Article
Multidisciplinary Sciences
Zoe L. Grange, Tracey Goldstein, Christine K. Johnson, Simon Anthony, Kirsten Gilardi, Peter Daszak, Kevin J. Olival, Tammie O'Rourke, Suzan Murray, Sarah H. Olson, Eri Togami, Gema Vidal, Expert Panel, Jonna A. K. Mazet
Summary: This study used expert opinions and scientific evidence to identify risk factors contributing to zoonotic virus spillover and spread, developing a framework and interactive tool to assess the potential risk of wildlife-origin viruses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Infectious Diseases
Engin Berber, Emrah Simsek, Nurettin Canakoglu, Neslihan Sursal, Ayse Gencay Goksu
Summary: This study successfully identified and characterized Cryptosporidium parvum virus-1 (CSpV1) in newborn calves, and explored the impact of parasite-virus symbiont relationship on the severity of disease cases.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Mohd Sajid Ali, Mohd Waseem, Naidu Subbarao, Hamad A. Al-Lohedan
Summary: The noncovalent molecular interactions between hen egg white lysozyme (HEWL) and the antineoplastic drug gemcitabine were studied using spectroscopic techniques and in silico approaches. The interaction was dominated by hydrophobic forces with a possible contribution of hydrogen bonding. Gemcitabine induced slight changes in the secondary structure of HEWL and was inferred to bind in a large hydrophobic cavity of the protein.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Microbiology
Thomas H. A. Haverkamp, Julien Lossouarn, Olga Zhaxybayeva, Jie Lyu, Nadege Bienvenu, Claire Geslin, Camilla L. Nesbo
Summary: Phylogenomic analyses have revealed extensive lateral gene transfer between bacteria of the phylum Thermotogota and distantly related organisms, particularly with Firmicutes, possibly mediated by viruses. This study identified 17 proviruses integrated into the genomes of bacteria from eight different genera within Thermotogota, with evidence of viral particle production from one provirus. Genes carried by these proviruses are closely related to those of Firmicutes and (pro)viruses, indicating a significant role of viruses in gene flow between Firmicutes and Thermotogota.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Microbiology
Harry T. Child, George Airey, Daniel M. Maloney, Abby Parker, Jonathan Wild, Suzie Mcginley, Nicholas Evens, Jonathan Porter, Kate Templeton, Steve Paterson, Ronny van Aerle, Matthew J. Wade, Aaron R. Jeffries, Irene Bassano
Summary: Wastewater-based epidemiology is a powerful tool for monitoring the emergence and spread of viral pathogens at the population scale. Metagenomic sequencing methods, which are target-agnostic, can detect a wide range of target viruses. Deep shotgun metagenomic sequencing is unable to provide sufficient genome coverage, while hybrid-capture enrichment sequencing and tiled-PCR sequencing have stronger capabilities for detecting and genotyping viruses in wastewater samples.
Article
Oncology
Rong Wei, Guoye Qi, Zixin Zeng, Ningning Shen, Ziyue Wang, Honghong Shen, Lifang Gao, Chen Song, Wenxia Ma, Chen Wang
Summary: Through multiple bioinformatic analyses and experimental validation, this study identified that GPRC5A and IMUP were abnormally up-regulated in pancreatic cancer, showing significant associations with patients' survival rates.
CANCER CELL INTERNATIONAL
(2021)
Article
Virology
Philipp Golke, Mario Hoenemann, Sandra Bergs, Uwe Gerd Liebert
Summary: The study demonstrates a pronounced genetic diversity of Rhinoviruses in adults, with co-infections playing an important role in disease severity and length of hospital stay.
Article
Virology
Franziska Neugebauer, Sandra Bergs, Uwe Gerd Liebert, Mario Honemann
Summary: This study assessed the abundance and genetic diversity of rhinoviruses (RVs) in pediatric patients. The findings showed that RVs were present throughout the year with peaks in fall and winter, and exhibited significant intra- and interseasonal diversity in genotypes. RV-C was associated with asthma and bronchiolitis, while RV-A was associated with fever and pneumonia. Co-infections with other pathogens were also found to be associated with longer hospital stay, need for ventilation, and pneumonia.
Review
Public, Environmental & Occupational Health
Homa Hajjaran, Reza Saberi, Alireza Borjian, Mahdi Fakhar, Seyed Abdollah Hosseini, Sajjad Ghodrati, Mehdi Mohebali
Summary: This study provides a comprehensive investigation into the species identification and geographical distribution of causative agents of cutaneous, mucosal, and visceral leishmaniasis in Iran, with L. major and L. infantum identified as the main causative agents. Kinetoplast DNA (kDNA) and internal transcriber spacer (ITS) are the most commonly used markers for identifying Leishmania species.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Thermodynamics
Ahmed Saad Soliman, Ali Radwan, Li Xu, Junguo Dong, Ping Cheng
Summary: This study proposes a new design of exhaust waste heat recovery heat exchanger for preheating the intake air in cold start-up conditions, improving the performance of diesel engines. The results show that the heat exchanger can increase the intake air temperature from 273 K to 302.2 K in less than 1 minute, overcoming the difficulties of cold start-up.
CASE STUDIES IN THERMAL ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Lu Qi, Ying Zhang, Fuyao Song, Yue Han, Yanqing Ding
Summary: In this study, a new protein kinase inhibitor, ZINC65387069, was identified, which showed stronger kinase inhibitory activity in CRC cells compared to traditional TKIs. ZINC65387069 was able to inhibit cell migration, disrupt the cell cytoskeleton, and promote cell apoptosis.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Naoki Matsumoto, Yoko Nemoto-Sasaki, Saori Oka, Seisuke Arai, Ikuo Wada, Atsushi Yamashita
Summary: Phospholipase A1 (PLA1) hydrolyzes glycerophospholipid fatty acids in cellular membranes and genetic mutations in DDHD1 gene result in hereditary spastic paraplegia (HSP). This study identified multiple phosphorylation sites in human DDHD1 and the protein kinases responsible for regulating these sites, suggesting potential implications for HSP pathogenesis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Rui Yin, Xianghe Zhu, Min Zeng, Pengfei Wu, Min Li, Chee Keong Kwoh
Summary: This paper develops a general framework using machine learning approaches to predict B-cell epitopes specific for human-adapted viruses. The framework reliably identifies linear B-cell epitopes using protein sequence analysis and provides viral category results, making it important for vaccine design and future pandemics.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Construction & Building Technology
Jiacheng Fu, Yupeng Wang, Dian Zhou, Shi-Jie Cao
Summary: This research is based on Xingqing Palace Park in Xi'an and focuses on the impact of urban park design on urban microclimate. The study found that green coverage rate is a key factor affecting urban microclimate, while building density and mean building height have significant effects on microclimate changes during nights.
SUSTAINABLE CITIES AND SOCIETY
(2022)
Article
Construction & Building Technology
Rui Miao, Xiaoou Hu, Yao Yu, Yan Zhang, Mark Wood, Gaylord Olson
Summary: The study introduces a innovative dual purpose solar thermal collector capable of collecting solar heat and utilizing night sky cooling for cold collection. Compared with conventional collectors, this design offers enhanced cooling power and cost-effectiveness.
ENERGY AND BUILDINGS
(2021)
Article
Immunology
Mohinder Sarna, Asma Alsaleh, Stephen B. Lambert, Robert S. Ware, Lebogang P. Mhango, Ian M. Mackay, David M. Whiley, Theo P. Sloots, Keith Grimwood
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2016)
Article
Infectious Diseases
Sonja Hall-Mendelin, Alyssa T. Pyke, Peter R. Moore, Ian M. Mackay, Jamie L. McMahon, Scott A. Ritchie, Carmel T. Taylor, Frederick A. J. Moore, Andrew F. van den Hurk
PLOS NEGLECTED TROPICAL DISEASES
(2016)
Article
Virology
Katherine E. Arden, Claire Heney, Babak Shaban, Graeme R. Nimmo, Michael D. Nissen, Theo P. Sloots, Ian M. Mackay
JOURNAL OF MEDICAL VIROLOGY
(2017)
Review
Virology
Ian M. Mackay, Katherine E. Arden
Article
Infectious Diseases
Heidi C. Smith-Vaughan, Michael J. Binks, Jemima Beissbarth, Anne B. Chang, Gabrielle B. McCallum, Ian M. Mackay, Peter S. Morris, Robyn L. Marsh, Paul J. Torzillo, Danielle F. Wurzel, Keith Grimwood, Elizabeth Nosworthy, Jane E. Gaydon, Amanda J. Leach, Barbara MacHunter, Mark D. Chatfield, Theo P. Sloots, Allen C. Cheng
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2018)
Article
Virology
Donna McNeale, Claire Y. T. Wang, Katherine E. Arden, Ian M. Mackay
JOURNAL OF CLINICAL VIROLOGY
(2018)
Article
Virology
Carmel T. Taylor, Ian M. Mackay, Jamie L. McMahon, Sarah L. Wheatley, Peter R. Moore, Mitchell J. Finger, Glen R. Hewitson, Frederick A. Moore
Article
Parasitology
Ana L. Ramirez, Andrew F. van den Hurk, Ian M. Mackay, Annie S. P. Yang, Glen R. Hewitson, Jamie L. McMahon, Justin A. Boddey, Scott A. Ritchie, Sara M. Erickson
PARASITES & VECTORS
(2019)
Article
Virology
Jamie McMahon, Ian M. Mackay, Stephen B. Lambert
Article
Environmental Sciences
Jianyun Lu, Zhicong Yang, Anjana C. Karawita, Myrna Bunte, Keng Yih Chew, Cassandra Pegg, Ian Mackay, David Whiley, Kirsty R. Short
Summary: The study found minimal changes in environmental factors in Brisbane during the 2018-2019 summer, except for a significant decrease in rainfall. DLNM analysis showed a correlation between reduced rainfall and an increased risk of influenza. Sulfur dioxide levels increased during this period but were not associated with influenza risk. Sequencing of pediatric influenza strains from 2018-2019 revealed multiple mutations in the viral HA gene.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Medicine, General & Internal
Kym Lowry, Claire Wang, Amanda Bordin, Cameron Buckley, Steven Badman, Patrick Harris, Ian Mackay, David Whiley
Summary: In response to the continuous transmission and evolution of SARS-CoV-2, this study developed a rapid in-house RT-PCR assay to target a specific mutation in the Delta variant. The assay showed high sensitivity and specificity, providing rapid screening results to assist clinicians in making effective treatment and surveillance decisions.
Correction
Infectious Diseases
Alyssa T. Pyke, Wendy Gunn, Carmel Taylor, Ian M. Mackay, Jamie McMahon, Lauren Jelley, Ben Waite, Fiona May
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2019)
Article
Infectious Diseases
Alyssa T. Pyke, Wendy Gunn, Carmel Taylor, Ian M. Mackay, Jamie McMahon, Lauren Jelley, Ben Waite, Fiona May
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2018)