期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 170, 期 3, 页码 279-286出版社
ELSEVIER
DOI: 10.1016/j.resp.2010.01.017
关键词
Ventilatory constraint; Respiratory mechanics; Cycling; Pulmonary function
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- British Columbia Lung Association
- Michael Smith Foundation for Health Research
- Sir James Lougheed Award of Distinction
- MSFHR
- Canadian Institutes of Health Research
Expiratory flow limitation (EFL) during exercise may be overestimated or falsely detected when superimposing tidal breaths within a pre-exercise maximal expiratory flow volume (MEFV) curve due to thoracic gas compression (TGC) and bronchodilation. Accordingly, the purpose of this study was to determine the effects of TGC and bronchodilation on the assessment of EFL in 35 healthy subjects. A pre-exercise forced vital capacity (FVC) maneuver was performed that did not account for TGC (MEFVpre). Subjects then performed graded expirations from total lung capacity to residual volume at different efforts to account for TGC (MEFVpre-TGC). Post-exercise FVC (MEFVpost) and post-exercise graded expirations (MEFVpost-TGC) were performed to account for bronchodilation and TGC. EFL occurred in 29 subjects when using MEFVpre. The magnitude of EFL in these subjects was 47 +/- 23% which was significantly higher than MEFV(pre-TGC)d (28 +/- 28%), MEFVpost (24 +/- 27%) and MEFVpost-TGC (19 +/- 24%) (P<0.00001). Using the traditional MEFVpre curve overestimates and falsely detects EFL since it does not account for TGC and bronchodilation. (C) 2010 Elsevier B.V. All rights reserved.
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