Article
Microbiology
Kuan-Jen Chen, Ming-Hui Sun, Yen-Po Chen, Yi-Hsing Chen, Nan-Kai Wang, Laura Liu, An-Ning Chao, Wei-Chi Wu, Yih-Shiou Hwang, Chi-Chun Lai
Summary: This study retrospectively analyzed the data of 37 patients with endogenous fungal endophthalmitis and found that diabetes was the most common risk factor. Yeasts were more commonly detected than mold, and Candida spp. were the most common fungal isolates. Retinal detachment was a common complication, and better initial visual acuity was associated with superior visual outcomes.
Review
Microbiology
Abid A. Haseeb, Abdelrahman M. Elhusseiny, Mohammad Z. Siddiqui, Kinza T. Ahmad, Ahmed B. Sallam
Summary: Endophthalmitis is a serious ophthalmologic condition involving purulent inflammation of the intraocular spaces. Infectious endophthalmitis is typically caused by bacteria or fungi, with Candida albicans being the most common organism for fungal endophthalmitis. Diagnosis is clinical and treatment involves systemic and intravitreal antifungal medications.
Article
Medicine, General & Internal
Hao Wang, Yongye Chang, Yifan Zhang, Rong Yang, Huijun Shi, Minglian Zhang
Summary: This article discusses a successfully treated case of endogenous fungal endophthalmitis, focusing on the diagnostic and treatment procedures. The patient, a 31-year-old female, presented with progressive visual decrease in both eyes after induced abortion. Bilateral fungal endogenous endophthalmitis was diagnosed and treated with oral itraconazole and intravitreal voriconazole initially, followed by vitrectomy and intravenous fluconazole. The intraocular inflammation alleviated and visual acuity improved after treatment.
Article
Medicine, General & Internal
Dian Nadia Abu Talib, Meng Hsien Yong, Rona Asnida Nasaruddin, Jemaima Che-Hamzah, Mae-Lynn Catherine Bastion
Summary: This case report focuses on a chronic case of endogenous fungal endophthalmitis (EFE), which was difficult to treat and posed challenges. Despite the poor initial response, adjusting the treatment plan led to improvements in ocular symptoms.
Article
Infectious Diseases
Jessica Seidelman, Molly Fleece, Allison Bloom, Emily Lydon, Wesley Yang, Christopher Arnold, David J. Weber, Nwora Lance Okeke
Summary: Through multivariate logistic regression analysis, we found that the main risk factors for developing endogenous Candida endophthalmitis in candidemic patients include the presence of a central venous catheter, intravenous drug use, immunosuppression, total parenteral nutrition recipient, race, age, and Candida albicans infection. Clinicians should develop targeted and cost-effective screening strategies based on these risk factors.
JOURNAL OF INFECTION
(2021)
Article
Ophthalmology
Daraius Shroff, Ritesh Narula, Neelam Atri, Arindam Chakravarti, Arpan Gandhi, Neelam Sapra, Gagan Bhatia, Shraddha R. Pawar, Shishir Narain
Summary: This study reports cases of endogenous fungal endophthalmitis in patients who recovered from severe COVID-19 infection and were treated with prolonged systemic steroids. The patients developed floaters and blurred vision after discharge, which were initially misdiagnosed as noninfectious uveitis. Treatment with vitrectomy and antifungal therapy led to anatomical and functional improvement in all eyes.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Infectious Diseases
Dawid Zyrek, Joanna Nowicka, Magdalena Pajaczkowska, Ewa Morgiel
Summary: Research confirms that Candida strains resistant to fluconazole may occur slightly more frequently in patients on systemic methotrexate therapy, but there is no solid evidence to support the hypothesis that methotrexate induces resistance to azoles among endogenous Candida strains in patients with rheumatological diseases.
Letter
Ophthalmology
Pooja Bansal, Meenakshi Thakar, Ravinesh Kumar, Poonam Loomba
Summary: Postpartum fungal endogenous endophthalmitis is a rare condition that requires early diagnosis and treatment. This case report describes a 26-year-old lactating mother diagnosed with endogenous endophthalmitis caused by a rare fungus, Candida ciferrii, leading to improved visual acuity after treatment.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Ophthalmology
Sara Spelta, Antonio Di Zazzo, Marco Antonini, Stefano Bonini, Marco Coassin
Summary: Endogenous endophthalmitis is a significant cause of visual impairment, and prompt treatment with appropriate pharmacological or surgical therapy is essential to preserve visual function.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Ophthalmology
Jamel Corredores, Itzhak Hemo, Tareq Jaouni, Zohar Habot-Wilner, Michal Kramer, Shiri Shulman, Haneen Jabaly-Habib, Ala'a Al-Talbishi, Michael Halpert, Edward Averbukh, Jaime Levy, Iris Deitch-Harel, Radgonde Amer
Summary: This study analyzed the risk factors, ophthalmological features, treatment modalities, and their effects on visual outcomes in patients with endogenous fungal endophthalmitis. Early suspicion of inciting risk factors is crucial, and prompt institution of systemic and intravitreal pharmacotherapy can lead to improved visual prognosis. Oral +/- local steroids may help control inflammation and limit ocular complications in cases of prolonged or marked inflammatory responses.
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2021)
Letter
Ophthalmology
Murat Hasanreisoglu, Sarakshi Mahajan, Huseyin Baran Ozdemir, Pinar Cakar Ozdal, M. Sohail Halim, Muhammad Hassan, Quan Dong Nguyen
Summary: This case report describes a pregnant woman who developed fungal endophthalmitis after in-vitro fertilization, highlighting the importance of recognizing this potential risk factor and considering local intravitreal antifungal injections as an effective treatment option.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Microbiology
Sneha Singh, Sukhvinder Singh, Ashok Kumar
Summary: Candida albicans is the leading cause of endogenous fungal endophthalmitis. This study developed a mouse model and investigated the molecular pathology of ocular candidiasis. The results showed that Candida infection led to inflammation and disruption of the blood-retinal barrier in the eyes of mice. In vitro studies also revealed an inflammatory response and increased cellular permeability upon Candida infection.
MICROBIOLOGY SPECTRUM
(2022)
Article
Ophthalmology
Wen-fei Zhang, Xin-yu Zhao, Huan Chen, Li-hui Meng, You-xin Chen
Summary: This study aimed to investigate the etiology, pathogens, treatment, and prognosis of endogenous endophthalmitis (EE). A total of 97 eyes from 81 patients were retrospectively reviewed and analyzed. The most common predisposing medical condition was diabetes, and liver abscess was the predominant cause of EE. The study found that patients who initially underwent pars plana vitrectomy (PPV) with silicone oil tamponade required fewer additional treatments. In the past 10 years, there has been an increasing trend in the proportion of Gram-positive cocci, Gram-negative bacilli, and Candida, as well as an increase in EE after liver abscess and immunosuppression, and a decrease in EE from genitourinary systems.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Medicine, General & Internal
Shuang Wu, Cunbo Wang, Yanbing Zhang
Summary: This article reports a case of endogenous fungal endophthalmitis in a patient with COVID-19 infection, emphasizing the importance of early diagnosis and targeted treatment in high-risk populations.
CLINICAL CASE REPORTS
(2023)
Article
Ophthalmology
Michael J. Ammar, Robert Carroll, Anton Kolomeyer, Gui-Shuang Ying, Gideon Whitehead, Alexander J. Brucker, Benjamin J. Kim
Summary: The study evaluated the role of serum BDG in endogenous fungal eye infection, demonstrating good sensitivity and specificity for fungal endophthalmitis with a high negative predictive value. There is a recommendation for a larger ophthalmic study to further investigate the findings.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Review
Ophthalmology
Didar Abdulla, Yasser Ali, Victor Menezo, Simon R. J. Taylor
Summary: The development of sustained-release corticosteroid implants has revolutionized the treatment of non-infectious uveitis affecting the posterior segment of the eye. Their use is now supported by healthcare systems based on high-quality randomized controlled trials, providing clinicians with information on their benefits and risks.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Ophthalmology
Yousef A. Fouad, Mahmood O. Mekkawy, Ahmed B. Sallam
Summary: This study retrospectively reviewed three cases of post-febrile retinitis in patients traveling from Sudan, with a history and clinical picture suggestive of Rift Valley fever (RVF) retinitis. The study presents multimodal imaging data and highlights the challenges in diagnosing RVF due to the lack of standardized testing methods for most epidemic retinitis-causing pathogens.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Letter
Ophthalmology
Abdelrahman M. Elhusseiny, Riley N. Sanders, Mohammad Z. Siddiqui, Ahmed B. Sallam
Summary: This case report highlights a possible association between COVID-19 vaccination and the development of NAAION, although it remains unclear whether the vaccine was the triggering factor or a coincidental finding.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Ophthalmology
Kinza T. Ahmad, Michelle L. Huynh, Ramakrishnaiah Raghu, Mohamed Kamel Soliman, William Henry, Ahmed Sallam
Summary: This case report describes an individual who developed eyelid edema and corneal erosions after treatment with triamcinolone acetonide for tractional retinal detachment caused by diabetes. A computed tomography scan and clinical observations confirmed the association between the symptoms and the triamcinolone acetonide injection.
CASE REPORTS IN OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Victoria Ly, Abdelrahman M. Elhusseiny, Ahmed B. Sallam
Summary: This study evaluated the clinical characteristics and visual outcomes of ocular syphilis in HIV-positive and negative patients. The results showed that posterior uveitis was the most common ophthalmic feature, and neurosyphilis was relatively high in both groups. There were no significant differences in laterality, presence of concurrent rash, RPR titers, and visual acuity between the two groups.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Yousef A. Fouad, Ahmed M. Habib, Riley N. Sanders, Ahmed B. Sallam
Summary: This article provides an updated critical summary of literature on persistent subretinal fluid (PSF) following successful rhegmatogenous retinal detachment surgery. The incidence rates of PSF vary significantly, and there is no conclusive evidence for its etiology or risk factors. PSF usually resolves gradually without affecting final visual acuity, and observation is currently the preferred management approach for uncomplicated cases.
SEMINARS IN OPHTHALMOLOGY
(2022)
Review
Cell Biology
Muhammad Z. Chauhan, Peyton A. Rather, Sajida M. Samarah, Abdelrahman M. Elhusseiny, Ahmed B. Sallam
Summary: Diabetic macular edema (DME) is a complex ocular complication of diabetes mellitus, and its treatment includes diabetes management, laser photocoagulation, and anti-VEGF therapies. Anti-VEGF therapies have shown significant clinical improvements compared to laser therapy alone.
Article
Ophthalmology
Abdelrahman M. Elhusseiny, Mohamed K. Soliman, Ahmed F. Shakarchi, Yousef A. Fouad, Yit C. Yang, Ahmed B. Sallam
Summary: This study compared the visual outcomes and rates of intraoperative complications between combined cataract extraction and pars plana vitrectomy (combined group) and sequential surgery (sequential group). The results showed that the postoperative visual acuity was worse in the combined group and there was a higher rate of posterior capsular rupture. However, the differences in visual improvement between the two groups decreased with longer follow-up time.
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2023)
Article
Ophthalmology
Yousef A. Fouad, Sayena Jabbehdari, Adam Neuhouser, Mohamed K. Soliman, Aman Chandra, Yit C. Yang, Ahmed B. Sallam
Summary: Eyes undergoing phacoemulsification complicated by posterior capsule rupture (PCR) and dropped lens fragments (DLFs) have worse visual outcomes and higher chances of developing cystoid macular edema (CME), epiretinal membrane (ERM), and rhegmatogenous retinal detachment (RRD) compared to eyes with uneventful surgery.
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2023)
Article
Ophthalmology
Peter J. McCluskey, Danny Lam, Timothy Ang, Michael J. Todd, Gabor M. Halmagyi
Summary: This study reviewed the experience of 35 patients who underwent optic nerve sheath fenestration (ONSF) at Royal Prince Alfred Hospital Sydney between 2002 and 2021. The results showed that ONSF can improve visual field and visual acuity, even in cases of severe acute visual impairment.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Kinza T. Ahmad, Muhammad Z. Chauhan, Mohamed K. Soliman, Abdelrahman M. Elhusseiny, Yit C. Yang, Ahmed B. Sallam
Summary: This study aims to analyze the impact of axial length (AL) on the visual outcome and rate of perioperative complications in phacoemulsification surgery. The data from 217,556 eyes undergoing cataract surgery were analyzed. The study found that AL did not have a significant impact on visual acuity improvement or the risk of encountering certain complications, but short AL eyes had a higher risk of torn iris and long AL eyes had a higher risk of retinal detachment.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Letter
Ophthalmology
Anup Kelgaonkar, Anamika Patel, Mudit Tyagi, Tapas Ranjan Padhi, Soumyava Basu, Peter McCluskey
Summary: This case report presents an unusual case of bilateral syphilitic chorioretinitis. The patient, a young male, exhibited bilateral pigmentary retinal changes and multifocal chorioretinal lesions along the blood vessels, resembling beaded pearls. The patient was previously undiagnosed with human immunodeficiency virus infection and was subsequently diagnosed with syphilis. Treatment led to favorable visual and anatomical outcomes.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Medicine, General & Internal
Otman Sandali, Mohamed El Sanharawi, Rachid Tahiri Joutei Hassani, Ashraf Armia Balamoun, Cedric Duliere, Sidi Mohammed Ezzouhairi, Ahmed B. Sallam, Vincent Borderie
Summary: This study aimed to evaluate the effectiveness of digital visualization in enhancing the visualization of iridocorneal structures during surgical gonioscopy. The images of 26 cases of trabecular stent implantation were recorded with standard colors and optimized digital settings, and were evaluated subjectively by two glaucoma surgeons and objectively through contrast measurements. The optimized digital settings, including the cyan filter and warmer color, were found to enhance the visibility of trabecular meshwork pigmentation and Schlemm's canal, making them useful in minimally invasive glaucoma surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Otman Sandali, Rachid Tahiri Joutei Hassani, Ashraf Armia Balamoun, Alan Franklin, Ahmed B. Sallam, Vincent Borderie
Summary: This study demonstrates the feasibility of using optimized digital filters to enhance macular pigmentation visualization during macular surgery, opening up new possibilities for future research.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Danica M. Joseph, Lyndell L. Lim, Priya D. Samalia, Jane M. Wells, Peter J. McCluskey, Eldho Paul, Anthony J. Hall
Summary: This study aimed to determine the risk factors for progression in patients with Posner-Schlossman syndrome. The study found that patients with this syndrome have a high relapse rate, and factors such as older age, immunocompromise, chronic elevation of intraocular pressure, and presence of glaucomatous optic neuropathy are associated with increased risk of disease progression.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
