Lipoic acid decreases Mcl-1, Bcl-xL and up regulates Bim on ovarian carcinoma cells leading to cell death

PI3K/mTOR dual inhibitor NVP-BEZ235 decreases Mcl-1 expression and sensitizes ovarian carcinoma cells to Bcl-xL-targeting strategies, provided that Bim expression is induced

(2014) Abdelghani Jebahi et al.   CANCER LETTERS

Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L)

(2014) K-j Min et al.   Cell Death & Disease

Platinum compounds sensitize ovarian carcinoma cells to ABT-737 by modulation of the Mcl-1/Noxa axis

(2013) Karin Simonin et al.   APOPTOSIS

Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim

(2013) Tom Verfaillie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aspirin overcomes Navitoclax-resistance in hepatocellular carcinoma cells through suppression of Mcl-1

(2013) Gongquan Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice

(2013) O. Meynet et al.   BLOOD

α-Lipoic acid-induced inhibition of proliferation and met phosphorylation in human non-small cell lung cancer cells

(2013) Hiromitsu Michikoshi et al.   CANCER LETTERS

Oncogenic BRAF signalling increases Mcl-1 expression in cutaneous metastatic melanoma

(2013) Christopher S. McKee et al.   EXPERIMENTAL DERMATOLOGY

Lipoic acid increases glutamate uptake, glutamine synthetase activity and glutathione content in C6 astrocyte cell line

(2013) Juliana Kleinkauf-Rocha et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

α-Lipoic acid suppresses migration and invasion via downregulation of cell surface β1-integrin expression in bladder cancer cells

(2013) Masao Yamasaki et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

BIM, PUMA, and the Achilles' Heel of Oncogene Addiction

(2013) A. Roulston et al.   Science Signaling

Sensitization of ovarian carcinoma cells to Bcl-xL-targeting strategies through indirect modulation of Mcl-1 activity by MR22388, a molecule of the tripentone family

(2013) Julie Tomasina et al.   Journal of Ovarian Research

Inhibition of Mcl-1 expression by citrate enhances the effect of Bcl-xL inhibitors on human ovarian carcinoma cells

(2013) Hubert Lincet et al.   Journal of Ovarian Research

Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo

(2012) Benedikt Feuerecker et al.   CANCER BIOLOGY & THERAPY

A review of the role of Puma, Noxa and Bim in the tumorigenesis, therapy and drug resistance of chronic lymphocytic leukemia

(2012) L-N Zhang et al.   CANCER GENE THERAPY

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

The secrets of the Bcl-2 family

(2012) A J García-Sáez   CELL DEATH AND DIFFERENTIATION

Citrate kills tumor cells through activation of apical caspases

(2012) Björn Kruspig et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tumor regression with a combination of drugs interfering with the tumor metabolism: efficacy of hydroxycitrate, lipoic acid and capsaicin

(2012) Laurent Schwartz et al.   INVESTIGATIONAL NEW DRUGS

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Prognostic impact of the expression/phosphorylation of the BH3-only proteins of the BCL-2 family in glioblastoma multiforme

(2012) P F Cartron et al.   Cell Death & Disease

Regulation of mitochondrial metabolism: yet another facet in the biology of the oncoprotein Bcl-2

(2011) Shefali Krishna et al.   BIOCHEMICAL JOURNAL

The effects of lipoic acid and α-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial

(2011) Andreia Madruga de Oliveira et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

NF- B in Cancer: A Matter of Life and Death

(2011) B. B. Aggarwal et al.   Cancer Discovery

Downregulation of Bcl-x L and Mcl-1 is sufficient to induce cell death in mesothelioma cells highly refractory to conventional chemotherapy

(2010) Emilie Varin et al.   CARCINOGENESIS

The natural antioxidant alpha-lipoic acid induces p27Kip1-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells

(2010) Elena Dozio et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

α-Lipoic acid reduces matrix metalloproteinase activity in MDA-MB-231 human breast cancer cells

(2010) Hyun Sook Lee et al.   NUTRITION RESEARCH

Effects of α-lipoic acid on cell proliferation and apoptosis in MDA-MB-231 human breast cells

(2010) Mi Hee Na et al.   Nutrition Research and Practice

Mcl-1 is an important determinant of the apoptotic response to the BH3-mimetic molecule HA14-1 in cisplatin-resistant ovarian carcinoma cells

(2009) K. Simonin et al.   MOLECULAR CANCER THERAPEUTICS

Bim Expression Is Reduced in Human Cutaneous Melanomas

(2007) Derek L. Dai et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY