Article
Multidisciplinary Sciences
Natalie Ella Miller, Andrew Steptoe
Summary: Depressive symptoms are associated with increased risk for cardiovascular disease in men, and pericardial fat and inflammation may contribute to this relationship. No significant associations were found between depressive symptoms and pericardial fat in women.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Simone Battaglia, Jasper H. Fabius, Katarina Moravkova, Alessio Fracasso, Sara Borgomaneri
Summary: The ability to adaptively follow conspecific eye movements is crucial for establishing shared attention and survival. This article discusses the neural bases of gaze-cueing and the perception of gaze direction, as well as the interaction between contextual factors and attention shift. The concept of invariant representation is proposed as a valuable framework for future research in gaze perception.
Article
Clinical Neurology
Hye Jin Joo, Kyung A. Kwon, Jaeyong Shin, Sohee Park, Sung-In Jang
Summary: This study investigated the association between sleep quality and depressive symptoms in the South Korean population. The results showed that poor sleep quality may contribute to the onset of depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Geriatrics & Gerontology
Ibrahim Demirer, Michael Kuhhirt, Ute Karbach, Holger Pfaff
Summary: The study found a positive longitudinal relationship between multimorbidity and depressive symptoms, both of which were negatively associated with positive affect. Long-term multimorbidity had a more substantial effect on depressive symptoms through the depletion of positive affect, while the direct impact of multimorbidity on depressive symptoms diminished for short-term cases. Strengthening positive affect could alleviate depressive symptoms in individuals with multimorbidity.
AGING & MENTAL HEALTH
(2022)
Article
Clinical Neurology
Elisa Dal Bo, Claudio Gentili, Andrea Castellani, Carmen Tripodi, Florian Ph S. Fischmeister, Cinzia Cecchetto
Summary: This study found that symptoms of anxiety were associated with higher levels of awareness of common odors, while symptoms of depression and social anxiety were associated with increased awareness of social odors. Assessing meta-cognitive abilities may be a useful tool in preventing and evaluating symptoms of depression, anxiety, and social anxiety.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Cell Biology
Mahasish Shome, Yunro Chung, Ramani Chavan, Jin G. Park, Ji Qiu, Joshua LaBaer
Summary: Autoantibodies are found in both autoimmune disease and cancer, as well as in healthy individuals. Through a meta-analysis of multiple datasets, we identified 77 common autoantibodies in healthy individuals. These autoantibodies are not affected by gender, but increase in number with age and plateau around adolescence. Bioinformatics analysis revealed potential molecular mimicry peptides that may contribute to the development of these autoantibodies. Common autoantigens are enriched in intrinsic properties of proteins and have specific subcellular localization and tissue expression patterns.
Article
Medicine, General & Internal
Roy H. Perlis, Matthew D. Simonson, Jon Green, Jennifer Lin, Alauna Safarpour, Kristin Lunz Trujillo, Alexi Quintana, Hanyu Chwe, John Della Volpe, Katherine Ognyanova, Mauricio Santillana, James Druckman, David Lazer, Matthew A. Baum
Summary: The study found that firearm ownership is common among individuals with major depressive symptoms, suggesting a public health opportunity to address the overlap of suicide risk factors.
Article
Medicine, General & Internal
Maude Lambert, Elena Sheldrake, Audrey-Ann Deneault, Anne Wheeler, Matthew Burke, Shannon Scratch
Summary: Individuals with a history of concussion, approximately 15% to 30% of them experience persistent postconcussion symptoms (PPCS). Those with PPCS are at a higher risk of developing depressive symptoms.
Article
Clinical Neurology
Julian Klingbeil, Max-Lennart Brandt, Max Wawrzyniak, Anika Stockert, Hans R. Schneider, Petra Baum, Karl-Titus Hoffmann, Dorothee Saur
Summary: Lesions in the left ventrolateral prefrontal cortex increase the risk of depressive symptoms 6 months poststroke. Lesions within the right hemisphere are unrelated to depressive symptoms.
Article
Public, Environmental & Occupational Health
Yinyin Liang, Zixuan Li, Xinrou Wang, Pengcheng Liu, Liang Ma, Xiaojie Wang
Summary: This study examines the correlation between overtime and depressive symptoms, and found that working overtime increased the likelihood of depressive symptoms. The worsening of depressive symptoms was more pronounced in the heavy overtime group. The moderating effect results showed that younger employees, high-educated employees, and employees with high income level were more vulnerable to the negative effects of overtime on mental health.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Psychiatry
Chunsu Zhu, Hongyu Yu, Zhiwei Lian, Jianmin Wang
Summary: This study examines the association between depressive symptoms and hip fracture as well as falls in a nationally representative Chinese population. The findings suggest that elevated depressive symptoms are associated with an increased risk of hip fracture and falls among the Chinese population.
Article
Dentistry, Oral Surgery & Medicine
S. Fukuhara, K. Asai, A. Kakeno, C. Umebachi, S. Yamanaka, T. Watanabe, T. Yamazaki, K. Nakao, K. Setoh, T. Kawaguchi, S. Morita, T. Nakayama, F. Matsuda, K. Bessho
Summary: The study reveals a significant association between lower educational attainment and tooth loss, as well as a partial interactive association between lower educational attainment and depressive symptoms in the general Japanese population.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Ming-Hui Chou, Yen Kuang Yang, Jung-Der Wang, Chung-Ying Lin, Sheng-Hsiang Lin
Summary: Depression is a major global burden of disease and its relation to nutrients, including magnesium, is inconclusive. This study analyzed data from a national survey in Taiwan and found that higher serum magnesium levels were associated with lower depressive symptoms. However, dietary magnesium intake showed no association with depression. Sex differences were also observed. Chronic latent magnesium deficiency should be considered when assessing the relationship between magnesium status and depressive symptoms.
Article
Psychiatry
Hyunwoo Jeong, Seong-Jin Cho, Sehyun Jeon, Jooyoung Lee, Yu Jin Lee, Seog Ju Kim
Summary: The study revealed a significant association between self-reported snoring and increased depressive symptoms and suicidality in adolescents. This connection remained significant even after adjusting for sleep duration, insomnia, and daytime sleepiness. Depressive symptoms mediated the relationship between snoring frequency and suicidal ideation.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Clinical Neurology
Xiaowen Wang, Ahmed Arafa, Keyang Liu, Ehab S. Eshak, Yonghua Hu, Jia- Yi Dong
Summary: The meta-analysis found that a healthy lifestyle is associated with a reduced risk of depressive symptoms. Adherence to an overall healthy lifestyle is crucial for the primary prevention of depression in general populations.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Geriatrics & Gerontology
Y. Lu, X. Gwee, D. Q. Chua, T. S. Lee, W. S. Lim, M. S. Chong, P. Yap, K. B. Yap, I. Rawtaer, T. M. Liew, F. Pan, Tze Pin Ng
Summary: Research suggests that older adults at high nutritional risk are more likely to develop cognitive decline and neurocognitive disorders, including MCI or dementia. Identifying vulnerable subpopulations for correction of malnutrition risk may help prevent neurocognitive disorders.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Psychiatry
Junhong Yu, Iris Rawtaer, Lei Feng, Johnson Fam, Alan Prem Kumar, Irwin Kee-Mun Cheah, William G. Honer, Wayne Su, Yuan Kun Lee, Ene Choo Tan, Ee Heok Kua, Rathi Mahendran
Summary: Mindfulness-based interventions can enhance cognitive abilities among older adults and delay cognitive decline. Research suggests that mindfulness training leads to cognitive improvements and changes in cortical thickness, offering therapeutic effects for certain cognitive impairments.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Geriatrics & Gerontology
Yanxia Lu, Crystal Tze Ying Tan, Xinyi Gwee, Keng Bee Yap, Tamas Fulop, Fang Pan, Anis Larbi, Tze Pin Ng
Summary: The study found that a high pathogen load is associated with gait speed, functional mobility, cognitive function, and frailty index, as well as with inflammatory biomarker levels. Blood biomarkers did not fully explain the observed association between pathogen load and functional aging measures.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Li-Ting Sheng, Yi-Wen Jiang, Lei Feng, An Pan, Woon-Puay Koh
Summary: The study found a significant association between midlife dietary total antioxidant capacity and cognitive function in later life, with higher antioxidant capacity associated with lower odds of cognitive impairment. Higher intakes of vitamin C, vitamin E, carotenoids, and flavonoids were found to be protective against cognitive impairment.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Clinical Neurology
Junhong Yu, Iris Rawtaer, Lei Feng, Ee-Heok Kua, Rathi Mahendran
Summary: Geriatric depression and anxiety often exhibit as neuropsychiatric symptoms in older adults with mild cognitive impairment. Using connectome-based predictive modeling, researchers found that both types of symptoms are largely underpinned by common patterns of altered functional and structural connectivity, indicating a transdiagnostic neurobiological susceptibility in both disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Christophe Carre, Glenn Wong, Vipin Narang, Crystal Tan, Joni Chong, Hui Xian Chin, Weili Xu, Yanxia Lu, Michelle Chua, Michael Poidinger, Paul Tambyah, Ma Nyunt, Tze Pin Ng, Daniel Larocque, Catherine Hessler, Nabil Bosco, Laurence Quemeneur, Anis Larbi
Summary: The study evaluated the immune and metabolic profiles of elderly Singaporeans vaccinated with Vaxigrip, finding heterogeneity in response and suggesting that activation of the ER-stress pathway could improve influenza vaccination in the elderly.
Article
Psychiatry
Ling-Yun Liu, Yanxia Lu, Liang Shen, Chun-Bo Li, Jin-Tai Yu, Chua Ru Yuan, Kaisy Xinhong Ye, Yin Xia Chao, Qing-Feng Shen, Rathi Mahendran, Ee Heok Kua, De-Hua Yu, Lei Feng
Summary: This study investigated the prevalence, risk, and protective factors for MCI among Singaporean Chinese older adults, finding that age, education level, social activity, depression, hypertension, stroke, and other factors are related to MCI. Males are more likely to have amnestic MCI, while females are more likely to have non-amnestic MCI.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Environmental Sciences
Ted Kheng Siang Ng, Lei Feng, Johnson Fam, Iris Rawtaer, Alan Prem Kumar, Grishma Rane, Irwin Kee-Mun Cheah, Ratha Mahendran, Yuan Kun Lee, Ene Choo Tan, Lee Gan Goh, Ee Heok Kua, Rathi Mahendran
Summary: This study aims to investigate the effects of mindfulness awareness practice on cognitive decline and peripheral biomarkers in community-dwelling older adults diagnosed with MCI. Conducted as a single-blinded parallel-group randomized controlled trial, the results have the potential to inform mindfulness intervention as a novel approach to delay dementia.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Immunology
Yanxia Lu, Bao-Peng Liu, Crystal T. Y. Tan, Fang Pan, Anis Larbi, Tze Pin Ng
Summary: The link between pathogen exposure and mental health has been investigated in a study of over 800 participants in the Singapore Longitudinal Ageing Studies. The study found that high pathogen burden is associated with increased prevalence of depressive symptoms and impaired mental health. Certain infections and inflammatory markers were found to mediate this association. These findings highlight the potential impact of pathogens on mental health.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Nutrition & Dietetics
Li-Ting Sheng, Yi-Wen Jiang, Derrick Johnston Alperet, Lei Feng, An Pan, Woon-Puay Koh
Summary: This study aimed to investigate the relationship between fruit and vegetable intake in midlife and cognitive function in late life. The results suggest that increasing the quantity and variety of fruits and vegetables consumed may reduce the risk of cognitive impairment in late life.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Geriatrics & Gerontology
Yi Huang, Narun Pat, Bing Cai Kok, Jingwen Chai, Lei Feng, Rongjun Yu
Summary: This study investigated how older adults experience regret and how they make choices to avoid potential regret in making decisions for themselves and on behalf of others. The findings suggest that although older adults experience blunted regret, their ability to use prospective regret to guide decision-making remains intact.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Keith M. Harris, Lu Wang, Guanglun M. Mu, Yanxia Lu, Cheryl So, Wei Zhang, Jing Ma, Kefei Liu, Wei Wang, Melvyn Wei-bin Zhang, Roger C. Ho
Summary: Clinicians face challenges in providing accurate and useful mental health assessments, especially in emergency situations. The development of a reliable and accessible Suicidality Scale (SS) addresses the urgent need for better suicide risk assessment tools. Through rigorous testing and validation, the SS has demonstrated strong psychometric properties and is applicable to diverse populations. This open-source scale represents a significant advancement in accurate assessment for individuals aged 13 and older.
Review
Geriatrics & Gerontology
Adrian Matysek, Sumudu Perera Kimmantudawage, Lei Feng, Andrea B. Maier
Summary: This study systematically summarizes compounds that inhibit the GSK3 pathway to treat cognitive impairment and dementia. The findings indicate that some natural and synthetic compounds show positive effects on cognition in animal models, but there is a clear lack of translation from animal models to humans.
FRONTIERS IN AGING
(2022)
Article
Cell Biology
Yanxia Lu, Mathew Niti, Keng Bee Yap, Crystal Tze Ying Tan, Ma Shwe Zin Nyunt, Liang Feng, Boon Yeow Tan, Gribson Chan, Sue Anne Khoo, Sue Mei Chan, Philip Yap, Anis Larbi, Tze Pin Ng
Summary: This study revealed that multi-domain lifestyle interventions can significantly reduce sarcopenia, improve gait speed, and enhance lower limb strength. Blood biomarkers related to muscle metabolism, steroid hormone regulation, insulin-leptin signaling, and tissue oxygenation are associated with sarcopenia status and reduction. Physical, nutritional, and cognitive interventions are linked to measures of sarcopenia reduction and changes in circulating biomarkers of anabolic and catabolic metabolism underlying sarcopenia.
