Article
Environmental Sciences
Le-Cai Ji, Jin-Feng Yin, Chun-Rong Lu, Hong-Yun Guan, Wei-Guo Tan, Ling-Wei Wang, Qi Jiang
Summary: The prevalence of COPD in residents aged 40 and above in Shenzhen was found to be low, with most patients classified as having mild symptoms. It is recommended to use spirometry for early-stage COPD detection in primary health care settings. The study also highlighted the increased risk of COPD from exposure to air pollutants, underscoring the urgent need for environmental improvement in urban areas.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Medicine, General & Internal
Sang Hyuk Kim, Hyun Lee, Youlim Kim, Chin Kook Rhee, Kyung Hoon Min, Yong Il Hwang, Deog Kyeom Kim, Yong Bum Park, Kwang Ha Yoo, Ji-Yong Moon
Summary: The prevalence of COPD in South Korea remains stable, with a relatively high rate among individuals aged 70 years and older. Aging is a significant risk factor for COPD, along with male sex, asthma, and current smoking. Conversely, a higher body mass index is inversely associated with COPD.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Review
Cardiac & Cardiovascular Systems
Sami O. Simons, Adrian Elliott, Manuel Sastry, Jeroen M. Hendriks, Michael Arzt, Michiel Rienstra, Jonathan M. Kalman, Hein Heidbuchel, Stanley Nattel, Geertjan Wesseling, Ulrich Schotten, Isabelle C. van Gelder, Frits M. E. Franssen, Prashanthan Sanders, Harry J. G. M. Crijns, Dominik Linz
Summary: COPD is highly prevalent in AF patients and may promote AF progression and reduce treatment efficacy. Close interdisciplinary collaboration between electrophysiologists/cardiologists and pulmonologists is required for the diagnosis and treatment of COPD in AF patients. Acute exacerbation of COPD may transiently increase AF risk.
EUROPEAN HEART JOURNAL
(2021)
Article
Oncology
Sophie Corriveau, Gregory R. Pond, Grace H. Tang, John R. Goffin
Summary: The study assessed the diagnosis of COPD in lung cancer patients and found that over a third of lung cancer patients had a prior diagnosis of COPD, with spirometry being more commonly undertaken in early stage disease. In individuals with advanced lung cancer, greater use of spirometry and diagnosis of COPD may help to mitigate respiratory symptoms.
Article
Environmental Sciences
Veronica A. Wang, Petros Koutrakis, Longxiang Li, Man Liu, Carolina L. Z. Vieira, Brent A. Coull, Edward F. Maher, Choong-Min Kang, Eric Garshick
Summary: This study found that short-term exposure to indoor radioactive particles was associated with a reduction in pulmonary function in patients with chronic obstructive pulmonary disease (COPD). The harmful effects of radon exposure in residential areas on pulmonary function in COPD patients are a matter of concern.
ENVIRONMENTAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Katarzyna Czerwaty, Karolina Dzaman, Krystyna Maria Sobczyk, Katarzyna Irmina Sikorska
Summary: This systematic review aims to define the significance of the coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA), known as overlap syndrome (OS), based on the current state of knowledge. After searching multiple databases, 38 eligible studies were included in this review, covering a total population of 27,064 participants. The paper summarizes the most important and up-to-date information regarding OS, including its prevalence, impact of age/gender/body mass index, polysomnography findings, pulmonary function, comorbidities, prediction of OSA in COPD patients, and treatment options for this syndrome.
Review
Medicine, General & Internal
Naozumi Hashimoto, Keiko Wakahara, Koji Sakamoto
Summary: Proper diagnosis and early treatment of COPD are crucial, as many patients are underdiagnosed. The clinical impact of systemic comorbidities in COPD is increasingly recognized, and pharmacotherapeutic approaches to COPD continue to advance.
Article
Critical Care Medicine
Yunus Colak, Borge G. Nordestgaard, Peter Lange, Jorgen Vestbo, Shoaib Afzal
Summary: Most patients with chronic obstructive pulmonary disease are not included in major clinical trials, but they experience significant exacerbations and early death.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Physiology
Xiaohu Wang, Hui Gan, Yimin Wang, Xinxin Yu, Jiaying An, Baoqing Sun, Yi Gao, Zheng Zhu
Summary: BMI has a significant impact on spirometry indices in patients with COPD and asthma. Both underweight and obesity can affect the diagnosis and severity of these diseases. Recognizing these effects is essential for better management and diagnosis of these patients.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Dermatology
Abdullah Demirbas, Yusuf Yumer, Omer Faruk Elmas, Gozde Ulutas Demirbas, Mustafa Atasoy, Umit Tursen, Recep Dursun, Torello Lotti
Summary: The study showed that patients with rosacea may have impaired respiratory function compared to healthy individuals, with disease severity being associated with worse respiratory functions. Forced expiratory volume in one second (FEV 1%), FEV 1/FVC ratio, and forced expiratory flow at 25-75% of FVC (FEF 25-75%) were found to be more useful in differentiating patients from healthy subjects.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Review
Critical Care Medicine
Bartolome R. Celli, Julie A. Anderson, Nicholas J. Cowans, Courtney Crim, Benjamin F. Hartley, Fernando J. Martinez, Andrea N. Morris, Holly Quasny, Julie Yates, Jorgen Vestbo, Peter M. A. Calverley
Summary: The study found that pharmacotherapy for chronic obstructive pulmonary disease can slow down the decline in lung function, with relative benefits similar to those reported for health status and exacerbations. Guidelines should be adjusted based on these findings.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Otorhinolaryngology
Wenche Moe Thorstensen, Marte Rystad Oie, Malcolm Sue-Chu, Sverre Karmhus Steinsvag, Anne-S. Helvik
Summary: Nasal airflow is reduced in COPD patients, possibly due to lower airway diseases. Peak nasal inspiratory flow (PNIF) is significantly lower in COPD patients compared to controls. PNIF is associated with COPD and pre-bronchodilator forced expiratory volume in the first second (FEV1) (% predicted), but not with chronic rhinosinusitis without nasal polyps (CRS-sNP) or other factors.
Article
Medicine, General & Internal
Brett G. Toelle, Rosario D. Ampon, Michael J. Abramson, Alan L. James, Graeme P. Maguire, Richard Wood-Baker, David P. Johns, Guy B. Marks
Summary: Access to current disease prevalence estimates in Australia is crucial for health services and consumer organizations to effectively plan and allocate resources. The Burden of Obstructive Lung Disease study conducted between 2006 and 2012 provided COPD prevalence estimates, and an updated estimate from the 2016 Australian census shows a prevalence rate of 8.30% for adults aged 40 or more years, including varying degrees of breathlessness.
INTERNAL MEDICINE JOURNAL
(2021)
Article
Immunology
Alok Kumar, Ravneet Kaur, Vijay Hadda, Kalaivani Mani, Baridalyne Nongkynrih, Sanjeev Kumar Gupta, Shashi Kant
Summary: COPD prevalence is high among rural elderly in India, with higher rates in men than women, and significant associations with smoking, age, and low body mass index. Interventions are needed to control COPD prevalence, as well as improve diagnosis and management readiness in healthcare systems.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiaxing Sun, Ximing Liao, Yusheng Yan, Xin Zhang, Jian Sun, Weixiong Tan, Baiyun Liu, Jiangfen Wu, Qian Guo, Shaoyong Gao, Zhang Li, Kun Wang, Qiang Li
Summary: The study developed weakly supervised deep learning models using computed tomography (CT) image data for the automated detection and staging of spirometry-defined chronic obstructive pulmonary disease (COPD). The models achieved high accuracy in detecting COPD and categorizing patients according to the GOLD scale, making it a potentially effective tool for COPD diagnosis and staging.
EUROPEAN RADIOLOGY
(2022)
Article
Geriatrics & Gerontology
Myung Jin Song, Song Yee Kim, Young Ae Kang, Young Sam Kim, Moo Suk Park, Byoung Seok Ye, Ji Ye Jung
Summary: Assessing cognitive function in older adults with airway diseases using K-MMSE can predict inhaler competence.
Article
Medicine, General & Internal
Jinsoo Min, Yousang Ko, Hyung Woo Kim, Hyeon-Kyoung Koo, Jee Youn Oh, Yun-Jeong Jeong, Hyeon Hui Kang, Kwang Joo Park, Yong Il Hwang, Jin Woo Kim, Joong Hyun Ahn, Yangjin Jegal, Ji Young Kang, Sung-Soon Lee, Jae Seuk Park, Ju Sang Kim
Summary: This study investigated delays in TB treatment during the first wave of the COVID-19 pandemic in Korea. The results showed that healthcare delays were significantly higher during the pandemic period, while presentation delays remained similar.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Respiratory System
Ji Soo Choi, Se Hyun Kwak, Min Chul Kim, Chang Hwan Seol, Sung Ryeol Kim, Byung Hoon Park, Eun Hye Lee, Seung Hyun Yong, Ah Young Leem, Song Yee Kim, Sang Hoon Lee, Kyungsoo Chung, Eun Young Kim, Ji Ye Jung, Young Ae Kang, Moo Suk Park, Young Sam Kim, Su Hwan Lee
Summary: The study found that pneumothorax was more likely to occur in PCP patients with cytomegalovirus co-infection. Pneumothorax may lead to prolonged weaning from mechanical ventilators and treatment planning should take this into consideration for better patient outcomes.
BMC PULMONARY MEDICINE
(2022)
Article
Respiratory System
Hyewon Seo, Yun Su Sim, Kyung Hoon Min, Jae Ha Lee, Byung-Keun Kim, Yeon Mok Oh, Seung Won Ra, Tae-Hyung Kim, Yong Il Hwang, Jeong-Woong Park
Summary: There is limited data on the relationship between microbiological features and comorbidities in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This multicenter observational study in South Korea aimed to correlate microbiological findings with comorbidities in moderate to severe AECOPD patients. The study found that bacterial infections and co-infections with bacteria and viruses were more prevalent in patients with pulmonary comorbidities, while bacterial pathogens were detected at a higher rate in patients with extrapulmonary comorbidities. Previous pulmonary tuberculosis, bronchiectasis, and diabetes mellitus were identified as risk factors for bacterial infection, and congestive heart failure was a risk factor for bacterial and viral co-infection. The risk of bacterial infection increased significantly with the number of comorbidities. Pseudomonas aeruginosa was more frequently identified in patients with previous pulmonary tuberculosis and bronchiectasis. Overall, AECOPD patients with comorbidities had a higher risk of infection-related exacerbations compared to those without comorbidities.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Public, Environmental & Occupational Health
Hayoung Choi, Hang A. Park, In Gyu Hyun, Joo-Hee Kim, Yong-Il Hwang, Seung Hun Jang, Yun Su Sim, Tae Rim Shin, Yousang Ko, Ga Young Ban, Ji Young Hong, Chang Youl Lee, Myung Goo Lee, Jeong-Hee Choi
Summary: This study aimed to investigate the incidence of adverse drug reactions (ADRs) to first-line anti-TB drugs and their impact on quality of life (QoL). The results showed that ADRs were common and associated with lower QoL, especially in older adults. However, most patients were able to successfully complete their treatments.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2022)
Article
Oncology
Min Seo Ki, Song Yee Kim, Eun Young Kim, Ji Ye Jung, Young Ae Kang, Moo Suk Park, Young Sam Kim, Seong Yong Park, Sang Hoon Lee
Summary: We compared the prognosis after lung cancer surgery between 104 patients with ILD and 104 patients without ILD who were matched by key variables. The findings showed that patients with ILD had worse survival rates, especially those with concomitant IPF or high physiological severity of ILD. Evaluating the underlying ILD before surgery is considered helpful in predicting the prognosis after lung cancer surgery.
CLINICAL LUNG CANCER
(2023)
Article
Medicine, General & Internal
Hye Jin Jang, Ala Woo, Song Yee Kim, Seung Hyun Yong, Youngmok Park, Kyungsoo Chung, Su Hwan Lee, Ah Young Leem, Sang Hoon Lee, Eun Young Kim, Ji Ye Jung, Young Ae Kang, Young Sam Kim, Moo Suk Park
Summary: This study aimed to identify risk factors for mortality and compare the clinical characteristics of patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD). The study found that approximately 10% of SSc-ILD patients showed disease progression, and ILD was detected within less than five years from the first visit. Therefore, careful monitoring of symptoms and signs from an early stage and long-term surveillance are necessary.
ANNALS OF MEDICINE
(2023)
Article
Oncology
Kangjoon Kim, Jibeom Lee, Jeong-Yun Lee, Seung Hyun Yong, Eun Young Kim, Ji Ye Jung, Young Ae Kang, Moo Suk Park, Young Sam Kim, Chang-Myung Oh, Sang Hoon Lee
Summary: This study evaluated the incidence and risk factors of brain metastasis in patients with suspected early-stage non-small-cell lung cancer. It found that tumor size was the only predictor of brain metastasis, and suggested considering selective screening with brain MRI in patients with high-risk features.
FRONTIERS IN ONCOLOGY
(2023)
Article
Microbiology
Eun-Young Kim, Seung-Hyun Yong, Min-Dong Sung, A-La Woo, Young-Mok Park, Ha-Eun Kim, Su-Jin Jung, Song-Yee Kim, Jin-Gu Lee, Young-Sam Kim, Hyo-Chae Paik, Moo-Suk Park
Summary: The potential of Aspergillus galactomannan antigen titer (AGT) in serum and bronchoalveolar lavage fluid (BALF) and serum titers of beta-D-glucan (BDG) in predicting invasive pulmonary aspergillosis (IPA) were investigated in lung transplantation recipients. The cutoff values for AGT were found to be 0.560 in serum and 0.600 in BALF, with sensitivities and specificities ranging from 50% to 85%, and AUCs ranging from 0.724 to 0.895. A lower cutoff value of 1.0 was suggested when IPA was highly suspicious. Serum and BALF AGT showed a correlation with a history of diabetes mellitus.
Article
Multidisciplinary Sciences
Eunki Chung, Youngmok Park, Song Yee Kim, Moo Suk Park, Young Sam Kim, Hye-Jeong Lee, Young Ae Kang
Summary: This study found that myosteatosis is associated with prognosis in patients with Mycobacterium avium complex pulmonary disease (MAC-PD) by analyzing their body composition.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Se Hyun Kwak, Sunyoung Ahn, Mi Hwa Shin, Ah Young Leem, Su Hwan Lee, Kyungsoo Chung, Young Sam Kim, Sang-Guk Lee, Moo Suk Park
Summary: Purpose: AKI following sepsis is associated with higher mortality, but reliable biomarkers for AKI development and recovery remain unclear. Materials and Methods: Patients with sepsis in the medical ICU were analyzed. They were divided into AKI and non-AKI groups within 48 hours. Patients with septic AKI were further divided into recovery and non-recovery groups within 7 days. Results: Baseline creatinine, Comorbidity Index, Organ Failure Assessment, and Acute Physiology and Chronic Health Evaluation II scores were higher in the non-recovery AKI group. Non-recovery from AKI was associated with lower survival. High-lactate and kynurenine levels were associated with non-recovery of renal function following AKI. Conclusion: Patients who recovered from AKI had comparable mortality to those without AKI. Lactate and kynurenine could be useful biomarkers for the diagnosis and recovery of AKI following sepsis.
YONSEI MEDICAL JOURNAL
(2023)
Article
Respiratory System
Youngmok Park, Jiyoung Kim, Young Sam Kim, Ah Young Leem, Jinyeon Jo, Kyungsoo Chung, Moo Suk Park, Sungho Won, Ji Ye Jung
Summary: This study aimed to investigate the long-term association between adiposity changes and lung function in middle-aged Asians. The results showed an inverse relationship between adiposity and lung function, with central obesity being the main driver of lung function impairment.
RESPIRATORY RESEARCH
(2023)
Article
Respiratory System
Ah Young Leem, Young Sam Kim, Kung Soo Chung, Moo Suk Park, Young Ae Kang, Young-Mok Park, Ji Ye Jung
Summary: This study found a significant association between sarcopenia and increased risk for atherosclerotic cardiovascular disease in men with chronic obstructive pulmonary disease, independent of central obesity and fat mass. High ASCVD risk was particularly associated with sarcopenia in participants with moderate to very severe airflow limitation.
RESPIRATORY RESEARCH
(2022)
Article
Immunology
Su Hwan Lee, Ju Hye Shin, Min Woo Park, Junhyung Kim, Kyung Soo Chung, Sungwon Na, Ji-Hwan Ryu, Jin Hwa Lee, Moo Suk Park, Young Sam Kim, Jong-Seok Moon
Summary: The impairment of mitochondrial ATP synthesis may induce RIPK3-dependent necroptosis in lung epithelial cells during lung injury by lung inflammation, exacerbating lung tissue damage.
Article
Respiratory System
Sang Hoon Lee, Mi Hwa Shin, Ah Young Leem, Su Hwan Lee, Kyung Soo Chung, Young Sam Kim, Moo Suk Park
Summary: This study investigated the role of NOX4 in ventilator-induced lung injury (VILI) and found that NOX4 knockout, EphA2 knockout, or monoclonal antibodies could attenuate VILI. Furthermore, NOX4 and EphA2 levels were significantly higher in patients with pneumonia and those receiving mechanical ventilation in the intensive care unit. Inhibition of NOX4 may be a potential therapeutic target for the prevention and reduction of VILI.
RESPIRATORY RESEARCH
(2022)