期刊
REVIEW OF SCIENTIFIC INSTRUMENTS
卷 80, 期 4, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.3117204
关键词
biomedical optical imaging; bio-optics; brain; eye; fluorescence; image resolution; neurophysiology; optical microscopy; optical tomography; phantoms; skin
资金
- NIH National Institute for Neurological Disorders and Stroke [R21NS053684, R01NS063226, R01NS05118]
- National Institute for Biomedical Imaging and Bioengineering [R01EB000790]
- National Heart lung and Blood Institute [R01HL071635]
- National Cancer Institute [U54CA126513]
- Wallace H, Coulter Foundation
- Rodriguez family
- NATIONAL CANCER INSTITUTE [U54CA126513] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL071635] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB000790] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS063226, R21NS053684] Funding Source: NIH RePORTER
Laminar optical tomography (LOT) is a new three-dimensional in vivo functional optical imaging technique. Adopting a microscopy-based setup and diffuse optical tomography (DOT) imaging principles, LOT can perform both absorption- and fluorescence-contrast imaging with higher resolution (100-200 mu m) than DOT and deeper penetration (2-3 mm) than laser scanning microscopy. These features, as well as a large field of view and acquisition speeds up to 100 frames per second, make LOT suitable for depth-resolved imaging of stratified tissues such as retina, skin, endothelial tissues and the cortex of the brain. In this paper, we provide a detailed description of a new LOT system design capable of imaging both absorption and fluorescence contrast, and present characterization of its performance using phantom studies.
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