Article
Nutrition & Dietetics
Man Liu, Samuel C. Dudley
Summary: Magnesium is essential for cell functions and its deficiency (HypoMg) can lead to cardiovascular diseases. Magnesium supplementation and TRPM7 kinase inhibition may have therapeutic effects for HypoMg and other diseases.
Article
Biochemistry & Molecular Biology
Xiao-Min Zhang, Ying Song, Xin-Yi Zhu, Wen-Jun Wang, Xu-Li Fan, Tarek Mohamed Abd El-Aziz
Summary: Mitochondria are crucial for oxidative stress and maintenance of cell functionality and energy demand. The TRPM2 channel, which influences mitochondrial function, plays a role in the occurrence and progression of diseases. TRPM2 promotes Ca2+ influx affecting TSPO, MMP, ROS, ATP production, and mitochondrial autophagy. The mechanism of Ca2+ influx by TRPM2 into mitochondria is diverse. Interestingly, TRPM2 inhibits mitochondrial ROS production in cancer cells but promotes it in normal cells, leading to cell death in normal cells and proliferation in cancer cells. TRPM2 can be a potential target for treating various diseases by acting as a molecular link between mitochondria and Ca2+ signals.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jian Huang, Ruilin Zhang, Shangwen Wang, Dongxian Zhang, Chi-Kwan Leung, Genmeng Yang, Yuanyuan Li, Liu Liu, Yue Xu, Shucheng Lin, Chan Wang, Xiaofeng Zeng, Juan Li
Summary: The cooperation between METH and HIV-Tat exacerbates BBB impairment, involving oxidative stress and TRPM2 channel activation. Inhibiting oxidative stress or TRPM2 channel activity may provide therapeutic targets for attenuating BBB injury in HIV-positive METH abusers.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiao-Yu Cheng, Shu-Fang Li, Yong Chen, Ying-Jie Zhao, Wei Hu, Chao Lu, Ren-Peng Zhou
Summary: TRPM7 is a channel protein located on the cell membrane that regulates the balance of intracellular Mg2+. It plays an important role in cell proliferation, adhesion, migration, and is directly related to disease occurrence and development.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Pathology
Qin Li, Haicheng Wang, Liwei Liu, Yuteng Weng, Shuyu Xu, Lin Li, Zuolin Wang
Summary: This study investigated the role of the TRPM2/NLRP3 axis in osteogenesis during healing of tooth extraction sockets. It was found that inhibiting TRPM2 expression mitigated the detrimental effect of NLRP3 inflammasome on osteogenesis, suggesting that targeting the TRPM2/Ca2 /NLRP3 pathway could be beneficial in the healing process of tooth extraction sockets in patients with periodontitis.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Cell Biology
Feng Hu, Yun Yu, Feng Lu, Xiaoshu Cheng
Summary: The study demonstrated that TRPM2 gene silencing significantly attenuated fibrosis and inflammation in the kidneys of mice with HFD/STZ-induced diabetes, largely achieved via the inhibition of TGF-I31-activated JNK1 activation.
Article
Pharmacology & Pharmacy
Md Zubayer Hossain Saad, Liuruimin Xiang, Yan-Shin Liao, Leah R. Reznikov, Jianyang Du
Summary: The study identified molecular determinants responsible for the pH regulation of TRPM3, showing that both intracellular and extracellular protons block TRPM3 through binding sites in the pore region. Specific residue D1073 was found to be essential for pH sensitivity in TRPM3 channel.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Ana Flavia F. Ferreira, Luiz Roberto G. Britto
Summary: Transient receptor potential melastatin 2 (TRPM2) is an oxidative stress-activated calcium-permeable cation channel that plays a role in neurodegenerative diseases such as Alzheimer's disease and ischemia. However, its involvement in Parkinson's disease pathology has only recently been studied. This review summarizes and discusses the existing studies on the role of TRPM2 in Parkinson's disease, highlighting its activation and enhanced expression in different models, as well as the protective effects of TRPM2 antagonists and genetic approaches.
NEURAL REGENERATION RESEARCH
(2023)
Article
Immunology
Omar Rafael Aleman, Nancy Mora, Carlos Rosales
Summary: Human neutrophils express two unique antibody receptors for IgG, Fc gamma RIIa and Fc gamma RIIIb, which are capable of initiating distinct cellular functions. Fc gamma RIIa induces an increase in L-selectin expression and phagocytosis, while Fc gamma RIIIb promotes actin polymerization, activation of beta 1 integrins, and formation of neutrophils extracellular traps (NET) more efficiently.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Juhua Luo, Michael Hendryx, Yi Dong
Summary: A study shows that the use of SGLT2 inhibitors is associated with improved overall survival in non-small cell lung cancer patients with pre-existing diabetes, even after considering potential confounders. This study provides evidence for the potential role of SGLT2 inhibitors in the treatment of non-small cell lung cancer.
BRITISH JOURNAL OF CANCER
(2023)
Article
Pharmacology & Pharmacy
Hiroshi Moriyama, Sadahiro Nomura, Hirochika Imoto, Takao Inoue, Yuichi Fujiyama, Kohei Haji, Yuichi Maruta, Hideyuki Ishihara, Michiyasu Suzuki
Summary: TRPM8 agonist suppresses EDs and epileptic seizures in wildtype mice, but not in TRPM8KO mice. TRPM8KO mice show exacerbated EDs and epileptic seizures compared to wildtype mice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Bo Huang, Xuecheng Sun, Aie Xu
Summary: Oxidative stress induces upregulation of TRPM2 and downregulation of miR-145-5p in melanocytes. Overexpression of miR-145-5p alleviates melanocyte destruction by targeting TRPM2, suggesting miR-145-5p as a potential target for anti-oxidative therapy in vitiligo.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2021)
Article
Medicine, Research & Experimental
Rasha Assad Assiri, Thanaa A. El-Masry, Sahar M. El-Haggar, Engy Elekhnawy, Salwa Seif Eldin, Aya H. El-Kadem, Sally Abdallah Mostafa, Aya Ibrahim Elberri, Sameh Magdeldin, Walaa A. Negm, Fatma A. Mokhtar
Summary: Acute lung injury (ALI) is a serious and often fatal condition characterized by inflammation and oxidative stress. This study investigates the potential beneficial effects of Tamarix nilotica, a Middle Eastern plant, on ALI induced by lipopolysaccharide (LPS). The results show that certain fractions of T. nilotica exhibit anti-inflammatory and antioxidant effects, reducing the levels of inflammatory mediators and improving lung function in mice with ALI. Additionally, the study found that T. nilotica has antibacterial activity against Klebsiella pneumoniae and can inhibit biofilm formation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Anesthesiology
Lukas Martin Mueller-Wirtz, Daniel Kiefer, Felix Maurer, Maximilian Alexander Floss, Jonas Doneit, Tobias Hueppe, Theodora Shopova, Beate Wolf, Daniel I. Sessler, Thomas Volk, Sascha Kreuer, Tobias Fink
Summary: Exhaled pentanal may serve as a potential biomarker for early detection of ventilator-induced lung injury in rats. Ventilation at high tidal volumes led to significantly increased exhaled pentanal concentrations, while short-term ventilation at high tidal volumes did not result in significant increases in white blood cell concentrations and cleaved caspase 3 in lung tissue.
ANESTHESIA AND ANALGESIA
(2021)
Article
Peripheral Vascular Disease
Rheure Alves-Lopes, Silvia Lacchini, Karla B. Neves, Adam Harvey, Augusto C. Montezano, Rhian M. Touyz
Summary: The activation of NOX4 has been shown to have vasoprotective and blood pressure-lowering effects. This study reveals that NOX4-induced regulation of TRPM2 and effects on eNOS-nitric oxide signaling may play a crucial role in these effects.
JOURNAL OF HYPERTENSION
(2023)