Article
Critical Care Medicine
Tommaso Pettenuzzo, Annalisa Boscolo, Alessandro De Cassai, Nicolo Sella, Francesco Zarantonello, Paolo Persona, Laura Pasin, Giovanni Landoni, Paolo Navalesi
Summary: The study found that for ICU patients not suffering from ARDS, the use of higher positive end-expiratory pressure (PEEP) was not significantly associated with hospital mortality compared to lower PEEP. However, it was associated with improved oxygenation, higher respiratory system compliance, and reduced risk of hypoxemia and ARDS.
Article
Physiology
Alberto Giardina, Danilo Cardim, Pietro Ciliberti, Denise Battaglini, Lorenzo Ball, Magdalena Kasprowicz, Erta Beqiri, Peter Smielewski, Marek Czosnyka, Shirin Frisvold, Matjaz Groznik, Paolo Pelosi, Chiara Robba
Summary: This study aims to assess the effect of increasing positive end-expiratory pressure (PEEP) on cerebral autoregulation in brain injured patients. The results showed that increasing PEEP did not worsen cerebral autoregulation and did not require clinical intervention.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Veterinary Sciences
Marcela L. Machado, Joao H. N. Soares, Bruno H. Pypendop, Antonio J. A. Aguiar, Christina Braun, Gabriel C. Motta-Ribeiro, Frederico C. Jandre
Summary: In cats under anesthesia with isoflurane and mechanical ventilation for 3 hours, all levels of PEEP had mild improvements in gas exchange with higher levels causing more cardiovascular depression. Dopamine was effective in treating low blood pressure in some cases.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Critical Care Medicine
Chiara Robba, Lorenzo Ball, Denise Battaglini, Francesca Iannuzzi, Iole Brunetti, Pietro Fiaschi, Gianluigi Zona, Fabio Silvio Taccone, Antonio Messina, Silvia Mongodi, Paolo Pelosi
Summary: This study aimed to evaluate the effects of two levels of positive end-expiratory pressure (PEEP) on lung ultrasound patterns and intracranial pressure (ICP) in brain injured patients. The results showed that increasing PEEP can reduce lung ultrasound scores in the posterior regions and is correlated with changes in respiratory mechanics and clinical variables.
Article
Critical Care Medicine
Alessandro Protti, Alessandro Santini, Francesca Pennati, Chiara Chiurazzi, Massimo Cressoni, Michele Ferrari, Giacomo E. Iapichino, Luca Carenzo, Ezio Lanza, Giorgio Picardo, Pietro Caironi, Andrea Aliverti, Maurizio Cecconi
Summary: Patients with early ARDS due to COVID-19 have a large potential for lung recruitment, but their compliance and Pa-CO2 may not improve with higher PEEP, possibly due to hyperinflation.
Review
Endocrinology & Metabolism
Nareshni Moodley
Summary: Copeptin, as an alternative to arginine vasopressin measurement, has advantages of high stability, simple analysis, and ease of automation. Research has shown its suitability for differentiating arginine vasopressin resistance and deficiency as well as primary polydipsia in adults, but further studies are needed in Syndrome of Inappropriate Antidiuretic Hormone (SIADH) and the pediatric population.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Anesthesiology
Martin Scharffenberg, Maura Mandelli, Thomas Bluth, Francesca Simonassi, Jakob Wittenstein, Robert Teichmann, Katharina Birr, Thomas Kiss, Lorenzo Ball, Paolo Pelosi, Marcus J. Schultz, Marcelo Gama de Abreu, Robert Huhle
Summary: The study aimed to examine the impact of low or high positive end-expiratory pressure (PEEP) and recruitment manoeuvres (RM) on intra-tidal recruitment/derecruitment and overdistension in obese patients. The results showed that higher PEEP and RM reduced intra-tidal recruitment/derecruitment, driving pressure, elastance, resistance, and mechanical power.
JOURNAL OF CLINICAL ANESTHESIA
(2024)
Article
Physiology
Chiara Robba, Lorenzo Ball, Stefano Nogas, Denise Battaglini, Antonio Messina, Iole Brunetti, Giuseppe Minetti, Lucio Castellan, Patricia R. M. Rocco, Paolo Pelosi
Summary: This study aimed to assess the effects of PEEP augmentation on respiratory mechanics, lung CT findings, and ICP in acute brain-injured patients. The main factors associated with increased ICP after PEEP augmentation included reduced Crs, lower MAP, lung recruitment, and increased PaCO2. However, none of these factors was able to predict, at baseline, the ICP response to PEEP.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medical Laboratory Technology
Danni Mu, Chaochao Ma, Jin Cheng, Yutong Zou, Ling Qiu, Xinqi Cheng
Summary: Copeptin, a stable and easy-to-measure surrogate marker of AVP, has excellent potential in the diagnosis, differentiation and prognosis of diseases related to fluid disorders and stress.
CLINICA CHIMICA ACTA
(2022)
Article
Critical Care Medicine
Christelle Soule, Laure Crognier, Floriane Puel, Stephanie Ruiz, Thierry Seguin, Olivier Fourcade, Bernard Georges, Jean-Marie Conil, Vincent Minville, Fanny Vardon-Bounes
Summary: This study aimed to evaluate the ability of electrical impedance tomography to assist physicians in selecting the optimal positive end-expiratory pressure in venoarterial extracorporeal membrane oxygenation treated patients. The results showed that the impedance tomography data correlated well with the positive end-expiratory pressure selected based on respiratory parameters by physicians. However, high intrathoracic pressure had a negative impact on hemodynamic and cardiac tolerances.
CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Luis Schulz, Antony Stewart, William O'Regan, Peter McCanny, Danielle Austin, Magnus Hallback, Mats Wallin, Anders Aneman
Summary: This study reveals that increased positive end-expiratory pressure (PEEP) can improve oxygenation in mechanically ventilated COVID-19 patients with respiratory failure, and this improvement is correlated with the increase in end-expiratory lung volume and pulmonary perfusion.
Review
Medicine, General & Internal
Jing Zhou, Zhimin Lin, Xiumei Deng, Baiyun Liu, Yu Zhang, Yongxin Zheng, Haichong Zheng, Yingzhi Wang, Yan Lai, Weixiang Huang, Xiaoqing Liu, Weiqun He, Yuanda Xu, Yimin Li, Yongbo Huang, Ling Sang
Summary: In mechanically ventilated patients without ARDS, higher PEEP was associated with significantly higher PaO2/FiO2 ratio and increased incidence of pneumothorax. However, no significant differences were observed among the four levels of PEEP in terms of other outcomes.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Anna Sjostrom, Simona Chisalita, Charlotte Hoybye
Summary: Growth hormone treatment increases copeptin levels, potentially compensating for the anti-natriuretic effect of the treatment. It also has an impact on body composition and water balance.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Monica Rodrigues da Cruz, Luciana Moises Camilo, Tiago Batista da Costa Xavier, Gabriel Casulari da Motta Ribeiro, Denise Machado Medeiros, Luis Felipe da Fonseca Reis, Bruno Leonardo da Silva Guimaraes, Andre Miguel Japiassu, Alysson Roncally Silva Carvalho
Summary: This study investigated the relationship between airway driving pressure (dP(aw)) and positive-end expiratory pressure (PEEP) in ARDS patients with COVID-19. The majority of patients exhibited a J-shaped curve, while a smaller proportion had a U-shaped or inverted J-shaped curve. Patients with inverted J-shaped curves had higher BMI and lower baseline partial pressure of arterial oxygen/FiO(2) ratio. These findings suggest that adjusting PEEP based on dP(aw) changes can enable individualized protective ventilation.
Article
Critical Care Medicine
Ethan M. Estoos, Kevin P. Jocham, Chengda Zhang, Lauren M. Benson, Anamaria Milas, Bishoy Zakhary
Summary: This retrospective study aimed to investigate the effect of PEEP titration using esophageal manometry on pulmonary and cardiac function in VV ECMO patients. The results showed that patients with the optimal PEEP strategy had higher applied PEEP levels, lower incidence of RV dysfunction with low pulmonary arterial pressure, and higher survival.
JOURNAL OF CRITICAL CARE
(2023)
Article
Anesthesiology
S. Morgenroth, J. Thomas, V. Cannizzaro, M. Weiss, A. R. Schmidt
Article
Pediatrics
Marc-Andre Buchwald, Ursula Laasner, Christian Balmer, Vincenzo Cannizzaro, Beatrice Latal, Vera Bernet
JOURNAL OF PEDIATRIC SURGERY
(2019)
Article
Anesthesiology
Jorg Thomas, Markus Weiss, Vincenzo Cannizzaro, Christian Peter Both, Alexander Robert Schmidt
PEDIATRIC ANESTHESIA
(2018)
Article
Medicine, Research & Experimental
Francesco Greco, Susanne Wiegert, Philipp Baumann, Sven Wellmann, Giovanni Pellegrini, Vincenzo Cannizzaro
JOURNAL OF TRANSLATIONAL MEDICINE
(2019)
Article
Physiology
Susanne Wiegert, Francesco Greco, Philipp Baumann, Sven Wellmann, Paula Grest, Udo Hetzel, Vincenzo Cannizzaro
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2020)
Article
Physiology
Philipp Baumann, Susanne Wiegert, Francesco Greco, Joerg Ersch, Vincenzo Cannizzaro
Summary: This study demonstrated strain-specific differences in ventilator-induced lung injury (VILI) in infant Sprague-Dawley and Wistar rats. The severity of VILI depends on ventilation strategy and selected strain, with fundamental and time-dependent differences in respiratory system mechanics. Hence, strain-specific characteristics of the respiratory system should be considered in VILI studies with infant rats.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Philipp Baumann, Francesco Greco, Susanne Wiegert, Sven Wellmann, Giovanni Pellegrini, Vincenzo Cannizzaro
Summary: This study found that the endothelin-1 receptor antagonist macitentan can attenuate cardiovascular remodeling caused by chronic lung disease in a preterm infant rat model, highlighting its potential to reduce cardiovascular morbidity in preterm infants.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Pediatrics
Philipp Baumann, Verena Gotta, Andrew Atkinson, Markus Deisenberg, Martin Hersberger, Adam Roggia, Kevin Schmid, Vincenzo Cannizzaro
Summary: This study analyzed the course of blood copeptin in critically ill children and found that high copeptin values were associated with arterial hypotension and disease severity, while low copeptin values did not indicate arginine-vasopressin deficiency.
Article
Anesthesiology
Markus Weiss, Pedro David Wendel-Garcia, Vincenzo Cannizzaro, Philipp K. Buehler, Maren Kleine-Brueggeney
Summary: This study demonstrates the impact of central venous pressure on fluid delivery during the start-up of syringe infusion pumps. A central venous pressure of 0 mmHg results in significant antegrade fluid delivery, while central venous pressure levels of 10 and 20 mmHg result in retrograde flows. This has important implications for clinical practice and calls for further research on improving start-up performance.
PEDIATRIC ANESTHESIA
(2023)
Article
Anesthesiology
Markus Weiss, Pedro David Wendel-Garcia, Vincenzo Cannizzaro, Philipp Karl Buehler, Maren Kleine-Brueggeney
Summary: The study aims to investigate the effect of the venting principle on the delivery of drugs through microinfusions using syringe pump assemblies. It was found that although the venting principle led to faster start-up times, it also resulted in higher backflow volumes when opening the three-way stopcock, thus not improving the timely delivery of drugs to the patients.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Oncology
Philipp Baumann, Francesco Greco, Pietro L'Abate, Sven Wellmann, Susanne Wiegert, Vincenzo Cannizzaro
Summary: Changes in positive end-expiratory pressure (PEEP), fraction of inspired oxygen (FiO2), and respiratory rate induce a significant systemic inflammatory response in infant rat plasma, emphasizing the importance of lung-protective ventilation strategies.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Physiology
Philipp Baumann, Vincenzo Cannizzaro
Summary: Insights from applied respiratory physiology are crucial for tailoring mechanical ventilation strategies, however clinicians often underutilize available lung function tools. This review highlights difficult conditions in evaluating lung function in critically ill children, discusses the importance of standardization and operator impact, and provides suggestions for addressing bedside lung function challenges.
CURRENT OPINION IN PHYSIOLOGY
(2021)
Letter
Pediatrics
Carsten Doell, Aurelie De Mul, Duy-Anh Nguyen, Marie-Helene Perez, Oliver Karam, Vincenzo Cannizzaro
JOURNAL OF PEDIATRIC INTENSIVE CARE
(2019)
Article
Pediatrics
Aurelie De Mul, Duy-Anh Nguyen, Carsten Doell, Marie-Helene Perez, Vincenzo Cannizzaro, Oliver Karam
JOURNAL OF PEDIATRIC INTENSIVE CARE
(2019)
Article
Physiology
Philipp Baumann, Susanne Wiegert, Francesco Greco, Sven Wellmann, Pietro L'Abate, Vincenzo Cannizzaro
PHYSIOLOGICAL REPORTS
(2018)
Article
Physiology
Alyssa R. Mickle, Jesus D. Penaloza-Aponte, Richard Coffey, Natale A. Hall, David Baekey, Erica A. Dale
Summary: Closed-loop epidural stimulation (CL-ES) can improve respiratory deficits caused by cervical spinal cord injury, restoring diaphragm activity and enhancing contralateral activity. This treatment has the potential to lead to lasting recovery and device independence.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Shawn Miller Jr, Edgar Juarez Lopez, Jessica M. L. Grittner, Brendan J. Dougherty
Summary: This study tested the impact of CO2 supplementation at different concentrations on ventilatory long-term facilitation (vLTF) in rats and found that 2% CO2 supplementation during and after acute, intermittent hypoxia (AIH) was sufficient to maintain isocapnia and induce significant vLTF.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Behnam Vafadari, Yoshitaka Oku, Charlotte Tacke, Ali Harb, Swen Huelsmann
Summary: The preBo·tzinger Complex (preBo·tC) in the brainstem plays a critical role in generating respiratory rhythm. This study aimed to investigate the activity of inhibitory glycinergic neurons in the preBo·tC of anesthetized mice. Using juxtacellular recordings and optogenetic activation, the researchers were able to identify and characterize the activity pattern of these inhibitory neurons in relation to the breathing rhythm.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Stephen M. Johnson, Maia G. Gumnit, Sarah M. Johnson, Tracy L. Baker, Jyoti J. Watters
Summary: Low-level activation of mu-opioid receptors can increase the amplitude of inspiratory bursts in neonatal rat brainstem-spinal cord preparations. Endomorphin-2, an endogenous ligand for these receptors, was found to have similar effects. Disinhibition of inhibitory synaptic transmission may not be involved in the changes induced by endomorphin-2, and different mechanisms may underlie the increase in burst amplitude and decrease in burst frequency.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Raphael Martins de Abreu, Beatrice Cairo, Patricia Rehder-Santos, Claudio Donisete da Silva, Etore De Favari Signini, Juliana Cristina Milan-Mattos, Camila Akemi Sakaguchi, Aparecida Maria Catai, Alberto Porta
Summary: The purpose of this study was to determine the association between exercise capacity based on peak oxygen uptake (VO2peak) and resting cardiorespiratory coupling (CRC) levels. The results showed that resting CRC values were associated with exercise capacity in athletes but not in non-athletes.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Sarah M. Russel, Raluca E. Gosman, Katherine Gonzalez, Joshua Wright, Dennis O. Frank-Ito
Summary: This study aimed to characterize the response of different nasal morphologies to airflow-related variables during rapid/deep inspiration. The results showed that notched nasal vestibules had higher resistance values and airflow velocities, while standard nasal vestibules had higher mucosal heat flux. Different nasal phenotypes may predispose individuals to exercise-induced rhinitis.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Ivan Poliacek, Lukas Martvon, Michal Simera, Marcel Veternik, Jakub Misek, Lucia Cibulkova, Kimberly E. Iceman, Donald C. Bolser, Teresa Pitts
Summary: An animal model study evaluated the effects of an abdominal incision on cough and swallow, revealing that abdominal wall manipulations can increase pharyngeal muscle activity during swallow without affecting the cough reflex. Swallowing tended to occur more during the inspiratory phase. The results highlight the important role of abdominal wall sensory feedback in regulating swallow motor patterns.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Rui Yu, Tatsuma Okazaki, Yuzhuo Ren, Junko Okuyama, Satoru Ebihara, Shin-Ichi Izumi
Summary: Body postures significantly influence respiratory muscle force, cough pressure, subjective ease of coughing, and pulmonary function. The 60-degree semi-recumbent posture and sitting posture show better results compared to the supine posture.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Suzuna Sato, Koji Ishida, Noriko I. Tanaka, Keisho Katayama
Summary: Respiratory muscle endurance training has beneficial effects on whole-body endurance performance. A novel high-intensity interval (HII) protocol is found to enhance the efficacy of respiratory muscle training programs.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Letter
Physiology
R. Arieli
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Correction
Physiology
Ivan Poliacek, Michal Simera, Marcel Veternik, Zuzana Kotmanova, Teresa Pitts, Jan Hanacek, Jana Plevkova, Peter Machac, Nadezda Visnovcova, Jakub Misek, Jan Jakus
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Dimitrios I. Bourdas, Nickos D. Geladas
Summary: This study examined the effects of breath-hold training on the performance of novice and elite breath-hold divers. The results showed that breath-hold training significantly improved red blood cell concentration, hemoglobin oxygen saturation steady state duration, and breath-hold time in novice divers. Elite divers had better breath-hold performance and higher peak mean arterial pressure compared to novices. The study suggests that breath-hold training can enhance the performance of divers.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)