4.3 Article

Surface modification of poly(dimethylsiloxane) and its applications in microfluidics-based biological analysis

期刊

REVIEWS IN ANALYTICAL CHEMISTRY
卷 31, 期 3-4, 页码 177-192

出版社

WALTER DE GRUYTER GMBH
DOI: 10.1515/revac-2012-0016

关键词

biological analysis; microfluidic device; poly(dimethylsiloxane); surface modification

资金

  1. National Natural Science Foundation of China [20975082, 21175107]
  2. Natural Science Foundation of Shaanxi [2011JQ2006]
  3. Ministry of Education of the People's Republic of China [NCET-08-0464]
  4. State Forestry Administration of the People's Republic of China [200904004]
  5. Scientific Research Foundation for the Returned Overseas Chinese Scholars
  6. State Education Ministry
  7. Northwest AF University

向作者/读者索取更多资源

Poly(dimethylsiloxane) (PDMS)-based microfluidic systems have been gaining popularity in various applications, particularly for biological analyses because of their non-toxicity, easy fabrication, practical scalability, optical transparency, and low cost. However, because of the inherent hydrophobicity of PDMS-based material, biological samples easily and strongly interact with PDMS surfaces in biological environments, which prevents the immediate use of PDMS-based microfluidics without any surface processing. To date, various surface modification methods and different materials have been utilized to improve the repelling properties of the PDMS surface and to introduce new functional groups. Based on the recent advances in this field, we outline the main strategies utilized in PDMS surface modification in this review. We also present several applications of modified PDMS surfaces in biological analysis, such as biomolecule separation, immunoassay, cell culture, and DNA hybridization.

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