Article
Biochemistry & Molecular Biology
Xin Li, Fengri Jin, Hyun Jae Lee, Choong Jae Lee
Summary: The study found that kaempferol can regulate the gene expression and production of mucin through the NF-kappa B and MAPK signaling pathways in human airway epithelial cells.
BIOMOLECULES & THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Katie H. Barker, James P. Higham, Luke A. Pattison, Iain P. Chessell, Fraser Welsh, Ewan St J. Smith, David C. Bulmer
Summary: The effective management of visceral pain is an important unmet clinical need for patients with gastrointestinal diseases. The rational design of novel analgesics requires a deeper understanding of the mediators and mechanisms underlying visceral pain. Elevated levels of interleukin-13 (IL-13) production by immune cells in the gut have been observed in inflammatory bowel disease (IBD), and IL-13 may play a role in the development of experimental colitis. IL-13 stimulates nociceptors and enhances the response to colon distention, implicating JAK and p38 kinases in pronociceptive signaling downstream of IL-13.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Yasuhiro Kimura, Masahiro Shinoda, Masaharu Shinkai, Takeshi Kaneko
Summary: Solithromycin, a fluoroketolide antibiotic, can attenuate IL-13-induced goblet cell hyperplasia and mucin production by inhibiting CLCA1 and ANO1 mRNA and protein expression, without affecting STAT6 and ERK phosphorylation. However, further research is needed to clarify the molecular mechanisms underlying this inhibition.
Article
Pharmacology & Pharmacy
Jun Iwashita, Hikari Maeda, Momo Ishimura, Jun Murata
Summary: The excess secretion of MUC5AC in the respiratory tract of asthma patients can be suppressed by type IV collagen exposure, which modulates integrin expression and Akt/ERK phosphorylation in the respiratory tract of OVA-sensitized mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Jerome Carpenter, Yang Wang, Richa Gupta, Yuanli Li, Prashamsha Haridass, Durai B. Subramani, Boris Reidel, Lisa Morton, Caroline Ridley, Wanda K. O'Neal, Marie-Pierre Buisine, Camille Ehre, David J. Thornton, Mehmet Kesimer
Summary: The study compared the biophysical properties and macromolecular assembly of MUC5AC and MUC5B, revealing that MUC5AC forms a network structure with higher branching compared to MUC5B. Additionally, MUC5AC binds more to hydrophobic surfaces, is stiffer, and exhibits greater viscoelasticity than MUC5B.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Rodolfo Soria-Castro, Angel R. Alfaro-Doblado, Gloria Rodriguez-Lopez, Marcia Campillo-Navarro, Yatsiri G. Meneses-Preza, Adrian Galan-Salinas, Violeta Alvarez-Jimenez, Juan C. Yam-Puc, Rosario Munguia-Fuentes, Adriana Dominguez-Flores, Sergio Estrada-Parra, Sonia M. Perez-Tapia, Alma D. Chavez-Blanco, Rommel Chacon-Salinas
Summary: The study found that MC infected with L.m were able to clear the bacterial load and responded by degranulating and producing various cytokines. TLR2 was shown to mediate some MC activation pathways during L.m infection, particularly those related to IL-6 and IL-13 production. Interestingly, p38 activation depended on TLR2, but not ERK or NF-kappa B activation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Tom Breugelmans, Wout Arras, Baptiste Oosterlinck, Aranzazu Jauregui-Amezaga, Michael Somers, Bart Cuypers, Kris Laukens, Joris G. De Man, Heiko U. De Schepper, Benedicte Y. De Winter, Annemieke Smet
Summary: This study investigates the role of MUC13 in disrupting epithelial barrier integrity and the involvement of MUC1 in inflammatory bowel diseases (IBD). The results demonstrate that MUC13 overexpression affects the expression of junctional proteins and barrier mediators, leading to intestinal barrier dysfunction. Furthermore, MUC13 modulates several signaling pathways, including JAK1/STAT3, SNAI1/ZEB1, and ROCK2/MAPK, in cooperation with MUC1. The findings suggest that aberrant MUC13 signaling plays an active role in inducing intestinal barrier dysfunction during inflammation.
Article
Biochemistry & Molecular Biology
Rajib Hossain, Kyung-Il Kim, Fengri Jin, Hyun Jae Lee, Choong Jae Lee
Summary: Betulin regulates the gene expression of MUC5AC mucin through the NF-kB signaling pathway, thereby inhibiting the production of mucin in human airway epithelial cells.
BIOMOLECULES & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Jiho Ryu, Kyung-il Kim, Rajib Hossain, Misoon Lee, Jin Tae Hong, Hyun Jae Lee, Choong Jae Lee
Summary: The study investigated the potential effect of meclofenamate, a nonsteroidal anti-inflammatory drug, on airway MUC5AC mucin gene expression. Human pulmonary mucoepidermoid NCI-H292 cells were pretreated with meclofenamate and stimulated with phorbol 12-myristate 13-acetate (PMA). Meclofenamate was found to inhibit glycoprotein production and mRNA expression of MUC5AC mucins by regulating the NF-kB signaling pathway in human pulmonary epithelial cells.
BIOMOLECULES & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Rajib Hossain, Kyung-Il Kim, Xin Li, Hyun Jae Lee, Choong Jae Lee
Summary: In this study, it was found that engeletin inhibits the gene expression of MUC5AC mucin in human airway epithelial cells through the regulation of NF-kB signaling pathway.
BIOMOLECULES & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Kyung-il Kim, Rajib Hossain, Jiho Ryu, Hyun Jae Lee, Choong Jae Lee
Summary: This study found that artesunate can suppress the gene expression of MUC5AC mucin by regulating the NF-kB signaling pathway, thereby inhibiting the development of respiratory diseases.
BIOMOLECULES & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Chawon Yun, Hyun Jae Lee, Choong Jae Lee
Summary: The study found that eriodictyol inhibits the production and gene expression of MUC5AC mucin in human pulmonary epithelial cells by regulating the NF-kappa B signaling pathway.
BIOMOLECULES & THERAPEUTICS
(2021)
Article
Immunology
Xiaoting Liao, Weikang Zhang, Huijun Dai, Ren Jing, Mengling Ye, Wanyun Ge, Shenglin Pei, Linghui Pan
Summary: The study found that IL-17 plays a pro-inflammatory role in ventilator-induced lung injury (VILI) and could serve as a new target for treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Sara Francisco, Alicia Arranz, Javier Merino, Carmen Punzon, Rosario Perona, Manuel Fresno
Summary: The study found that TLR2 ligands activate MAPKs p38 and ERK earlier in macrophages, leading to higher levels of IL-10/IL-12 and IL-10/TNF-alpha ratios compared to TLR4 ligand LPS. Early TLR2-mediated p38 induction contributes to high IL-10 production, likely suppressing host Th1 response against certain pathogens.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Physiology
Johnathan D. Keith, Alexander G. Henderson, Courtney M. Fernandez-Petty, Joy M. Davis, Ashley M. Oden, Susan E. Birket
Summary: Cystic fibrosis (CF) airway disease is characterized by excessive and accumulative mucus in the airways. This study found that the concentration of Muc5b in the airway, and to a lesser extent Muc5ac, was increased in CF rats compared to normal rats, and that the concentration of Muc5b was directly related to the viscosity of the mucus. Methacholine administration exacerbated the disease characteristics in CF rats. Additionally, CF rats had mucus adhered to the airway epithelium, which was reversed by ivacaftor therapy.
FRONTIERS IN PHYSIOLOGY
(2022)