期刊
RETROVIROLOGY
卷 7, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1742-4690-7-22
关键词
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类别
资金
- Brazilian CNPq/PROSUL [490585/2007-8]
- Agencia Nacional de Promocion Cientifica y Tecnologica [PICT 2004-25830]
- CONICET [PIP 6057]
- Plan Nacional del SIDA [SAF 2005/03833, SAF 2007/61036]
- Fondo de Investigaciones Sanitarias de la Seguridad Social (FISss) [173]
- Brazilian CNPq/FIOCRUZ
Background: Although HIV-1 CRF12_BF and CRF38_BF are two epidemiologically important recombinant lineages circulating in Argentina and Uruguay, little is known about their population dynamics. Methods: A total of 120 CRF12_BF-like and 20 CRF38_BF-like pol recombinant sequences collected in Argentina and Uruguay from 1997 to 2009 were subjected to phylogenetic and Bayesian coalescent-based analyses to estimate evolutionary and demographic parameters. Results: Phylogenetic analyses revealed that CRF12_BF viruses from Argentina and Uruguay constitute a single epidemic with multiple genetic exchanges among countries; whereas circulation of the CRF38_BF seems to be confined to Uruguay. The mean estimated substitution rate of CRF12_BF at pol gene (2.5 x 10-3 substitutions/site/year) was similar to that previously described for subtype B. According to our estimates, CRF12_BF and CRF38_BF originated at 1983 (1978-1988) and 1986 (1981-1990), respectively. After their emergence, the CRF12_BF and CRF38_BF epidemics seem to have experienced a period of rapid expansion with initial growth rates of around 1.2 year(-1) and 0.9 year(-1), respectively. Later, the rate of spread of these CRFs_BF seems to have slowed down since the mid-1990s. Conclusions: Our results suggest that CRF12_BF and CRF38_BF viruses were generated during the 1980s, shortly after the estimated introduction of subtype F1 in South America (similar to 1975-1980). After an initial phase of fast exponential expansion, the rate of spread of both CRFs_BF epidemics seems to have slowed down, thereby following a demographic pattern that resembles those previously reported for the HIV-1 epidemics in Brazil, USA, and Western Europe.
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