghana Rastogi, Smriti Dogra, Sunit K. Singh
JOURNAL OF MEDICAL VIROLOGY
(2020)
Article
Immunology
Meghana Rastogi, Sunit K. Singh
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2019)
Editorial Material
Infectious Diseases
Peter J. Hotez, Maria E. Bottazzi, Sunit K. Singh, Paul J. Brindley, Shaden Kamhawi
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Biochemistry & Molecular Biology
Meghana Rastogi, Sunit K. Singh
Article
Virology
Utkarsh Bhardwaj, Neha Pandey, Meghana Rastogi, Sunit K. Singh
Summary: Zika virus is a mosquito-borne neurotropic flavivirus that can cause microcephaly in developing fetus and GBS-like symptoms in adults. The virus was first reported in humans in 1952 and has caused major outbreaks in various regions since then. Understanding the molecular mechanism of Zika virus pathogenesis is crucial for developing potential diagnostic and therapeutic interventions.
Article
Neurosciences
Utkarsh Bhardwaj, Sunit K. Singh
Summary: Zika virus disrupts the barrier integrity of the blood-brain barrier through NS1 protein and hsa-miR-101-3p interaction, which may contribute to neurological diseases.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Immunology
Neha Pandey, Sunit K. Singh
Summary: In this study, miR-155 was found to enhance the type I interferon signaling in CHPV-infected microglial cells by suppressing SOCS1, thereby promoting the cellular antiviral response.
MICROBES AND INFECTION
(2023)
Article
Neurosciences
Astha Shukla, Utkarsh Bhardwaj, Apoorva, Pankaj Seth, Sunit K. Singh
Summary: This study revealed that miRNA-101 decreases the expression of VE-cadherin and claudin-5 in brain endothelial cells exposed to hypoxic conditions, leading to the disruption of endothelial barrier integrity and increased permeability.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Neha Pandey, Meghana Rastogi, Sunit K. Singh
Summary: This study highlights the role of hsa-miR-21-5p in regulating pro-inflammatory genes in CHPV-infected human microglial cells. Upregulation of hsa-miR-21-5p during CHPV infection leads to downregulation of PTEN and subsequent phosphorylation of AKT and NF-kappa Bp65 in microglial cells. Overexpression of hsa-miR-21-5p further promotes AKT and NF-kappa Bp65 phosphorylation, while inhibition of hsa-miR-21-5p restores expression levels.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Review
Respiratory System
Meghana Rastogi, Neha Pandey, Astha Shukla, Sunit K. Singh
RESPIRATORY RESEARCH
(2020)
