Article
Optics
Victoria Helloiza Silva Silveira, Marcela Rodrigues de Camargo, Camila Loreta Rocha, Carmen Lucia Cardoso, Valdecir Farias Ximenes
Summary: The study focuses on a chemiluminescent reaction mediated by cobalt(II) as an efficient catalyst for the oxidation of 2-methylindol by hydrogen peroxide. The reaction exhibits strong chemiluminescence, with selectivity towards 2-methylindol compared to other indole derivatives. Cobalt(II) outperforms nine other transition metals as a catalyst, and factors such as pH, buffer constituents, and H2O2 concentration were optimized for efficient light emission.
JOURNAL OF LUMINESCENCE
(2023)
Article
Biochemistry & Molecular Biology
Shibo Sun, Weiping Xu, Yue Zhang, Yijia Yang, Qiang Ma, Jianqiang Xu
Summary: This study reveals that TrxR1 catalyzes the reduction of menadione in a Sec-independent manner, depending highly on Cys(498) instead. Mutation results showed that the U498C variant supported high-efficiency menadione reduction. The study also reveals that the Sec(498) of TrxR1 is the primary target of menadione.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biophysics
Hui Wang, Cuifang Liu, Xiaoting Zhang, Tiancong Xiu, Ping Li, Wei Zhang, Wen Zhang, Xin Wang, Zhenzhen Liu, Bo Tang
Summary: Investigating the use of a fluorescence probe to detect increased Golgi ROS levels in hypertensive mice, evaluating the efficacy of antihypertensive drugs, and identifying ROS post-transcriptional modification sites on dihydrofolate reductase. This suggests a new therapeutic target for hypertension and the development of new antihypertensive drugs.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemistry & Molecular Biology
Sandeep Negi, Deepti Chopra, Saumya Shukla, Apeksha Vikram, Sunil Kumar Patel, Lakshmi Bala, Ashish Dwivedi, Ratan Singh Ray
Summary: Tattooing is a popular fashion trend worldwide, but it poses risks of skin allergies and diseases. Benzo[ghi]perylene (BP) is a significant component of tattoo ink and absorbs ultraviolet radiation. A thorough safety study of BP exposed to UVR and sunlight is crucial to understand its hazardous impact on the skin.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maciej Jaskiewicz, Adrianna Moszynska, Jaroslaw Kroliczewski, Aleksandra Cabaj, Sylwia Bartoszewska, Agata Charzynska, Magda Gebert, Michal Dabrowski, James F. Collawn, Rafal Bartoszewski
Summary: HIF is a transcription factor that activates the adaptive hypoxic response during low oxygen levels. HIF-1 and HIF-2 mediate this response in a sequential manner, but their transcriptional profiles differ and the transition between them is not well understood.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Chemistry, Analytical
Ivana Novak Jovanovic, Robert Vianello, Dijana Jadresko, Livio Racane, Marijana Hranjec
Summary: This study reports on the electrochemical properties and antioxidant activity of four 2-hydroxy/methoxy-phenylbenzothiazole derivatives. The results show that two derivatives have the main electroactive center at the C6-amino group of the benzothiazole molecule, while the other two derivatives have the main electroactive center at the pyrogallol group.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Wenqing Wang, Shunjie Li, Qianqian Wang, Xuguang Ding, Yong Fang, Huapeng Ruan, Yue Zhao, Xinping Wang
Summary: The monoradical cation 1(center dot+) and anion 1(center dot-) based on tetracene were generated by oxidation and reduction, respectively. These species have the largest pi-fused skeletons reported to date. In the solid state, they form crystalline structures with intermolecular interactions supported by van der Waals forces and metal ions. EPR and DFT calculations confirm the delocalization of spin density over the whole molecules.
CHEMICAL COMMUNICATIONS
(2022)
Article
Cell & Tissue Engineering
Toshiharu Yamashita, Cat-Khanh Vuong, Nhat-Hoang Ngo, Motoo Osaka, Yuji Hiramatsu, Osamu Ohneda
Summary: Long-term glucocorticoid treatment impairs wound healing ability in adipose tissue-derived mesenchymal stem cells (sAT-MSC) due to downregulation of SDF-1. Our study found that sAT-MSC showed impaired HIF-1a and upregulated HIF-2a levels, with HIF-2a inhibition leading to compensatory overexpression of HIF-1a and SDF-1, improving wound healing ability. Additionally, HIF-2a reduction promoted wound healing effects and increased inflammatory cell recruitment through HIF-1a/SDF-1 axis.
STEM CELLS AND DEVELOPMENT
(2023)
Article
Immunology
Liwei Zhang, Mingxing Li, Zhiwei Wang, Peng Sun, Shunbo Wei, Cong Zhang, Haoliang Wu, Hualong Bai
Summary: This study elucidated the mechanisms underlying the cardiovascular risk associated with COVID-19 through multiple omics data analysis. The IL18/IL18R1/HIF1A axis was identified as a potential therapeutic target for cardiovascular protection after SARS-CoV-2 infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Liza Douiev, Chaya Miller, Shmuel Ruppo, Hadar Benyamini, Bassam Abu-Libdeh, Ann Saada
Summary: COX4-1 deficiency results in upregulation of COX4-2, leading to stabilization, nuclear localization, and upregulation of HIF-1 alpha as well as hypoxia and glycolysis pathways. This suggests a compensatory mechanism of COX4-2 and HIF-1 alpha in normoxia during COX4-1 deficiency.
Review
Gastroenterology & Hepatology
Zi-Niu Ding, Zhao-Ru Dong, Zhi-Qiang Chen, Ya-Fei Yang, Lun-Jie Yan, Hai-Chao Li, Kai-Xuan Liu, Cheng-Yu Yao, Yu-Chuan Yan, Chun-Cheng Yang, Tao Li
Summary: The study revealed that overexpression of HIF-1 alpha in hepatocellular carcinoma is associated with poorer prognosis and clinicopathological features, while HIF-2 alpha overexpression does not show the same associations. This suggests different roles of HIF-1 alpha and HIF-2 alpha in the progression and prognosis of hepatocellular carcinoma.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Engineering, Environmental
Yuhao Wu, Junke Wang, Tianxin Zhao, Jiadong Chen, Lian Kang, Yuexin Wei, Lindong Han, Lianju Shen, Chunlan Long, Shengde Wu, Guanghui Wei
Summary: Subacute exposure to DEHP leads to ferroptosis in mouse testes via the HIF-1 alpha/HO-1 signaling pathway.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Shisheng Wang, Xu Wang, Yujie Shao, Kun Shao, Yang Wang, Xiuhan Guo, Hongxu Dong, Weijie Zhao, Yueqing Li, Guangzhe Li
Summary: In this study, a series of compounds were synthesized with compound 9i showing potent HIF-1 inhibitory activity and potential as an antitumor agent. It effectively suppressed tumor cell growth and migration, demonstrating significant inhibition in a mouse breast cancer model.
BIOORGANIC CHEMISTRY
(2021)
Article
Genetics & Heredity
Soumitra Mohanty, Witchuda Kamolvit, Silvia Zambrana, Eduardo Gonzales, Jonas Tovi, Kerstin Brismar, Claes-Goran Ostenson, Annelie Brauner
Summary: Infections are common in patients with diabetes, and antibiotic resistance hampers bacterial clearance, calling for alternative treatment strategies. The study found that activation of HIF-1 in diabetic patients can enhance antimicrobial defense through factors such as LL-37. Pharmacological activation of HIF-1 decreased bacterial load in mice, suggesting a potential therapeutic role for HIF-1 along with antibiotics in patients where traditional therapy is not possible.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Medicine, General & Internal
Zhou Lan, Ke-Long Zou, Hao Cui, Hao Chen, Yu-Yue Zhao, Guang-Tao Yu
Summary: Hypoxia in solid tumors affects tumor therapy, but targeting the hypoxic tumor microenvironment shows promise. In this study, a drug carrier was developed to alleviate hypoxia and inhibit the growth of oral squamous cell carcinoma (OSCC).
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Physiology
Alyssa R. Mickle, Jesus D. Penaloza-Aponte, Richard Coffey, Natale A. Hall, David Baekey, Erica A. Dale
Summary: Closed-loop epidural stimulation (CL-ES) can improve respiratory deficits caused by cervical spinal cord injury, restoring diaphragm activity and enhancing contralateral activity. This treatment has the potential to lead to lasting recovery and device independence.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Shawn Miller Jr, Edgar Juarez Lopez, Jessica M. L. Grittner, Brendan J. Dougherty
Summary: This study tested the impact of CO2 supplementation at different concentrations on ventilatory long-term facilitation (vLTF) in rats and found that 2% CO2 supplementation during and after acute, intermittent hypoxia (AIH) was sufficient to maintain isocapnia and induce significant vLTF.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Behnam Vafadari, Yoshitaka Oku, Charlotte Tacke, Ali Harb, Swen Huelsmann
Summary: The preBo·tzinger Complex (preBo·tC) in the brainstem plays a critical role in generating respiratory rhythm. This study aimed to investigate the activity of inhibitory glycinergic neurons in the preBo·tC of anesthetized mice. Using juxtacellular recordings and optogenetic activation, the researchers were able to identify and characterize the activity pattern of these inhibitory neurons in relation to the breathing rhythm.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Stephen M. Johnson, Maia G. Gumnit, Sarah M. Johnson, Tracy L. Baker, Jyoti J. Watters
Summary: Low-level activation of mu-opioid receptors can increase the amplitude of inspiratory bursts in neonatal rat brainstem-spinal cord preparations. Endomorphin-2, an endogenous ligand for these receptors, was found to have similar effects. Disinhibition of inhibitory synaptic transmission may not be involved in the changes induced by endomorphin-2, and different mechanisms may underlie the increase in burst amplitude and decrease in burst frequency.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Raphael Martins de Abreu, Beatrice Cairo, Patricia Rehder-Santos, Claudio Donisete da Silva, Etore De Favari Signini, Juliana Cristina Milan-Mattos, Camila Akemi Sakaguchi, Aparecida Maria Catai, Alberto Porta
Summary: The purpose of this study was to determine the association between exercise capacity based on peak oxygen uptake (VO2peak) and resting cardiorespiratory coupling (CRC) levels. The results showed that resting CRC values were associated with exercise capacity in athletes but not in non-athletes.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Sarah M. Russel, Raluca E. Gosman, Katherine Gonzalez, Joshua Wright, Dennis O. Frank-Ito
Summary: This study aimed to characterize the response of different nasal morphologies to airflow-related variables during rapid/deep inspiration. The results showed that notched nasal vestibules had higher resistance values and airflow velocities, while standard nasal vestibules had higher mucosal heat flux. Different nasal phenotypes may predispose individuals to exercise-induced rhinitis.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Ivan Poliacek, Lukas Martvon, Michal Simera, Marcel Veternik, Jakub Misek, Lucia Cibulkova, Kimberly E. Iceman, Donald C. Bolser, Teresa Pitts
Summary: An animal model study evaluated the effects of an abdominal incision on cough and swallow, revealing that abdominal wall manipulations can increase pharyngeal muscle activity during swallow without affecting the cough reflex. Swallowing tended to occur more during the inspiratory phase. The results highlight the important role of abdominal wall sensory feedback in regulating swallow motor patterns.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Rui Yu, Tatsuma Okazaki, Yuzhuo Ren, Junko Okuyama, Satoru Ebihara, Shin-Ichi Izumi
Summary: Body postures significantly influence respiratory muscle force, cough pressure, subjective ease of coughing, and pulmonary function. The 60-degree semi-recumbent posture and sitting posture show better results compared to the supine posture.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Suzuna Sato, Koji Ishida, Noriko I. Tanaka, Keisho Katayama
Summary: Respiratory muscle endurance training has beneficial effects on whole-body endurance performance. A novel high-intensity interval (HII) protocol is found to enhance the efficacy of respiratory muscle training programs.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Letter
Physiology
R. Arieli
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Correction
Physiology
Ivan Poliacek, Michal Simera, Marcel Veternik, Zuzana Kotmanova, Teresa Pitts, Jan Hanacek, Jana Plevkova, Peter Machac, Nadezda Visnovcova, Jakub Misek, Jan Jakus
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Dimitrios I. Bourdas, Nickos D. Geladas
Summary: This study examined the effects of breath-hold training on the performance of novice and elite breath-hold divers. The results showed that breath-hold training significantly improved red blood cell concentration, hemoglobin oxygen saturation steady state duration, and breath-hold time in novice divers. Elite divers had better breath-hold performance and higher peak mean arterial pressure compared to novices. The study suggests that breath-hold training can enhance the performance of divers.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)