Article
Ophthalmology
Niroj Kumar Sahoo, Joshua Ong, Amrish Selvam, Dmitri Maltsev, Riccardo Sacconi, Ramesh Venkatesh, Nikitha Gurram Reddy, Shivam Madan, Beatrice Tombolini, Luiz H. Lima, Varsha Pramil, Giridhar Anantharaman, Antonio Marcelo Casella, Gerardo Ledesma-Gil, Nadia Waheed, Enrico Borrelli, Giuseppe Querques, Jay Chhablani
Summary: This study analyzed the longitudinal changes in visual acuity and risk factors for recurrence or development of choroidal neovascularisation (CNV) in eyes with acute or chronic central serous chorioretinopathy (CSCR). The results showed that the recurrence rate of CNV was approximately 30%, and higher age and a higher number of recurrences were associated with a higher risk of early de novo CNV formation.
Article
Ophthalmology
Samir Khandhadia, Suresh Thulasidharan, Nguyen Thuy Vy Hoang, Sameh Alkhalili Ibrahim, Yanling Ouyang, Andrew Lotery
Summary: We conducted a retrospective analysis on the outcomes of photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSCR) in a single centre over a nine-year period. The results showed that PDT led to improvement in visual acuity and retinal thickness.
Article
Ophthalmology
Sema Tamer Kaderli, Aylin Karalezli, Ahmet Kaderli, Simay Can Taskin, Sabahattin Sul
Summary: This study assessed the choroidal vascularity index (CVI) in patients with central serous chorioretinopathy (CSC) after subthreshold laser treatment. The findings suggest that CVI may be a useful index for evaluating treatment response in CSC.
Article
Ophthalmology
Raphael Lejoyeux, Francine Behar-Cohen, Irmela Mantel, Jorge Ruiz-Medrano, Sarah Mrejen, Ramin Tadayoni, Alain Gaudric, Elodie Bousquet
Summary: The study aimed to evaluate the short-term effect of anti-VEGF treatment on CSCR secondary MNV, finding that a deeper SRD height and the presence of SHRM were associated with a poor response to treatment.
Review
Ophthalmology
Sumit Randhir Singh, John Thomas Gote, Jay Chhablani
Summary: Central serous chorioretinopathy (CSCR) is a common chorioretinal disease with various manifestations. Acute CSCR presents with localized neurosensory detachment, while chronic CSCR may show widespread changes in the retinal pigment epithelium (RPE), chronic shallow subretinal fluid, and choroidal neovascularization (CNV). Despite multiple treatment options, there is a lack of standardized treatment protocol or gold standard treatment modality.
Article
Ophthalmology
Andrea Servillo, Riccardo Sacconi, Ilaria Zucchiatti, Elena Grachova, Lea Querques, Francesco Prascina, Beatrice Tombolini, Giorgio Dorin, Martin Mainster, Francesco Bandello, Giuseppe Querques
Summary: This study aimed to describe the effects of no-dose full-fluence photodynamic therapy without verteporfin (no-dose PDT) and to compare it with half-dose verteporfin full-fluence photodynamic therapy for managing chronic central serous chorioretinopathy (cCSC). The results showed significant improvement in BVCA and CT after no-dose PDT, and the short-term functional and anatomical treatment outcomes for cCSC were similar for HDFF PDT and no-dose PDT.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Oncology
Carlos Oribio-Quinto, Jose Ignacio Fernandez-Vigo, Valentina Bilbao-Malave, Pilar Perez-Garcia, Barbara Burgos-Blasco, Luis Arias-Barquet, Juan Donate-Lopez
Summary: A prospective observational study was conducted to investigate the impact of the worldwide shortage of verteporfin on patients diagnosed with cCSCR who had to delay their treatment with PDT. The study showed that there was no significant impact on BCVA, but one-third of patients experienced BCVA loss. Additionally, although there was a significant spontaneous decrease in MSRF height, it persisted in the majority of patients, indicating the need for PDT treatment.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Multidisciplinary Sciences
Hidetaka Matsumoto, Junki Hoshino, Kosuke Nakamura, Shoji Kishi, Hideo Akiyama
Summary: The study retrospectively analyzed 12 eyes of patients with central serous chorioretinopathy (CSC) to investigate choroidal thickness changes following half-fluence photodynamic therapy (PDT). The results showed a significant decrease in choroidal thickness in the irradiated macular area and the region of vortex veins, with 90.9% of eyes exhibiting intervortex venous anastomosis. It is suggested that half-fluence PDT may decrease choroidal thickness by occluding choriocapillaris in the irradiated macula, leading to reduced venous drainage.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Gabriel Katz, Efrat Gur, Joseph Moisseiev, Ari Leshno
Summary: In this study, the results of Photodynamic Therapy (PDT) in patients with long-standing Central serous chorioretinopathy (CSCR) were analyzed. The success rate of PDT treatment was 76% and 77% in the early and delayed treatment groups, respectively. Both groups showed significant improvement in central retina measurements, but the visual acuity remained low in the delayed treatment group. Therefore, PDT can be considered for CSCR patients if the disease does not improve spontaneously after 3 months to prevent vision loss from long-term subretinal fluid.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Article
Oncology
Susana Penas, Joao Beato, Patricia Rosinha, Joana Araujo, Ana Costa, Angela Carneiro, Fernando Falcao-Reis, Amandio Rocha-Sousa
Summary: This study on CSC patients after HD-PDT treatment shows that while there is a sustained improvement in BCVA and CMT in the first 12 to 24 months, macular sensitivity or electrical response do not show the same sustained improvement. Long-term functional deterioration might be related to the disease itself.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Multidisciplinary Sciences
Naomi Nishigori, Yuki Muraoka, Masaharu Ishikura, Takahiro Kogo, Naoko Ueda-Arakawa, Manabu Miyata, Hiroshi Tamura, Masayuki Hata, Ayako Takahashi, Masahiro Miyake, Akitaka Tsujikawa
Summary: We investigated the change in wide-field choroidal thickness in patients with central serous chorioretinopathy (CSC) after reduced fluence photodynamic therapy (rf-PDT). The study found that before treatment, all eyes showed choroidal thickening, and after rf-PDT, the choroidal thickness significantly decreased in the irradiated macular area as well as outside the arcade vessels in all quadrants. The choroidal thickness did not differ in the control group between the initial visit and follow-up.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Jeewoo Yoon, Jinyoung Han, Junseo Ko, Seong Choi, Ji In Park, Joon Seo Hwang, Jeong Mo Han, Kyuhwan Jang, Joonhong Sohn, Kyu Hyung Park, Daniel Duck-Jin Hwang
Summary: This study developed a deep learning system model to distinguish subtypes of central serous chorioretinopathy (CSC) using a convolutional neural network (CNN). The model showed high accuracy in classifying CSC subtypes, indicating the potential usefulness of automated deep learning systems in the classification and management of CSC.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Yukihiro Aoyama, Ichiro Maruko, Taizo Kawano, Tatsuro Yokoyama, Yuki Ogawa, Ruka Maruko, Tomohiro Iida
Summary: Deep learning can diagnose central serous chorioretinopathy (CSC) with high accuracy from en face images of the choroidal vasculature, using different programs, convolutional layer structures, and small data sets. Heatmap analyses reveal that DL focuses on the area occupied by the choroidal vessels and their uniformity.
Article
Medicine, General & Internal
Shuhei Hosoda, Yoichi Sakurada, Taiyo Shijo, Kenji Kashiwagi
Summary: This case report describes a 58-year-old man with persistent subretinal fluid in both eyes due to cuticular drusen presenting with central serous chorioretinopathy (CSC). Despite the rarity of CSC in eyes with cuticular drusen, the patient's left eye showed improvement in visual acuity after photodynamic therapy. Physicians should be aware of the possibility of CSC development in eyes with cuticular drusen.
Article
Ophthalmology
Lisa Toto, Maria Ludovica Ruggeri, Federica Evangelista, Pasquale Viggiano, Rossella D'Aloisio, Chiara De Nicola, Gennaro Falconio, Marta Di Nicola, Annamaria Porreca, Rodolfo Mastropasqua
Summary: This study investigated the changes in choroidal vascularity index (CVI) after oral eplerenone treatment in patients with chronic central serous chorioretinopathy (cCSC). The results showed that CVI decreased during follow-up in both eyes with subretinal fluid (SRF) and fellow eyes, indicating the effectiveness of mineral corticoid receptor antagonists in restoring choroidal morphology.
Article
Ophthalmology
Adrian Koh, Timothy Y. Y. Lai, Wen Bin Wei, Ryusaburo Mori, Harumi Wakiyama, Kyu Hyung Park, Fariza Ngah, Wayne Macfadden, Cornelia Dunger-Baldauf, Soumil Parikh
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2020)
Editorial Material
Ophthalmology
Xinyuan Zhang, Timothy Y. Y. Lai
Article
Multidisciplinary Sciences
Robin D. Hamilton, Andreas Clemens, Angelo Maria Minnella, Timothy Y. Y. Lai, Hong Dai, Taiji Sakamoto, Chui Ming Gemmy Cheung, Nor Fariza Ngah, Cornelia Dunger-Baldauf, Frank G. Holz
Article
Ophthalmology
Zhen Ji Chen, Li Ma, Marten E. Brelen, Haoyu Chen, Motokazu Tsujikawa, Timothy Y. Lai, Mary Ho, Kaori Sayanagi, Chikako Hara, Noriyasu Hashida, Pancy O. S. Tam, Alvin L. Young, Kohji Nishida, Clement C. Tham, Chi Pui Pang, Li Jia Chen
Summary: The study identified TIE2 as a novel susceptibility gene for nAMD and PCV in Japanese and Chinese populations, with further research needed to confirm its role.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Veronica Castro-Navarro, Francine Behar-Cohen, Woohyok Chang, Antonia M. Joussen, Timothy Y. Y. Lai, Rafael Navarro, Ian Pearce, Yasuo Yanagi, Annabelle A. Okada
Summary: Pachychoroid is a newly described phenotype in retinal disorders, characterized by the presence of hypertrophic or congested vessels under an area of reduced or absent choriocapillaris. Understanding the important features and pathogenesis of disorders within the pachychoroid spectrum may aid in patient management.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Jeffrey S. Heier, Rishi P. Singh, Charles C. Wykoff, Karl G. Csaky, Timothy Y. Y. Lai, Anat Loewenstein, Patricio G. Schlottmann, Liliana P. Paris, Peter D. Westenskow, Carlos Quezada-Ruiz
Summary: This review aims to provide ophthalmologists and practicing retina specialists with an overview of clinical evidence and therapeutic potential of targeting the angiopoietin/Tie pathway in retinal vascular diseases. Literature search and clinical trials suggest that drugs targeting this pathway may have potential benefits in treating retinal vascular diseases due to the synergistic nature of the pathways involved.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Review
Ophthalmology
Danny Siu-Chun Ng, Leo Ka-Yu Chan, Ching Man Ng, Timothy Y. Y. Lai
Summary: The choriocapillaris plays a vital role in the physiology of the eye and various diseases, making it crucial to assess changes in order to understand normal aging, visual impairment pathogenesis, and systemic diseases. In vivo imaging technologies, such as OCTA, have advanced, but challenges remain in visualizing the intricate microvascular networks within the choriocapillaris. Qualitative and quantitative analyses of choriocapillaris changes can provide clinical information for diseases like AMD, DR, myopia, and CSC, as well as systemic vascular diseases and pregnancy complications.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Beau J. Fenner, Chui Ming Gemmy Cheung, Shaun S. Sim, Won Ki Lee, Giovanni Staurenghi, Timothy Y. Y. Lai, Paisan Ruamviboonsuk, Gregg Kokame, Yasuo Yanagi, Kelvin Y. C. Teo
Summary: PCV, a subtype of nAMD, is common in Asia and worldwide. Current treatment strategies involve anti-VEGF therapy and photodynamic therapy, but the optimal treatment approach and interval are unclear. New imaging modalities offer potential for guiding treatment initiation and re-treatment.
Article
Health Care Sciences & Services
Timothy Y. Y. Lai, Ricky Y. K. Lai
Summary: This study found that eyes undergoing treatment for nAMD with more stable retinal thickness variability had better visual outcomes after 2 years, suggesting that reducing retinal thickness fluctuations during the course of treatment can lead to improved outcomes for nAMD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Ophthalmology
Da Wei Yang, Zi Qi Tang, Fang Yao Tang, Simon K. H. Szeto, Jason Chan, Fanny Yip, Cherie Y. K. Wong, An Ran Ran, Timothy Y. Y. Lai, Carol Y. Cheung
Summary: This study investigated the factors associated with diabetic macular ischaemia (DMI) as assessed by optical coherence tomography angiography (OCTA). The results showed that age, visual acuity, ganglion cell-inner plexiform layer thickness, diabetic retinopathy severity, haemoglobin A1c level, estimated glomerular filtration rate, and low-density lipoprotein cholesterol level were associated with SCP-DMI. In addition, the presence of diabetic macular oedema and shorter axial length were associated with DCP-DMI.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Timothy Y. Y. Lai, Ziqi Tang, Adrian C. W. Lai, Simon K. H. Szeto, Ricky Y. K. Lai, Carol Y. Cheung
Summary: The specific form of drusen, known as pachydrusen, is associated with pachychoroid eye diseases, such as central serous chorioretinopathy (CSC) and polypoidal choroidal vasculopathy (PCV). This study found that pachydrusen are more prevalent in PCV than CSC and may be linked to age and more extensive abnormalities in fundus autofluorescence (FAF).
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Ophthalmology
Danny S. C. Ng, Leo K. Y. Chan, Timothy Y. Y. Lai
Summary: Recent evidence shows that global myopia is becoming a significant public health issue, leading to various eye disorders that can cause irreversible visual impairment. Technological advancements in ophthalmic imaging have helped identify different macular complications associated with pathologic myopia. Understanding the natural progression of these myopic macular diseases and standardizing their classification criteria are crucial for effective clinical surveillance and personalized treatment approaches.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Medicine, General & Internal
Dawei Yang, An Ran Ran, Truong X. X. Nguyen, Timothy P. H. Lin, Hao Chen, Timothy Y. Y. Lai, Clement C. C. Tham, Carol Y. Y. Cheung
Summary: Optical coherence tomography angiography (OCT-A) provides non-invasive visualization of retinal microvasculature, and deep learning (DL) has been applied in OCT-A image analysis to enhance its clinical values. However, the deployment of this combination in real-world clinics is still in the proof-of-concept stage due to limitations in training sample size, data preprocessing, external dataset testing, and results interpretation standardization. In this review, we introduce the applications of DL in OCT-A, summarize the challenges of clinical deployment, and discuss future research directions.
Letter
Ophthalmology
Kelvin Yi Chong Teo, Srinivas R. Sadda, Chui Ming Gemmy Cheung, Usha Chakravarthy, Vishali Gupta, Won Ki Lee, Timothy Y. Y. Lai
OPHTHALMOLOGY RETINA
(2021)
Review
Ophthalmology
Paisan Ruamviboonsuk, Timothy Y. Y. Lai, Andrew Chang, Chi-Chun Lai, William F. Mieler, Dennis S. C. Lam
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2020)