期刊
MATERIALS
卷 8, 期 3, 页码 1162-1175出版社
MDPI
DOI: 10.3390/ma8031162
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类别
资金
- Natural Science Foundation of China [51222506, 81372366, 81472058]
- High Technology Research and Development Program of China [2015AA033503]
- Overseas, Hong Kong & Macao Scholars Collaborated Researching Fund of National Natural Science Foundation of China [81428018]
- Hunan Provincial Natural Science Foundation of China [14JJ1006]
- Shenzhen Strategic Emerging Industrial Development Funds [JCYJ20130401160614372]
- Open-End Fund for the Valuable and Precision Instruments of Central South University
- Central South University [2013JSJJ011, 2013JSJJ046]
- State Key Laboratory of New Ceramic and Fine Processing Tsinghua University [KF201413]
CaO-Al2O3-SiO2 (CAS) as a liquid phase was introduced into hydroxyapatite (HAp) to prepare bone scaffolds. The effects of the CAS content (1, 2, 3, 4 and 5 wt%) on microstructure and mechanical properties of HAp ceramics were investigated. The optimal compression strength, fracture toughness and Vickers hardness reached 22.22 MPa, 1.68 MPa center dot m(1/2) and 4.47 GPa when 3 wt% CAS was added, which were increased by 105%, 63% and 11% compared with those of HAp ceramics without CAS, respectively. The improvement of the mechanical properties was attributed to the improved densification, which was caused by the solid particle to rearrange during liquid phase sintering. Moreover, simulated body fluid (SBF) study indicated the HAp ceramics could maintain the mechanical properties and form a bone-like apatite layer when they were immersed in SBF. Cell culture was used to evaluate biocompatibility of the HAp ceramics. The results demonstrated MG-63 cells adhered and spread well.
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