Article
Pharmacology & Pharmacy
Haopeng Zhi, Mingyu Zhong, Junfeng Huang, Ziwen Zheng, Xiaolong Ji, Yilin Xu, Junguo Dong, Wenbo Yan, Zhe Chen, Chen Zhan, Ruchong Chen
Summary: This study investigated the anti-tussive effect of gabapentin and its underlying neuromodulatory mechanism. The results showed that gabapentin can reduce cough sensitivity, inhibit airway inflammation, and alleviate neurogenic inflammation in a guinea pig model of gastroesophageal reflux-related cough.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Respiratory System
Jianmeng Zhou, Fang Yi, Feng Wu, Pusheng Xu, Meihua Chen, Huahao Shen, Lin Lin, Yunhui Zhang, Suyun Li, Changgui Wu, Yadong Yuan, Gang Wang, Xianwei Ye, Ping Zhang, Huaping Tang, Qianli Ma, Lanqing Huang, Zhongmin Qiu, Haiyan Deng, Chen Qiu, Guochao Shi, Jiayu Pan, Wei Luo, Kian Fan Chun, Nanshan Zhong, Kefang Lai
Summary: This study compared the clinical and pathophysiological characteristics of different phenotypes of asthma, and found differences in cough sensitivity and airflow obstruction between patients with cough predominant asthma and patients with cough variant asthma.
RESPIRATORY RESEARCH
(2022)
Review
Agriculture, Dairy & Animal Science
Ioannis Savvas, Kiriaki Pavlidou, Tilemachos Anagnostou, Eugenia Flouraki, George Kazakos, Dimitrios Raptopoulos
Summary: This systematic review investigates the effect of preoperative fasting duration and drugs on gastro-oesophageal reflux (GOR) in dogs and cats during anaesthesia. The study found that many factors seem to affect the development of GOR, but due to the limited number of studies and low level of evidence, no reliable conclusions can be drawn.
Review
Physiology
Dominic L. Sykes, Alyn H. Morice
Summary: This article discusses the impact of chronic cough and dysfunction of the cough reflex on quality of life and mortality in the elderly, focusing on the etiology and sequelae of these two disease states. The physiological and pharmacological mechanisms of cough are detailed, and the potential of P2X3 receptor antagonists as the first pharmaceutical agent licensed for chronic cough is explored.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Respiratory System
Jiafen Cheng, Zhuangli Xie, Shengyuan Wang, Siwan Wen, Shanshan Niu, Cuiqin Shi, Li Yu, Xianghuai Xu
Summary: The study revealed that increased capsaicin cough sensitivity in MetS patients may be closely related to sleep apnea and gastroesophageal reflux. For MetS patients without OSAHS, gastroesophageal reflux is an important factor influencing capsaicin cough sensitivity. Airway inflammation, particularly airway neurogenic inflammation, may also play a role in the pathogenesis of increased capsaicin cough sensitivity.
BMC PULMONARY MEDICINE
(2021)
Review
Agriculture, Dairy & Animal Science
Anna Carolina Fernandez Alasia, Olivier Levionnois, Mathieu Raillard
Summary: Regurgitation and gastro-oesophageal reflux (GOR) are common complications in dogs under anaesthesia. Studies on these complications showed inconsistencies in definitions and assessment methods, making meaningful comparisons difficult. Standardization and re-evaluation of methods may be necessary to address these discrepancies.
Article
Gastroenterology & Hepatology
Kentaro Sugano, Stuart Jon Spechler, Emad M. El-Omar, Kenneth E. L. McColl, Kaiyo Takubo, Takuji Gotoda, Mitsuhiro Fujishiro, Katsunori Iijima, Haruhiro Inoue, Takashi Kawai, Yoshikazu Kinoshita, Hiroto Miwa, Ken-ichi Mukaisho, Kazunari Murakami, Yasuyuki Seto, Hisao Tajiri, Shobna Bhatia, Myung-Gyu Choi, Rebecca C. Fitzgerald, Kwong Ming Fock, Khean-Lee Goh, Khek Yu Ho, Varocha Mahachai, Maria O'Donovan, Robert Odze, Richard Peek, Massimo Rugge, Prateek Sharma, Jose D. Sollano, Michael Vieth, Justin Wu, Ming-Shiang Wu, Duowu Zou, Michio Kaminishi, Peter Malfertheiner
Summary: This study aims to achieve international consensus on the new definitions of Barrett's esophagus, gastro-esophageal junction, and gastro-esophageal junctional zone, which will provide support for future research addressing many issues concerning this important anatomical area and hopefully lead to improved classification and management of diseases related to the gastro-esophageal junction.
Article
Allergy
Ryota Kurokawa, Yoshihiro Kanemitsu, Kensuke Fukumitsu, Norihisa Takeda, Tomoko Tajiri, Hirono Nishiyama, Jennifer Maries Yap, Keima Ito, Satoshi Fukuda, Takehiro Uemura, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Masaya Takemura, Akio Niimi
Summary: The study found that higher HARQ scores may be useful in predicting airway neuronal dysfunction in patients with asthma and are associated with worsening of asthma condition.
ALLERGOLOGY INTERNATIONAL
(2022)
Article
Agriculture, Dairy & Animal Science
Paraskevi Tsompanidou, Joris H. Robben, Ioannis Savvas, Tilemahos Anagnostou, Nikitas N. Prassinos, George M. Kazakos
Summary: This study compares the effects of three different pre-anaesthetic fasting regimens on the incidence of gastro-oesophageal reflux (GOR) in dogs under anaesthesia. The results suggest that feeding the dogs 3 hours before anaesthesia does not reduce the GOR incidence compared to feeding them 12 hours before anaesthesia. However, the 3-hour fasting resulted in a lower oesophageal pH.
Article
Respiratory System
Christian Friedrich, Klaus Francke, Surinder S. Birring, Jan Willem K. van den Berg, Paul A. Marsden, Lorcan McGarvey, Alice M. Turner, Pascal Wielders, Isabella Gashaw, Stefan Klein, Alyn H. Morice
Summary: This study investigated the efficacy, safety, and tolerability of the P2X3 receptor antagonist filapixant in patients with refractory chronic cough. The results showed that filapixant significantly reduced cough frequency and severity, improved cough health-related quality of life, and was well tolerated with only minor taste-related adverse events.
RESPIRATORY RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Adam Frankel, Hock Soo Ong, B. Mark Smithers, Les K. Nathanson, David C. Gotley
Summary: This study evaluated the efficacy of laparoscopic fundoplication in patients with chronic cough without asthma and pathologic gastro-oesophageal reflux. It found that 61% of the patients experienced relief in cough after the surgery, while predictors of cough response to fundoplication were not accurately predicted by typical GORD symptoms or pH study variables.
Article
Medicine, General & Internal
Anna Plocek, Beata Gebora-Kowalska, Wojciech Fendler, Ewa Toporowska-Kowalska
Summary: Diagnosis of gastro-oesophageal reflux disease in children with chronic neurological impairment remains a clinical challenge. This study validated reference values for assessing GOR in these children and determined the optimal cut-off level of the pH-impedance parameter for predicting endoscopic outcomes. Endoscopic findings showed that even with a low number of GOR episodes recorded by pH-impedance, children with chronic NI may still have endoscopic lesions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Deepika Razia, Sumeet K. Mittal, Sarah Fournier, Rajat Walia, Michael A. Smith, Ross M. Bremner, Jasmine L. Huang
Summary: Gastro-oesophageal reflux disease after lung transplantation may contribute to chronic lung allograft dysfunction. Antireflux surgery can improve long-term allograft function and show a survival benefit. This study compares outcomes between medical and surgical management of reflux in lung recipients.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Allergy
Bronwyn K. Brew, Catarina Almqvist, Cecilia Lundholm, Anna Andreasson, Kelli Lehto, Nicholas J. Talley, Tong Gong
Summary: GERD is a common comorbidity in adults with asthma, hay fever, and/or eczema. There is evidence for shared mechanisms suggesting common underlying causes that may involve affective traits requiring further investigation.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Respiratory System
Peter S. P. Cho, Hannah Fletcher, Irem S. Patel, Richard D. Turner, Caroline J. Jolley, Surinder S. Birring
Summary: Patients with COPD-chronic cough and CRC both exhibited heightened cough reflex sensitivity, but only those with CRC were unable to suppress capsaicin-evoked cough. This indicates differing mechanisms of cough between patients with COPD and CRC, highlighting the need for disease-specific approaches to management.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Review
Health Care Sciences & Services
Ambedkar Kumar Yadav, Siwan Wen, Xianghuai Xu, Li Yu
Summary: Many molecules and therapeutics have shown potential antiviral effects in in vitro studies, small sample-sized clinical trials, and independent case studies. However, there are limitations in these trials that need to be addressed to find the most promising antiviral against SARS-CoV-2. Larger, randomized, placebo-controlled trials on COVID-19 patients are needed to reach a proper conclusion on the most effective antiviral agent.
ANNALS OF PALLIATIVE MEDICINE
(2021)
Review
Physiology
Haodong Bai, Bingxian Sha, Xianghuai Xu, Li Yu
Summary: Chronic cough is a common complaint worldwide, with more female patients, although in some regions of China the prevalence between sexes is similar. Estrogen and progesterone may increase cough sensitivity in women, leading to a more negatively affected quality of life.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Infectious Diseases
Q. Chen, M. Zhang, F. Si, S. Wang, X. Xu, L. Yu, K. Lai, Z. Qiu
Summary: The study found that flupentixol/melitracen could be an effective option for patients with chronic refractory cough who did not respond to gabapentin and baclofen. The treatment led to a significant improvement in cough symptoms and related scores, with some patients experiencing adverse effects and cough recurrence after cessation of treatment.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Yiqing Zhu, Xianghuai Xu, Mengru Zhang, Fengli Si, Huihui Sun, Li Yu, Zhongmin Qiu
Summary: The study identified therapeutic predictors of baclofen in the treatment of refractory gastroesophageal reflux-induced chronic cough (GERC), with lower esophageal sphincter pressure and length being independent predictors of baclofen efficacy. These factors can help improve the therapeutic precision in selecting suitable patients for baclofen therapy.
RESPIRATORY MEDICINE
(2021)
Article
Engineering, Biomedical
Mingyu You, Weihao Wang, You Li, Jiaming Liu, Xianghuai Xu, Zhongmin Qiu
Summary: The paper presents a deep convolutional bidirectional long short-term memory (C-BiLSTM) model with boundary regression for cough detection, achieving higher detection accuracy and more accurate boundaries. The authors designed, collected and labeled a realistic audio dataset, demonstrating significantly improved detection criteria on cough detection.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2022)
Article
Medicine, Research & Experimental
Ronglin Gao, Xianghuai Xu, Shengyuan Wang, Jincheng Pu, Cuiqin Shi, Siwan Wen, Yiqing Zhu, Jianping Tang, Xuan Wang, Li Yu
Summary: This study will be the first randomized, controlled clinical trial to investigate the effectiveness of gabapentin in treating refractory cough associated with interstitial lung disease. It aims to provide data on efficacy, safety, and quality of life, and explore potential therapeutic mechanisms.
Article
Medicine, General & Internal
Kefang Lai, Wenzhi Zhan, Feng Wu, Yunhui Zhang, Lin Lin, Wen Li, Fang Yi, Ziyu Jiang, Yuanrong Dai, Suyun Li, Jiangtao Lin, Yadong Yuan, Yong Jiang, Chen Qiu, Limin Zhao, Meihua Chen, Zhongmin Qiu, Hu Li, Ruchong Chen, Wei Luo, Jiaxing Xie, Chunxing Guo, Mei Jiang, Xiaohong Yang, Guochao Shi, Dejun Sun, Rongchang Chen, Kian Fan Chung, Huahao Shen, Nanshan Zhong
Summary: Cough variant asthma (CVA) is distinct from classic asthma (CA) in terms of clinical features, lung function, and airway inflammation. Despite better asthma control scores, quality of life is severely impaired in CVA.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Qingling Zhang, Xiuhua Fu, Changzheng Wang, Huahao Shen, Lei Zhu, Guochao Shi, Zhongmin Qiu, Zhongguang Wen, Wei Gu, Wei Luo, Lina Zhao, Yunqin Chen, Sam Lim, Chang Xiao, Jian Kang, Yunhui Zhang, Mao Huang, Jinfu Xu, Kewu Huang, Qiang Li, Xiangyan Zhang, Jianping Zhao, Xiaoxia Liu, Shenghua Sun, Huaping Tang, Bei He, Shaoxi Cai, Ping Chen, Chunhua Wei, Guangfa Wang, Ping Chen, Lixin Xie, Jiangtao Lin, Yuling Tang, Zhihai Han, Kian Fan Chung, Nanshan Zhong
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Physiology
Qiang Chen, Ran Dong, Li Zhang, Mengru Zhang, Xianghuai Xu, Li Yu, Zhongmin Qiu
Summary: The esophageal-tracheobronchial reflex is considered the main mechanism underlying cough due to gastroesophageal reflux, but our study suggests that a tracheobronchial-esophageal reflex may also exist and be related to esophageal hypersensitivity. Our findings show that recurrent airway nociceptive stimuli induce esophageal hyperreactivity and enhance cough due to reflux.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2022)
Article
Respiratory System
Shengyuan Wang, Shanshan Niu, Siwan Wen, Mengru Zhang, Cuiqin Shi, Zhongmin Qiu, Li Yu, Xianghuai Xu
Summary: This study aimed to investigate the cough-reflex sensitivity and airway inflammation in patients with sinobronchial syndrome (SBS). The results showed that patients with SBS had higher levels of neutrophils in sputum compared to healthy controls, while patients with upper airway cough syndrome (UACS) induced by rhinitis had higher cough-reflex sensitivity. The findings suggest that the mechanism of cough may differ between these two patient populations.
CANADIAN RESPIRATORY JOURNAL
(2022)
Article
Respiratory System
Mengru Zhang, Alyn H. Morice, Fengli Si, Li Zhang, Qiang Chen, Shengyuan Wang, Yiqing Zhu, Xianghuai Xu, Li Yu, Zhongmin Qiu
Summary: This study summarized the outcomes of the current treatments for refractory chronic cough (RCC) and found that trying different neuromodulators is a pragmatic strategy that helps around two-thirds of patients with RCC. Relapse is common on withdrawal or reduction of dosage, indicating an urgent need for novel medication for RCC.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2023)
Review
Respiratory System
Hao Mei, Wenhua Gu, Linxin Ran, Siwan Wen, Li Yu, Xianghuai Xu
Summary: Increased cough sensitivity is a significant mechanism of chronic cough. Evaluating cough sensitivity helps understand the cough mechanism and explore effective ways to reduce cough.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2022)
Article
Pharmacology & Pharmacy
Yiqing Zhu, Junjun Tang, Wenbo Shi, Shengyuan Wang, Mingyan Wu, Lihua Lu, Mengru Zhang, Siwan Wen, Cuiqin Shi, Li Yu, Xianghuai Xu
Summary: The study found that both AET and DMS have high diagnostic value for acid-induced GERC. A diagnosis of GERC should be considered when AET is greater than 4.8%, while a diagnosis of acid GERC should be considered when AET is greater than 6.2%.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)
Article
Respiratory System
Na Li, Qiang Chen, Siwan Wen, Mengru Zhang, Ran Dong, Xianghuai Xu, Li Yu, Zhongmin Qiu
Summary: MII-pH is more sensitive than 24-h esophageal pH monitoring in identifying GERC, but with suboptimal diagnostic efficacy. The combination of esophageal acid exposure time and symptom associated probability greatly improves diagnostic yield, even with a suboptimal efficacy.
CHRONIC RESPIRATORY DISEASE
(2021)
