Article
Cardiac & Cardiovascular Systems
Sebastian Wolfrum, Kevin Roedl, Alexia Hanebutte, Rudiger Pfeifer, Volkhard Kurowski, Reimer Riessen, Anne Daubmann, Stephan Braune, Gerold Soffker, Eric Bibiza-Freiwald, Karl Wegscheider, Heribert Schunkert, Holger Thiele, Stefan Kluge
Summary: This study found that hypothermic temperature control after IHCA did not improve survival nor functional outcome. The study may have been underpowered to detect clinically important differences between hypothermic temperature control and normothermia.
Article
Medicine, General & Internal
Stig Nikolaj Blomberg, Helle Collatz Christensen, Freddy Lippert, Annette Kjaer Ersboll, Christian Torp-Petersen, Michael R. Sayre, Peter J. Kudenchuk, Fredrik Folke
Summary: This randomized clinical trial found that using machine learning model to identify out-of-hospital cardiac arrest in emergency calls did not significantly improve dispatchers' ability to recognize cardiac arrest, despite artificial intelligence surpassing human recognition.
Article
Endocrinology & Metabolism
Ping Fu, Yang Xiang, Guangfu Bai, Jianping Wang, Haitao Sun
Summary: Mild hypothermia therapy has protective effects on oxidative stresses and immune functions of SCA patient post CPR.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Cardiac & Cardiovascular Systems
Tobias Pantel, Axel Neulen, Marius Marc-Daniel Mader, Elena Kurz, Andras Piffko, Verena Fassl, Manfred Westphal, Jens Gempt, Florian Ringel, Patrick Czorlich
Summary: Cardiac arrest is occasionally seen in patients with aneurysmal subarachnoid hemorrhage (SAH). The impact of pre-hospital and emergency room treatment on SAH patients with out-of-hospital cardiac arrest (OHCA) remains unclear. This study found that time to resuscitation was significantly shorter with lay cardiopulmonary resuscitation (CPR), and delayed cranial computed tomography (CCT) diagnosis was associated with longer time to first CCT. Overall survival to discharge was 31.6%. The study recommends considering CCT diagnostics as part of the diagnostic algorithm in OHCA patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Computer Science, Information Systems
Yushun Gong, Liang Wei, Supeng Yan, Feng Zuo, Hehua Zhang, Yongqin Li
Summary: In this study, a self-supervised UNet deep learning network is designed to restore the underlying ECG signals during CPR and provide accurate shock advice without interrupting CPR. The proposed method significantly improves the overall signal-to-noise ratio and rhythm detection accuracy.
INFORMATION SCIENCES
(2023)
Article
Medicine, General & Internal
Bruno Levy, Nicolas Girerd, Julien Amour, Emmanuel Besnier, Nicolas Nesseler, Julie Helms, Clement Delmas, Romain Sonneville, Catherine Guidon, Bertrand Rozec, Helene David, David Bougon, Oussama Chaouch, Oulehri Walid, Dupont Herve, Nicolas Belin, Lucie Gaide-Chevronnay, Patrick Rossignol, Antoine Kimmoun, Kevin Duarte, Arthur S. Slutsky, Daniel Brodie, Jean-Luc Fellahi, Alexandre Ouattara, Alain Combes
Summary: A randomized clinical trial was conducted to investigate whether early use of moderate hypothermia during venoarterial ECMO treatment improves mortality in patients with cardiogenic shock. The results showed that early application of moderate hypothermia for 24 hours did not significantly increase survival compared with normothermia.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Health Care Sciences & Services
Tak Kyu Oh, You Hwan Jo, In-Ae Song
Summary: The rate of in-hospital cardiopulmonary resuscitation and cost of care have significantly increased in South Korea since 2010, while the 6-month and 1-year rates of survival post in-hospital resuscitation remain low.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Neurosciences
Marlena Ornowska, Andrew Wormsbecker, Gary Andolfatto, Tim S. Leung, Idan Khan, George Medvedev
Summary: Review of literature on the use of ketamine as a neuroprotective agent following cardiac arrest. No clinical trials were identified, so a scoping review was conducted instead of a systematic review. Ketamine functions as an NMDA antagonist, and preclinical models indicate its efficacy in neuroprotection. Clinical studies in other conditions also support its use in improving neurological outcomes. Future research should explore the potential of ketamine as a clinical intervention in post-cardiac arrest scenarios.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Critical Care Medicine
Tak Kyu Oh, You Hwan Jo, In-Ae Song
Summary: This study investigated the association between physician turnover and survival outcomes after in-hospital cardiopulmonary resuscitation (ICPR) in South Korea and did not find a significant association.
Article
Critical Care Medicine
Tasuku Matsuyama, Bon Ohta, Kosuke Kiyohara, Tetsuhisa Kitamura
Summary: This study aimed to assess the association between cardiopulmonary resuscitation (CPR)duration and outcomes after out-of-hospital cardiac arrest (OHCA). The results demonstrated that the probability of favorable neurological outcomes decreased with CPR duration. The impact of CPR duration may be influenced by each patient's clinical features.
Review
Medicine, General & Internal
Kazuya Kikutani, Mitsuaki Nishikimi, Tatsutoshi Shimatani, Michihito Kyo, Shinichiro Ohshimo, Nobuaki Shime
Summary: Current research suggests that hypothermic targeted temperature management (TTM) may not be superior to normothermic TTM in improving neurological outcomes in post-cardiac arrest syndrome (PCAS) patients. However, studies indicate that the efficacy of hypothermic TTM may vary based on the severity of PCAS, suggesting the potential for individualized treatment approaches.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Hyo Joon Kim, Chun Song Youn, Kyu Nam Park, Young-Min Kim, Byung Kook Lee, Kyung Woon Jeung, Won Young Kim, Seung Pill Choi, Soo Hyun Kim
Summary: This study found no significant difference in neurological outcomes and survival at six months between patients treated with a target temperature of 33 degrees C and those treated with a target temperature of 36 degrees C.
Article
Critical Care Medicine
Robert A. A. Berg, Ryan W. W. Morgan, Ron W. W. Reeder, Tageldin Ahmed, Michael J. J. Bell, Robert Bishop, Matthew Bochkoris, Candice Burns, Joseph A. A. Carcillo, Todd C. C. Carpenter, J. Michael Dean, J. Wesley Diddle, Myke Federman, Richard Fernandez, Ericka L. L. Fink, Deborah Franzon, Aisha H. H. Frazier, Stuart H. H. Friess, Kathryn Graham, Mark Hall, David A. A. Hehir, Christopher M. M. Horvat, Leanna L. L. Huard, Tensing Maa, Arushi Manga, Patrick S. S. McQuillen, Kathleen L. L. Meert, Peter M. M. Mourani, Vinay M. M. Nadkarni, Maryam Y. Y. Naim, Daniel Notterman, Chella A. A. Palmer, Murray M. M. Pollack, Anil Sapru, Carleen Schneiter, Matthew P. P. Sharron, Neeraj Srivastava, Sarah Tabbutt, Bradley Tilford, Shirley Viteri, David Wessel, Heather A. A. Wolfe, Andrew R. R. Yates, Athena F. F. Zuppa, Robert M. M. Sutton
Summary: Arterial diastolic blood pressure (DBP) greater than 25 mm Hg in infants and greater than 30 mm Hg in children greater than 1 year old during CPR is associated with survival to hospital discharge, as validated by a multicenter prospective observational study.
CRITICAL CARE MEDICINE
(2023)
Review
Critical Care Medicine
Filippo Annoni, Lorenzo Peluso, Marco Fiore, Per Nordberg, Leif Svensson, Benjamin Abella, Lorenzo Calabro, Sabino Scolletta, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone
Summary: Following a systematic search of almost 21,000 studies, 8 studies with a total of 3493 patients were included in the analysis, showing that intra arrest therapeutic hypothermia did not significantly improve neurological outcome, return of spontaneous circulation rate, or survival compared to standard targeted temperature management. Studies on trans-nasal evaporative cooling and cold fluids also did not show any notable differences in outcomes for OHCA patients with initial shockable rhythm. Additionally, the meta-analysis revealed significant heterogeneity among studies in the analysis of return of spontaneous circulation rate.
Article
Biology
Jason Coult, Thomas D. Rea, Jennifer Blackwood, Peter J. Kudenchuk, Chenguang Liu, Heemun Kwok
Summary: A novel algorithm was developed to predict outcomes of defibrillation success and functional survival during ongoing CPR following VF arrest. The algorithm utilized ECG features and patient characteristics to predict outcomes, with promising performance evaluated by AUC in validation data.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Anesthesiology
Arthur Hosmann, Philipp Schnackenburg, Steffen Rauscher, Andreas Hopf, Isabelle Bohl, Adrian Engel, Jonas Brugger, Alexandra Graf, Walter Ploechl, Andrea Reinprecht, Andreas Gruber
Summary: This study found that a 3-minute hyperoxic challenge can effectively identify SAH patients at risk for cerebral ischemia. The absolute increase in PbtO(2) during the challenge may serve as a useful surrogate marker for estimating cerebral lactate concentrations and identifying patients at risk for impending ischemia.
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Judith Stift, Alexandra Graf, Barbara Neudert, Merima Herac, Katharina Woeran, Dietmar Tamandl, Johannes Laengle, Christoph Schwarz, Friedrich Wrba, Klaus Kaczirek, Stefan Stremitzer
Summary: This study retrospectively investigated the clinical value of immune checkpoint expression as prognostic biomarkers in patients with resected microsatellite-stable colorectal liver metastases who were pretreated with bevacizumab. The results showed that the expression of IDO-1 and CTLA-4 were associated with treatment response and survival, suggesting their potential as predictive biomarkers in this patient population.
Article
Medicine, General & Internal
Denise Traxler, Pavla Krotka, Maria Laggner, Michael Mildner, Alexandra Graf, Berthold Reichardt, Ralph Wendt, Johann Auer, Bernhard Moser, Julia Mascherbauer, Hendrik Jan Ankersmit
Summary: This study found that patients aged 50-65 who underwent bioprosthetic aortic valve replacement (B-AVR) had lower long-term survival rates and higher risks compared to mechanical aortic valve replacement (M-AVR). B-AVR also had higher risks of reoperation and myocardial infarction. However, the risk of heart failure and stroke did not significantly differ after AVR in any age group.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Ophthalmology
Martin Stattin, Anna-Maria Haas, Daniel Ahmed, Alexandra Graf, Katharina Krepler, Siamak Ansari-Shahrezaei
Summary: During the first Austrian COVID-19 lockdown, a model was calculated to estimate the impact of short-term treatment interruption on visual acuity in nAMD patients. The study found an overall VA loss due to the treatment delay, demonstrating the potentially negative impact of the pandemic lockdown on patients with nAMD.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Correction
Anesthesiology
Christian Reiterer, Barbara Kabon, Alexander Taschner, Markus Falkner von Sonnenburg, Alexandra Graf, Nikolas Adamowitsch, Patrick Starlinger, Julius Goschin, Melanie Fraunschiel, Edith Fleischmann
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Article
Obstetrics & Gynecology
Rosa Maria Laterza, Stefano Uccella, Maurizio Serati, Wolfgang Umek, Rene Wenzl, Alexandra Graf, Fabio Ghezzi
Summary: The study demonstrates that deep endometriosis surgery improves bladder function, as evidenced by improved urodynamic parameters and bladder questionnaire scores.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2022)
Article
Multidisciplinary Sciences
Johannes Mueller, Walter Ploechl, Paul Muehlbacher, Alexandra Graf, Anne-Margarethe Kramer, Bruno Karl Podesser, Thomas Stimpfl, Thomas Hamp
Summary: In an animal experiment, intraperitoneal application of ethanol significantly reduced the minimum alveolar concentration of sevoflurane in adult Wistar rats, indicating a potential interaction between alcohol and general anesthesia.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Christian Reiterer, Barbara Kabon, Alexander Taschner, Nikolas Adamowitsch, Alexandra Graf, Melanie Fraunschiel, Katharina Horvath, Melanie Kuhrn, Theresa Clement, Sascha Treskatsch, Christian Berger, Edith Fleischmann
Summary: This study aims to test the effect of pre-emptive administration of Levosimendan on postoperative NT-pro-BNP concentration compared to a placebo in patients undergoing major abdominal surgery. The study will include 230 patients at-risk for cardiovascular complications. The results will provide insights into the risk of postoperative cardiac complications and mortality.
Article
Biochemistry & Molecular Biology
Adelheid Weidinger, Linda Birgisdottir, Julia Schaeffer, Andras T. Meszaros, Sergejs Zavadskis, Andrea Muellebner, Matthias Hecker, Johanna Catharina Duvigneau, Natascha Sommer, Andrey V. Kozlov
Summary: This study investigated the effects of mtAOX mitoTEMPO and TPP in a rat model of systemic inflammatory response induced by LPS. MitoTEMPO reduced liver inflammation and tissue damage markers, while TPP slightly increased LPS-induced effects. Both substances reduced lung wet/dry ratio but increased pulmonary arterial pressure.
Article
Medicine, General & Internal
Alexander Taschner, Barbara Kabon, Markus Falkner von Sonnenburg, Alexandra Graf, Nikolas Adamowitsch, Melanie Fraunschiel, Edith Fleischmann, Christian Reiterer
Summary: Perioperative stress can cause increased heart rate and blood pressure, leading to perioperative myocardial ischemia. Previous studies have shown that supplemental oxygen can reduce sympathetic nerve activity. This study aimed to investigate whether perioperative supplemental oxygen can attenuate sympathetic nerve activity in patients at risk for cardiovascular complications. The results indicate that supplemental oxygen during surgery does not appear to affect endogenous catecholamine release.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Johannes Mueller, Walter Ploechl, Paul Muehlbacher, Alexandra Graf, Thomas Stimpfl, Thomas Hamp
Summary: The aim of this study was to investigate the effect of two different doses of pregabalin on the minimum alveolar concentration (MAC) of sevoflurane. The researchers found that a dose of 300mg pregabalin significantly reduced the MAC of sevoflurane, while a dose of 150mg had a less significant effect. Pregabalin use led to a slight reduction in post-operative pain levels but increased side effects as the dose increased.
FRONTIERS IN MEDICINE
(2022)
Article
Rehabilitation
Eva M. Strasser, Bernhard Franzke, Marlene Hofmann, Barbara Schober-Halper, Stefan Oesen, Waltraud Jandrasits, Alexandra Graf, Martin Ploder, Norbert Bachl, Michael Quittan, Karl-Heinz Wagner, Barbara Wessner
Summary: In institutionalized elderly individuals, six months of resistance training with or without nutritional supplementation did not alter muscle thickness of the quadriceps, but baseline values and health status significantly influenced the training effect. Further studies may focus on individualizing training regimes based on accompanying diseases and medications in this population.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Biochemical Research Methods
Sonja Zehetmayer, Martin Posch, Alexandra Graf
Summary: The study shows that filtering can improve the power of RNA-sequencing data, but overly aggressive filtering may lead to a decrease in power. There is no uniformly optimal filter, and different filters may be optimal depending on the scenario. An adaptive filtering strategy is proposed to maximize the number of rejections.
BMC BIOINFORMATICS
(2022)
Article
Ophthalmology
Martin Stattin, Daniel Ahmed, Anna-Maria Haas, Alexandra Graf, Claus Zehetner, Stefan Mihalics, Katharina Krepler, Siamak Ansari-Shahrezaei
Summary: The study aimed to describe the characteristics of indocyanine green (ICG) angiographic plaques in the nonexudative fellow eye of White patients with unilateral treatment-naive exudative neovascular age-related macular degeneration using OCT and OCTA. The results showed that the ICG angiographic plaques were consistent with macular neovascularization in OCTA.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Editorial Material
Medicine, General & Internal
Wolfgang Weihs, Andrey Kozlov, Hiroshi Saito, Johanna Catharina Duvigneau
FRONTIERS IN MEDICINE
(2022)
Article
Critical Care Medicine
Veerle Heesters, Janneke Dekker, Timothy J. R. Panneflek, Kristel L. A. M. Kuypers, Stuart B. Hooper, Remco Visser, Arjan B. te Pas
Summary: This study visualized the closure of vocal cords during apnea, in between breaths, and during breath holds in preterm infants using ultrasonography. The closure of vocal cords impaired the effect of respiratory support.