Article
Medicine, General & Internal
Wangjing Yao, Jiawen Xu, Xiangjun She, Jiangxin Yu, Zhi Liang, Xin Ye, Jiwei Tao, Sulan Wu, Jianbo Mao, Yiqi Chen, Yun Zhang, Lijun Shen
Summary: This study summarized the features of perforating scleral vessels (PSVs) in patients with myopic choroidal neovascularization (mCNV) using OCTA, and identified the associations with the response after intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy. The eyes with PSVs adjacent to mCNV showed poor therapeutic responses after intravitreal anti-VEGF therapy.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Shih-Lin Chen, Pei-Ling Tang, Tsung-Tien Wu
Summary: The study demonstrated that primary intravitreal aflibercept injections can provide long-term improvement in visual acuity in patients with myopic CNV. Some patients showed a decrease in the size of the CNV area and flow area after treatment, with those displaying an interlacing or disorganized pattern showing a better anatomical improvement trend after injection.
Article
Ophthalmology
Xin Nie, Yulong Wang, Hong Yi, Yanbin Qiao
Summary: The study evaluated the efficacy and safety of intravitreal conbercept for myopic choroidal neovascularization (CNV) over 12 months. Results showed significant improvements in best corrected visual acuity, central retinal thickness, and CNV size with no severe adverse events observed. 94.12% of eyes had no CNV leakage at the end of the study period.
Review
Pharmacology & Pharmacy
Danny S. C. Ng, Mary Ho, Lawrence P. L. Iu, Timothy Y. Y. Lai
Summary: Anti-VEGF therapy with currently available drugs generally has favorable safety outcomes in the short-term for myopic CNV, but ocular adverse events such as worsening myopic traction maculopathy, increased risk of retinal detachment, and progression of chorioretinal atrophy may develop following the treatment. Clinicians should be aware of these potential complications and evaluate them before and after anti-VEGF therapy.
EXPERT OPINION ON DRUG SAFETY
(2022)
Article
Oncology
Gilda Cennamo, Luigi Massa, Lucia Montanaro, Adriano Magli, Ciro Costagliola
Summary: Choroidal neovascularization (CNV) is a common lesion in various chorioretinopathies. Although rare in children and adolescents, it severely affects their visual acuity and quality of life. The management of CNV in pediatric patients is challenging due to limited guidelines, but the use of VEGF inhibitors shows promise.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Multidisciplinary Sciences
Keiichiro Tanaka, Yasuharu Oguchi, Tomoko Omori, Yumi Ishida, Hiroaki Shintake, Ryutaro Tomita, Akihito Kasai, Masashi Ogasawara, Yukinori Sugano, Kanako Itagaki, Akira Ojima, Takeshi Machida, Hideharu Sekine, Tetsuju Sekiryu
Summary: This study found that anti-vascular endothelial growth factor (VEGF) therapy can lead to changes in the complement system in eyes with age-related choroidal neovascularization (CNV), including significant increases in C3a and C4a levels. However, these changes did not impact visual outcomes in the eyes with CNV.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Medicinal
Fabiana Mallone, Rosalia Giustolisi, Federica Franzone, Marco Marenco, Rocco Plateroti, Marcella Nebbioso, Alessandro Lambiase, Magda Gharbiya
Summary: This study evaluated the efficacy and safety of intravitreal bevacizumab (IVB) for the treatment of myopic choroidal neovascularisation (mCNV) over a 10-year follow-up. The results showed that IVB was a long-term effective and safe therapy for mCNV, with sustained visual acuity stability over the 10-year period.
Article
Medicine, General & Internal
Rui Gao, Jingxue Ma, Zhengwei Zhang, Qingli Shang, Jialiang Duan
Summary: This study compared retinal biomarkers of choroidal neovascularization secondary to MFC, mCNV, and ICNV using OCT. The key findings were that biomarkers such as CNV diameter, sub-retinal fluids, the pitchfork sign, and choroidal thickness under CNV can help distinguish different types of CNV. There were no differences between the MFC group and ICNV group except in refractive error.
ANNALS OF MEDICINE
(2021)
Article
Ophthalmology
Paolo Corazza, Jamil Kabbani, Taha Soomro, Mostafa Mohamed Ragheb Alam, Francesco Maria D'Alterio, Saad Younis
Summary: In this study, Aflibercept and Ranibizumab showed significant improvement in BCVA in treating myopic CNV, with similar duration of effects compared to previous studies. However, by the third year of treatment, Ranibizumab and Bevacizumab did not show significant BCVA improvement. There were no significant differences in the number of injections or adverse events between the three drugs over the follow-up period.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Hai-Yan Wang, Meng-Zhang Tao, Xi-Xi Wang, Man-Hong Li, Zi-Feng Zhang, Dong-Jie Sun, Jin-Ting Zhu, Yu-Sheng Wang
Summary: Age has a significant impact on the visual acuity, choroidal thickness, and vitreoretinal interface abnormalities of mCNV patients. Conbercept treatment is effective in improving visual acuity in older mCNV patients, with baseline BCVA, external limiting membrane damage, CNV area, and CNV location influencing visual acuity at 1-year follow-up. Patients over 50 years with greater central macular thickness have a higher risk of recurrence, emphasizing the importance of close follow-up for this subgroup.
SCIENTIFIC REPORTS
(2021)
Review
Chemistry, Medicinal
Abraham Hang, Samuel Feldman, Aana Amin, Jorge A. Rivas Ochoa, Susanna Park
Summary: Vascular endothelial growth factors (VEGFs) are important in mediating complications associated with common retinal disorders and drugs that inhibit VEGF have been developed to minimize vision loss. These drugs are injected into the vitreous cavity in a clinic setting.
Article
Medicine, Research & Experimental
Wei Zhu, Yanlei Hao, Zhongfang Yuan, Chunmei Huang
Summary: The aim of this study was to evaluate the 1-year outcomes of high-dose aflibercept injection for individuals with myopic choroidal neovascularization (mCNV). The results showed that the vision of all individuals improved following the aflibercept injection, with a significant reduction in metamorphopsia and central retinal thickness (CRT). The study concluded that high-dose aflibercept injection is effective for vision improvement and stabilization in mCNV patients.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Review
Ophthalmology
Alessandro Feo, Luca De Simone, Luca Cimino, Martina Angi, Mario R. Romano
Summary: Myopic choroidal neovascularization (mCNV) is a common condition among young individuals. Accurate diagnosis and differentiation from similar conditions are crucial for effective treatment. Multimodal imaging, particularly optical coherence tomography (OCT), plays a crucial role in precise assessment. Future research should focus on defining biomarkers and distinguishing features to facilitate prompt treatment.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Laura Glachs, Stefan Embacher, Andrea Berghold, Brigitte Wildner, Monja Michelitsch, Anna Tscherne, Andreas Wedrich, Laura Posch-Pertl
Summary: This study is the first network meta-analysis comparing all treatment modalities for myopic choroidal neovascularization (CNV). The results confirm that anti-VEGF is the most effective treatment, and using the 1 + PRN treatment strategy can lead to better visual outcomes.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Jooseppi Puranen, Sanna Koponen, Tiina Nieminen, Iiris Kanerva, Emmi Kokki, Pyry Toivanen, Arto Urtti, Seppo Yla-Herttuala, Marika Ruponen
Summary: This study evaluated the efficacy and safety of gene therapy for inhibiting ocular neovascularization. The results showed that gene therapy effectively reduced the formation of new blood vessels and could potentially be used as a therapeutic tool for retinal diseases associated with neovascularization.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Ophthalmology
Hyun Goo Kang, Tae Young Kim, Min Kim, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee, Christopher Seungkyu Lee
Summary: This study evaluated the clinical features and OCTA findings of MEWDS patients and found that some patients may develop overlapping MFC in the same or fellow eyes, with dynamic changes in choroidal thickness.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Ophthalmology
Seonghee Choi, Hae Min Kang, Hyoung Jun Koh
Summary: Identifying a super stable subset of polypoidal choroidal vasculopathy (PCV) patients who have a long period of remission following anti-vascular endothelial growth factor (VEGF) therapy can help prevent overtreatment and lessen treatment burden. Patients in the super stable group were younger, had a higher ratio of females, greater choroidal thickness, more single polyps, smaller largest polyp diameter, and showed superior response in OCT features at 3 months after treatment. Factors such as age, polyp configuration, PED diameter at 3 months, and change in PED height at 3 months were associated with super stable remission.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Eun Young Choi, Chul Hee Lee, Hyun Goo Kang, Jae Yong Han, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Min Kim
Summary: The study demonstrated that primary retropupillary iris claw intraocular lens implantation combined with pars plana vitrectomy is effective and safe in patients with IOL dislocation, leading to significant improvement in visual acuity and stable intraocular pressure and endothelial cell count. Complications such as IOP elevation, cystoid macular edema, and R-IOL dislocation during surgery were successfully managed.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Hyun Goo Kang, Jae Yong Han, Min Kim, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Christopher Seungkyu Lee
Summary: The study discovered an association between pachydrusen and PHS in patients with PCV or PNV, with frequent localization of new drusen to these choroidal lesions observed over long-term follow-up. PHS may be a form of late-staining forme fruste drusen, possibly associated with micro-ischemic changes to the choriocapillaris.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Hyun Goo Kang, Jung Dong Kim, Eun Young Choi, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Min Kim
Summary: This retrospective study in Korea assessed the clinical features, treatment strategies, and long-term outcomes of patients with Coats' disease, finding a higher proportion of adult-onset cases and suggesting that aggressive treatment with the addition of anti-VEGF may yield the most favorable long-term visual outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Hyun Goo Kang, Jae Won Jun, Eun Young Choi, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Min Kim
Summary: The study compared the clinical features and treatment outcomes of patients undergoing secondary IOL surgery with SFIOL versus RPICIOL. Results showed that the RPICIOL group had faster visual recovery, shorter operation times, and lower redislocation rate.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Hae Min Kang, Jeong Hoon Choi, Hyoung Jun Koh, Sung Chul Lee
Summary: The study found that both peripapillary and subfoveal choroidal thickness significantly decreased over 12 months in patients with unilateral central retinal vein occlusion (CRVO), while no significant changes were observed in the contralateral eyes. The absolute reduction amount and reduction ratio of PCT and SFCT were significantly greater in the CRVO-affected eyes compared to the contralateral eyes.
Article
Multidisciplinary Sciences
Hae Min Kang, Md. Hasanuzzaman, So Won Kim, Hyoung Jun Koh, Sung Chul Lee
Summary: This study compared aqueous humor concentrations of ET-1 in patients with CRVO, BRVO, and a normal control group. The findings showed that ET-1 levels were significantly higher in CRVO patients compared to BRVO patients and controls, and after IVB treatment, levels were significantly decreased in both CRVO and BRVO patients.
Article
Multidisciplinary Sciences
Tae Young Kim, Hyun Goo Kang, Chan Yun Kim, Hyoung Jun Koh, Sung Soo Kim, Min Kim
Summary: This study investigates the etiology and clinical features of delayed vitreous prolapse after cataract surgery and evaluates the long-term surgical and visual outcomes. YAG laser capsulotomy or a history of defective posterior capsule from iatrogenic causes may trigger delayed vitreous prolapse. The long-term outcomes were favorable, particularly after posterior vitrectomy, with improved IOP control and symptom resolution.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Eun Young Choi, Dong Hyun Lee, Jae Won Jun, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Min Kim
Summary: Surgical intervention such as vitrectomy and intraoperative prophylactic laser use may decrease the risk of late retinal detachment in eyes with acute retinal necrosis, thus reducing the risk of vision loss. Factors associated with an increased risk of vision loss include worse initial visual acuity, zone 1 involvement of necrotic retinitis, and late-onset retinal detachment.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Hyo Jin Seong, Yong Joon Kim, Eun Young Choi, Junwon Lee, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee, Christopher Seungkyu Lee
Summary: This retrospective study on choroidal osteoma aimed to report complications, treatments, and visual prognosis. Findings revealed that choroidal neovascularization (CNV) and subretinal fluid were the main visually significant complications, with intravitreal anti-VEGF injection being the common treatment choice. Results showed that the presence of CNV and outer retinal tubulation (ORT) were independent risk factors for vision loss, emphasizing the importance of regular check-ups and appropriate treatment options for better visual outcomes.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Hae Min Kang, Na Eun Lee, Jeong Hoon Choi, Hyoung Jun Koh, Sung Chul Lee
Summary: The prevalence of focal lamina cribrosa defect is not significantly different between patients with pachychoroid disease spectrum and those without, suggesting that focal lamina cribrosa defect may not be a primary characteristic of pachychoroid diseases.
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Hae Min Kang, Md Hasanuzzaman, So Won Kim, Hyoung Jun Koh, Sung Chul Lee
Summary: The aqueous endothelin-1 (ET-1) level is significantly higher in eyes with advanced diabetic retinopathy (DR) compared to those with early DR and control group. Moreover, the ET-1 level significantly reduces after intravitreal injections in patients with advanced DR.
Article
Ophthalmology
Ji Hwan Lee, Hee Suk Kim, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee, Christopher Seungkyu Lee
Summary: Endogenous Klebsiella pneumoniae endophthalmitis (EKE) usually has a poor visual prognosis, and early diagnosis with fair initial visual acuity would be crucial in saving vision.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Hyun Goo Kang, Minha Kim, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee, Min Kim
Summary: In Korean patients with uveal metastases, there is a higher proportion of women and a higher prevalence of lung and gastrointestinal tract cancers as primary tumor origins. Patients with pancreatic cancer had the worst survival rate, while those with gastrointestinal tract cancers had the best survival rate.
OPHTHALMOLOGY RETINA
(2021)
