Article
Cell Biology
Antonio Sancho-Munoz, Maria Guitart, Diego A. Rodriguez, Joaquim Gea, Juana Martinez-Llorens, Esther Barreiro
Summary: In the vastus lateralis of sarcopenic COPD patients, there was an increase in myostatin content, activated satellite cells, hybrid fiber proportions, TUNEL-positive cells, internal nuclei, and muscle damage. Conversely, muscle strength, numbers of Pax-7+/Myf-5- cells, and slow- and fast-twitch myofiber areas decreased. Muscle regeneration markers were lower in both sarcopenic and nonsarcopenic patients compared to controls. However, in severe COPD patients, regardless of sarcopenia status, there was evidence of muscle regeneration activation along with significant alterations in muscle phenotype and damage, and increased myostatin levels.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell & Tissue Engineering
Jacopo Morroni, Anna Benedetti, Lorenza Esposito, Marco De Bardi, Giovanna Borsellino, Carles Sanchez Riera, Lorenzo Giordani, Marina Bouche, Biliana Lozanoska-Ochser
Summary: Muscle injury has a lasting effect on muscle stem cells, making them respond faster to subsequent injuries and contribute to accelerated muscle regeneration.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Biotechnology & Applied Microbiology
Martina Sandona, Lorena Di Pietro, Federica Esposito, Alessia Ventura, Antonietta Rosa Silini, Ornella Parolini, Valentina Saccone
Summary: Mesenchymal stromal cells (MSCs) are multipotent cells found in various tissues that have anti-fibrotic and immunoregulatory properties. Their secretome, including extracellular vesicles (EVs), can mimic the therapeutic effects of MSCs and offer advantages such as easier storage and safer administration for muscle regeneration in different diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Physiology
Fengjiao Huo, Qing Liu, Hailiang Liu
Summary: This review focuses on the etiology, assessment, and treatment of sarcopenia, as well as the functional and regulatory mechanisms of muscle satellite cells. Patients with sarcopenia often exhibit dysregulation of muscle satellite cell homeostasis, highlighting the importance of improving muscle satellite cell function in the treatment of sarcopenia.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yan Yan, Ming Li, Jie Lin, Yanan Ji, Kexin Wang, Dajun Yan, Yuntian Shen, Wei Wang, Zhongwei Huang, Haiyan Jiang, Hualin Sun, Lei Qi
Summary: This review summarizes the role of AMPK in regulating mitochondrial function and its impact on skeletal muscle metabolism and health.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Chung-Ju Yeh, Kristina M. Sattler, Christoph Lepper
Summary: Somatic stem cells, specifically satellite cells in skeletal muscle tissue, play a crucial role in maintaining tissue homeostasis and regenerating injured muscle fibers. These cells are maintained in a quiescent state during adulthood but are rapidly activated upon injury to produce myoblasts, which differentiate and fuse to regenerate the damaged muscle fibers. Intrinsic gene regulatory networks control the quiescent state and activation, proliferation, differentiation, and self-renewal of satellite cells. Molecular signals from the environment of satellite cells determine their behavior in terms of remaining quiescent or initiating regenerative myogenesis. This review provides a concise overview of the major intercellular signaling pathways involved in regulating satellite cells during quiescence and skeletal muscle regeneration after injury.
Review
Developmental Biology
Brittany C. Collins, Gabrielle Kardon
Summary: Vertebrate skeletal muscle is composed of multinucleate myofibers surrounded by muscle connective tissue, and can robustly regenerate following injury through satellite cells. Satellite cells and FAPs are heterogeneous cell populations, with current understanding focusing on gene expression, anatomical location, age, and timing during the regenerative process.
Article
Nutrition & Dietetics
Tolulope Peter Saliu, Thanutchaporn Kumrungsee, Koji Mitsumoto, Siyi Chen, Noriyuki Yanaka
Summary: This study found that NAFLD significantly reduces the number of satellite cells in the skeletal muscle of mice, impairing muscle regeneration. Additionally, NAFLD also impairs the differentiation ability of satellite cells, possibly associated with inflammatory cytokines and oxidative stress.
Article
Biochemistry & Molecular Biology
Hiroyuki Iio, Tadahiko Kikugawa, Yuichiro Sawada, Hiroshi Sakai, Shuhei Yoshida, Yuta Yanagihara, Aoi Ikedo, Noritaka Saeki, So-ichiro Fukada, Takashi Saika, Yuuki Imai
Summary: Dnmt1 plays a crucial role in skeletal muscle regeneration, as indicated by the significant decrease in muscle weight and cell number in Dnmt1 knockout mice. RNA sequencing analysis revealed alterations in gene expression related to cell adhesion and apoptosis in satellite cells from knockout mice.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Geriatrics & Gerontology
Daria Neyroud, Rachel L. Nosacka, Chandler S. Callaway, Jose G. Trevino, Hui Hu, Sarah M. Judge, Andrew R. Judge
Summary: The study identified FoxP1 as a novel repressor of skeletal muscle gene expression that is increased in cancer cachexia, whose up-regulation is sufficient to induce skeletal muscle wasting and weakness, and required for the normal wasting response to cancer.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Geriatrics & Gerontology
Kyung Min Kim, Gi Don Yoo, Woong Heo, Ho Taek Oh, Jeekeon Park, Somin Shin, Youjin Do, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Summary: This study reveals that the transcriptional co-activator TAZ promotes muscle regeneration by activating satellite cells. TAZ interacts with Pax7 to induce Myf5 expression and activates the mammalian target of rapamycin signaling pathway. Additionally, the p38 MAPK-TAZ signaling axis is found to be crucial for muscle regeneration.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Cell Biology
Iwona Bronisz-Budzynska, Magdalena Kozakowska, Katarzyna Pietraszek-Gremplewicz, Magdalena Madej, Alicja Jozkowicz, Agnieszka Loboda, Jozef Dulak
Summary: Increased oxidative stress can hinder skeletal muscle regeneration and affect muscle satellite cells (mSCs) activity. NRF2 transcription factor plays an important role in muscle cell biology by promoting myoblast proliferation and viability, reducing reactive oxygen species production, and inhibiting myoblast differentiation. NRF2 is also crucial for the viability of mSCs.
Article
Developmental Biology
Ryo Fujita, Solene Jamet, Graham Lean, Harry Chun Man Cheng, Steven Hebert, Claudia L. Kleinman, Colin Crist
Summary: Translation control of gene expression through P-eIF2α enables the expansion of satellite cells. Certain genes are upregulated at the protein level without corresponding changes at the mRNA level. Deficiency of Tacc3 results in defects in the expansion, self-renewal, and regeneration of skeletal muscle in satellite cells.
Article
Rehabilitation
Mario Parstorfer, Francesca Profit, Nadine Weiberg, Michaela Wehrstein, Alexander Barie, Birgit Friedmann-Bette
Summary: This study investigated satellite cell content and function of the vastus lateralis muscle after anterior ligament reconstruction. The findings showed that satellite cell apoptosis increased while the total satellite cell number decreased post-reconstruction, suggesting a potential explanation for prolonged quadriceps muscle atrophy.
JOURNAL OF REHABILITATION MEDICINE
(2021)
Review
Cell Biology
Xingyu Wang, Lan Zhou
Summary: Skeletal muscle plays a crucial role in physical activity and energy metabolism. Satellite cells, residing in skeletal muscle, are essential for maintaining homeostasis and regeneration post-injury. Macrophages, a diverse group of immune cells, are key regulators in the interaction with myogenic cells for proper muscle regeneration under both normal and diseased conditions like muscular dystrophy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)