期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 187, 期 3, 页码 217-223出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2013.04.009
关键词
Carotid body; Neuropeptide; Variability; Neonatal apnea; Sudden infant death syndrome (SIDS)
资金
- CIHR
- Alberta Innovates - Health Solutions
- Alberta Children's Hospital Research Institute's CIHR Training Program in Genetics, Child Development, and Health
- O'Brien Center
- Alberta Children's Hospital Research Institute's CIHR Training Program
- Hotchkiss Brain Institute's Dr. T. Chen Fong Doctoral Scholarship in Neuroscience
Pituitary adenylate cyclase-activating peptide (PACAP) is an important mediator of the stress response and is crucial in maintaining breathing in neonates. Here we investigate the role of exogenously applied PACAP in neonatal breathing using the neonatal rat in situ working heart-brainstem preparation. A 1-min bolus of 250 nM PACAP-38 caused an increased in respiratory frequency that was rapid and transient, but had no effect on neural tidal volume or neural minute ventilation. Denervation of the carotid body abolished this effect. PACAP had a persistent effect on breathing stability in both carotid body-intact and -denervated preparations, as shown by decreases in respiratory variability 5 min following application. These data suggest that PACAP released during stress acts via carotid body dependent and independent mechanisms to stimulate and stabilize breathing. These mechanisms may account for PACAP's critical role in defending neonatal breathing against environmental stress. (C) 2013 Elsevier B.V. All rights reserved.
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