Article
Public, Environmental & Occupational Health
Alessandro Marinaccio, Davide Di Marzio, Carolina Mensi, Dario Consonni, Carmela Gioscia, Enrica Migliore, Carlo Genova, Roberta Rossetto Giaccherino, Silvia Eccher, Stefano Murano, Vera Comiati, Veronica Casotto, Corrado Negro, Lucia Mangone, Lucia Miligi, Sara Piro, Alessia Angelini, Iolanda Grappasonni, Gabriella Madeo, Ilaria Cozzi, Laura Ancona, Tommaso Staniscia, Francesco Carrozza, Domenica Cavone, Luigi Vimercati, Michele Labianca, Federico Tallarigo, Giuseppe Cascone, Massimo Melis, Michela Bonafede, Alberto Scarselli, Alessandra Binazzi
Summary: Mesothelioma incidence surveillance and individual research on asbestos exposure are important for monitoring health effects and preventing exposure risks. Young mesothelioma cases with non-occupational asbestos exposure signal potential clusters of cases.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Environmental Sciences
C. Airoldi, C. Magnani, F. Lazzarato, D. Mirabelli, S. Tunesi, D. Ferrante
Summary: This study found an increasing pattern of mesothelioma risk in the area around a big AC factory, with secondary clusters of cases detected due to local exposure points, possibly associated with the use of asbestos materials.
ENVIRONMENTAL HEALTH
(2021)
Review
Oncology
Fraser Brims
Summary: Mesothelioma is a cancer of the lining of the lungs caused by breathing in asbestos fibres, which remains a challenge in terms of treatment and has an uncertain survival time. The disease mainly occurs in males, with a clear risk associated with exposure to asbestos. There have been significant advances in diagnosis, but further research and treatment are still needed.
Article
Environmental Sciences
Suresh Moolgavkar, Ellen T. Chang, E. Georg Luebeck
Summary: The current understanding is that cancer is caused by mutations in a few crucial genes, which has implications for the epidemiology of cancer. These include the impact of age on cancer risk, the role of inherited tumor predisposition syndromes, and the interaction of genetics and environmental exposures on cancer risk.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biology
Michael T. Mumma, Jennifer L. Sirko, John D. Boice, William J. Blot
Summary: This study examined the risk of mesothelioma in two cohorts of workers exposed to ionizing radiation. The results showed an increased risk of mesothelioma among shipyard and nuclear power plant workers, suggesting that asbestos exposure rather than low-dose occupational radiation was the main cause for the elevated rate of mesothelioma in these workers.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Environmental Sciences
Yuhe Gao, Jacek M. Mazurek, Yaming Li, David Blackley, David N. Weissman, Shirley V. Burton, Waqas Amin, Douglas Landsittel, Michael J. Becich, Ye Ye
Summary: This study examines the work histories and survival time of patients with suspected exposure to asbestos. The most frequent cases of mesothelioma occurred in patients working in manufacturing, construction, and education services. Males or individuals over 40 tended to work in traditionally asbestos-associated industries, while females or individuals aged 20-40 tended to work in non-traditionally associated industries. The results highlight the importance of considering all potential sources of asbestos exposure when evaluating mesothelioma patients.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Karen Walker-Bone, Geza Benke, Ewan MacFarlane, S. Klebe, Ken Takahashi, Fraser Brims, Malcolm Ross Sim, Tim R. Driscoll
Summary: Mesothelioma, a rare and deadly cancer associated with asbestos exposure, continues to be diagnosed in Australia despite the ban on asbestos since 2003. The Australian Mesothelioma Registry was established to gather comprehensive data on incidence, mortality, and asbestos exposure. Results show a decline in incidence and mortality rates due to effective control of occupational asbestos use, but the rates among women remain stable, suggesting other sources of exposure.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Respiratory System
Job P. van Kooten, Robert A. Belderbos, Jan H. von der Thusen, Mieke J. Aarts, Cornelis Verhoef, Jacobus A. Burgers, Paul Baas, Arend G. J. Aalbers, Alexander P. W. M. Maat, Joachim G. J. Aerts, Robin Cornelissen, Eva V. E. Madsen
Summary: The incidence of malignant mesothelioma in the Netherlands is declining, especially in male patients under 80 years old. The use of systemic chemotherapy has increased since 2003, which may contribute to improved overall survival. However, the majority of patients do not receive antitumor treatment, and prognosis remains poor.
Article
Biology
John E. Till, Harold L. Beck, John D. Boice, H. Justin Mohler, Michael T. Mumma, Jill W. Aanenson, Helen A. Grogan
Summary: This study provides the first quantitative assessment of asbestos-related mesothelioma among military personnel who participated in above-ground nuclear weapons testing. The results show that enlisted naval personnel who participated in these tests had a significantly increased risk of developing mesothelioma, while there was no increased risk observed in other services or among naval personnel with minimal exposure to asbestos.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Health Care Sciences & Services
Veronica Filetti, Carla Loreto, Luca Falzone, Claudia Lombardo, Emanuele Cannizzaro, Sergio Castorina, Caterina Ledda, Venerando Rapisarda
Summary: This study aimed to validate the diagnostic significance of hsa-miR-323a-3p, hsa-miR-101-3p, and hsa-miR-20b-5p in MM patients exposed to FE. Results showed the down-regulation of these miRNAs in MM cases, with hsa-miR-323a-3p and hsa-miR-20b-5p having diagnostic value for MM. Computational analysis suggested a potential prognostic role of hsa-miR-101-3p in MM patients, correlating higher expression with increased overall survival.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, Research & Experimental
Antonia Marazioti, Anthi C. Krontira, Sabine J. Behrend, Georgia A. Giotopoulou, Giannoula Ntaliarda, Christophe Blanquart, Hasan Bayram, Marianthi Iliopoulou, Malamati Vreka, Lilith Trassl, Mario A. A. Pepe, Caroline M. Hackl, Laura Klotz, Stefanie A. Weiss, Ina Koch, Michael Lindner, Rudolph A. Hatz, Juergen Behr, Darcy E. Wagner, Helen Papadaki, Sophia G. Antimisiaris, Didier Jean, Sophie Deshayes, Marc Gregoire, Ozgecan Kayalar, Deniz Mortazavi, Sukru Dilege, Serhan Tanju, Suat Erus, Omer Yavuz, Pinar Bulutay, Pinar Firat, Ioannis Psallidas, Magda Spella, Ioanna Giopanou, Ioannis Lilis, Anne-Sophie Lamort, Georgios T. Stathopoulos
Summary: A portion of human MPM cases have mutations in KRAS, and mouse models suggest that KRAS mutations can lead to MPM, especially when combined with TP53 deletion. These findings indicate that KRAS alterations may play an important and underestimated role in certain MPM patients.
EMBO MOLECULAR MEDICINE
(2022)
Article
Environmental Sciences
Trudie Vorster, Julian Mthombeni, Jim TeWaterNaude, James Ian Phillips
Summary: Asbestos mining in South Africa has resulted in asbestos contamination and related diseases. This study investigates the demographics of deceased individuals diagnosed with mesothelioma and explores the connection between mesothelioma histological morphology and asbestos characteristics.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
A. Scarselli, A. Marinaccio, S. Iavicoli
Summary: The study aimed to estimate the potential health impact of naturally occurring asbestos from ophiolitic outcrops in certain areas of Calabria, southern Italy. By analyzing employment, compensation, and mortality data, statistically significant excess risks were observed in several municipalities, some of which were located in areas where asbestos outcrops had been identified.
Article
Respiratory System
Jonghoon Han, Seoyeon Park, Dong Keon Yon, Seung Won Lee, Wongi Woo, Elena Dragioti, Ai Koyanagi, Louis Jacob, Karel Kostev, Joaquim Radua, Sungsoo Lee, Jae Il Shin, Lee Smith
Summary: Mesothelioma has become a major health burden worldwide due to its link with asbestos exposure. Despite bans on asbestos in many countries, the disease continues to cause significant mortality and morbidity. This study assessed the global burden of mesothelioma from 1990 to 2019 and found decreasing incidence and mortality rates, although it remains a public health challenge in many parts of the world.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Public, Environmental & Occupational Health
Jason Y. Y. Wong, Carol Rice, Aaron Blair, Debra T. Silverman
Summary: The study found that exposure to both long and short chrysotile fibers increased the risk of mesothelioma compared to no exposure. The highest risk was associated with a complex mixture of extra-long amosite, short and long chrysotile, tremolite and anthophyllite fibers.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2021)