Article
Critical Care Medicine
Simon W. Lam, Gretchen L. Sacha, Abhijit Duggal, Anita J. Reddy, Seth R. Bauer
Summary: This study compared the outcomes of patients recovering from septic shock who had abrupt discontinuation or tapering discontinuation of AVP. The results showed no significant difference in time to ICU discharge, mortality rates, or incidence of hypotension between the two groups. However, patients in the tapering discontinuation group more frequently required an escalation of AVP dose.
Article
Neurosciences
Lindsay J. Agostinelli, Scott C. Seaman, Clifford B. Saper, Dustin P. Fykstra, Marco M. Hefti, Timothy R. Koscik, Brian J. Dlouhy, Alexander G. Bassuk
Summary: Researchers report a study that combines high-resolution MRI and detailed histology to study the impact of neurologic disease on specific cell groups in the human brainstem and cerebellum. These findings are crucial for understanding and diagnosing brainstem lesions.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Psychiatry
Anya Savransky, Joshua Chiappelli, Xiaoming Du, Kathleen Carino, Mark Kvarta, Heather Bruce, Peter Kochunov, Eric Goldwaser, Yunlong Tan, Stephanie Hare, L. Elliot Hong
Summary: This study found significantly higher levels of overnight norepinephrine in patients with schizophrenia, along with reduced working memory performance, compared to healthy controls. There was a significant negative correlation between norepinephrine and working memory in patients, independent of age, sex, and medication. These results suggest a potential peripheral impact of norepinephrine on working memory in schizophrenia that warrants further investigation.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Medicine, General & Internal
Agoston Patthy, Janos Murai, Janos Hanics, Anna Pinter, Peter Zahola, Tomas G. M. Hokfelt, Tibor Harkany, Alan Alpar
Summary: Alzheimer's disease (AD) is a devastating neurodegenerative disorder for which an effective therapy has yet to be found. Research suggests that early damage to the ascending monoaminergic system in the brainstem may be an early sign and potential trigger of AD. In addition, cortical malfunction and local neurohistopathology are also related to the progression of AD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Engineering, Environmental
Jia An, Yuxia Shi, Junan Fang, Yongqin Hu, Yufei Liu
Summary: This study successfully developed a fluorescence turn-on strategy to distinguish catecholamines (CAs) molecules, such as dopamine, epinephrine, and norepinephrine, as well as their precursor levodopa, with high sensitivity and selectivity. The ratiometric fluorescent probes were validated for quantitative detection in real human serum and urine samples, opening up a novel avenue for the rapid identification and clinical diagnosis of CAs.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Cindy Bandala, Alberto Avila-Luna, Modesto Gomez-Lopez, Erendira Estrada-Villasenor, Sergio Montes, Alfonso Alfaro-Rodriguez, Angel Miliar-Garcia, Jose L. Cortes-Altamirano, Raul Peralta, Gabriela Ibanez-Cervantes, Saul Gomez-Manzo, Noemi Cardenas-Rodriguez, Eleazar Lara-Padilla
Summary: This study identified higher levels of 3,4-dihydroxyphenylacetic acid and norepinephrine in osteosarcoma tissue compared to adjacent and non-oncological bone, suggesting they could be potential molecular markers for osteosarcoma progression. Additionally, gene expression of key receptors and enzymes related to catecholamines was also found to be significantly higher in tumour tissue, indicating their potential role in the development of osteosarcoma.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Neurosciences
Kanza M. Khan, Nagalakshmi Balasubramanian, Gabriel Gaudencio, Ruixiang Wang, Govindhasamy Pushpavathi Selvakumar, Louis Kolling, Samantha Pierson, Satya M. Tadinada, Ted Abel, Marco Hefti, Catherine A. Marcinkiewcz
Summary: Alzheimer's disease (AD) affects over 6 million Americans and presents with mood and sleep changes in the early stages. This study evaluated depressive and anxiety-like behaviors in a mouse model of AD and found a correlation with tau pathology, neuroinflammation, and monoaminergic dysregulation. The results suggest that tau pathology in brainstem monoaminergic nuclei may underpin the behavioral changes observed in the early stages of AD.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Immunology
Cengiz Korkmaz, Dondu Uskudar Cansu, Guven Baris Cansu
Summary: This article discusses the effects of Colchicine on the central nervous system (CNS) and peripheral nervous system (PNS), and emphasizes the potential mechanisms of action. Research on this topic will help uncover the pathogenesis of FMF attacks and other mechanisms of action of Col apart from its anti-inflammatory features.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
David Coquerel, Julie Lamoureux, Frederic Chagnon, Kien Tran, Michael Sage, Etienne Fortin-Pellerin, Eugenie Delile, Xavier Sainsily, Justin Fournier, Audrey-Ann Dumont, Mannix Auger-Messier, Philippe Sarret, Eric Marsault, Jean-Paul Praud, Tamas Fulop, Olivier Lesur
Summary: The study found that in an experimental design of septic shock, apelinergics could effectively improve cardiovascular function, but in the early stage of human sepsis, endogenous apelinergic levels rose, potentially threatened by specific enzymatic breakdown activities, which negatively impacted the outcome of human sepsis.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Safwan Omran, Larissa Schawe, Frank Konietschke, Stefan Angermair, Benjamin Weixler, Sascha Treskatsch, Andreas Greiner, Christian Berger
Summary: This retrospective study evaluated perioperative and ICU variables to predict colonic ischemia after infrarenal RAAA surgery. The study found that most patients developed CI within the first 3 postoperative days. Laboratory findings such as serum lactate, minimum pH, serum bicarbonate, and platelet count were associated with the development of CI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Geriatrics & Gerontology
Christopher H. van Dyck, Amy F. T. Arnsten, Prasad R. Padala, Olga Brawman-Mintzer, Alan J. Lerner, Anton P. Porsteinsson, Roberta W. Scherer, Allan I. Levey, Nathan Herrmann, Nimra Jamil, Jacobo E. Mintzer, Krista L. Lanctot, Paul B. Rosenberg
Summary: Apathy is a common symptom in patients with Alzheimer's disease, and previous treatment methods have been ineffective. Methylphenidate has shown promising results in initial trials for treating apathy, possibly by boosting norepinephrine and dopamine actions in brain circuits. Understanding the role of neuronal circuits and neurotransmitters in motivated behavior may provide insight into developing more effective treatments for apathy in Alzheimer's disease.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Michiaki Nagai, Sergey Shityakov, Manuel Smetak, Hannah Jill Hunkler, Christian Baer, Nicolas Schlegel, Thomas Thum, Carola Yvette Foerster
Summary: Takotsubo syndrome (TTS), characterized by transient wall motion abnormalities of the left ventricle, presents challenges in diagnosis. A comprehensive blood analysis of TTS patients revealed differences in proinflammatory cytokine expression patterns and receptor expression levels. Surprisingly, catecholamine levels in TTS patients were significantly lower than experimentally induced TTS in animals, and exposure to these lower levels did not damage endothelial cells or cardiomyocytes in vitro. Computational analysis identified blood markers and microRNAs associated with TTS development and inflammation. In addition to known risk factors, inflammaging-related pathways were found to contribute to TTS.
Article
Biochemistry & Molecular Biology
Monojit Bhattacharjee, Suryaa Manoharan, Uma Maheswari Deshetty, Ekambaram Perumal
Summary: This study investigates the effects of acute HH on CA and BH4 levels and their impact on neurobehavior. The results show significant alterations in CA levels in different brain regions of rats exposed to HH, which leads to reduced motor activity, motor coordination, and spatial memory. The study provides novel insights into the role of BH4 and CA in HH-induced neurobehavioral impairments.
NEUROCHEMICAL RESEARCH
(2023)
Article
Behavioral Sciences
Jesse D. Hoffmeister, Cynthia A. Kelm-Nelson, Michelle R. Ciucci
Summary: Vocal communication impairment and anxiety are common symptoms of Parkinson's Disease and both are influenced by the noradrenergic system. The study revealed significant relationships between vocal impairment, anxiety, and brainstem norepinephrine in a genetic rat model of PD.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Cristina M. Santana Maldonado, Dong-Suk Kim, Benton Purnell, Rui Li, Gordon F. Buchanan, Jodi Smith, Daniel R. Thedens, Phillip Gauger, Wilson K. Rumbeiha
Summary: Hydrogen sulfide (H2S) is a toxic gas that affects the cardiovascular, respiratory, and central nervous systems. This study aimed to investigate the toxic mechanisms and effects of acute H2S poisoning on the brainstem. The results showed that H2S exposure caused differential effects on brainstem neurotransmitters, induced neurodegeneration, and biochemical changes. Further research is needed to fully understand the implications of acute H2S poisoning on vital functions regulated by the brainstem.
Article
Neurosciences
K. Tree, J. C. Viemari, F. Cayetanot, J. Peyronnet
JOURNAL OF NEUROPHYSIOLOGY
(2016)
Article
Neurosciences
Jean-Charles Viemari, Alfredo J. Garcia, Atsushi Doi, Jan-Marino Ramirez
EUROPEAN JOURNAL OF NEUROSCIENCE
(2011)
Article
Neurosciences
Aurelie Stil, Celine Jean-Xavier, Sylvie Liabeuf, Cecile Brocard, Eric Delpire, Laurent Vinay, Jean-Charles Viemari
EUROPEAN JOURNAL OF NEUROSCIENCE
(2011)
Review
Clinical Neurology
Charles J. Marcuccilli, Andrew K. Tryba, Wim van Drongelen, Henner Koch, Jean Charles Viemari, Fernando Pena-Ortega, Erin L. Doren, Peter Pytel, Marc Chevalier, Ana Mrejeru, Michael H. Kohrman, Robert E. Lasky, Sean M. Lew, David M. Frim, Jan-Marino Ramirez
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2010)
Article
Neurosciences
Michael S. Carroll, Jean-Charles Viemari, Jan-Marino Ramirez
JOURNAL OF NEUROPHYSIOLOGY
(2013)
Article
Neurosciences
Steven A. Crone, Jean-Charles Viemari, Steven Droho, Ana Mrejeru, Jan-Marino Ramirez, Kamal Sharma
JOURNAL OF NEUROSCIENCE
(2012)
Review
Medicine, Research & Experimental
Jean-Charles Viemari, Clement Menuet, Gerard Hilaire
M S-MEDECINE SCIENCES
(2013)
Article
Pediatrics
Blandine Bellot, Julie Peyronnet-Roux, Catherine Gire, Umberto Simeoni, Laurent Vinay, Jean-Charles Viemari
PEDIATRIC RESEARCH
(2014)
Article
Multidisciplinary Sciences
Loubna Khalki, Saadia Ba M'hamed, Zahra Sokar, Mohamed Bennis, Laurent Vinay, Helene Bras, Jean-Charles Viemari
Article
Multidisciplinary Sciences
Hind Benammi, Hasna Erazi, Omar El Hiba, Laurent Vinay, Helene Bras, Jean-Charles Viemari, Halima Gamrani
Review
Physiology
Jean-Charles Viemari, Andrew K. Tryba
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2009)
Article
Neurosciences
Jean-Charles Viemari, Alfredo J. Garcia, Atsushi Doi, Gina Elsen, Jan-Marino Ramirez
FRONTIERS IN NEURAL CIRCUITS
(2013)
Article
Physiology
Alfredo J. Garcia, Jean Charles Viemari, Maggie A. Khuu
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2019)
Article
Clinical Neurology
Diego Alzate-Correa, Jillian Mei-ling Liu, Mikayla Jones, Talita M. Silva, Michele Joana Alves, Elizabeth Burke, Jessica Zuniga, Behiye Kaya, Giuliana Zaza, Mehmet Tahir Aslan, Jessica Blackburn, Marina Y. Shimada, Silvio A. Fernandes-Junior, Lisa A. Baer, Kristin Stanford, Amber Kempton, Sakima Smith, Caroline C. Szujewski, Abby Silbaugh, Jean-Charles Viemari, Ana C. Takakura, Alfredo J. Garcia, Thiago S. Moreira, Catherine M. Czeisler, Jose J. Otero
Summary: The mutated Phox2b protein expression in neurons is associated with apneic episodes in CCHS patients shortly after birth, possibly due to disruptions in visceral motor neuron development.
Review
Clinical Neurology
Lucile Brun, Jean-Charles Viemari, Laurent Villard
Summary: Variants in the KCNQ2 gene can cause epileptic disorders of different severities, but the biological mechanisms are still unclear. Previous studies using KCNQ2 models have helped to elucidate the pathological mechanisms and identify new therapeutic targets.
Article
Physiology
Alyssa R. Mickle, Jesus D. Penaloza-Aponte, Richard Coffey, Natale A. Hall, David Baekey, Erica A. Dale
Summary: Closed-loop epidural stimulation (CL-ES) can improve respiratory deficits caused by cervical spinal cord injury, restoring diaphragm activity and enhancing contralateral activity. This treatment has the potential to lead to lasting recovery and device independence.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Shawn Miller Jr, Edgar Juarez Lopez, Jessica M. L. Grittner, Brendan J. Dougherty
Summary: This study tested the impact of CO2 supplementation at different concentrations on ventilatory long-term facilitation (vLTF) in rats and found that 2% CO2 supplementation during and after acute, intermittent hypoxia (AIH) was sufficient to maintain isocapnia and induce significant vLTF.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Behnam Vafadari, Yoshitaka Oku, Charlotte Tacke, Ali Harb, Swen Huelsmann
Summary: The preBo·tzinger Complex (preBo·tC) in the brainstem plays a critical role in generating respiratory rhythm. This study aimed to investigate the activity of inhibitory glycinergic neurons in the preBo·tC of anesthetized mice. Using juxtacellular recordings and optogenetic activation, the researchers were able to identify and characterize the activity pattern of these inhibitory neurons in relation to the breathing rhythm.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Stephen M. Johnson, Maia G. Gumnit, Sarah M. Johnson, Tracy L. Baker, Jyoti J. Watters
Summary: Low-level activation of mu-opioid receptors can increase the amplitude of inspiratory bursts in neonatal rat brainstem-spinal cord preparations. Endomorphin-2, an endogenous ligand for these receptors, was found to have similar effects. Disinhibition of inhibitory synaptic transmission may not be involved in the changes induced by endomorphin-2, and different mechanisms may underlie the increase in burst amplitude and decrease in burst frequency.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Raphael Martins de Abreu, Beatrice Cairo, Patricia Rehder-Santos, Claudio Donisete da Silva, Etore De Favari Signini, Juliana Cristina Milan-Mattos, Camila Akemi Sakaguchi, Aparecida Maria Catai, Alberto Porta
Summary: The purpose of this study was to determine the association between exercise capacity based on peak oxygen uptake (VO2peak) and resting cardiorespiratory coupling (CRC) levels. The results showed that resting CRC values were associated with exercise capacity in athletes but not in non-athletes.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Sarah M. Russel, Raluca E. Gosman, Katherine Gonzalez, Joshua Wright, Dennis O. Frank-Ito
Summary: This study aimed to characterize the response of different nasal morphologies to airflow-related variables during rapid/deep inspiration. The results showed that notched nasal vestibules had higher resistance values and airflow velocities, while standard nasal vestibules had higher mucosal heat flux. Different nasal phenotypes may predispose individuals to exercise-induced rhinitis.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Ivan Poliacek, Lukas Martvon, Michal Simera, Marcel Veternik, Jakub Misek, Lucia Cibulkova, Kimberly E. Iceman, Donald C. Bolser, Teresa Pitts
Summary: An animal model study evaluated the effects of an abdominal incision on cough and swallow, revealing that abdominal wall manipulations can increase pharyngeal muscle activity during swallow without affecting the cough reflex. Swallowing tended to occur more during the inspiratory phase. The results highlight the important role of abdominal wall sensory feedback in regulating swallow motor patterns.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Rui Yu, Tatsuma Okazaki, Yuzhuo Ren, Junko Okuyama, Satoru Ebihara, Shin-Ichi Izumi
Summary: Body postures significantly influence respiratory muscle force, cough pressure, subjective ease of coughing, and pulmonary function. The 60-degree semi-recumbent posture and sitting posture show better results compared to the supine posture.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Suzuna Sato, Koji Ishida, Noriko I. Tanaka, Keisho Katayama
Summary: Respiratory muscle endurance training has beneficial effects on whole-body endurance performance. A novel high-intensity interval (HII) protocol is found to enhance the efficacy of respiratory muscle training programs.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Letter
Physiology
R. Arieli
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Correction
Physiology
Ivan Poliacek, Michal Simera, Marcel Veternik, Zuzana Kotmanova, Teresa Pitts, Jan Hanacek, Jana Plevkova, Peter Machac, Nadezda Visnovcova, Jakub Misek, Jan Jakus
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)
Article
Physiology
Dimitrios I. Bourdas, Nickos D. Geladas
Summary: This study examined the effects of breath-hold training on the performance of novice and elite breath-hold divers. The results showed that breath-hold training significantly improved red blood cell concentration, hemoglobin oxygen saturation steady state duration, and breath-hold time in novice divers. Elite divers had better breath-hold performance and higher peak mean arterial pressure compared to novices. The study suggests that breath-hold training can enhance the performance of divers.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2024)